2a9b - Revision history

OCA at 07:21, 23 August 2023

OCA — Wed, 23 Aug 2023 07:21:24 GMT

←Older revision		Revision as of 07:21, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='2a9b' size='340' side='right'caption='[[2a9b]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2a9b' size='340' side='right'caption='[[2a9b]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2a9b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Chick Chick~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A9B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A9B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2a9b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A9B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A9B FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MO:MOLYBDENUM+ATOM'>MO</scene>, <scene name='pdbligand=MTE:PHOSPHONIC+ACIDMONO-(2-AMINO-5,6-DIMERCAPTO-4-OXO-3,7,8A,9,10,10A-HEXAHYDRO-4H-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-7-YLMETHYL)ESTER'>MTE</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.503Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2a99\|2a99]], [[2a9a\|2a9a]], [[2a9c\|2a9c]], [[2a9d\|2a9d]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MO:MOLYBDENUM+ATOM'>MO</scene>, <scene name='pdbligand=MTE:PHOSPHONIC+ACIDMONO-(2-AMINO-5,6-DIMERCAPTO-4-OXO-3,7,8A,9,10,10A-HEXAHYDRO-4H-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-7-YLMETHYL)ESTER'>MTE</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SUOX ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Sulfite_oxidase Sulfite oxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.3.1 1.8.3.1] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a9b OCA], [https://pdbe.org/2a9b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a9b RCSB], [https://www.ebi.ac.uk/pdbsum/2a9b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a9b ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a9b OCA], [https://pdbe.org/2a9b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a9b RCSB], [https://www.ebi.ac.uk/pdbsum/2a9b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a9b ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SUOX_CHICK SUOX_CHICK]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Chick~~]]	+	[[Category: Gallus gallus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Sulfite oxidase]]~~	+	[[Category: Graf TN]]
-	[[Category: Graf~~, T N~~]]	+	[[Category: Jaramillo-Busquets S]]
-	[[Category: Jaramillo-Busquets, S]]	+	[[Category: Karakas E]]
-	[[Category: Karakas, E]]	+	[[Category: Kisker C]]
-	[[Category: Kisker, C]]	+	[[Category: Rajagopalan KV]]
-	[[Category: Rajagopalan~~, K V~~]]	+	[[Category: Wilson HL]]
-	[[Category: Wilson~~, H L~~]]	+	[[Category: Xiang S]]
-	[[Category: Xiang, S]]	+
-	~~[[Category: Molybdenum]]~~	+
-	~~[[Category: Molybdopterin]]~~	+
-	~~[[Category: Mutant]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: R138q]]~~	+
-	~~[[Category: R160q~~]]	+

OCA at 08:28, 27 January 2021

OCA — Wed, 27 Jan 2021 08:28:01 GMT

←Older revision		Revision as of 08:28, 27 January 2021
Line 1:		Line 1:

	==Crystal structure of R138Q mutant of recombinant sulfite oxidase at resting state==		==Crystal structure of R138Q mutant of recombinant sulfite oxidase at resting state==
-	<StructureSection load='2a9b' size='340' side='right' caption='[[2a9b]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='2a9b' size='340' side='right'caption='[[2a9b]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2a9b]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A9B OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2A9B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2a9b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A9B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A9B FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MO:MOLYBDENUM+ATOM'>MO</scene>, <scene name='pdbligand=MTE:PHOSPHONIC+ACIDMONO-(2-AMINO-5,6-DIMERCAPTO-4-OXO-3,7,8A,9,10,10A-HEXAHYDRO-4H-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-7-YLMETHYL)ESTER'>MTE</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MO:MOLYBDENUM+ATOM'>MO</scene>, <scene name='pdbligand=MTE:PHOSPHONIC+ACIDMONO-(2-AMINO-5,6-DIMERCAPTO-4-OXO-3,7,8A,9,10,10A-HEXAHYDRO-4H-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-7-YLMETHYL)ESTER'>MTE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2a99\|2a99]], [[2a9a\|2a9a]], [[2a9c\|2a9c]], [[2a9d\|2a9d]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2a99\|2a99]], [[2a9a\|2a9a]], [[2a9c\|2a9c]], [[2a9d\|2a9d]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SUOX ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SUOX ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Sulfite_oxidase Sulfite oxidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.3.1 1.8.3.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Sulfite_oxidase Sulfite oxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.3.1 1.8.3.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2a9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a9b OCA], [~~http~~://pdbe.org/2a9b PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2a9b RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2a9b PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2a9b ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a9b OCA], [https://pdbe.org/2a9b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a9b RCSB], [https://www.ebi.ac.uk/pdbsum/2a9b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a9b ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Chick]]		[[Category: Chick]]
		+	[[Category: Large Structures]]
	[[Category: Sulfite oxidase]]		[[Category: Sulfite oxidase]]
	[[Category: Graf, T N]]		[[Category: Graf, T N]]

