2ad7 - Revision history

OCA at 08:16, 15 May 2024

OCA — Wed, 15 May 2024 08:16:56 GMT

←Older revision		Revision as of 08:16, 15 May 2024
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	<StructureSection load='2ad7' size='340' side='right'caption='[[2ad7]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='2ad7' size='340' side='right'caption='[[2ad7]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ad7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Methylophilus_methylotrophus~~ Methylophilus methylotrophus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AD7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ad7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Methylophilus_methylotrophus_W3A1 Methylophilus methylotrophus W3A1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AD7 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~, ~~<scene name='pdbligand=PQQ:PYRROLOQUINOLINE+QUINONE'>PQQ</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[4aah\|4aah]], [[1g72\|1g72]], [[2ad6\|2ad6]], [[2ad8\|2ad8]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PQQ:PYRROLOQUINOLINE+QUINONE'>PQQ</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Oxidoreductase Oxidoreductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.2.7 and 1.1.2.8 1.1.2.7 and 1.1.2.8]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ad7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ad7 OCA], [https://pdbe.org/2ad7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ad7 RCSB], [https://www.ebi.ac.uk/pdbsum/2ad7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ad7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ad7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ad7 OCA], [https://pdbe.org/2ad7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ad7 RCSB], [https://www.ebi.ac.uk/pdbsum/2ad7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ad7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DHM1_METME DHM1_METME~~]] Catalyzes the oxidation of primary alcohols including methanol. [[https://www.uniprot.org/uniprot/DHM2_METME DHM2_METME]~~] Catalyzes the oxidation of primary alcohols including methanol ~~(By similarity)~~.	+	[https://www.uniprot.org/uniprot/DHM1_METME DHM1_METME] Catalyzes the oxidation of primary alcohols including methanol.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Methylophilus methylotrophus]]	+	[[Category: Methylophilus methylotrophus W3A1]]
-	~~[[Category: Oxidoreductase~~]]	+	[[Category: Gan J-H]]
-	[[Category: Gan, J H]]	+	[[Category: Li J]]
-	[[Category: Li, J]]	+	[[Category: Mathews FS]]
-	[[Category: Mathews~~, F S~~]]	+	[[Category: Xia Z-X]]
-	[[Category: Xia, Z X]]	+
-	~~[[Category: Methanol]]~~	+
-	~~[[Category: Methanol dehydrogenase]]~~	+
-	~~[[Category: Pqq configuration~~]]	+

OCA at 14:39, 17 November 2021

OCA — Wed, 17 Nov 2021 14:39:35 GMT

←Older revision		Revision as of 14:39, 17 November 2021
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	<StructureSection load='2ad7' size='340' side='right'caption='[[2ad7]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='2ad7' size='340' side='right'caption='[[2ad7]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ad7]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Methylophilus_methylotrophus Methylophilus methylotrophus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AD7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2AD7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ad7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Methylophilus_methylotrophus Methylophilus methylotrophus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AD7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PQQ:PYRROLOQUINOLINE+QUINONE'>PQQ</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PQQ:PYRROLOQUINOLINE+QUINONE'>PQQ</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4aah\|4aah]], [[1g72\|1g72]], [[2ad6\|2ad6]], [[2ad8\|2ad8]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4aah\|4aah]], [[1g72\|1g72]], [[2ad6\|2ad6]], [[2ad8\|2ad8]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Oxidoreductase Oxidoreductase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.2.7 and 1.1.2.8 1.1.2.7 and 1.1.2.8] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Oxidoreductase Oxidoreductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.2.7 and 1.1.2.8 1.1.2.7 and 1.1.2.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ad7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ad7 OCA], [~~http~~://pdbe.org/2ad7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ad7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ad7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ad7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ad7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ad7 OCA], [https://pdbe.org/2ad7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ad7 RCSB], [https://www.ebi.ac.uk/pdbsum/2ad7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ad7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DHM1_METME DHM1_METME]] Catalyzes the oxidation of primary alcohols including methanol. [[~~http~~://www.uniprot.org/uniprot/DHM2_METME DHM2_METME]] Catalyzes the oxidation of primary alcohols including methanol (By similarity).	+	[[https://www.uniprot.org/uniprot/DHM1_METME DHM1_METME]] Catalyzes the oxidation of primary alcohols including methanol. [[https://www.uniprot.org/uniprot/DHM2_METME DHM2_METME]] Catalyzes the oxidation of primary alcohols including methanol (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 05:19, 13 February 2020

