1zyo - Revision history

OCA at 08:14, 15 May 2024

OCA — Wed, 15 May 2024 08:14:07 GMT

←Older revision		Revision as of 08:14, 15 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1zyo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sesbania_mosaic_virus Sesbania mosaic virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZYO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZYO FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zyo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sesbania_mosaic_virus Sesbania mosaic virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZYO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZYO FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;'>[[1lvm\|1lvm]]~~, [[~~1q31~~\|~~1q31~~]]~~</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>ORF2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~12558 Sesbania mosaic virus])</td~~><~~/tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Glutamyl_endopeptidase Glutamyl endopeptidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.19 3.4.21.19]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zyo OCA], [https://pdbe.org/1zyo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zyo RCSB], [https://www.ebi.ac.uk/pdbsum/1zyo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zyo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zyo OCA], [https://pdbe.org/1zyo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zyo RCSB], [https://www.ebi.ac.uk/pdbsum/1zyo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zyo ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9EB08_9VIRU Q9EB08_9VIRU]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Glutamyl endopeptidase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Sesbania mosaic virus]]		[[Category: Sesbania mosaic virus]]
-	[[Category: Gayathri, P]]	+	[[Category: Gayathri P]]
-	[[Category: Murthy~~, M R.N~~]]	+	[[Category: Murthy MRN]]
-	[[Category: Prasad, K]]	+	[[Category: Prasad K]]
-	[[Category: Satheshkumar~~, P S~~]]	+	[[Category: Satheshkumar PS]]
-	[[Category: Savithri~~, H S]]~~	+	[[Category: Savithri HS]]
-	~~[[Category: Beta-barrel]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Viral serine protease of trypsin fold~~]]	+

OCA at 08:20, 27 January 2021

OCA — Wed, 27 Jan 2021 08:20:25 GMT

←Older revision		Revision as of 08:20, 27 January 2021
Line 1:		Line 1:

	==Crystal Structure of the Serine Protease Domain of Sesbania Mosaic Virus polyprotein==		==Crystal Structure of the Serine Protease Domain of Sesbania Mosaic Virus polyprotein==
-	<StructureSection load='1zyo' size='340' side='right' caption='[[1zyo]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='1zyo' size='340' side='right'caption='[[1zyo]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1zyo]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Sesbania_mosaic_virus Sesbania mosaic virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZYO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ZYO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1zyo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sesbania_mosaic_virus Sesbania mosaic virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZYO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZYO FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lvm\|1lvm]], [[1q31\|1q31]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1lvm\|1lvm]], [[1q31\|1q31]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ORF2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=12558 Sesbania mosaic virus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ORF2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=12558 Sesbania mosaic virus])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Glutamyl_endopeptidase Glutamyl endopeptidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.19 3.4.21.19] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glutamyl_endopeptidase Glutamyl endopeptidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.19 3.4.21.19] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1zyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zyo OCA], [~~http~~://pdbe.org/1zyo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1zyo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1zyo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1zyo ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zyo OCA], [https://pdbe.org/1zyo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zyo RCSB], [https://www.ebi.ac.uk/pdbsum/1zyo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zyo ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Glutamyl endopeptidase]]		[[Category: Glutamyl endopeptidase]]
		+	[[Category: Large Structures]]
	[[Category: Sesbania mosaic virus]]		[[Category: Sesbania mosaic virus]]
	[[Category: Gayathri, P]]		[[Category: Gayathri, P]]

OCA at 09:17, 2 May 2018

OCA — Wed, 02 May 2018 09:17:43 GMT

←Older revision		Revision as of 09:17, 2 May 2018
Line 1:		Line 1:
		+
	==Crystal Structure of the Serine Protease Domain of Sesbania Mosaic Virus polyprotein==		==Crystal Structure of the Serine Protease Domain of Sesbania Mosaic Virus polyprotein==
	<StructureSection load='1zyo' size='340' side='right' caption='[[1zyo]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1zyo' size='340' side='right' caption='[[1zyo]], [[Resolution\|resolution]] 2.40Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ORF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=12558 Sesbania mosaic virus])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ORF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=12558 Sesbania mosaic virus])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamyl_endopeptidase Glutamyl endopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.19 3.4.21.19] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamyl_endopeptidase Glutamyl endopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.19 3.4.21.19] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zyo OCA], [http://pdbe.org/1zyo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zyo RCSB], [http://www.ebi.ac.uk/pdbsum/1zyo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zyo OCA], [http://pdbe.org/1zyo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zyo RCSB], [http://www.ebi.ac.uk/pdbsum/1zyo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1zyo ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zy/1zyo_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zy/1zyo_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zyo ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 13:15, 11 September 2015

