2a4n - Revision history

OCA at 07:19, 23 August 2023

OCA — Wed, 23 Aug 2023 07:19:04 GMT

←Older revision		Revision as of 07:19, 23 August 2023
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	<StructureSection load='2a4n' size='340' side='right'caption='[[2a4n]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2a4n' size='340' side='right'caption='[[2a4n]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2a4n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_19434 Atcc 19434~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A4N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A4N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2a4n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecium Enterococcus faecium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A4N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A4N FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=COA:COENZYME+A'>COA</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[1n71\|1n71]], [[1b87\|1b87]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>aac(6')-Ii ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~1352 ATCC 19434])</td~~><~~/tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>[https://en.wikipedia.org/wiki/Aminoglycoside_N(6')-acetyltransferase Aminoglycoside N(6')-acetyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.82 2.3.1.82] </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a4n OCA], [https://pdbe.org/2a4n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a4n RCSB], [https://www.ebi.ac.uk/pdbsum/2a4n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a4n ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a4n OCA], [https://pdbe.org/2a4n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a4n RCSB], [https://www.ebi.ac.uk/pdbsum/2a4n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a4n ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q47764_ENTFC Q47764_ENTFC]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc 19434~~]]	+	[[Category: Enterococcus faecium]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Berghuis~~, A M~~]]	+	[[Category: Berghuis AM]]
-	[[Category: Breitbach, C]]	+	[[Category: Breitbach C]]
-	[[Category: Burk~~, D L~~]]	+	[[Category: Burk DL]]
-	[[Category: Xiong, B]]	+	[[Category: Xiong B]]
-	~~[[Category: Alpha beta protein]]~~	+
-	~~[[Category: N-acetyl transferase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 08:25, 27 January 2021

OCA — Wed, 27 Jan 2021 08:25:40 GMT

←Older revision		Revision as of 08:25, 27 January 2021
Line 1:		Line 1:

	==Crystal structure of aminoglycoside 6'-N-acetyltransferase complexed with coenzyme A==		==Crystal structure of aminoglycoside 6'-N-acetyltransferase complexed with coenzyme A==
-	<StructureSection load='2a4n' size='340' side='right' caption='[[2a4n]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='2a4n' size='340' side='right'caption='[[2a4n]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2a4n]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_19434 Atcc 19434]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A4N OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2A4N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2a4n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_19434 Atcc 19434]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A4N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A4N FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1n71\|1n71]], [[1b87\|1b87]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1n71\|1n71]], [[1b87\|1b87]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aac(6')-Ii ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1352 ATCC 19434])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aac(6')-Ii ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1352 ATCC 19434])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Aminoglycoside_N(6')-acetyltransferase Aminoglycoside N(6')-acetyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.82 2.3.1.82] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Aminoglycoside_N(6')-acetyltransferase Aminoglycoside N(6')-acetyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.82 2.3.1.82] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2a4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a4n OCA], [~~http~~://pdbe.org/2a4n PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2a4n RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2a4n PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2a4n ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a4n OCA], [https://pdbe.org/2a4n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a4n RCSB], [https://www.ebi.ac.uk/pdbsum/2a4n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a4n ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a4/2a4n_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a4/2a4n_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 19434]]		[[Category: Atcc 19434]]
		+	[[Category: Large Structures]]
	[[Category: Berghuis, A M]]		[[Category: Berghuis, A M]]
	[[Category: Breitbach, C]]		[[Category: Breitbach, C]]

OCA at 10:17, 12 October 2017

OCA — Thu, 12 Oct 2017 10:17:40 GMT

←Older revision		Revision as of 10:17, 12 October 2017
Line 1:		Line 1:
		+
	==Crystal structure of aminoglycoside 6'-N-acetyltransferase complexed with coenzyme A==		==Crystal structure of aminoglycoside 6'-N-acetyltransferase complexed with coenzyme A==
	<StructureSection load='2a4n' size='340' side='right' caption='[[2a4n]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2a4n' size='340' side='right' caption='[[2a4n]], [[Resolution\|resolution]] 2.20Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aac(6')-Ii ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1352 ATCC 19434])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aac(6')-Ii ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1352 ATCC 19434])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoglycoside_N(6')-acetyltransferase Aminoglycoside N(6')-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.82 2.3.1.82] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoglycoside_N(6')-acetyltransferase Aminoglycoside N(6')-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.82 2.3.1.82] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a4n OCA], [http://pdbe.org/2a4n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2a4n RCSB], [http://www.ebi.ac.uk/pdbsum/2a4n PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a4n OCA], [http://pdbe.org/2a4n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2a4n RCSB], [http://www.ebi.ac.uk/pdbsum/2a4n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2a4n ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 07:14, 9 February 2016