OCA — Thu, 13 Feb 2020 05:19:21 GMT

←Older revision		Revision as of 05:19, 13 February 2020
Line 1:		Line 1:

	==crystal structure of methanol dehydrogenase from M. W3A1 (form C) in the presence of methanol==		==crystal structure of methanol dehydrogenase from M. W3A1 (form C) in the presence of methanol==
-	<StructureSection load='2ad7' size='340' side='right' caption='[[2ad7]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='2ad7' size='340' side='right'caption='[[2ad7]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ad7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylophilus_methylotrophus Methylophilus methylotrophus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AD7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AD7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ad7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylophilus_methylotrophus Methylophilus methylotrophus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AD7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AD7 FirstGlance]. <br>
Line 37:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Methylophilus methylotrophus]]		[[Category: Methylophilus methylotrophus]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 07:10, 9 May 2018

OCA — Wed, 09 May 2018 07:10:25 GMT

←Older revision		Revision as of 07:10, 9 May 2018
Line 1:		Line 1:
		+
	==crystal structure of methanol dehydrogenase from M. W3A1 (form C) in the presence of methanol==		==crystal structure of methanol dehydrogenase from M. W3A1 (form C) in the presence of methanol==
	<StructureSection load='2ad7' size='340' side='right' caption='[[2ad7]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='2ad7' size='340' side='right' caption='[[2ad7]], [[Resolution\|resolution]] 1.50Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4aah\|4aah]], [[1g72\|1g72]], [[2ad6\|2ad6]], [[2ad8\|2ad8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4aah\|4aah]], [[1g72\|1g72]], [[2ad6\|2ad6]], [[2ad8\|2ad8]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Oxidoreductase Oxidoreductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.2.7 and 1.1.2.8 1.1.2.7 and 1.1.2.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Oxidoreductase Oxidoreductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.2.7 and 1.1.2.8 1.1.2.7 and 1.1.2.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ad7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ad7 OCA], [http://pdbe.org/2ad7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ad7 RCSB], [http://www.ebi.ac.uk/pdbsum/2ad7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ad7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ad7 OCA], [http://pdbe.org/2ad7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ad7 RCSB], [http://www.ebi.ac.uk/pdbsum/2ad7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ad7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ad/2ad7_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ad/2ad7_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 02:57, 7 February 2016

OCA — Sun, 07 Feb 2016 02:57:46 GMT

←Older revision		Revision as of 02:57, 7 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ad7 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 21:00, 9 September 2015

OCA — Wed, 09 Sep 2015 21:00:01 GMT

←Older revision		Revision as of 21:00, 9 September 2015
Line 6:		Line 6:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4aah\|4aah]], [[1g72\|1g72]], [[2ad6\|2ad6]], [[2ad8\|2ad8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4aah\|4aah]], [[1g72\|1g72]], [[2ad6\|2ad6]], [[2ad8\|2ad8]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Oxidoreductase Oxidoreductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.2.7 and 1.1.2.8 1.1.2.7 and 1.1.2.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Oxidoreductase Oxidoreductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.2.7 and 1.1.2.8 1.1.2.7 and 1.1.2.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ad7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ad7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ad7 RCSB], [http://www.ebi.ac.uk/pdbsum/2ad7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ad7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ad7 OCA], [http://pdbe.org/2ad7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ad7 RCSB], [http://www.ebi.ac.uk/pdbsum/2ad7 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2ad7" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 07:18, 24 December 2014

