2ajy - Revision history

OCA at 07:25, 23 August 2023

OCA — Wed, 23 Aug 2023 07:25:30 GMT

←Older revision		Revision as of 07:25, 23 August 2023
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	<StructureSection load='2ajy' size='340' side='right'caption='[[2ajy]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2ajy' size='340' side='right'caption='[[2ajy]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ajy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AJY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AJY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ajy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AJY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AJY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>, <scene name='pdbligand=ECG:3-HYDROXY-8-METHYL-8-AZA-BICYCLO[3.2.1]OCTANE-2-CARBOXYLIC+ACID+METHYL+ESTER'>ECG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ajs\|2ajs]], [[2aju\|2aju]], [[2ajv\|2ajv]], [[2ajx\|2ajx]], [[2ajz\|2ajz]], [[2ak1\|2ak1]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>, <scene name='pdbligand=ECG:3-HYDROXY-8-METHYL-8-AZA-BICYCLO[3.2.1]OCTANE-2-CARBOXYLIC+ACID+METHYL+ESTER'>ECG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ajy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ajy OCA], [https://pdbe.org/2ajy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ajy RCSB], [https://www.ebi.ac.uk/pdbsum/2ajy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ajy ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ajy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ajy OCA], [https://pdbe.org/2ajy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ajy RCSB], [https://www.ebi.ac.uk/pdbsum/2ajy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ajy ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/IGKC_MOUSE IGKC_MOUSE]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Wilson~~, I A~~]]	+	[[Category: Wilson IA]]
-	[[Category: Zhu, X]]	+	[[Category: Zhu X]]
-	~~[[Category: Benzoic acid]]~~	+
-	~~[[Category: Catalytic antibody]]~~	+
-	~~[[Category: Ecgonine methyl ester]]~~	+
-	~~[[Category: Fab]]~~	+
-	~~[[Category: Hydrolytic]]~~	+
-	~~[[Category: Immune system~~]]	+

OCA at 09:40, 5 May 2021

OCA — Wed, 05 May 2021 09:40:11 GMT

←Older revision		Revision as of 09:40, 5 May 2021
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	<StructureSection load='2ajy' size='340' side='right'caption='[[2ajy]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2ajy' size='340' side='right'caption='[[2ajy]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ajy]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AJY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2AJY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ajy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AJY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AJY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>, <scene name='pdbligand=ECG:3-HYDROXY-8-METHYL-8-AZA-BICYCLO[3.2.1]OCTANE-2-CARBOXYLIC+ACID+METHYL+ESTER'>ECG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>, <scene name='pdbligand=ECG:3-HYDROXY-8-METHYL-8-AZA-BICYCLO[3.2.1]OCTANE-2-CARBOXYLIC+ACID+METHYL+ESTER'>ECG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ajs\|2ajs]], [[2aju\|2aju]], [[2ajv\|2ajv]], [[2ajx\|2ajx]], [[2ajz\|2ajz]], [[2ak1\|2ak1]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ajs\|2ajs]], [[2aju\|2aju]], [[2ajv\|2ajv]], [[2ajx\|2ajx]], [[2ajz\|2ajz]], [[2ak1\|2ak1]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ajy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ajy OCA], [~~http~~://pdbe.org/2ajy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ajy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ajy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ajy ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ajy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ajy OCA], [https://pdbe.org/2ajy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ajy RCSB], [https://www.ebi.ac.uk/pdbsum/2ajy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ajy ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 09:05, 24 July 2019

OCA — Wed, 24 Jul 2019 09:05:26 GMT

←Older revision		Revision as of 09:05, 24 July 2019
Line 1:		Line 1:

	==Crystal Structure of Cocaine catalytic Antibody 7A1 Fab' in Complex with ecgonine methyl ester and benzoic acid==		==Crystal Structure of Cocaine catalytic Antibody 7A1 Fab' in Complex with ecgonine methyl ester and benzoic acid==
-	<StructureSection load='2ajy' size='340' side='right' caption='[[2ajy]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='2ajy' size='340' side='right'caption='[[2ajy]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ajy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AJY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AJY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ajy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AJY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AJY FirstGlance]. <br>
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aj/2ajy_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aj/2ajy_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 29:

	==See Also==		==See Also==
-	*[[3D structures ~~of monoclonal antibody~~\|3D structures ~~of monoclonal antibody~~]]	+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Wilson, I A]]		[[Category: Wilson, I A]]

