1zs4 - Revision history

OCA at 09:06, 14 February 2024

OCA — Wed, 14 Feb 2024 09:06:33 GMT

←Older revision		Revision as of 09:06, 14 February 2024
Line 3:		Line 3:
	<StructureSection load='1zs4' size='340' side='right'caption='[[1zs4]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1zs4' size='340' side='right'caption='[[1zs4]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1zs4]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Bacteriophage_lambda Bacteriophage lambda~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZS4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZS4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1zs4]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_Lambda Escherichia virus Lambda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZS4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZS4 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1zpq\|1zpq]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">CII ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=10710 Bacteriophage lambda])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zs4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zs4 OCA], [https://pdbe.org/1zs4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zs4 RCSB], [https://www.ebi.ac.uk/pdbsum/1zs4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zs4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zs4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zs4 OCA], [https://pdbe.org/1zs4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zs4 RCSB], [https://www.ebi.ac.uk/pdbsum/1zs4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zs4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/RPC2_LAMBD RPC2_LAMBD]] This protein and protein CIII form a complex that is involved in the initiation of lysogeny. The complex binds at either of the cy regulatory sites preceding the CI repressor protein and integrase coding regions and induces transcription of these genes.	+	[https://www.uniprot.org/uniprot/RPC2_LAMBD RPC2_LAMBD] This protein and protein CIII form a complex that is involved in the initiation of lysogeny. The complex binds at either of the cy regulatory sites preceding the CI repressor protein and integrase coding regions and induces transcription of these genes.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 20:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zs4 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zs4 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The tetrameric cII protein from bacteriophage lambda activates transcription from the phage promoters P(RE), P(I), and P(AQ) by binding to two direct repeats that flank the promoter -35 element. Here, we present the X-ray crystal structure of cII alone (2.8 A resolution) and in complex with its DNA operator from P(RE) (1.7 A resolution). The structures provide a basis for modeling of the activation complex with the RNA polymerase holoenzyme, and point to the key role for the RNA polymerase alpha subunit C-terminal domain (alphaCTD) in cII-dependent activation, which forms a bridge of protein/protein interactions between cII and the RNA polymerase sigma subunit. The model makes specific predictions for protein/protein interactions between cII and alphaCTD, and between alphaCTD and sigma, which are supported by previous genetic studies.
-
-	Crystal structure of bacteriophage lambda cII and its DNA complex.,Jain D, Kim Y, Maxwell KL, Beasley S, Zhang R, Gussin GN, Edwards AM, Darst SA Mol Cell. 2005 Jul 22;19(2):259-69. PMID:16039594<ref>PMID:16039594</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1zs4" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacteriophage lambda~~]]	+	[[Category: Escherichia virus Lambda]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Beasley, S]]	+	[[Category: Beasley S]]
-	[[Category: Darst~~, S A~~]]	+	[[Category: Darst SA]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: Edwards AM]]
-	[[Category: Gussin~~, G N~~]]	+	[[Category: Gussin GN]]
-	[[Category: Jain, D]]	+	[[Category: Jain D]]
-	[[Category: Kim, Y]]	+	[[Category: Kim Y]]
-	[[Category: Maxwell~~, K L]]~~	+	[[Category: Maxwell KL]]
-	~~[[Category: Helix-turn-helix]]~~	+
-	~~[[Category: Transcription activator]]~~	+
-	~~[[Category: Transcription-dna complex~~]]	+

OCA at 08:15, 27 January 2021

OCA — Wed, 27 Jan 2021 08:15:42 GMT

←Older revision		Revision as of 08:15, 27 January 2021
Line 1:		Line 1:

	==Structure of bacteriophage lambda cII protein in complex with DNA==		==Structure of bacteriophage lambda cII protein in complex with DNA==
-	<StructureSection load='1zs4' size='340' side='right' caption='[[1zs4]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='1zs4' size='340' side='right'caption='[[1zs4]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1zs4]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bacteriophage_lambda Bacteriophage lambda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZS4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ZS4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1zs4]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacteriophage_lambda Bacteriophage lambda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZS4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZS4 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zpq\|1zpq]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1zpq\|1zpq]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CII ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10710 Bacteriophage lambda])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CII ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10710 Bacteriophage lambda])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1zs4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zs4 OCA], [~~http~~://pdbe.org/1zs4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1zs4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1zs4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1zs4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zs4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zs4 OCA], [https://pdbe.org/1zs4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zs4 RCSB], [https://www.ebi.ac.uk/pdbsum/1zs4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zs4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RPC2_LAMBD RPC2_LAMBD]] This protein and protein CIII form a complex that is involved in the initiation of lysogeny. The complex binds at either of the cy regulatory sites preceding the CI repressor protein and integrase coding regions and induces transcription of these genes.	+	[[https://www.uniprot.org/uniprot/RPC2_LAMBD RPC2_LAMBD]] This protein and protein CIII form a complex that is involved in the initiation of lysogeny. The complex binds at either of the cy regulatory sites preceding the CI repressor protein and integrase coding regions and induces transcription of these genes.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Bacteriophage lambda]]		[[Category: Bacteriophage lambda]]
		+	[[Category: Large Structures]]
	[[Category: Beasley, S]]		[[Category: Beasley, S]]
	[[Category: Darst, S A]]		[[Category: Darst, S A]]

OCA at 09:08, 2 May 2018

OCA — Wed, 02 May 2018 09:08:38 GMT

←Older revision		Revision as of 09:08, 2 May 2018
Line 1:		Line 1:
		+
	==Structure of bacteriophage lambda cII protein in complex with DNA==		==Structure of bacteriophage lambda cII protein in complex with DNA==
	<StructureSection load='1zs4' size='340' side='right' caption='[[1zs4]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1zs4' size='340' side='right' caption='[[1zs4]], [[Resolution\|resolution]] 1.70Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zpq\|1zpq]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zpq\|1zpq]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10710 Bacteriophage lambda])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10710 Bacteriophage lambda])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zs4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zs4 OCA], [http://pdbe.org/1zs4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zs4 RCSB], [http://www.ebi.ac.uk/pdbsum/1zs4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zs4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zs4 OCA], [http://pdbe.org/1zs4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zs4 RCSB], [http://www.ebi.ac.uk/pdbsum/1zs4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1zs4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zs/1zs4_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zs/1zs4_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zs4 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:47, 11 September 2015

OCA — Fri, 11 Sep 2015 10:47:55 GMT

←Older revision		Revision as of 10:47, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1zs4' size='340' side='right' caption='[[1zs4]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1zs4' size='340' side='right' caption='[[1zs4]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1zs4]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Enterobacteria_phage_lambda Enterobacteria phage~~ lambda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZS4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZS4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1zs4]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacteriophage_lambda Bacteriophage lambda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZS4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZS4 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zpq\|1zpq]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zpq\|1zpq]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10710 ~~Enterobacteria phage~~ lambda])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10710 Bacteriophage lambda])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zs4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zs4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zs4 RCSB], [http://www.ebi.ac.uk/pdbsum/1zs4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zs4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zs4 OCA], [http://pdbe.org/1zs4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zs4 RCSB], [http://www.ebi.ac.uk/pdbsum/1zs4 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1zs4" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Enterobacteria phage~~ lambda]]	+	[[Category: Bacteriophage lambda]]
	[[Category: Beasley, S]]		[[Category: Beasley, S]]
	[[Category: Darst, S A]]		[[Category: Darst, S A]]

