1zxl - Revision history

OCA at 07:16, 23 August 2023

OCA — Wed, 23 Aug 2023 07:16:13 GMT

←Older revision		Revision as of 07:16, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='1zxl' size='340' side='right'caption='[[1zxl]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='1zxl' size='340' side='right'caption='[[1zxl]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1zxl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Plafa Plafa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZXL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZXL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1zxl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZXL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZXL FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=JP1:N~~-~~[3-CHLORO-4-(4-CHLORO-2-HYDROXYPHENOXY)PHENYL]MORPHOLINE-4-CARBOXAMIDE'>JP1</scene>~~, ~~<scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[1nhd\|1nhd]], [[1nhg\|1nhg]], [[1nhw\|1nhw]], [[1nnu\|1nnu]], [[1zw1\|1zw1]], [[1zsn\|1zsn]], [[1zxb\|1zxb]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JP1:N-[3-CHLORO-4-(4-CHLORO-2-HYDROXYPHENOXY)PHENYL]MORPHOLINE-4-CARBOXAMIDE'>JP1</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>PfENR ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id~~=5833 PLAFA])</td></tr>~~	+
-	~~<tr id='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[https~~:~~//en.wikipedia.org/wiki/Enoyl~~-[~~acyl~~-~~carrier~~-~~protein]_reductase_~~(~~NADH) Enoyl~~-~~[acyl~~-~~carrier~~-~~protein] reductase (NADH~~)], ~~with EC number [https~~:~~//www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zxl OCA], [https://pdbe.org/1zxl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zxl RCSB], [https://www.ebi.ac.uk/pdbsum/1zxl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zxl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zxl OCA], [https://pdbe.org/1zxl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zxl RCSB], [https://www.ebi.ac.uk/pdbsum/1zxl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zxl ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9BH77_PLAFA Q9BH77_PLAFA]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Plafa~~]]	+	[[Category: Plasmodium falciparum]]
-	[[Category: Anderson~~, J W~~]]	+	[[Category: Anderson JW]]
-	[[Category: Fidock~~, D A~~]]	+	[[Category: Fidock DA]]
-	[[Category: Freundlich~~, J S~~]]	+	[[Category: Freundlich JS]]
-	[[Category: Jacobs~~, W R~~]]	+	[[Category: Jacobs Jr WR]]
-	[[Category: Jacobus~~, D P~~]]	+	[[Category: Jacobus DP]]
-	[[Category: Kuo, M]]	+	[[Category: Kuo M]]
-	[[Category: Lucumi, E]]	+	[[Category: Lucumi E]]
-	[[Category: Sacchettini~~, J C~~]]	+	[[Category: Sacchettini JC]]
-	[[Category: Sarantakis, D]]	+	[[Category: Sarantakis D]]
-	[[Category: Schiehser~~, G A~~]]	+	[[Category: Schiehser GA]]
-	[[Category: Shieh~~, H M~~]]	+	[[Category: Shieh HM]]
-	[[Category: Yu, M]]	+	[[Category: Yu M]]
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 09:37, 5 May 2021

OCA — Wed, 05 May 2021 09:37:27 GMT

←Older revision		Revision as of 09:37, 5 May 2021
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	<StructureSection load='1zxl' size='340' side='right'caption='[[1zxl]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='1zxl' size='340' side='right'caption='[[1zxl]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1zxl]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZXL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ZXL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1zxl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZXL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZXL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JP1:N-[3-CHLORO-4-(4-CHLORO-2-HYDROXYPHENOXY)PHENYL]MORPHOLINE-4-CARBOXAMIDE'>JP1</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JP1:N-[3-CHLORO-4-(4-CHLORO-2-HYDROXYPHENOXY)PHENYL]MORPHOLINE-4-CARBOXAMIDE'>JP1</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nhd\|1nhd]], [[1nhg\|1nhg]], [[1nhw\|1nhw]], [[1nnu\|1nnu]], [[1zw1\|1zw1]], [[1zsn\|1zsn]], [[1zxb\|1zxb]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1nhd\|1nhd]], [[1nhg\|1nhg]], [[1nhw\|1nhw]], [[1nnu\|1nnu]], [[1zw1\|1zw1]], [[1zsn\|1zsn]], [[1zxb\|1zxb]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PfENR ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PfENR ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1zxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zxl OCA], [~~http~~://pdbe.org/1zxl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1zxl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1zxl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1zxl ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zxl OCA], [https://pdbe.org/1zxl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zxl RCSB], [https://www.ebi.ac.uk/pdbsum/1zxl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zxl ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 07:09, 24 July 2019

