1zw8 - Revision history

OCA at 08:13, 15 May 2024

OCA — Wed, 15 May 2024 08:13:30 GMT

←Older revision		Revision as of 08:13, 15 May 2024
Line 1:		Line 1:

	==Solution structure of a ZAP1 zinc-responsive domain provides insights into metalloregulatory transcriptional repression in Saccharomyces cerevisiae==		==Solution structure of a ZAP1 zinc-responsive domain provides insights into metalloregulatory transcriptional repression in Saccharomyces cerevisiae==
-	<StructureSection load='1zw8' size='340' side='right'caption='[[1zw8~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='1zw8' size='340' side='right'caption='[[1zw8]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1zw8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZW8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZW8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1zw8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZW8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZW8 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~ZAP1 ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zw8 OCA], [https://pdbe.org/1zw8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zw8 RCSB], [https://www.ebi.ac.uk/pdbsum/1zw8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zw8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zw8 OCA], [https://pdbe.org/1zw8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zw8 RCSB], [https://www.ebi.ac.uk/pdbsum/1zw8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zw8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ZAP1_YEAST ZAP1_YEAST]] Involved in zinc ion homeostasis by zinc-responsive transcriptional regulation.	+	[https://www.uniprot.org/uniprot/ZAP1_YEAST ZAP1_YEAST] Involved in zinc ion homeostasis by zinc-responsive transcriptional regulation.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Feng~~, L S~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: Laity~~, J H~~]]	+	[[Category: Feng LS]]
-	[[Category: Matskevich~~, V A~~]]	+	[[Category: Laity JH]]
-	[[Category: Parasuram, P]]	+	[[Category: Matskevich VA]]
-	[[Category: Venkataraman, K]]	+	[[Category: Parasuram P]]
-	[[Category: Wang, Z]]	+	[[Category: Venkataraman K]]
-	~~[[Category: Beta-beta-alpha]]~~	+	[[Category: Wang Z]]
-	~~[[Category: Interacting c2h2 zinc finger]]~~	+
-	~~[[Category: Nmr solution structure]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Zap1~~]]	+

OCA at 08:18, 27 January 2021

OCA — Wed, 27 Jan 2021 08:18:49 GMT

←Older revision		Revision as of 08:18, 27 January 2021
Line 1:		Line 1:

	==Solution structure of a ZAP1 zinc-responsive domain provides insights into metalloregulatory transcriptional repression in Saccharomyces cerevisiae==		==Solution structure of a ZAP1 zinc-responsive domain provides insights into metalloregulatory transcriptional repression in Saccharomyces cerevisiae==
-	<StructureSection load='1zw8' size='340' side='right' caption='[[1zw8]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='1zw8' size='340' side='right'caption='[[1zw8]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1zw8]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZW8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ZW8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1zw8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZW8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZW8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ZAP1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ZAP1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1zw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zw8 OCA], [~~http~~://pdbe.org/1zw8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1zw8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1zw8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1zw8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zw8 OCA], [https://pdbe.org/1zw8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zw8 RCSB], [https://www.ebi.ac.uk/pdbsum/1zw8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zw8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ZAP1_YEAST ZAP1_YEAST]] Involved in zinc ion homeostasis by zinc-responsive transcriptional regulation.	+	[[https://www.uniprot.org/uniprot/ZAP1_YEAST ZAP1_YEAST]] Involved in zinc ion homeostasis by zinc-responsive transcriptional regulation.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
		+	[[Category: Large Structures]]
	[[Category: Feng, L S]]		[[Category: Feng, L S]]
	[[Category: Laity, J H]]		[[Category: Laity, J H]]

OCA at 09:09, 2 May 2018

OCA — Wed, 02 May 2018 09:09:44 GMT

←Older revision		Revision as of 09:09, 2 May 2018
Line 1:		Line 1:
		+
	==Solution structure of a ZAP1 zinc-responsive domain provides insights into metalloregulatory transcriptional repression in Saccharomyces cerevisiae==		==Solution structure of a ZAP1 zinc-responsive domain provides insights into metalloregulatory transcriptional repression in Saccharomyces cerevisiae==
	<StructureSection load='1zw8' size='340' side='right' caption='[[1zw8]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1zw8' size='340' side='right' caption='[[1zw8]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ZAP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ZAP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zw8 OCA], [http://pdbe.org/1zw8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zw8 RCSB], [http://www.ebi.ac.uk/pdbsum/1zw8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zw8 OCA], [http://pdbe.org/1zw8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zw8 RCSB], [http://www.ebi.ac.uk/pdbsum/1zw8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1zw8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zw/1zw8_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zw/1zw8_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 04:43, 9 February 2016

