1zz9 - Revision history

OCA at 07:17, 23 August 2023

OCA — Wed, 23 Aug 2023 07:17:00 GMT

←Older revision		Revision as of 07:17, 23 August 2023
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	<StructureSection load='1zz9' size='340' side='right'caption='[[1zz9]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1zz9' size='340' side='right'caption='[[1zz9]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1zz9]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"actinomyces_wedmorensis"_milard_and_burr_1926 "actinomyces~~ wedmorensis~~" milard and burr 1926~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZZ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZZ9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1zz9]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_wedmorensis Streptomyces wedmorensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZZ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZZ9 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1zz6\|1zz6]], [[1zz7\|1zz7]], [[1zz8\|1zz8]], [[1zzb\|1zzb]], [[1zzc\|1zzc]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">fom4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=43759 "Actinomyces wedmorensis" Milard and Burr 1926])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zz9 OCA], [https://pdbe.org/1zz9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zz9 RCSB], [https://www.ebi.ac.uk/pdbsum/1zz9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zz9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zz9 OCA], [https://pdbe.org/1zz9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zz9 RCSB], [https://www.ebi.ac.uk/pdbsum/1zz9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zz9 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/HPPE_STRWE HPPE_STRWE] Non-heme-dependent dioxygenase that catalyzes the oxidative epoxidation of (S)-2-hydroxypropylphosphonate into (1R,2S)-epoxypropylphosphonate, the final step in the biosynthesis of fosfomycin antibiotic.<ref>PMID:16015285</ref> <ref>PMID:16186494</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Actinomyces wedmorensis milard and burr 1926]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Drennan, C L~~]]	+	[[Category: Streptomyces wedmorensis]]
-	[[Category: ~~Higgins, L J~~]]	+	[[Category: Drennan CL]]
-	[[Category: ~~Liu, H W~~]]	+	[[Category: Higgins LJ]]
-	[[Category: Liu~~, P~~]]	+	[[Category: Liu HW]]
-	[[Category: ~~Yan, F~~]]	+	[[Category: Liu P]]
-	[[Category: ~~Cupin]]~~	+	[[Category: Yan F]]
-	~~[[Category: Holo-hppe]]~~	+
-	~~[[Category: Mononuclear iron enzyme]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 08:20, 27 January 2021

OCA — Wed, 27 Jan 2021 08:20:47 GMT

←Older revision		Revision as of 08:20, 27 January 2021
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	==Crystal Structure of FeII HppE==		==Crystal Structure of FeII HppE==
-	<StructureSection load='1zz9' size='340' side='right' caption='[[1zz9]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='1zz9' size='340' side='right'caption='[[1zz9]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1zz9]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"actinomyces_wedmorensis"_milard_and_burr_1926 "actinomyces wedmorensis" milard and burr 1926]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZZ9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ZZ9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1zz9]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/"actinomyces_wedmorensis"_milard_and_burr_1926 "actinomyces wedmorensis" milard and burr 1926]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZZ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZZ9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zz6\|1zz6]], [[1zz7\|1zz7]], [[1zz8\|1zz8]], [[1zzb\|1zzb]], [[1zzc\|1zzc]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1zz6\|1zz6]], [[1zz7\|1zz7]], [[1zz8\|1zz8]], [[1zzb\|1zzb]], [[1zzc\|1zzc]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fom4 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=43759 "Actinomyces wedmorensis" Milard and Burr 1926])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fom4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=43759 "Actinomyces wedmorensis" Milard and Burr 1926])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1zz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zz9 OCA], [~~http~~://pdbe.org/1zz9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1zz9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1zz9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1zz9 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zz9 OCA], [https://pdbe.org/1zz9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zz9 RCSB], [https://www.ebi.ac.uk/pdbsum/1zz9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zz9 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	</div>		</div>
	<div class="pdbe-citations 1zz9" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1zz9" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Epoxidase 3D structures\|Epoxidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Actinomyces wedmorensis milard and burr 1926]]		[[Category: Actinomyces wedmorensis milard and burr 1926]]
		+	[[Category: Large Structures]]
	[[Category: Drennan, C L]]		[[Category: Drennan, C L]]
	[[Category: Higgins, L J]]		[[Category: Higgins, L J]]