OCA — Wed, 24 Jul 2019 07:09:15 GMT

←Older revision		Revision as of 07:09, 24 July 2019
Line 1:		Line 1:

	==Synthesis, Biological Activity, and X-Ray Crystal Structural Analysis of Diaryl Ether Inhibitors of Malarial Enoyl ACP Reductase. Part 1:4'-Substituted Triclosan Derivatives==		==Synthesis, Biological Activity, and X-Ray Crystal Structural Analysis of Diaryl Ether Inhibitors of Malarial Enoyl ACP Reductase. Part 1:4'-Substituted Triclosan Derivatives==
-	<StructureSection load='1zxl' size='340' side='right' caption='[[1zxl]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='1zxl' size='340' side='right'caption='[[1zxl]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1zxl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZXL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZXL FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zxl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZXL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZXL FirstGlance]. <br>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1zxl" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1zxl" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Enoyl-Acyl-Carrier Protein Reductase 3D structures\|Enoyl-Acyl-Carrier Protein Reductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Plafa]]		[[Category: Plafa]]
	[[Category: Anderson, J W]]		[[Category: Anderson, J W]]

OCA at 09:13, 2 May 2018

OCA — Wed, 02 May 2018 09:13:49 GMT

←Older revision		Revision as of 09:13, 2 May 2018
Line 1:		Line 1:
		+
	==Synthesis, Biological Activity, and X-Ray Crystal Structural Analysis of Diaryl Ether Inhibitors of Malarial Enoyl ACP Reductase. Part 1:4'-Substituted Triclosan Derivatives==		==Synthesis, Biological Activity, and X-Ray Crystal Structural Analysis of Diaryl Ether Inhibitors of Malarial Enoyl ACP Reductase. Part 1:4'-Substituted Triclosan Derivatives==
	<StructureSection load='1zxl' size='340' side='right' caption='[[1zxl]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='1zxl' size='340' side='right' caption='[[1zxl]], [[Resolution\|resolution]] 3.00Å' scene=''>
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PfENR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PfENR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zxl OCA], [http://pdbe.org/1zxl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zxl RCSB], [http://www.ebi.ac.uk/pdbsum/1zxl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zxl OCA], [http://pdbe.org/1zxl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zxl RCSB], [http://www.ebi.ac.uk/pdbsum/1zxl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1zxl ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zx/1zxl_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zx/1zxl_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zxl ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1zxl" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1zxl" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Enoyl-Acyl-Carrier Protein Reductase\|Enoyl-Acyl-Carrier Protein Reductase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:59, 11 September 2015

OCA — Fri, 11 Sep 2015 16:59:08 GMT

←Older revision		Revision as of 16:59, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1zxl' size='340' side='right' caption='[[1zxl]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='1zxl' size='340' side='right' caption='[[1zxl]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1zxl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Plasmodium_falciparum Plasmodium falciparum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZXL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZXL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1zxl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZXL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZXL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JP1:N-[3-CHLORO-4-(4-CHLORO-2-HYDROXYPHENOXY)PHENYL]MORPHOLINE-4-CARBOXAMIDE'>JP1</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JP1:N-[3-CHLORO-4-(4-CHLORO-2-HYDROXYPHENOXY)PHENYL]MORPHOLINE-4-CARBOXAMIDE'>JP1</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nhd\|1nhd]], [[1nhg\|1nhg]], [[1nhw\|1nhw]], [[1nnu\|1nnu]], [[1zw1\|1zw1]], [[1zsn\|1zsn]], [[1zxb\|1zxb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nhd\|1nhd]], [[1nhg\|1nhg]], [[1nhw\|1nhw]], [[1nnu\|1nnu]], [[1zw1\|1zw1]], [[1zsn\|1zsn]], [[1zxb\|1zxb]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PfENR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 ~~Plasmodium falciparum~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PfENR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zxl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zxl RCSB], [http://www.ebi.ac.uk/pdbsum/1zxl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zxl OCA], [http://pdbe.org/1zxl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zxl RCSB], [http://www.ebi.ac.uk/pdbsum/1zxl PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1zxl" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Plasmodium falciparum~~]]	+	[[Category: Plafa]]
	[[Category: Anderson, J W]]		[[Category: Anderson, J W]]
	[[Category: Fidock, D A]]		[[Category: Fidock, D A]]