OCA — Tue, 09 Feb 2016 04:43:36 GMT

←Older revision		Revision as of 04:43, 9 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zw8 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 18:44, 10 September 2015

OCA — Thu, 10 Sep 2015 18:44:18 GMT

←Older revision		Revision as of 18:44, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1zw8' size='340' side='right' caption='[[1zw8]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1zw8' size='340' side='right' caption='[[1zw8]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1zw8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZW8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZW8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1zw8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZW8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZW8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ZAP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ~~Saccharomyces cerevisiae~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ZAP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zw8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zw8 RCSB], [http://www.ebi.ac.uk/pdbsum/1zw8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zw8 OCA], [http://pdbe.org/1zw8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zw8 RCSB], [http://www.ebi.ac.uk/pdbsum/1zw8 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1zw8" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Saccharomyces cerevisiae~~]]	+	[[Category: Atcc 18824]]
	[[Category: Feng, L S]]		[[Category: Feng, L S]]
	[[Category: Laity, J H]]		[[Category: Laity, J H]]

OCA at 04:30, 25 December 2014

OCA — Thu, 25 Dec 2014 04:30:34 GMT

←Older revision		Revision as of 04:30, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1zw8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZW8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZW8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zw8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZW8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZW8 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ZAP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ZAP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zw8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zw8 RCSB], [http://www.ebi.ac.uk/pdbsum/1zw8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zw8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zw8 RCSB], [http://www.ebi.ac.uk/pdbsum/1zw8 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ZAP1_YEAST ZAP1_YEAST]] Involved in zinc ion homeostasis by zinc-responsive transcriptional regulation.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Feng, L S.]]	+	[[Category: Feng, L S]]
-	[[Category: Laity, J H.]]	+	[[Category: Laity, J H]]
-	[[Category: Matskevich, V A.]]	+	[[Category: Matskevich, V A]]
-	[[Category: Parasuram, P.]]	+	[[Category: Parasuram, P]]
-	[[Category: Venkataraman, K.]]	+	[[Category: Venkataraman, K]]
-	[[Category: Wang, Z.]]	+	[[Category: Wang, Z]]
	[[Category: Beta-beta-alpha]]		[[Category: Beta-beta-alpha]]
	[[Category: Interacting c2h2 zinc finger]]		[[Category: Interacting c2h2 zinc finger]]

OCA at 02:46, 30 September 2014

OCA — Tue, 30 Sep 2014 02:46:35 GMT

←Older revision		Revision as of 02:46, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1zw8.~~png~~\|~~left~~\|200px]]	+	==Solution structure of a ZAP1 zinc-responsive domain provides insights into metalloregulatory transcriptional repression in Saccharomyces cerevisiae==
		+	<StructureSection load='1zw8' size='340' side='right' caption='[[1zw8]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1zw8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZW8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZW8 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ZAP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zw8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zw8 RCSB], [http://www.ebi.ac.uk/pdbsum/1zw8 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zw/1zw8_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Zap1 transcription factor controls expression of genes that regulate zinc homeostasis in Saccharomyces cerevisiae. The solution structure of two zinc fingers (zf1-2(CA3)) derived from a zinc-responsive domain of Zap1 (zf1-2) has been determined. Under zinc-limiting conditions, zinc finger 2 (zf2) from this domain has been shown to be a constitutive transcriptional activator. Moreover, repression of zf2 function in zinc-replete cells required zinc coordination to both canonical finger 1 (zf1) and zf2 metal sites, suggesting zf1-zf2 cooperativity underlies Zap1 metalloregulation. A structural basis for this cooperativity is identified here. Favorable inter-helical contacts in zf1-2(CA3) extend the individual finger hydrophobic cores through the zf1-zf2 interface. Tryptophan residues at position 5 in each finger provide numerous non-helical inter-finger contacts reminiscent of those observed in GLI1 zinc fingers 1 and 2. The molecular mechanism for zf1-dependent repression of zf2 transcriptional activation is explored further using NMR and CD titration studies. While zf1 independently forms a betabetaalpha solution structure, the majority of zf2 ensemble solution states do not adopt the canonical betabetaalpha zinc finger fold without zf1-zf2 interactions. Cooperative effects on Zn(II) affinities stemming from these finger-finger interactions are observed also in calorimetric studies, in which the 160(+/-20)nM (zf1) and 250(+/-40)nM (zf2) K(d) values for each individual finger increased substantially in the context of the zf1-2 protein (apparent K(dzf1-2WT)=4.6(+/-1.2)nM). On the basis of the above observations, we propose a mechanism for Zap1 transcriptional regulation in which zf1-zf2 interactions stabilize the betabetaalpha folded "repressed state" of the zf2 activation domain in the presence of cellular Zn(II) excess. Moreover, in contrast to earlier reports of <<1 labile zinc ion/Escherichia coli cell, the zf1-zf2 zinc affinities determined calorimetrically are consistent with Zn(II) levels >>1 labile zinc ion/eukaryotic cell.