OCA at 08:58, 2 May 2018

OCA — Wed, 02 May 2018 08:58:55 GMT

←Older revision		Revision as of 08:58, 2 May 2018
Line 1:		Line 1:
		+
	==Crystal Structure of FeII HppE==		==Crystal Structure of FeII HppE==
	<StructureSection load='1zz9' size='340' side='right' caption='[[1zz9]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1zz9' size='340' side='right' caption='[[1zz9]], [[Resolution\|resolution]] 2.40Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zz6\|1zz6]], [[1zz7\|1zz7]], [[1zz8\|1zz8]], [[1zzb\|1zzb]], [[1zzc\|1zzc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zz6\|1zz6]], [[1zz7\|1zz7]], [[1zz8\|1zz8]], [[1zzb\|1zzb]], [[1zzc\|1zzc]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fom4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=43759 "Actinomyces wedmorensis" Milard and Burr 1926])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fom4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=43759 "Actinomyces wedmorensis" Milard and Burr 1926])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zz9 OCA], [http://pdbe.org/1zz9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zz9 RCSB], [http://www.ebi.ac.uk/pdbsum/1zz9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zz9 OCA], [http://pdbe.org/1zz9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zz9 RCSB], [http://www.ebi.ac.uk/pdbsum/1zz9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1zz9 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zz/1zz9_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zz/1zz9_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zz9 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 17:33, 11 September 2015

OCA — Fri, 11 Sep 2015 17:33:08 GMT

←Older revision		Revision as of 17:33, 11 September 2015
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	<StructureSection load='1zz9' size='340' side='right' caption='[[1zz9]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='1zz9' size='340' side='right' caption='[[1zz9]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1zz9]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Streptomyces_wedmorensis Streptomyces~~ wedmorensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZZ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZZ9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1zz9]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinomyces_wedmorensis"_milard_and_burr_1926 "actinomyces wedmorensis" milard and burr 1926]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZZ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZZ9 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zz6\|1zz6]], [[1zz7\|1zz7]], [[1zz8\|1zz8]], [[1zzb\|1zzb]], [[1zzc\|1zzc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zz6\|1zz6]], [[1zz7\|1zz7]], [[1zz8\|1zz8]], [[1zzb\|1zzb]], [[1zzc\|1zzc]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fom4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=43759 ~~Streptomyces~~ wedmorensis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fom4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=43759 "Actinomyces wedmorensis" Milard and Burr 1926])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zz9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zz9 RCSB], [http://www.ebi.ac.uk/pdbsum/1zz9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zz9 OCA], [http://pdbe.org/1zz9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zz9 RCSB], [http://www.ebi.ac.uk/pdbsum/1zz9 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1zz9" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Streptomyces~~ wedmorensis]]	+	[[Category: Actinomyces wedmorensis milard and burr 1926]]
	[[Category: Drennan, C L]]		[[Category: Drennan, C L]]
	[[Category: Higgins, L J]]		[[Category: Higgins, L J]]

OCA at 10:12, 8 January 2015

OCA — Thu, 08 Jan 2015 10:12:11 GMT

←Older revision		Revision as of 10:12, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1zz9]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_wedmorensis Streptomyces wedmorensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZZ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZZ9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1zz9]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_wedmorensis Streptomyces wedmorensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZZ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZZ9 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zz6\|1zz6]], [[1zz7\|1zz7]], [[1zz8\|1zz8]], [[1zzb\|1zzb]], [[1zzc\|1zzc]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zz6\|1zz6]], [[1zz7\|1zz7]], [[1zz8\|1zz8]], [[1zzb\|1zzb]], [[1zzc\|1zzc]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fom4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=43759 Streptomyces wedmorensis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fom4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=43759 Streptomyces wedmorensis])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zz9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zz9 RCSB], [http://www.ebi.ac.uk/pdbsum/1zz9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zz9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zz9 RCSB], [http://www.ebi.ac.uk/pdbsum/1zz9 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Streptomyces wedmorensis]]		[[Category: Streptomyces wedmorensis]]
-	[[Category: Drennan, C L.]]	+	[[Category: Drennan, C L]]
-	[[Category: Higgins, L J.]]	+	[[Category: Higgins, L J]]
-	[[Category: Liu, H W.]]	+	[[Category: Liu, H W]]
-	[[Category: Liu, P.]]	+	[[Category: Liu, P]]
-	[[Category: Yan, F.]]	+	[[Category: Yan, F]]
	[[Category: Cupin]]		[[Category: Cupin]]
	[[Category: Holo-hppe]]		[[Category: Holo-hppe]]
	[[Category: Mononuclear iron enzyme]]		[[Category: Mononuclear iron enzyme]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 00:56, 30 September 2014