OCA at 15:25, 25 December 2014

OCA — Thu, 25 Dec 2014 15:25:32 GMT

←Older revision		Revision as of 15:25, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1zs4]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_lambda Enterobacteria phage lambda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZS4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZS4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zs4]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_lambda Enterobacteria phage lambda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZS4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZS4 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zpq\|1zpq]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zpq\|1zpq]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10710 Enterobacteria phage lambda])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10710 Enterobacteria phage lambda])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zs4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zs4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zs4 RCSB], [http://www.ebi.ac.uk/pdbsum/1zs4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zs4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zs4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zs4 RCSB], [http://www.ebi.ac.uk/pdbsum/1zs4 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RPC2_LAMBD RPC2_LAMBD]] This protein and protein CIII form a complex that is involved in the initiation of lysogeny. The complex binds at either of the cy regulatory sites preceding the CI repressor protein and integrase coding regions and induces transcription of these genes.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Enterobacteria phage lambda]]		[[Category: Enterobacteria phage lambda]]
-	[[Category: Beasley, S.]]	+	[[Category: Beasley, S]]
-	[[Category: Darst, S A.]]	+	[[Category: Darst, S A]]
-	[[Category: Edwards, A M.]]	+	[[Category: Edwards, A M]]
-	[[Category: Gussin, G N.]]	+	[[Category: Gussin, G N]]
-	[[Category: Jain, D.]]	+	[[Category: Jain, D]]
-	[[Category: Kim, Y.]]	+	[[Category: Kim, Y]]
-	[[Category: Maxwell, K L.]]	+	[[Category: Maxwell, K L]]
	[[Category: Helix-turn-helix]]		[[Category: Helix-turn-helix]]
	[[Category: Transcription activator]]		[[Category: Transcription activator]]
	[[Category: Transcription-dna complex]]		[[Category: Transcription-dna complex]]

OCA at 08:33, 3 October 2014

OCA — Fri, 03 Oct 2014 08:33:52 GMT

←Older revision		Revision as of 08:33, 3 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1zs4~~\| ~~PDB~~=1zs4 \| ~~SCENE~~= }}	+	==Structure of bacteriophage lambda cII protein in complex with DNA==
-	===~~Structure~~ of bacteriophage lambda cII ~~protein~~ in complex with DNA~~===~~	+	<StructureSection load='1zs4' size='340' side='right' caption='[[1zs4]], [[Resolution\|resolution]] 1.70Å' scene=''>
-	~~{{ABSTRACT_PUBMED_16039594}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1zs4]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_lambda Enterobacteria phage lambda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZS4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZS4 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zpq\|1zpq]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10710 Enterobacteria phage lambda])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zs4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zs4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zs4 RCSB], [http://www.ebi.ac.uk/pdbsum/1zs4 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zs/1zs4_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The tetrameric cII protein from bacteriophage lambda activates transcription from the phage promoters P(RE), P(I), and P(AQ) by binding to two direct repeats that flank the promoter -35 element. Here, we present the X-ray crystal structure of cII alone (2.8 A resolution) and in complex with its DNA operator from P(RE) (1.7 A resolution). The structures provide a basis for modeling of the activation complex with the RNA polymerase holoenzyme, and point to the key role for the RNA polymerase alpha subunit C-terminal domain (alphaCTD) in cII-dependent activation, which forms a bridge of protein/protein interactions between cII and the RNA polymerase sigma subunit. The model makes specific predictions for protein/protein interactions between cII and alphaCTD, and between alphaCTD and sigma, which are supported by previous genetic studies.

-	~~==Function==~~	+	Crystal structure of bacteriophage lambda cII and its DNA complex.,Jain D, Kim Y, Maxwell KL, Beasley S, Zhang R, Gussin GN, Edwards AM, Darst SA Mol Cell. 2005 Jul 22;19(2):259-69. PMID:16039594<ref>PMID:16039594</ref>
-	~~[[http://www.uniprot.org/uniprot/RPC2_LAMBD RPC2_LAMBD]] This protein~~ and ~~protein CIII form a~~ complex ~~that is involved in the initiation of lysogeny~~. ~~The complex binds at either of the cy regulatory sites preceding the CI repressor protein and integrase coding regions and induces transcription of these genes~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[1zs4]] is~~ a ~~6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Enterobacteria_phage_lambda Enterobacteria phage lambda]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1ZS4 OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:016039594</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Enterobacteria phage lambda]]		[[Category: Enterobacteria phage lambda]]
	[[Category: Beasley, S.]]		[[Category: Beasley, S.]]