OCA — Wed, 24 Dec 2014 07:18:14 GMT

←Older revision		Revision as of 07:18, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ad7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylophilus_methylotrophus Methylophilus methylotrophus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AD7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AD7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ad7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylophilus_methylotrophus Methylophilus methylotrophus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AD7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AD7 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PQQ:PYRROLOQUINOLINE+QUINONE'>PQQ</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PQQ:PYRROLOQUINOLINE+QUINONE'>PQQ</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4aah\|4aah]], [[1g72\|1g72]], [[2ad6\|2ad6]], [[2ad8\|2ad8]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4aah\|4aah]], [[1g72\|1g72]], [[2ad6\|2ad6]], [[2ad8\|2ad8]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Oxidoreductase Oxidoreductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.2.7 and 1.1.2.8 1.1.2.7 and 1.1.2.8] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Oxidoreductase Oxidoreductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.2.7 and 1.1.2.8 1.1.2.7 and 1.1.2.8] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ad7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ad7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ad7 RCSB], [http://www.ebi.ac.uk/pdbsum/2ad7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ad7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ad7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ad7 RCSB], [http://www.ebi.ac.uk/pdbsum/2ad7 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DHM1_METME DHM1_METME]] Catalyzes the oxidation of primary alcohols including methanol. [[http://www.uniprot.org/uniprot/DHM2_METME DHM2_METME]] Catalyzes the oxidation of primary alcohols including methanol (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Methylophilus methylotrophus]]		[[Category: Methylophilus methylotrophus]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
-	[[Category: Gan, J H.]]	+	[[Category: Gan, J H]]
-	[[Category: Li, J.]]	+	[[Category: Li, J]]
-	[[Category: Mathews, F S.]]	+	[[Category: Mathews, F S]]
-	[[Category: Xia, Z X.]]	+	[[Category: Xia, Z X]]
	[[Category: Methanol]]		[[Category: Methanol]]
	[[Category: Methanol dehydrogenase]]		[[Category: Methanol dehydrogenase]]
-	[[Category: Oxidoreductase]]
	[[Category: Pqq configuration]]		[[Category: Pqq configuration]]

OCA at 04:18, 3 October 2014

OCA — Fri, 03 Oct 2014 04:18:59 GMT

←Older revision		Revision as of 04:18, 3 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2ad7\| PDB=2ad7 \| SCENE= }}~~	+	==crystal structure of methanol dehydrogenase from M. W3A1 (form C) in the presence of methanol==
-	===crystal structure of methanol dehydrogenase from M. W3A1 (form C) in the presence of methanol===	+	<StructureSection load='2ad7' size='340' side='right' caption='[[2ad7]], [[Resolution\|resolution]] 1.50Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21356200}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2ad7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylophilus_methylotrophus Methylophilus methylotrophus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AD7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AD7 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PQQ:PYRROLOQUINOLINE+QUINONE'>PQQ</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4aah\|4aah]], [[1g72\|1g72]], [[2ad6\|2ad6]], [[2ad8\|2ad8]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Oxidoreductase Oxidoreductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.2.7 and 1.1.2.8 1.1.2.7 and 1.1.2.8] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ad7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ad7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ad7 RCSB], [http://www.ebi.ac.uk/pdbsum/2ad7 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ad/2ad7_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Methanol dehydrogenase is a heterotetrameric enzyme containing the prosthetic group pyrroloquinoline quinone (PQQ), which catalyzes the oxidation of methanol to formaldehyde. The crystal structure of methanol dehydrogenase from Methylophilus W3A1, previously determined at high resolution, exhibits a non-planar configuration of the PQQ ring system and lends support for a hydride transfer mechanism of the enzymatic reaction catalyzed by the enzyme. To investigate why PQQ is in the C5-reduced form and to better understand the catalytic mechanism of the enzyme, three structures of this enzyme in a new crystal form have been determined at higher resolution. Two of the three crystals were grown in the presence of 1 and 50 mM methanol, respectively, both structures of which show non-planar configurations of the PQQ ring system, confirming the previous conclusion; the other was crystallized in the presence of 50 mM ethanol, the structure of which displays a planar ring system for PQQ. Comparison of these structures reveals that the configuration change of PQQ is induced by the enzymatic reaction. The reaction takes place and the C5-reduced PQQ intermediate is produced when the enzyme co-crystallizes with methanol, but the enzymatic reaction does not take place and the PQQ ring retains a planar configuration of the oxidized orthoquinone form when ethanol instead of methanol is present in the crystallization solution.