OCA — Tue, 30 Sep 2014 00:56:41 GMT

←Older revision		Revision as of 00:56, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1zz9.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of FeII HppE==
		+	<StructureSection load='1zz9' size='340' side='right' caption='[[1zz9]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1zz9]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_wedmorensis Streptomyces wedmorensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZZ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZZ9 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zz6\|1zz6]], [[1zz7\|1zz7]], [[1zz8\|1zz8]], [[1zzb\|1zzb]], [[1zzc\|1zzc]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fom4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=43759 Streptomyces wedmorensis])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zz9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zz9 RCSB], [http://www.ebi.ac.uk/pdbsum/1zz9 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zz/1zz9_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The biosynthetic pathway of the clinically important antibiotic fosfomycin uses enzymes that catalyse reactions without precedent in biology. Among these is hydroxypropylphosphonic acid epoxidase, which represents a new subfamily of non-haem mononuclear iron enzymes. Here we present six X-ray structures of this enzyme: the apoenzyme at 2.0 A resolution; a native Fe(II)-bound form at 2.4 A resolution; a tris(hydroxymethyl)aminomethane-Co(II)-enzyme complex structure at 1.8 A resolution; a substrate-Co(II)-enzyme complex structure at 2.5 A resolution; and two substrate-Fe(II)-enzyme complexes at 2.1 and 2.3 A resolution. These structural data lead us to suggest how this enzyme is able to recognize and respond to its substrate with a conformational change that protects the radical-based intermediates formed during catalysis. Comparisons with other family members suggest why substrate binding is able to prime iron for dioxygen binding in the absence of alpha-ketoglutarate (a co-substrate required by many mononuclear iron enzymes), and how the unique epoxidation reaction of hydroxypropylphosphonic acid epoxidase may occur.

-	~~{{STRUCTURE_1zz9\| PDB=1zz9 \| SCENE= }}~~	+	Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme.,Higgins LJ, Yan F, Liu P, Liu HW, Drennan CL Nature. 2005 Oct 6;437(7060):838-44. Epub 2005 Jul 13. PMID:16015285<ref>PMID:16015285</ref>

-	~~===Crystal Structure~~ of ~~FeII HppE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16015285}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1zz9]] is a 3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Streptomyces_wedmorensis Streptomyces wedmorensis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1ZZ9 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016015285<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Streptomyces wedmorensis]]		[[Category: Streptomyces wedmorensis]]
	[[Category: Drennan, C L.]]		[[Category: Drennan, C L.]]

OCA: Protected "1zz9" [edit=sysop:move=sysop]

OCA — Sun, 06 Jan 2013 10:15:03 GMT

Protected "1zz9" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:15, 6 January 2013

OCA at 10:15, 6 January 2013

OCA — Sun, 06 Jan 2013 10:15:01 GMT

←Older revision		Revision as of 10:15, 6 January 2013
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-	{{Seed}}
	[[Image:1zz9.png\|left\|200px]]		[[Image:1zz9.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1zz9", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1zz9\| PDB=1zz9 \| SCENE= }}		{{STRUCTURE_1zz9\| PDB=1zz9 \| SCENE= }}

	===Crystal Structure of FeII HppE===		===Crystal Structure of FeII HppE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16015285}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16015285 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16015285}}		{{ABSTRACT_PUBMED_16015285}}