OCA at 08:16, 23 April 2014

OCA — Wed, 23 Apr 2014 08:16:04 GMT

←Older revision		Revision as of 08:16, 23 April 2014
Line 1:		Line 1:
-	[[Image:1zs4.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_1zs4", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1zs4\| PDB=1zs4 \| SCENE= }}		{{STRUCTURE_1zs4\| PDB=1zs4 \| SCENE= }}
-
	===Structure of bacteriophage lambda cII protein in complex with DNA===		===Structure of bacteriophage lambda cII protein in complex with DNA===
		+	{{ABSTRACT_PUBMED_16039594}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/RPC2_LAMBD RPC2_LAMBD]] This protein and protein CIII form a complex that is involved in the initiation of lysogeny. The complex binds at either of the cy regulatory sites preceding the CI repressor protein and integrase coding regions and induces transcription of these genes.
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_16039594}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov), where 16039594~~ is the ~~PubMed ID number~~.	+
-	~~-->~~	+
-	~~{{ABSTRACT_PUBMED_16039594}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:016039594</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016039594</ref><references group="xtra"/><references/>
	[[Category: Enterobacteria phage lambda]]		[[Category: Enterobacteria phage lambda]]
	[[Category: Beasley, S.]]		[[Category: Beasley, S.]]

OCA: Protected "1zs4" [edit=sysop:move=sysop]

OCA — Wed, 28 Dec 2011 05:41:01 GMT

Protected "1zs4" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:41, 28 December 2011

OCA at 05:40, 28 December 2011

OCA — Wed, 28 Dec 2011 05:40:57 GMT

←Older revision		Revision as of 05:40, 28 December 2011
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1zs4.png\|left\|200px]]		[[Image:1zs4.png\|left\|200px]]

Line 20:		Line 19:

	==About this Structure==		==About this Structure==
-	~~1ZS4~~ is a 6 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Enterobacteria_phage_lambda Enterobacteria phage lambda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZS4 OCA].	+	[[1zs4]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_lambda Enterobacteria phage lambda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZS4 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16039594~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016039594</ref><references group="xtra"/>
	[[Category: Enterobacteria phage lambda]]		[[Category: Enterobacteria phage lambda]]
	[[Category: Beasley, S.]]		[[Category: Beasley, S.]]
Line 34:		Line 33:
	[[Category: Helix-turn-helix]]		[[Category: Helix-turn-helix]]
	[[Category: Transcription activator]]		[[Category: Transcription activator]]
-		+	[[Category: Transcription-dna complex]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 20:16:41 2009''~~	+

OCA at 18:16, 17 February 2009

OCA — Tue, 17 Feb 2009 18:16:42 GMT

←Older revision		Revision as of 18:16, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1ZS4 is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Enterobacteria_phage_lambda Enterobacteria phage lambda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZS4 OCA].	+	1ZS4 is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Enterobacteria_phage_lambda Enterobacteria phage lambda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZS4 OCA].

	==Reference==		==Reference==
-	~~Crystal structure of bacteriophage lambda cII and its DNA complex., Jain D, Kim Y, Maxwell KL, Beasley S, Zhang R, Gussin GN, Edwards AM, Darst SA, Mol Cell. 2005 Jul 22;19(2):259-69.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16039594 16039594]~~	+	<ref group="xtra">PMID:16039594</ref><references group="xtra"/>
	[[Category: Enterobacteria phage lambda]]		[[Category: Enterobacteria phage lambda]]
-	[[Category: Single protein]]
	[[Category: Beasley, S.]]		[[Category: Beasley, S.]]
	[[Category: Darst, S A.]]		[[Category: Darst, S A.]]
Line 36:		Line 35:
	[[Category: Transcription activator]]		[[Category: Transcription activator]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 04~~:08:~~50 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 20:16:41 2009''