-	~~==Function==~~	+	The enzymatic reaction-induced configuration change of the prosthetic group PQQ of methanol dehydrogenase.,Li J, Gan JH, Mathews FS, Xia ZX Biochem Biophys Res Commun. 2011 Mar 25;406(4):621-6. Epub 2011 Feb 26. PMID:21356200<ref>PMID:21356200</ref>
-	~~[[http://www.uniprot.org/uniprot/DHM1_METME DHM1_METME]] Catalyzes~~ the ~~oxidation~~ of ~~primary alcohols including~~ methanol. ~~[[http~~:~~//www~~.~~uniprot~~.~~org~~/~~uniprot/DHM2_METME DHM2_METME]] Catalyzes the oxidation of primary alcohols including methanol (By similarity).~~	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[2ad7]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Methylophilus_methylotrophus Methylophilus methylotrophus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2AD7 OCA].~~	+	</div>

	==See Also==		==See Also==
	*[[Methanol dehydrogenase\|Methanol dehydrogenase]]		*[[Methanol dehydrogenase\|Methanol dehydrogenase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:021356200</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Methylophilus methylotrophus]]		[[Category: Methylophilus methylotrophus]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 02:48, 20 September 2013

OCA — Fri, 20 Sep 2013 02:48:13 GMT

←Older revision		Revision as of 02:48, 20 September 2013
Line 1:		Line 1:
-	[[Image:2ad7.png\|left\|200px]]
-
	{{STRUCTURE_2ad7\| PDB=2ad7 \| SCENE= }}		{{STRUCTURE_2ad7\| PDB=2ad7 \| SCENE= }}
-
	===crystal structure of methanol dehydrogenase from M. W3A1 (form C) in the presence of methanol===		===crystal structure of methanol dehydrogenase from M. W3A1 (form C) in the presence of methanol===
		+	{{ABSTRACT_PUBMED_21356200}}

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/DHM1_METME DHM1_METME]] Catalyzes the oxidation of primary alcohols including methanol. [[http://www.uniprot.org/uniprot/DHM2_METME DHM2_METME]] Catalyzes the oxidation of primary alcohols including methanol (By similarity).

	==About this Structure==		==About this Structure==
Line 11:		Line 11:
	==See Also==		==See Also==
	*[[Methanol dehydrogenase\|Methanol dehydrogenase]]		*[[Methanol dehydrogenase\|Methanol dehydrogenase]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021356200</ref><references group="xtra"/><references/>
	[[Category: Methylophilus methylotrophus]]		[[Category: Methylophilus methylotrophus]]
		+	[[Category: Oxidoreductase]]
	[[Category: Gan, J H.]]		[[Category: Gan, J H.]]
	[[Category: Li, J.]]		[[Category: Li, J.]]

OCA at 05:24, 20 October 2012

OCA — Sat, 20 Oct 2012 05:24:17 GMT

←Older revision		Revision as of 05:24, 20 October 2012
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[2ad7]] is a 4 chain structure ~~of [[Methanol dehydrogenase]]~~ with sequence from [http://en.wikipedia.org/wiki/Methylophilus_methylotrophus Methylophilus methylotrophus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AD7 OCA].	+	[[2ad7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylophilus_methylotrophus Methylophilus methylotrophus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AD7 OCA].

	==See Also==		==See Also==