OCA at 15:15, 12 October 2017

OCA — Thu, 12 Oct 2017 15:15:11 GMT

←Older revision		Revision as of 15:15, 12 October 2017
Line 1:		Line 1:
		+
	==Crystal Structure of Cocaine catalytic Antibody 7A1 Fab' in Complex with ecgonine methyl ester and benzoic acid==		==Crystal Structure of Cocaine catalytic Antibody 7A1 Fab' in Complex with ecgonine methyl ester and benzoic acid==
	<StructureSection load='2ajy' size='340' side='right' caption='[[2ajy]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2ajy' size='340' side='right' caption='[[2ajy]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ajy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AJY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AJY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ajy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AJY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AJY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>, <scene name='pdbligand=ECG:3-HYDROXY-8-METHYL-8-AZA-BICYCLO[3.2.1]OCTANE-2-CARBOXYLIC+ACID+METHYL+ESTER'>ECG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>, <scene name='pdbligand=ECG:3-HYDROXY-8-METHYL-8-AZA-BICYCLO[3.2.1]OCTANE-2-CARBOXYLIC+ACID+METHYL+ESTER'>ECG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ajs\|2ajs]], [[2aju\|2aju]], [[2ajv\|2ajv]], [[2ajx\|2ajx]], [[2ajz\|2ajz]], [[2ak1\|2ak1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ajs\|2ajs]], [[2aju\|2aju]], [[2ajv\|2ajv]], [[2ajx\|2ajx]], [[2ajz\|2ajz]], [[2ak1\|2ak1]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ajy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ajy OCA], [http://pdbe.org/2ajy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ajy RCSB], [http://www.ebi.ac.uk/pdbsum/2ajy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ajy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ajy OCA], [http://pdbe.org/2ajy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ajy RCSB], [http://www.ebi.ac.uk/pdbsum/2ajy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ajy ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 15:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ajy ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:

	==See Also==		==See Also==
-	*[[~~Monoclonal Antibody~~\|~~Monoclonal Antibody~~]]	+	*[[3D structures of monoclonal antibody\|3D structures of monoclonal antibody]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Wilson, I A]]		[[Category: Wilson, I A]]
	[[Category: Zhu, X]]		[[Category: Zhu, X]]

OCA at 02:09, 12 September 2015

OCA — Sat, 12 Sep 2015 02:09:11 GMT

←Older revision		Revision as of 02:09, 12 September 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>, <scene name='pdbligand=ECG:3-HYDROXY-8-METHYL-8-AZA-BICYCLO[3.2.1]OCTANE-2-CARBOXYLIC+ACID+METHYL+ESTER'>ECG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>, <scene name='pdbligand=ECG:3-HYDROXY-8-METHYL-8-AZA-BICYCLO[3.2.1]OCTANE-2-CARBOXYLIC+ACID+METHYL+ESTER'>ECG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ajs\|2ajs]], [[2aju\|2aju]], [[2ajv\|2ajv]], [[2ajx\|2ajx]], [[2ajz\|2ajz]], [[2ak1\|2ak1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ajs\|2ajs]], [[2aju\|2aju]], [[2ajv\|2ajv]], [[2ajx\|2ajx]], [[2ajz\|2ajz]], [[2ak1\|2ak1]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ajy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ajy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ajy RCSB], [http://www.ebi.ac.uk/pdbsum/2ajy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ajy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ajy OCA], [http://pdbe.org/2ajy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ajy RCSB], [http://www.ebi.ac.uk/pdbsum/2ajy PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2ajy" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 10:05, 8 January 2015

OCA — Thu, 08 Jan 2015 10:05:48 GMT

←Older revision		Revision as of 10:05, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ajy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AJY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AJY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ajy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AJY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AJY FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>, <scene name='pdbligand=ECG:3-HYDROXY-8-METHYL-8-AZA-BICYCLO[3.2.1]OCTANE-2-CARBOXYLIC+ACID+METHYL+ESTER'>ECG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>, <scene name='pdbligand=ECG:3-HYDROXY-8-METHYL-8-AZA-BICYCLO[3.2.1]OCTANE-2-CARBOXYLIC+ACID+METHYL+ESTER'>ECG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ajs\|2ajs]], [[2aju\|2aju]], [[2ajv\|2ajv]], [[2ajx\|2ajx]], [[2ajz\|2ajz]], [[2ak1\|2ak1]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ajs\|2ajs]], [[2aju\|2aju]], [[2ajv\|2ajv]], [[2ajx\|2ajx]], [[2ajz\|2ajz]], [[2ak1\|2ak1]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ajy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ajy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ajy RCSB], [http://www.ebi.ac.uk/pdbsum/2ajy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ajy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ajy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ajy RCSB], [http://www.ebi.ac.uk/pdbsum/2ajy PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Wilson, I A.]]	+	[[Category: Wilson, I A]]
-	[[Category: Zhu, X.]]	+	[[Category: Zhu, X]]
	[[Category: Benzoic acid]]		[[Category: Benzoic acid]]
	[[Category: Catalytic antibody]]		[[Category: Catalytic antibody]]

