2abw - Revision history

OCA at 08:17, 25 October 2023

OCA — Wed, 25 Oct 2023 08:17:07 GMT

←Older revision		Revision as of 08:17, 25 October 2023
Line 3:		Line 3:
	<StructureSection load='2abw' size='340' side='right'caption='[[2abw]], [[Resolution\|resolution]] 1.62Å' scene=''>		<StructureSection load='2abw' size='340' side='right'caption='[[2abw]], [[Resolution\|resolution]] 1.62Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2abw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Plafa Plafa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ABW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ABW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2abw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ABW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ABW FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.62Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[1r9g\|1r9g]]~~<~~/div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">Pdx2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2abw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2abw OCA], [https://pdbe.org/2abw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2abw RCSB], [https://www.ebi.ac.uk/pdbsum/2abw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2abw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2abw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2abw OCA], [https://pdbe.org/2abw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2abw RCSB], [https://www.ebi.ac.uk/pdbsum/2abw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2abw ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PDX2_PLAF7 PDX2_PLAF7] Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of Pdx1.<ref>PMID:15590634</ref> <ref>PMID:16339145</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Plafa~~]]	+	[[Category: Plasmodium falciparum]]
-	[[Category: Fitzpatrick~~, T B~~]]	+	[[Category: Fitzpatrick TB]]
-	[[Category: Flicker, K]]	+	[[Category: Flicker K]]
-	[[Category: Gengenbacher, M]]	+	[[Category: Gengenbacher M]]
-	[[Category: Kappes, B]]	+	[[Category: Kappes B]]
-	[[Category: Macheroux, P]]	+	[[Category: Macheroux P]]
-	[[Category: Mueller, S]]	+	[[Category: Mueller S]]
-	[[Category: Raschle, T]]	+	[[Category: Raschle T]]
-	[[Category: Sinning, I]]	+	[[Category: Sinning I]]
-	[[Category: Tews, I]]	+	[[Category: Tews I]]
-	~~[[Category: Glutaminase]]~~	+
-	~~[[Category: Malaria]]~~	+
-	~~[[Category: Plp-synthase]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Vitamin b6~~]]	+

OCA at 08:29, 27 January 2021

OCA — Wed, 27 Jan 2021 08:29:25 GMT

←Older revision		Revision as of 08:29, 27 January 2021
Line 1:		Line 1:

	==Glutaminase subunit of the plasmodial PLP synthase (Vitamin B6 biosynthesis)==		==Glutaminase subunit of the plasmodial PLP synthase (Vitamin B6 biosynthesis)==
-	<StructureSection load='2abw' size='340' side='right' caption='[[2abw]], [[Resolution\|resolution]] 1.62Å' scene=''>	+	<StructureSection load='2abw' size='340' side='right'caption='[[2abw]], [[Resolution\|resolution]] 1.62Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2abw]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ABW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ABW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2abw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ABW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ABW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1r9g\|1r9g]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1r9g\|1r9g]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pdx2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pdx2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2abw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2abw OCA], [~~http~~://pdbe.org/2abw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2abw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2abw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2abw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2abw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2abw OCA], [https://pdbe.org/2abw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2abw RCSB], [https://www.ebi.ac.uk/pdbsum/2abw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2abw ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ab/2abw_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ab/2abw_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Plafa]]		[[Category: Plafa]]
	[[Category: Fitzpatrick, T B]]		[[Category: Fitzpatrick, T B]]

OCA at 15:10, 12 October 2017

OCA — Thu, 12 Oct 2017 15:10:40 GMT

←Older revision		Revision as of 15:10, 12 October 2017
Line 1:		Line 1:
		+
	==Glutaminase subunit of the plasmodial PLP synthase (Vitamin B6 biosynthesis)==		==Glutaminase subunit of the plasmodial PLP synthase (Vitamin B6 biosynthesis)==
	<StructureSection load='2abw' size='340' side='right' caption='[[2abw]], [[Resolution\|resolution]] 1.62Å' scene=''>		<StructureSection load='2abw' size='340' side='right' caption='[[2abw]], [[Resolution\|resolution]] 1.62Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1r9g\|1r9g]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1r9g\|1r9g]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pdx2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pdx2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2abw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2abw OCA], [http://pdbe.org/2abw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2abw RCSB], [http://www.ebi.ac.uk/pdbsum/2abw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2abw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2abw OCA], [http://pdbe.org/2abw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2abw RCSB], [http://www.ebi.ac.uk/pdbsum/2abw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2abw ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2abw ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 02:08, 12 September 2015