OCA at 09:33, 8 January 2015

OCA — Thu, 08 Jan 2015 09:33:45 GMT

←Older revision		Revision as of 09:33, 8 January 2015
Line 1:		Line 1:
-	[[~~Image:~~1zxl.~~png~~\|~~left~~\|200px]]	+	==Synthesis, Biological Activity, and X-Ray Crystal Structural Analysis of Diaryl Ether Inhibitors of Malarial Enoyl ACP Reductase. Part 1:4'-Substituted Triclosan Derivatives==
		+	<StructureSection load='1zxl' size='340' side='right' caption='[[1zxl]], [[Resolution\|resolution]] 3.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1zxl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZXL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZXL FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JP1:N-[3-CHLORO-4-(4-CHLORO-2-HYDROXYPHENOXY)PHENYL]MORPHOLINE-4-CARBOXAMIDE'>JP1</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nhd\|1nhd]], [[1nhg\|1nhg]], [[1nhw\|1nhw]], [[1nnu\|1nnu]], [[1zw1\|1zw1]], [[1zsn\|1zsn]], [[1zxb\|1zxb]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PfENR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 Plasmodium falciparum])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zxl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zxl RCSB], [http://www.ebi.ac.uk/pdbsum/1zxl PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zx/1zxl_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A structure-based approach has been taken to develop 4'-substituted analogs of triclosan that target the key malarial enzyme Plasmodium falciparum enoyl acyl carrier protein reductase (PfENR). Many of these compounds exhibit nanomolar potency against purified PfENR enzyme and modest (2-10microM) potency against in vitro cultures of drug-resistant and drug-sensitive strains of the P. falciparum parasite. X-ray crystal structures of nitro 29, aniline 30, methylamide 37, and urea 46 demonstrate the presence of hydrogen-bonding interactions with residues in the active site and point to future rounds of optimization to improve compound potency against purified enzyme and intracellular parasites.

-	~~{{STRUCTURE_1zxl\| PDB=1zxl \| SCENE= }}~~	+	Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4'-substituted triclosan derivatives.,Freundlich JS, Anderson JW, Sarantakis D, Shieh HM, Yu M, Valderramos JC, Lucumi E, Kuo M, Jacobs WR Jr, Fidock DA, Schiehser GA, Jacobus DP, Sacchettini JC Bioorg Med Chem Lett. 2005 Dec 1;15(23):5247-52. Epub 2005 Sep 29. PMID:16198563<ref>PMID:16198563</ref>

-	~~===Synthesis~~, ~~Biological Activity, and X-Ray Crystal Structural Analysis~~ of ~~Diaryl Ether Inhibitors~~ of ~~Malarial Enoyl ACP Reductase~~. ~~Part 1:4'-Substituted Triclosan Derivatives===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16198563}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1zxl]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZXL OCA].~~	+

	==See Also==		==See Also==
	*[[Enoyl-Acyl-Carrier Protein Reductase\|Enoyl-Acyl-Carrier Protein Reductase]]		*[[Enoyl-Acyl-Carrier Protein Reductase\|Enoyl-Acyl-Carrier Protein Reductase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:016198563<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
-	[[Category: Anderson, J W.]]	+	[[Category: Anderson, J W]]
-	[[Category: Fidock, D A.]]	+	[[Category: Fidock, D A]]
-	[[Category: Freundlich, J S.]]	+	[[Category: Freundlich, J S]]
-	[[Category: Jacobs, W R.]]	+	[[Category: Jacobs, W R]]
-	[[Category: Jacobus, D P.]]	+	[[Category: Jacobus, D P]]
-	[[Category: Kuo, M.]]	+	[[Category: Kuo, M]]
-	[[Category: Lucumi, E.]]	+	[[Category: Lucumi, E]]
-	[[Category: Sacchettini, J C.]]	+	[[Category: Sacchettini, J C]]
-	[[Category: Sarantakis, D.]]	+	[[Category: Sarantakis, D]]
-	[[Category: Schiehser, G A.]]	+	[[Category: Schiehser, G A]]
-	[[Category: Shieh, H M.]]	+	[[Category: Shieh, H M]]
-	[[Category: Yu, M.]]	+	[[Category: Yu, M]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 20:28, 20 October 2012