OCA — Tue, 09 Feb 2016 07:14:43 GMT

←Older revision		Revision as of 07:14, 9 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a4n ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 19:52, 10 September 2015

OCA — Thu, 10 Sep 2015 19:52:03 GMT

←Older revision		Revision as of 19:52, 10 September 2015
Line 7:		Line 7:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aac(6')-Ii ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1352 ATCC 19434])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aac(6')-Ii ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1352 ATCC 19434])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoglycoside_N(6')-acetyltransferase Aminoglycoside N(6')-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.82 2.3.1.82] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoglycoside_N(6')-acetyltransferase Aminoglycoside N(6')-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.82 2.3.1.82] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a4n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2a4n RCSB], [http://www.ebi.ac.uk/pdbsum/2a4n PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a4n OCA], [http://pdbe.org/2a4n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2a4n RCSB], [http://www.ebi.ac.uk/pdbsum/2a4n PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2a4n" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:56, 8 January 2015

OCA — Thu, 08 Jan 2015 09:56:51 GMT

←Older revision		Revision as of 09:56, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2a4n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_19434 Atcc 19434]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A4N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A4N FirstGlance]. <br>		<table><tr><td colspan='2'>[[2a4n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_19434 Atcc 19434]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A4N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A4N FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1n71\|1n71]], [[1b87\|1b87]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1n71\|1n71]], [[1b87\|1b87]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aac(6')-Ii ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1352 ATCC 19434])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aac(6')-Ii ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1352 ATCC 19434])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoglycoside_N(6')-acetyltransferase Aminoglycoside N(6')-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.82 2.3.1.82] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoglycoside_N(6')-acetyltransferase Aminoglycoside N(6')-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.82 2.3.1.82] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a4n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2a4n RCSB], [http://www.ebi.ac.uk/pdbsum/2a4n PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a4n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2a4n RCSB], [http://www.ebi.ac.uk/pdbsum/2a4n PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 19434]]		[[Category: Atcc 19434]]
-	[[Category: Berghuis, A M.]]	+	[[Category: Berghuis, A M]]
-	[[Category: Breitbach, C.]]	+	[[Category: Breitbach, C]]
-	[[Category: Burk, D L.]]	+	[[Category: Burk, D L]]
-	[[Category: Xiong, B.]]	+	[[Category: Xiong, B]]
	[[Category: Alpha beta protein]]		[[Category: Alpha beta protein]]
	[[Category: N-acetyl transferase]]		[[Category: N-acetyl transferase]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 10:37, 3 October 2014

OCA — Fri, 03 Oct 2014 10:37:39 GMT

←Older revision		Revision as of 10:37, 3 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2a4n~~\| ~~PDB~~=2a4n \| ~~SCENE~~= }}	+	==Crystal structure of aminoglycoside 6'-N-acetyltransferase complexed with coenzyme A==
-	===~~Crystal~~ structure of aminoglycoside 6'-N-acetyltransferase ~~complexed~~ with coenzyme A===	+	<StructureSection load='2a4n' size='340' side='right' caption='[[2a4n]], [[Resolution\|resolution]] 2.20Å' scene=''>
-	~~{{ABSTRACT_PUBMED_16131761}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2a4n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_19434 Atcc 19434]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A4N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A4N FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1n71\|1n71]], [[1b87\|1b87]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aac(6')-Ii ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1352 ATCC 19434])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoglycoside_N(6')-acetyltransferase Aminoglycoside N(6')-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.82 2.3.1.82] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a4n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2a4n RCSB], [http://www.ebi.ac.uk/pdbsum/2a4n PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a4/2a4n_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The aminoglycoside-modifying enzyme aminoglycoside 6'-N-acetyltransferase type Ii [AAC(6')-Ii] has been crystallized with its cofactor coenzyme A in space group C222(1), with unit-cell parameters a = 71.5, b = 127.4, c = 76.9 A and one physiologically relevant dimer species per asymmetric unit. The space group previously observed for this complex was P2(1)2(1)2(1), with two dimers per asymmetric unit. By comparing the six available protomer structures of the AAC(6')-Ii-CoA complex, it has been possible to identify regions of plasticity within the protein. Normal-mode analysis of this complex suggests that this plasticity is not an artefact of crystal-packing forces, but that the region of the protomer that displays multiple conformations is intrinsically flexible. It is conjectured that the flexibility is relevant for the cooperative activity observed for the enzyme.