OCA — Sat, 12 Sep 2015 02:08:15 GMT

←Older revision		Revision as of 02:08, 12 September 2015
Line 2:		Line 2:
	<StructureSection load='2abw' size='340' side='right' caption='[[2abw]], [[Resolution\|resolution]] 1.62Å' scene=''>		<StructureSection load='2abw' size='340' side='right' caption='[[2abw]], [[Resolution\|resolution]] 1.62Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2abw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Plasmodium_falciparum Plasmodium falciparum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ABW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ABW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2abw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ABW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ABW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1r9g\|1r9g]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1r9g\|1r9g]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pdx2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 ~~Plasmodium falciparum~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pdx2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2abw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2abw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2abw RCSB], [http://www.ebi.ac.uk/pdbsum/2abw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2abw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2abw OCA], [http://pdbe.org/2abw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2abw RCSB], [http://www.ebi.ac.uk/pdbsum/2abw PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2abw" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Plasmodium falciparum~~]]	+	[[Category: Plafa]]
	[[Category: Fitzpatrick, T B]]		[[Category: Fitzpatrick, T B]]
	[[Category: Flicker, K]]		[[Category: Flicker, K]]

OCA at 10:04, 8 January 2015

OCA — Thu, 08 Jan 2015 10:04:21 GMT

←Older revision		Revision as of 10:04, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2abw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ABW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ABW FirstGlance]. <br>		<table><tr><td colspan='2'>[[2abw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ABW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ABW FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1r9g\|1r9g]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1r9g\|1r9g]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pdx2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 Plasmodium falciparum])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pdx2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 Plasmodium falciparum])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2abw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2abw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2abw RCSB], [http://www.ebi.ac.uk/pdbsum/2abw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2abw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2abw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2abw RCSB], [http://www.ebi.ac.uk/pdbsum/2abw PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
-	[[Category: Fitzpatrick, T B.]]	+	[[Category: Fitzpatrick, T B]]
-	[[Category: Flicker, K.]]	+	[[Category: Flicker, K]]
-	[[Category: Gengenbacher, M.]]	+	[[Category: Gengenbacher, M]]
-	[[Category: Kappes, B.]]	+	[[Category: Kappes, B]]
-	[[Category: Macheroux, P.]]	+	[[Category: Macheroux, P]]
-	[[Category: Mueller, S.]]	+	[[Category: Mueller, S]]
-	[[Category: Raschle, T.]]	+	[[Category: Raschle, T]]
-	[[Category: Sinning, I.]]	+	[[Category: Sinning, I]]
-	[[Category: Tews, I.]]	+	[[Category: Tews, I]]
	[[Category: Glutaminase]]		[[Category: Glutaminase]]
	[[Category: Malaria]]		[[Category: Malaria]]

OCA at 02:29, 30 September 2014

OCA — Tue, 30 Sep 2014 02:29:29 GMT

←Older revision		Revision as of 02:29, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2abw.~~png~~\|~~left~~\|200px]]	+	==Glutaminase subunit of the plasmodial PLP synthase (Vitamin B6 biosynthesis)==
		+	<StructureSection load='2abw' size='340' side='right' caption='[[2abw]], [[Resolution\|resolution]] 1.62Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2abw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ABW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ABW FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1r9g\|1r9g]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pdx2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 Plasmodium falciparum])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2abw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2abw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2abw RCSB], [http://www.ebi.ac.uk/pdbsum/2abw PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ab/2abw_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Vitamin B6 is one of nature's most versatile cofactors. Most organisms synthesize vitamin B6 via a recently discovered pathway employing the proteins Pdx1 and Pdx2. Here we present an in-depth characterization of the respective orthologs from the malaria parasite, Plasmodium falciparum. Expression profiling of Pdx1 and -2 shows that blood-stage parasites indeed possess a functional vitamin B6 de novo biosynthesis. Recombinant Pdx1 and Pdx2 form a complex that functions as a glutamine amidotransferase with Pdx2 as the glutaminase and Pdx1 as pyridoxal-5 '-phosphate synthase domain. Complex formation is required for catalytic activity of either domain. Pdx1 forms a chimeric bi-enzyme with the bacterial YaaE, a Pdx2 ortholog, both in vivo and in vitro, although this chimera does not attain full catalytic activity, emphasizing that species-specific structural features govern the interaction between the protein partners of the PLP synthase complexes in different organisms. To gain insight into the activation mechanism of the parasite bi-enzyme complex, the three-dimensional structure of Pdx2 was determined at 1.62 A. The obstruction of the oxyanion hole indicates that Pdx2 is in a resting state and that activation occurs upon Pdx1-Pdx2 complex formation.

-	~~{{STRUCTURE_2abw\| PDB=2abw \| SCENE= }}~~	+	Vitamin B6 biosynthesis by the malaria parasite Plasmodium falciparum: biochemical and structural insights.,Gengenbacher M, Fitzpatrick TB, Raschle T, Flicker K, Sinning I, Muller S, Macheroux P, Tews I, Kappes B J Biol Chem. 2006 Feb 10;281(6):3633-41. Epub 2005 Dec 8. PMID:16339145<ref>PMID:16339145</ref>

-	~~===Glutaminase subunit~~ of the ~~plasmodial PLP synthase (Vitamin B6 biosynthesis)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16339145}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2abw]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Plasmodium_falciparum Plasmodium falciparum]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2ABW OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016339145<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
	[[Category: Fitzpatrick, T B.]]		[[Category: Fitzpatrick, T B.]]