OCA at 07:12, 9 May 2018

OCA — Wed, 09 May 2018 07:12:14 GMT

←Older revision		Revision as of 07:12, 9 May 2018
Line 1:		Line 1:
		+
	==Crystal structure of R138Q mutant of recombinant sulfite oxidase at resting state==		==Crystal structure of R138Q mutant of recombinant sulfite oxidase at resting state==
	<StructureSection load='2a9b' size='340' side='right' caption='[[2a9b]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2a9b' size='340' side='right' caption='[[2a9b]], [[Resolution\|resolution]] 2.50Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SUOX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SUOX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sulfite_oxidase Sulfite oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.3.1 1.8.3.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sulfite_oxidase Sulfite oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.3.1 1.8.3.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a9b OCA], [http://pdbe.org/2a9b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2a9b RCSB], [http://www.ebi.ac.uk/pdbsum/2a9b PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a9b OCA], [http://pdbe.org/2a9b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2a9b RCSB], [http://www.ebi.ac.uk/pdbsum/2a9b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2a9b ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a9/2a9b_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a9/2a9b_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 03:23, 10 February 2016

OCA — Wed, 10 Feb 2016 03:23:19 GMT

←Older revision		Revision as of 03:23, 10 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a9b ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 04:53, 11 September 2015

OCA — Fri, 11 Sep 2015 04:53:34 GMT

←Older revision		Revision as of 04:53, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2a9b' size='340' side='right' caption='[[2a9b]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2a9b' size='340' side='right' caption='[[2a9b]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2a9b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Gallus_gallus Gallus gallus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A9B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A9B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2a9b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A9B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A9B FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MO:MOLYBDENUM+ATOM'>MO</scene>, <scene name='pdbligand=MTE:PHOSPHONIC+ACIDMONO-(2-AMINO-5,6-DIMERCAPTO-4-OXO-3,7,8A,9,10,10A-HEXAHYDRO-4H-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-7-YLMETHYL)ESTER'>MTE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MO:MOLYBDENUM+ATOM'>MO</scene>, <scene name='pdbligand=MTE:PHOSPHONIC+ACIDMONO-(2-AMINO-5,6-DIMERCAPTO-4-OXO-3,7,8A,9,10,10A-HEXAHYDRO-4H-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-7-YLMETHYL)ESTER'>MTE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2a99\|2a99]], [[2a9a\|2a9a]], [[2a9c\|2a9c]], [[2a9d\|2a9d]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2a99\|2a99]], [[2a9a\|2a9a]], [[2a9c\|2a9c]], [[2a9d\|2a9d]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SUOX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 ~~Gallus gallus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SUOX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sulfite_oxidase Sulfite oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.3.1 1.8.3.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sulfite_oxidase Sulfite oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.3.1 1.8.3.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a9b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2a9b RCSB], [http://www.ebi.ac.uk/pdbsum/2a9b PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a9b OCA], [http://pdbe.org/2a9b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2a9b RCSB], [http://www.ebi.ac.uk/pdbsum/2a9b PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2a9b" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Gallus gallus~~]]	+	[[Category: Chick]]
	[[Category: Sulfite oxidase]]		[[Category: Sulfite oxidase]]
	[[Category: Graf, T N]]		[[Category: Graf, T N]]