-	~~{{STRUCTURE_1zw8\| PDB=1zw8 \| SCENE= }}~~	+	Solution structure of a Zap1 zinc-responsive domain provides insights into metalloregulatory transcriptional repression in Saccharomyces cerevisiae.,Wang Z, Feng LS, Matskevich V, Venkataraman K, Parasuram P, Laity JH J Mol Biol. 2006 Apr 7;357(4):1167-83. Epub 2006 Jan 24. PMID:16483601<ref>PMID:16483601</ref>

-	~~===Solution structure~~ of ~~a ZAP1 zinc-responsive domain provides insights into metalloregulatory transcriptional repression in Saccharomyces cerevisiae===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16483601}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1zw8]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1ZW8 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016483601<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Feng, L S.]]		[[Category: Feng, L S.]]

OCA: Protected "1zw8" [edit=sysop:move=sysop]

OCA — Sat, 05 Jan 2013 17:29:49 GMT

Protected "1zw8" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:29, 5 January 2013

OCA at 17:29, 5 January 2013

OCA — Sat, 05 Jan 2013 17:29:44 GMT

←Older revision		Revision as of 17:29, 5 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1zw8.png\|left\|200px]]		[[Image:1zw8.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1zw8", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1zw8\| PDB=1zw8 \| SCENE= }}		{{STRUCTURE_1zw8\| PDB=1zw8 \| SCENE= }}

	===Solution structure of a ZAP1 zinc-responsive domain provides insights into metalloregulatory transcriptional repression in Saccharomyces cerevisiae===		===Solution structure of a ZAP1 zinc-responsive domain provides insights into metalloregulatory transcriptional repression in Saccharomyces cerevisiae===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16483601}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16483601 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16483601}}		{{ABSTRACT_PUBMED_16483601}}

	==About this Structure==		==About this Structure==
-	~~1ZW8~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZW8 OCA].	+	[[1zw8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZW8 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16483601~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016483601</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Feng, L S.]]		[[Category: Feng, L S.]]
Line 34:		Line 22:
	[[Category: Interacting c2h2 zinc finger]]		[[Category: Interacting c2h2 zinc finger]]
	[[Category: Nmr solution structure]]		[[Category: Nmr solution structure]]
		+	[[Category: Transcription]]
	[[Category: Zap1]]		[[Category: Zap1]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 06:34:05 2009''

OCA at 04:34, 17 February 2009

OCA — Tue, 17 Feb 2009 04:34:06 GMT

←Older revision		Revision as of 04:34, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1ZW8 is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZW8 OCA].	+	1ZW8 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZW8 OCA].

	==Reference==		==Reference==
-	Solution structure of a Zap1 zinc-responsive domain provides insights into metalloregulatory transcriptional repression in Saccharomyces cerevisiae., Wang Z, Feng LS, Matskevich V, Venkataraman K, Parasuram P, Laity JH, J Mol Biol. 2006 Apr 7;357(4):1167-83. Epub 2006 Jan 24. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16483601 16483601]~~	+	<ref group="xtra">PMID:16483601</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Single protein]]
	[[Category: Feng, L S.]]		[[Category: Feng, L S.]]
	[[Category: Laity, J H.]]		[[Category: Laity, J H.]]
Line 37:		Line 36:
	[[Category: Zap1]]		[[Category: Zap1]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28 10~~:09:~~08 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 06:34:05 2009''