OCA at 06:06, 29 September 2014

OCA — Mon, 29 Sep 2014 06:06:22 GMT

←Older revision		Revision as of 06:06, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2ajy.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of Cocaine catalytic Antibody 7A1 Fab' in Complex with ecgonine methyl ester and benzoic acid==
		+	<StructureSection load='2ajy' size='340' side='right' caption='[[2ajy]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2ajy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AJY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AJY FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>, <scene name='pdbligand=ECG:3-HYDROXY-8-METHYL-8-AZA-BICYCLO[3.2.1]OCTANE-2-CARBOXYLIC+ACID+METHYL+ESTER'>ECG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ajs\|2ajs]], [[2aju\|2aju]], [[2ajv\|2ajv]], [[2ajx\|2ajx]], [[2ajz\|2ajz]], [[2ak1\|2ak1]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ajy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ajy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ajy RCSB], [http://www.ebi.ac.uk/pdbsum/2ajy PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aj/2ajy_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Antibody 7A1 hydrolyzes cocaine to produce nonpsychoactive metabolites ecgonine methyl ester and benzoic acid. Crystal structures of 7A1 Fab' and six complexes with substrate cocaine, the transition state analog, products ecgonine methyl ester and benzoic acid together and individually, as well as heptaethylene glycol have been analyzed at 1.5-2.3 angstroms resolution. Here, we present snapshots of the complete cycle of the cocaine hydrolytic reaction at atomic resolution. Significant structural rearrangements occur along the reaction pathway, but they are generally limited to the binding site, including the ligands themselves. Several interacting side chains either change their rotamers or alter their mobility to accommodate the different reaction steps. CDR loop movements (up to 2.3 angstroms) and substantial side chain rearrangements (up to 9 angstroms) alter the shape and size (approximately 320-500 angstroms3) of the antibody active site from "open" to "closed" to "open" for the substrate, transition state, and product states, respectively.

-	~~{{STRUCTURE_2ajy\| PDB=2ajy \| SCENE= }}~~	+	Complete reaction cycle of a cocaine catalytic antibody at atomic resolution.,Zhu X, Dickerson TJ, Rogers CJ, Kaufmann GF, Mee JM, McKenzie KM, Janda KD, Wilson IA Structure. 2006 Feb;14(2):205-16. PMID:16472740<ref>PMID:16472740</ref>

-	~~===Crystal Structure~~ of ~~Cocaine catalytic Antibody 7A1 Fab' in Complex with ecgonine methyl ester and benzoic acid===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16472740}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2ajy]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2AJY OCA].~~	+

	==See Also==		==See Also==
-	*[[Antibody\|Antibody]]	+	*[[Monoclonal Antibody\|Monoclonal Antibody]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:016472740<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Wilson, I A.]]		[[Category: Wilson, I A.]]

OCA at 22:23, 20 October 2012

OCA — Sat, 20 Oct 2012 22:23:47 GMT

←Older revision		Revision as of 22:23, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2ajy]] is a 2 chain structure ~~of [[Antibody]]~~ with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AJY OCA].	+	[[2ajy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AJY OCA].

	==See Also==		==See Also==

OCA: Protected "2ajy" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 16:09:33 GMT

Protected "2ajy" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:09, 27 July 2012

OCA at 16:09, 27 July 2012

OCA — Fri, 27 Jul 2012 16:09:32 GMT

←Older revision		Revision as of 16:09, 27 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2ajy.png\|left\|200px]]		[[Image:2ajy.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2ajy", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2ajy\| PDB=2ajy \| SCENE= }}		{{STRUCTURE_2ajy\| PDB=2ajy \| SCENE= }}

	===Crystal Structure of Cocaine catalytic Antibody 7A1 Fab' in Complex with ecgonine methyl ester and benzoic acid===		===Crystal Structure of Cocaine catalytic Antibody 7A1 Fab' in Complex with ecgonine methyl ester and benzoic acid===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16472740}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16472740 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16472740}}		{{ABSTRACT_PUBMED_16472740}}

	==About this Structure==		==About this Structure==
-	~~2AJY~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AJY OCA].	+	[[2ajy]] is a 2 chain structure of [[Antibody]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AJY OCA].
		+
		+	==See Also==
		+	*[[Antibody\|Antibody]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16472740~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016472740</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Wilson, I A.]]		[[Category: Wilson, I A.]]
Line 32:		Line 23:
	[[Category: Fab]]		[[Category: Fab]]
	[[Category: Hydrolytic]]		[[Category: Hydrolytic]]
-		+	[[Category: Immune system]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Wed Feb 18 09:45:47 2009''~~	+