OCA — Fri, 11 Sep 2015 13:15:40 GMT

←Older revision		Revision as of 13:15, 11 September 2015
Line 7:		Line 7:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ORF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=12558 Sesbania mosaic virus])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ORF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=12558 Sesbania mosaic virus])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamyl_endopeptidase Glutamyl endopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.19 3.4.21.19] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamyl_endopeptidase Glutamyl endopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.19 3.4.21.19] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zyo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zyo RCSB], [http://www.ebi.ac.uk/pdbsum/1zyo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zyo OCA], [http://pdbe.org/1zyo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zyo RCSB], [http://www.ebi.ac.uk/pdbsum/1zyo PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1zyo" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:33, 8 January 2015

OCA — Thu, 08 Jan 2015 10:33:46 GMT

←Older revision		Revision as of 10:33, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1zyo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sesbania_mosaic_virus Sesbania mosaic virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZYO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZYO FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zyo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sesbania_mosaic_virus Sesbania mosaic virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZYO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZYO FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lvm\|1lvm]], [[1q31\|1q31]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lvm\|1lvm]], [[1q31\|1q31]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ORF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=12558 Sesbania mosaic virus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ORF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=12558 Sesbania mosaic virus])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamyl_endopeptidase Glutamyl endopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.19 3.4.21.19] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamyl_endopeptidase Glutamyl endopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.19 3.4.21.19] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zyo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zyo RCSB], [http://www.ebi.ac.uk/pdbsum/1zyo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zyo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zyo RCSB], [http://www.ebi.ac.uk/pdbsum/1zyo PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	[[Category: Glutamyl endopeptidase]]		[[Category: Glutamyl endopeptidase]]
	[[Category: Sesbania mosaic virus]]		[[Category: Sesbania mosaic virus]]
-	[[Category: Gayathri, P.]]	+	[[Category: Gayathri, P]]
-	[[Category: Murthy, M R.N.]]	+	[[Category: Murthy, M R.N]]
-	[[Category: Prasad, K.]]	+	[[Category: Prasad, K]]
-	[[Category: Satheshkumar, P S.]]	+	[[Category: Satheshkumar, P S]]
-	[[Category: Savithri, H S.]]	+	[[Category: Savithri, H S]]
	[[Category: Beta-barrel]]		[[Category: Beta-barrel]]
-	[[Category: Glutamyl endopeptidase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Viral serine protease of trypsin fold]]		[[Category: Viral serine protease of trypsin fold]]

OCA at 02:56, 30 September 2014

OCA — Tue, 30 Sep 2014 02:56:35 GMT

←Older revision		Revision as of 02:56, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1zyo.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of the Serine Protease Domain of Sesbania Mosaic Virus polyprotein==
		+	<StructureSection load='1zyo' size='340' side='right' caption='[[1zyo]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1zyo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sesbania_mosaic_virus Sesbania mosaic virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZYO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZYO FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lvm\|1lvm]], [[1q31\|1q31]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ORF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=12558 Sesbania mosaic virus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamyl_endopeptidase Glutamyl endopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.19 3.4.21.19] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zyo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zyo RCSB], [http://www.ebi.ac.uk/pdbsum/1zyo PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zy/1zyo_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Sesbania mosaic virus (SeMV) polyprotein is processed by its N-terminal serine protease domain. The crystal structure of the protease domain was determined to a resolution of 2.4 A using multiple isomorphous replacement and anomalous scattering. The SeMV protease domain exhibited the characteristic trypsin fold and was found to be closer to cellular serine proteases than to other viral proteases. The residues of the S1-binding pocket, H298, T279 and N308 were mutated to alanine in the DeltaN70-Protease-VPg polyprotein, and the cis-cleavage activity was examined. The H298A and T279A mutants were inactive, while the N308A mutant was partially active, suggesting that the interactions of H298 and T279 with P1-glutamate are crucial for the E-T/S cleavage. A region of exposed aromatic amino acids, probably essential for interaction with VPg, was identified on the protease domain, and this interaction could play a major role in modulating the function of the protease.

-	~~{{STRUCTURE_1zyo\| PDB=1zyo \| SCENE= }}~~	+	Crystal structure of the serine protease domain of Sesbania mosaic virus polyprotein and mutational analysis of residues forming the S1-binding pocket.,Gayathri P, Satheshkumar PS, Prasad K, Nair S, Savithri HS, Murthy MR Virology. 2006 Mar 15;346(2):440-51. Epub 2005 Dec 13. PMID:16356524<ref>PMID:16356524</ref>

-	~~===Crystal Structure~~ of the ~~Serine Protease Domain of Sesbania Mosaic Virus polyprotein===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16356524}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1zyo]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Sesbania_mosaic_virus Sesbania mosaic virus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1ZYO OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016356524<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Glutamyl endopeptidase]]		[[Category: Glutamyl endopeptidase]]
	[[Category: Sesbania mosaic virus]]		[[Category: Sesbania mosaic virus]]

OCA: Protected "1zyo" [edit=sysop:move=sysop]

OCA — Sun, 06 Jan 2013 12:06:57 GMT

Protected "1zyo" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:06, 6 January 2013