OCA — Sat, 20 Oct 2012 20:28:29 GMT

←Older revision		Revision as of 20:28, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1zxl]] is a 2 chain structure ~~of [[Enoyl-Acyl-Carrier Protein Reductase]]~~ with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZXL OCA].	+	[[1zxl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZXL OCA].

	==See Also==		==See Also==

OCA: Protected "1zxl" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 10:35:42 GMT

Protected "1zxl" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:35, 27 July 2012

OCA at 10:35, 27 July 2012

OCA — Fri, 27 Jul 2012 10:35:40 GMT

←Older revision		Revision as of 10:35, 27 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1zxl.png\|left\|200px]]		[[Image:1zxl.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1zxl", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1zxl\| PDB=1zxl \| SCENE= }}		{{STRUCTURE_1zxl\| PDB=1zxl \| SCENE= }}

	===Synthesis, Biological Activity, and X-Ray Crystal Structural Analysis of Diaryl Ether Inhibitors of Malarial Enoyl ACP Reductase. Part 1:4'-Substituted Triclosan Derivatives===		===Synthesis, Biological Activity, and X-Ray Crystal Structural Analysis of Diaryl Ether Inhibitors of Malarial Enoyl ACP Reductase. Part 1:4'-Substituted Triclosan Derivatives===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16198563}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16198563 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16198563}}		{{ABSTRACT_PUBMED_16198563}}

	==About this Structure==		==About this Structure==
-	~~1ZXL~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZXL OCA].	+	[[1zxl]] is a 2 chain structure of [[Enoyl-Acyl-Carrier Protein Reductase]] with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZXL OCA].
		+
		+	==See Also==
		+	*[[Enoyl-Acyl-Carrier Protein Reductase\|Enoyl-Acyl-Carrier Protein Reductase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16198563~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016198563</ref><references group="xtra"/>
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
	[[Category: Anderson, J W.]]		[[Category: Anderson, J W.]]
	[[Category: Fidock, D A.]]		[[Category: Fidock, D A.]]
	[[Category: Freundlich, J S.]]		[[Category: Freundlich, J S.]]
		+	[[Category: Jacobs, W R.]]
	[[Category: Jacobus, D P.]]		[[Category: Jacobus, D P.]]
-	[[Category: Jr., W R.Jacobs.]]
	[[Category: Kuo, M.]]		[[Category: Kuo, M.]]
	[[Category: Lucumi, E.]]		[[Category: Lucumi, E.]]
Line 38:		Line 29:
	[[Category: Yu, M.]]		[[Category: Yu, M.]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 04:17:16 2009''

OCA at 02:17, 18 February 2009

OCA — Wed, 18 Feb 2009 02:17:19 GMT

←Older revision		Revision as of 02:17, 18 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1ZXL is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZXL OCA].	+	1ZXL is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZXL OCA].

	==Reference==		==Reference==
-	Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4'-substituted triclosan derivatives., Freundlich JS, Anderson JW, Sarantakis D, Shieh HM, Yu M, Valderramos JC, Lucumi E, Kuo M, Jacobs WR Jr, Fidock DA, Schiehser GA, Jacobus DP, Sacchettini JC, Bioorg Med Chem Lett. 2005 Dec 1;15(23):5247-52. Epub 2005 Sep 29. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16198563 16198563]~~	+	<ref group="xtra">PMID:16198563</ref><references group="xtra"/>
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
-	[[Category: Single protein]]
	[[Category: Anderson, J W.]]		[[Category: Anderson, J W.]]
	[[Category: Fidock, D A.]]		[[Category: Fidock, D A.]]
Line 40:		Line 39:
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 10~~:54:~~12 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 04:17:16 2009''