2axr - Revision history

OCA at 07:31, 23 August 2023

OCA — Wed, 23 Aug 2023 07:31:19 GMT

←Older revision		Revision as of 07:31, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='2axr' size='340' side='right'caption='[[2axr]], [[Resolution\|resolution]] 1.98Å' scene=''>		<StructureSection load='2axr' size='340' side='right'caption='[[2axr]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2axr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_34717 Atcc 34717~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AXR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2axr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sarocladium_strictum Sarocladium strictum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AXR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABL:(2R,3R,4R,5R)-4,5-DIHYDROXY-2-(HYDROXYMETHYL)-6-OXOPIPERIDIN-3-YL+BETA-D-GLUCOPYRANOSIDE'>ABL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.98Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1zr6\|1zr6]]</div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABL:(2R,3R,4R,5R)-4,5-DIHYDROXY-2-(HYDROXYMETHYL)-6-OXOPIPERIDIN-3-YL+BETA-D-GLUCOPYRANOSIDE'>ABL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2axr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2axr OCA], [https://pdbe.org/2axr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2axr RCSB], [https://www.ebi.ac.uk/pdbsum/2axr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2axr ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2axr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2axr OCA], [https://pdbe.org/2axr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2axr RCSB], [https://www.ebi.ac.uk/pdbsum/2axr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2axr ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GOOX_SARSR GOOX_SARSR] Catalyzes the selective oxidation of C1 hydroxyl moieties on mono- and disaccharides with concomitant reduction of molecular oxygen to hydrogen peroxide. This results in the formation of the corresponding lactones, which typically undergo spontaneous hydrolysis. Glucooligosaccharide oxidase is able to oxidize the monosaccharide D-glucose as well as the disaccharides maltose, cellobiose, and lactose. In addition, it shows high selectivity for cello- and maltooligosaccharides, indicating that glucooligosaccharide oxidase prefers oligosaccharides with a beta-D-glucosyl unit on the reducing end and additional sugar units linked by alpha- or beta-1,4 glucosidic bonds.<ref>PMID:16332885</ref> <ref>PMID:1764476</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 34717]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Huang, C H]]	+	[[Category: Sarocladium strictum]]
-	[[Category: Lai, W L]]	+	[[Category: Huang C-H]]
-	[[Category: Liaw, S H]]	+	[[Category: Lai W-L]]
-	[[Category: Tsai, Y C]]	+	[[Category: Liaw S-H]]
-	[[Category: Vasella, A]]	+	[[Category: Tsai Y-C]]
-	~~[[Category: Alpha+beta]]~~	+	[[Category: Vasella A]]
-	~~[[Category: Covalent flavoenzyme]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 09:41, 5 May 2021

OCA — Wed, 05 May 2021 09:41:25 GMT

←Older revision		Revision as of 09:41, 5 May 2021
Line 3:		Line 3:
	<StructureSection load='2axr' size='340' side='right'caption='[[2axr]], [[Resolution\|resolution]] 1.98Å' scene=''>		<StructureSection load='2axr' size='340' side='right'caption='[[2axr]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2axr]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_34717 Atcc 34717]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2AXR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2axr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_34717 Atcc 34717]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AXR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABL:(2R,3R,4R,5R)-4,5-DIHYDROXY-2-(HYDROXYMETHYL)-6-OXOPIPERIDIN-3-YL+BETA-D-GLUCOPYRANOSIDE'>ABL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABL:(2R,3R,4R,5R)-4,5-DIHYDROXY-2-(HYDROXYMETHYL)-6-OXOPIPERIDIN-3-YL+BETA-D-GLUCOPYRANOSIDE'>ABL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zr6\|1zr6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1zr6\|1zr6]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2axr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2axr OCA], [~~http~~://pdbe.org/2axr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2axr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2axr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2axr ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2axr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2axr OCA], [https://pdbe.org/2axr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2axr RCSB], [https://www.ebi.ac.uk/pdbsum/2axr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2axr ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 09:15, 24 July 2019

OCA — Wed, 24 Jul 2019 09:15:18 GMT

←Older revision		Revision as of 09:15, 24 July 2019
Line 1:		Line 1:

	==Crystal structure of glucooligosaccharide oxidase from Acremonium strictum: a novel flavinylation of 6-S-cysteinyl, 8alpha-N1-histidyl FAD==		==Crystal structure of glucooligosaccharide oxidase from Acremonium strictum: a novel flavinylation of 6-S-cysteinyl, 8alpha-N1-histidyl FAD==
-	<StructureSection load='2axr' size='340' side='right' caption='[[2axr]], [[Resolution\|resolution]] 1.98Å' scene=''>	+	<StructureSection load='2axr' size='340' side='right'caption='[[2axr]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2axr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_34717 Atcc 34717]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AXR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2axr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_34717 Atcc 34717]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AXR FirstGlance]. <br>
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ax/2axr_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ax/2axr_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 34717]]		[[Category: Atcc 34717]]
		+	[[Category: Large Structures]]
	[[Category: Huang, C H]]		[[Category: Huang, C H]]
	[[Category: Lai, W L]]		[[Category: Lai, W L]]