	==About this Structure==		==About this Structure==
-	~~1ZZ9~~ is a 3 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Streptomyces_wedmorensis Streptomyces wedmorensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZZ9 OCA].	+	[[1zz9]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_wedmorensis Streptomyces wedmorensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZZ9 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16015285~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016015285</ref><references group="xtra"/>
	[[Category: Streptomyces wedmorensis]]		[[Category: Streptomyces wedmorensis]]
	[[Category: Drennan, C L.]]		[[Category: Drennan, C L.]]
Line 33:		Line 21:
	[[Category: Holo-hppe]]		[[Category: Holo-hppe]]
	[[Category: Mononuclear iron enzyme]]		[[Category: Mononuclear iron enzyme]]
-		+	[[Category: Oxidoreductase]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Wed Feb 18 04:49:41 2009''~~	+

OCA at 02:49, 18 February 2009

OCA — Wed, 18 Feb 2009 02:49:42 GMT

←Older revision		Revision as of 02:49, 18 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1ZZ9 is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Streptomyces_wedmorensis Streptomyces wedmorensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZZ9 OCA].	+	1ZZ9 is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Streptomyces_wedmorensis Streptomyces wedmorensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZZ9 OCA].

	==Reference==		==Reference==
-	~~Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme., Higgins LJ, Yan F, Liu P, Liu HW, Drennan CL, Nature. 2005 Oct 6;437(7060):838-44. Epub 2005 Jul 13.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16015285 16015285]~~	+	<ref group="xtra">PMID:16015285</ref><references group="xtra"/>
-	~~[[Category: Single protein]]~~	+
	[[Category: Streptomyces wedmorensis]]		[[Category: Streptomyces wedmorensis]]
	[[Category: Drennan, C L.]]		[[Category: Drennan, C L.]]
Line 35:		Line 34:
	[[Category: Mononuclear iron enzyme]]		[[Category: Mononuclear iron enzyme]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 11~~:37:~~17 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 04:49:41 2009''

OCA at 08:37, 29 July 2008

OCA — Tue, 29 Jul 2008 08:37:23 GMT

←Older revision		Revision as of 08:37, 29 July 2008
Line 1:		Line 1:
-	[[Image:1zz9.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1zz9.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_1zz9\| PDB=1zz9 \| SCENE= }}		{{STRUCTURE_1zz9\| PDB=1zz9 \| SCENE= }}

-	~~'''~~Crystal Structure of FeII HppE~~'''~~	+	===Crystal Structure of FeII HppE===


-	~~==Overview==~~	+	<!--
-	The ~~biosynthetic pathway of the clinically important antibiotic fosfomycin uses enzymes that catalyse reactions without precedent in biology. Among these is hydroxypropylphosphonic acid epoxidase~~, ~~which represents a new subfamily of non-haem mononuclear iron enzymes. Here we present six X-ray structures of this enzyme:~~ the ~~apoenzyme at 2.0 A resolution; a native Fe~~(~~II)-bound form~~ at 2.~~4 A resolution; a tris(hydroxymethyl)aminomethane-Co(II)-enzyme complex structure at 1~~.~~8 A resolution; a substrate-Co(II~~)~~-enzyme complex structure at 2.5 A resolution; and two substrate-Fe(II)-enzyme complexes at 2.1 and 2.3 A resolution. These structural data lead us to suggest how this enzyme~~ is ~~able to recognize and respond to its substrate with a conformational change that protects~~ the ~~radical-based intermediates formed during catalysis~~. ~~Comparisons with other family members suggest why substrate binding is able to prime iron for dioxygen binding in the absence of alpha~~-~~ketoglutarate (a co~~-~~substrate required by many mononuclear iron enzymes), and how the unique epoxidation reaction of hydroxypropylphosphonic acid epoxidase may occur.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_16015285}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 16015285 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_16015285}}

	==About this Structure==		==About this Structure==
Line 30:		Line 34:
	[[Category: Holo-hppe]]		[[Category: Holo-hppe]]
	[[Category: Mononuclear iron enzyme]]		[[Category: Mononuclear iron enzyme]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 18~~:15:51 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:37:17 2008''