-	~~==About this Structure==~~	+	Structures of aminoglycoside acetyltransferase AAC(6')-Ii in a novel crystal form: structural and normal-mode analyses.,Burk DL, Xiong B, Breitbach C, Berghuis AM Acta Crystallogr D Biol Crystallogr. 2005 Sep;61(Pt 9):1273-9. Epub 2005, Aug 16. PMID:16131761<ref>PMID:16131761</ref>
-	~~[[2a4n]] is~~ a ~~2 chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org/wiki/Atcc_19434 Atcc 19434]. Full crystallographic information is available from [http~~:~~//oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=2A4N OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:016131761</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Atcc 19434]]		[[Category: Atcc 19434]]
	[[Category: Berghuis, A M.]]		[[Category: Berghuis, A M.]]

OCA at 08:17, 23 April 2014

OCA — Wed, 23 Apr 2014 08:17:14 GMT

←Older revision		Revision as of 08:17, 23 April 2014
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-	[[Image:2a4n.png\|left\|200px]]
-
-	<!--
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	{{STRUCTURE_2a4n\| PDB=2a4n \| SCENE= }}		{{STRUCTURE_2a4n\| PDB=2a4n \| SCENE= }}
-
	===Crystal structure of aminoglycoside 6'-N-acetyltransferase complexed with coenzyme A===		===Crystal structure of aminoglycoside 6'-N-acetyltransferase complexed with coenzyme A===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16131761}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16131761 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_16131761}}		{{ABSTRACT_PUBMED_16131761}}

	==About this Structure==		==About this Structure==
-	[[2a4n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Enterococcus_faecium Enterococcus faecium~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A4N OCA].	+	[[2a4n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_19434 Atcc 19434]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A4N OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:016131761</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016131761</ref><references group="xtra"/><references/>
-	[[Category: ~~Enterococcus faecium~~]]	+	[[Category: Atcc 19434]]
	[[Category: Berghuis, A M.]]		[[Category: Berghuis, A M.]]
	[[Category: Breitbach, C.]]		[[Category: Breitbach, C.]]

OCA: Protected "2a4n" [edit=sysop:move=sysop]

OCA — Wed, 16 Nov 2011 09:47:56 GMT

Protected "2a4n" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:47, 16 November 2011

OCA at 09:47, 16 November 2011

OCA — Wed, 16 Nov 2011 09:47:54 GMT

←Older revision		Revision as of 09:47, 16 November 2011
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-	{{Seed}}
	[[Image:2a4n.png\|left\|200px]]		[[Image:2a4n.png\|left\|200px]]

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	==About this Structure==		==About this Structure==
-	~~2A4N~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Enterococcus_faecium Enterococcus faecium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A4N OCA].	+	[[2a4n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecium Enterococcus faecium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A4N OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16131761~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016131761</ref><references group="xtra"/>
	[[Category: Enterococcus faecium]]		[[Category: Enterococcus faecium]]
	[[Category: Berghuis, A M.]]		[[Category: Berghuis, A M.]]
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	[[Category: Alpha beta protein]]		[[Category: Alpha beta protein]]
	[[Category: N-acetyl transferase]]		[[Category: N-acetyl transferase]]
-		+	[[Category: Transferase]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 07:52:45 2009''~~	+