OCA at 09:33, 8 January 2015

OCA — Thu, 08 Jan 2015 09:33:22 GMT

←Older revision		Revision as of 09:33, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2a9b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A9B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A9B FirstGlance]. <br>		<table><tr><td colspan='2'>[[2a9b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A9B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A9B FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MO:MOLYBDENUM+ATOM'>MO</scene>, <scene name='pdbligand=MTE:PHOSPHONIC+ACIDMONO-(2-AMINO-5,6-DIMERCAPTO-4-OXO-3,7,8A,9,10,10A-HEXAHYDRO-4H-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-7-YLMETHYL)ESTER'>MTE</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MO:MOLYBDENUM+ATOM'>MO</scene>, <scene name='pdbligand=MTE:PHOSPHONIC+ACIDMONO-(2-AMINO-5,6-DIMERCAPTO-4-OXO-3,7,8A,9,10,10A-HEXAHYDRO-4H-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-7-YLMETHYL)ESTER'>MTE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2a99\|2a99]], [[2a9a\|2a9a]], [[2a9c\|2a9c]], [[2a9d\|2a9d]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2a99\|2a99]], [[2a9a\|2a9a]], [[2a9c\|2a9c]], [[2a9d\|2a9d]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SUOX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 Gallus gallus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SUOX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 Gallus gallus])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sulfite_oxidase Sulfite oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.3.1 1.8.3.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sulfite_oxidase Sulfite oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.3.1 1.8.3.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a9b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2a9b RCSB], [http://www.ebi.ac.uk/pdbsum/2a9b PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a9b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2a9b RCSB], [http://www.ebi.ac.uk/pdbsum/2a9b PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
	[[Category: Sulfite oxidase]]		[[Category: Sulfite oxidase]]
-	[[Category: Graf, T N.]]	+	[[Category: Graf, T N]]
-	[[Category: Jaramillo-Busquets, S.]]	+	[[Category: Jaramillo-Busquets, S]]
-	[[Category: Karakas, E.]]	+	[[Category: Karakas, E]]
-	[[Category: Kisker, C.]]	+	[[Category: Kisker, C]]
-	[[Category: Rajagopalan, K V.]]	+	[[Category: Rajagopalan, K V]]
-	[[Category: Wilson, H L.]]	+	[[Category: Wilson, H L]]
-	[[Category: Xiang, S.]]	+	[[Category: Xiang, S]]
	[[Category: Molybdenum]]		[[Category: Molybdenum]]
	[[Category: Molybdopterin]]		[[Category: Molybdopterin]]
Line 49:		Line 49:
	[[Category: R138q]]		[[Category: R138q]]
	[[Category: R160q]]		[[Category: R160q]]
-	[[Category: Sulfite oxidase]]

OCA at 00:20, 30 September 2014

OCA — Tue, 30 Sep 2014 00:20:22 GMT

←Older revision		Revision as of 00:20, 30 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2a9b\| PDB=2a9b \| SCENE= }}~~	+	==Crystal structure of R138Q mutant of recombinant sulfite oxidase at resting state==
-	===Crystal structure of R138Q mutant of recombinant sulfite oxidase at resting state===	+	<StructureSection load='2a9b' size='340' side='right' caption='[[2a9b]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~{{ABSTRACT_PUBMED_16048997}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2a9b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A9B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A9B FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MO:MOLYBDENUM+ATOM'>MO</scene>, <scene name='pdbligand=MTE:PHOSPHONIC+ACIDMONO-(2-AMINO-5,6-DIMERCAPTO-4-OXO-3,7,8A,9,10,10A-HEXAHYDRO-4H-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-7-YLMETHYL)ESTER'>MTE</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2a99\|2a99]], [[2a9a\|2a9a]], [[2a9c\|2a9c]], [[2a9d\|2a9d]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SUOX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 Gallus gallus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sulfite_oxidase Sulfite oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.3.1 1.8.3.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a9b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2a9b RCSB], [http://www.ebi.ac.uk/pdbsum/2a9b PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a9/2a9b_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Sulfite oxidase deficiency is a lethal genetic disease that results from defects either in the genes encoding proteins involved in molybdenum cofactor biosynthesis or in the sulfite oxidase gene itself. Several point mutations in the sulfite oxidase gene have been identified from patients suffering from this disease worldwide. Although detailed biochemical analyses have been carried out on these mutations, no structural data could be obtained because of problems in crystallizing recombinant human and rat sulfite oxidases and the failure to clone the chicken sulfite oxidase gene. We synthesized the gene for chicken sulfite oxidase de novo, working backward from the amino acid sequence of the native chicken liver enzyme by PCR amplification of a series of 72 overlapping primers. The recombinant protein displayed the characteristic absorption spectrum of sulfite oxidase and exhibited steady state and rapid kinetic parameters comparable with those of the tissue-derived enzyme. We solved the crystal structures of the wild type and the sulfite oxidase deficiency-causing R138Q (R160Q in humans) variant of recombinant chicken sulfite oxidase in the resting and sulfate-bound forms. Significant alterations in the substrate-binding pocket were detected in the structure of the mutant, and a comparison between the wild type and mutant protein revealed that the active site residue Arg-450 adopts different conformations in the presence and absence of bound sulfate. The size of the binding pocket is thereby considerably reduced, and its position relative to the cofactor is shifted, causing an increase in the distance of the sulfur atom of the bound sulfate to the molybdenum.