OCA: Protected "2abw" [edit=sysop:move=sysop]

OCA — Sun, 06 Jan 2013 11:41:29 GMT

Protected "2abw" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:41, 6 January 2013

OCA at 11:41, 6 January 2013

OCA — Sun, 06 Jan 2013 11:41:27 GMT

←Older revision		Revision as of 11:41, 6 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2abw.png\|left\|200px]]		[[Image:2abw.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2abw", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2abw\| PDB=2abw \| SCENE= }}		{{STRUCTURE_2abw\| PDB=2abw \| SCENE= }}

	===Glutaminase subunit of the plasmodial PLP synthase (Vitamin B6 biosynthesis)===		===Glutaminase subunit of the plasmodial PLP synthase (Vitamin B6 biosynthesis)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16339145}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16339145 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16339145}}		{{ABSTRACT_PUBMED_16339145}}

	==About this Structure==		==About this Structure==
-	~~2ABW~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ABW OCA].	+	[[2abw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ABW OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16339145~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016339145</ref><references group="xtra"/>
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
	[[Category: Fitzpatrick, T B.]]		[[Category: Fitzpatrick, T B.]]
Line 37:		Line 25:
	[[Category: Malaria]]		[[Category: Malaria]]
	[[Category: Plp-synthase]]		[[Category: Plp-synthase]]
		+	[[Category: Transferase]]
	[[Category: Vitamin b6]]		[[Category: Vitamin b6]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:45:06 2009''

OCA at 07:45, 18 February 2009

OCA — Wed, 18 Feb 2009 07:45:07 GMT

←Older revision		Revision as of 07:45, 18 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2ABW is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ABW OCA].	+	2ABW is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ABW OCA].

	==Reference==		==Reference==
-	Vitamin B6 biosynthesis by the malaria parasite Plasmodium falciparum: biochemical and structural insights., Gengenbacher M, Fitzpatrick TB, Raschle T, Flicker K, Sinning I, Muller S, Macheroux P, Tews I, Kappes B, J Biol Chem. 2006 Feb 10;281(6):3633-41. Epub 2005 Dec 8. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16339145 16339145]~~	+	<ref group="xtra">PMID:16339145</ref><references group="xtra"/>
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
-	[[Category: Single protein]]
	[[Category: Fitzpatrick, T B.]]		[[Category: Fitzpatrick, T B.]]
	[[Category: Flicker, K.]]		[[Category: Flicker, K.]]
Line 40:		Line 39:
	[[Category: Vitamin b6]]		[[Category: Vitamin b6]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 16~~:03:~~56 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:45:06 2009''

OCA at 13:03, 29 July 2008

OCA — Tue, 29 Jul 2008 13:03:59 GMT

←Older revision		Revision as of 13:03, 29 July 2008
Line 1:		Line 1:
-	[[Image:2abw.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2abw.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_2abw\| PDB=2abw \| SCENE= }}		{{STRUCTURE_2abw\| PDB=2abw \| SCENE= }}

-	~~'''~~Glutaminase subunit of the plasmodial PLP synthase (Vitamin B6 biosynthesis)~~'''~~	+	===Glutaminase subunit of the plasmodial PLP synthase (Vitamin B6 biosynthesis)===


-	~~==Overview==~~	+	<!--
-	~~Vitamin B6 is one of nature's most versatile cofactors. Most organisms synthesize vitamin B6 via a recently discovered pathway employing~~ the ~~proteins Pdx1 and Pdx2. Here we present an in-depth characterization of~~ the respective orthologs from the malaria parasite, Plasmodium falciparum. Expression profiling of Pdx1 and -2 shows that blood-stage parasites indeed possess a functional vitamin B6 de novo biosynthesis. Recombinant Pdx1 and Pdx2 form a complex that functions as ~~a glutamine amidotransferase with Pdx2 as the glutaminase and Pdx1 as pyridoxal-5 '-phosphate synthase domain~~. ~~Complex formation is required for catalytic activity of either domain~~. ~~Pdx1 forms a chimeric bi-enzyme with the bacterial YaaE~~, ~~a Pdx2 ortholog, both in vivo and in vitro, although this chimera does not attain full catalytic activity, emphasizing that species-specific structural features govern~~ the ~~interaction between the protein partners of the PLP synthase complexes in different organisms~~. ~~To gain insight into the activation mechanism of the parasite bi~~-~~enzyme complex, the three~~-~~dimensional structure of Pdx2 was determined at 1.62 A. The obstruction of the oxyanion hole indicates that Pdx2 is in a resting state and that activation occurs upon Pdx1-Pdx2 complex formation.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_16339145}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 16339145 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_16339145}}

	==About this Structure==		==About this Structure==
Line 35:		Line 39:
	[[Category: Plp-synthase]]		[[Category: Plp-synthase]]
	[[Category: Vitamin b6]]		[[Category: Vitamin b6]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 18~~:51:38 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:03:56 2008''