OCA at 12:06, 6 January 2013

OCA — Sun, 06 Jan 2013 12:06:54 GMT

←Older revision		Revision as of 12:06, 6 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1zyo.png\|left\|200px]]		[[Image:1zyo.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1zyo", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1zyo\| PDB=1zyo \| SCENE= }}		{{STRUCTURE_1zyo\| PDB=1zyo \| SCENE= }}

	===Crystal Structure of the Serine Protease Domain of Sesbania Mosaic Virus polyprotein===		===Crystal Structure of the Serine Protease Domain of Sesbania Mosaic Virus polyprotein===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16356524}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16356524 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16356524}}		{{ABSTRACT_PUBMED_16356524}}

	==About this Structure==		==About this Structure==
-	~~1ZYO~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Sesbania_mosaic_virus Sesbania mosaic virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZYO OCA].	+	[[1zyo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sesbania_mosaic_virus Sesbania mosaic virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZYO OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16356524~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016356524</ref><references group="xtra"/>
	[[Category: Glutamyl endopeptidase]]		[[Category: Glutamyl endopeptidase]]
	[[Category: Sesbania mosaic virus]]		[[Category: Sesbania mosaic virus]]
Line 33:		Line 21:
	[[Category: Beta-barrel]]		[[Category: Beta-barrel]]
	[[Category: Glutamyl endopeptidase]]		[[Category: Glutamyl endopeptidase]]
		+	[[Category: Hydrolase]]
	[[Category: Viral serine protease of trypsin fold]]		[[Category: Viral serine protease of trypsin fold]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 22:27:12 2009''

OCA at 20:27, 17 February 2009

OCA — Tue, 17 Feb 2009 20:27:16 GMT

←Older revision		Revision as of 20:27, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1ZYO is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Sesbania_mosaic_virus Sesbania mosaic virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZYO OCA].	+	1ZYO is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Sesbania_mosaic_virus Sesbania mosaic virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZYO OCA].

	==Reference==		==Reference==
-	Crystal structure of the serine protease domain of Sesbania mosaic virus polyprotein and mutational analysis of residues forming the S1-binding pocket., Gayathri P, Satheshkumar PS, Prasad K, Nair S, Savithri HS, Murthy MR, Virology. 2006 Mar 15;346(2):440-51. Epub 2005 Dec 13. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16356524 16356524]~~	+	<ref group="xtra">PMID:16356524</ref><references group="xtra"/>
	[[Category: Glutamyl endopeptidase]]		[[Category: Glutamyl endopeptidase]]
	[[Category: Sesbania mosaic virus]]		[[Category: Sesbania mosaic virus]]
-	[[Category: Single protein]]
	[[Category: Gayathri, P.]]		[[Category: Gayathri, P.]]
	[[Category: Murthy, M R.N.]]		[[Category: Murthy, M R.N.]]
Line 36:		Line 35:
	[[Category: Viral serine protease of trypsin fold]]		[[Category: Viral serine protease of trypsin fold]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 06~~:39:~~55 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 22:27:12 2009''

OCA at 03:39, 29 July 2008

OCA — Tue, 29 Jul 2008 03:39:56 GMT

←Older revision		Revision as of 03:39, 29 July 2008
Line 1:		Line 1:
-	[[Image:1zyo.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1zyo.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_1zyo\| PDB=1zyo \| SCENE= }}		{{STRUCTURE_1zyo\| PDB=1zyo \| SCENE= }}

-	~~'''~~Crystal Structure of the Serine Protease Domain of Sesbania Mosaic Virus polyprotein~~'''~~	+	===Crystal Structure of the Serine Protease Domain of Sesbania Mosaic Virus polyprotein===


-	~~==Overview==~~	+	<!--
-	~~Sesbania mosaic virus (SeMV) polyprotein is processed by its N~~-terminal serine protease domain. The crystal structure of the protease domain was determined to a resolution of 2.4 A using multiple isomorphous replacement and anomalous scattering. The SeMV protease domain exhibited the characteristic trypsin fold and was found to be closer to cellular serine proteases than to other viral proteases. The residues of the S1-~~binding pocket, H298, T279 and N308 were mutated to alanine in the DeltaN70-Protease-VPg polyprotein, and the cis-cleavage activity was examined.~~ The ~~H298A and T279A mutants were inactive~~, ~~while the N308A mutant was partially active~~, ~~suggesting that~~ the ~~interactions of H298 and T279 with P1-glutamate are crucial for~~ the ~~E-T~~/~~S cleavage~~. ~~A region of exposed aromatic amino acids~~, ~~probably essential for interaction with VPg, was identified on~~ the ~~protease domain, and this interaction could play a major role in modulating the function of the protease~~.	+	The line below this paragraph, {{ABSTRACT_PUBMED_16356524}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 16356524 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_16356524}}

	==About this Structure==		==About this Structure==
Line 31:		Line 35:
	[[Category: Glutamyl endopeptidase]]		[[Category: Glutamyl endopeptidase]]
	[[Category: Viral serine protease of trypsin fold]]		[[Category: Viral serine protease of trypsin fold]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 18~~:14:44 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:39:55 2008''