-	~~==About this Structure==~~	+	Structural insights into sulfite oxidase deficiency.,Karakas E, Wilson HL, Graf TN, Xiang S, Jaramillo-Busquets S, Rajagopalan KV, Kisker C J Biol Chem. 2005 Sep 30;280(39):33506-15. Epub 2005 Jul 27. PMID:16048997<ref>PMID:16048997</ref>
-	~~[[2a9b]] is a 1 chain structure with sequence from [http~~:~~//en~~.~~wikipedia.org/wiki/Gallus_gallus Gallus gallus]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=2A9B OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Sulfite Oxidase\|Sulfite Oxidase]]		*[[Sulfite Oxidase\|Sulfite Oxidase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:016048997<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
	[[Category: Sulfite oxidase]]		[[Category: Sulfite oxidase]]

OCA at 09:26, 11 March 2013

OCA — Mon, 11 Mar 2013 09:26:51 GMT

←Older revision		Revision as of 09:26, 11 March 2013
Line 1:		Line 1:
-	[[Image:2a9b.png\|left\|200px]]
-
	{{STRUCTURE_2a9b\| PDB=2a9b \| SCENE= }}		{{STRUCTURE_2a9b\| PDB=2a9b \| SCENE= }}
-
	===Crystal structure of R138Q mutant of recombinant sulfite oxidase at resting state===		===Crystal structure of R138Q mutant of recombinant sulfite oxidase at resting state===
-
	{{ABSTRACT_PUBMED_16048997}}		{{ABSTRACT_PUBMED_16048997}}

OCA: Protected "2a9b" [edit=sysop:move=sysop]

OCA — Sun, 06 Jan 2013 09:44:33 GMT

Protected "2a9b" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:44, 6 January 2013

OCA at 09:44, 6 January 2013

OCA — Sun, 06 Jan 2013 09:44:30 GMT

←Older revision		Revision as of 09:44, 6 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2a9b.png\|left\|200px]]		[[Image:2a9b.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2a9b", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2a9b\| PDB=2a9b \| SCENE= }}		{{STRUCTURE_2a9b\| PDB=2a9b \| SCENE= }}

	===Crystal structure of R138Q mutant of recombinant sulfite oxidase at resting state===		===Crystal structure of R138Q mutant of recombinant sulfite oxidase at resting state===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16048997}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16048997 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16048997}}		{{ABSTRACT_PUBMED_16048997}}

	==About this Structure==		==About this Structure==
-	~~2A9B~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A9B OCA].	+	[[2a9b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A9B OCA].
		+
		+	==See Also==
		+	*[[Sulfite Oxidase\|Sulfite Oxidase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16048997~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016048997</ref><references group="xtra"/>
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
	[[Category: Sulfite oxidase]]		[[Category: Sulfite oxidase]]
Line 36:		Line 27:
	[[Category: Molybdopterin]]		[[Category: Molybdopterin]]
	[[Category: Mutant]]		[[Category: Mutant]]
		+	[[Category: Oxidoreductase]]
	[[Category: R138q]]		[[Category: R138q]]
	[[Category: R160q]]		[[Category: R160q]]
	[[Category: Sulfite oxidase]]		[[Category: Sulfite oxidase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 15:02:27 2009''