OCA at 08:47, 12 October 2017

OCA — Thu, 12 Oct 2017 08:47:14 GMT

←Older revision		Revision as of 08:47, 12 October 2017
Line 1:		Line 1:
		+
	==Crystal structure of glucooligosaccharide oxidase from Acremonium strictum: a novel flavinylation of 6-S-cysteinyl, 8alpha-N1-histidyl FAD==		==Crystal structure of glucooligosaccharide oxidase from Acremonium strictum: a novel flavinylation of 6-S-cysteinyl, 8alpha-N1-histidyl FAD==
	<StructureSection load='2axr' size='340' side='right' caption='[[2axr]], [[Resolution\|resolution]] 1.98Å' scene=''>		<StructureSection load='2axr' size='340' side='right' caption='[[2axr]], [[Resolution\|resolution]] 1.98Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABL:(2R,3R,4R,5R)-4,5-DIHYDROXY-2-(HYDROXYMETHYL)-6-OXOPIPERIDIN-3-YL+BETA-D-GLUCOPYRANOSIDE'>ABL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABL:(2R,3R,4R,5R)-4,5-DIHYDROXY-2-(HYDROXYMETHYL)-6-OXOPIPERIDIN-3-YL+BETA-D-GLUCOPYRANOSIDE'>ABL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zr6\|1zr6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zr6\|1zr6]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2axr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2axr OCA], [http://pdbe.org/2axr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2axr RCSB], [http://www.ebi.ac.uk/pdbsum/2axr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2axr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2axr OCA], [http://pdbe.org/2axr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2axr RCSB], [http://www.ebi.ac.uk/pdbsum/2axr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2axr ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 03:04, 10 February 2016

OCA — Wed, 10 Feb 2016 03:04:30 GMT

←Older revision		Revision as of 03:04, 10 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2axr ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 04:45, 11 September 2015

OCA — Fri, 11 Sep 2015 04:45:31 GMT

←Older revision		Revision as of 04:45, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2axr' size='340' side='right' caption='[[2axr]], [[Resolution\|resolution]] 1.98Å' scene=''>		<StructureSection load='2axr' size='340' side='right' caption='[[2axr]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2axr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Sarocladium_strictum Sarocladium strictum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AXR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2axr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_34717 Atcc 34717]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AXR FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABL:(2R,3R,4R,5R)-4,5-DIHYDROXY-2-(HYDROXYMETHYL)-6-OXOPIPERIDIN-3-YL+BETA-D-GLUCOPYRANOSIDE'>ABL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABL:(2R,3R,4R,5R)-4,5-DIHYDROXY-2-(HYDROXYMETHYL)-6-OXOPIPERIDIN-3-YL+BETA-D-GLUCOPYRANOSIDE'>ABL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zr6\|1zr6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zr6\|1zr6]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2axr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2axr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2axr RCSB], [http://www.ebi.ac.uk/pdbsum/2axr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2axr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2axr OCA], [http://pdbe.org/2axr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2axr RCSB], [http://www.ebi.ac.uk/pdbsum/2axr PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2axr" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Sarocladium strictum~~]]	+	[[Category: Atcc 34717]]
	[[Category: Huang, C H]]		[[Category: Huang, C H]]
	[[Category: Lai, W L]]		[[Category: Lai, W L]]

OCA at 09:19, 8 January 2015

OCA — Thu, 08 Jan 2015 09:19:05 GMT

←Older revision		Revision as of 09:19, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2axr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sarocladium_strictum Sarocladium strictum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AXR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2axr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sarocladium_strictum Sarocladium strictum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AXR FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABL:(2R,3R,4R,5R)-4,5-DIHYDROXY-2-(HYDROXYMETHYL)-6-OXOPIPERIDIN-3-YL+BETA-D-GLUCOPYRANOSIDE'>ABL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABL:(2R,3R,4R,5R)-4,5-DIHYDROXY-2-(HYDROXYMETHYL)-6-OXOPIPERIDIN-3-YL+BETA-D-GLUCOPYRANOSIDE'>ABL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zr6\|1zr6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zr6\|1zr6]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2axr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2axr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2axr RCSB], [http://www.ebi.ac.uk/pdbsum/2axr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2axr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2axr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2axr RCSB], [http://www.ebi.ac.uk/pdbsum/2axr PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Sarocladium strictum]]		[[Category: Sarocladium strictum]]
-	[[Category: Huang, C H.]]	+	[[Category: Huang, C H]]
-	[[Category: Lai, W L.]]	+	[[Category: Lai, W L]]
-	[[Category: Liaw, S H.]]	+	[[Category: Liaw, S H]]
-	[[Category: Tsai, Y C.]]	+	[[Category: Tsai, Y C]]
-	[[Category: Vasella, A.]]	+	[[Category: Vasella, A]]
	[[Category: Alpha+beta]]		[[Category: Alpha+beta]]
	[[Category: Covalent flavoenzyme]]		[[Category: Covalent flavoenzyme]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 00:09, 30 September 2014

OCA — Tue, 30 Sep 2014 00:09:01 GMT

←Older revision		Revision as of 00:09, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2axr.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of glucooligosaccharide oxidase from Acremonium strictum: a novel flavinylation of 6-S-cysteinyl, 8alpha-N1-histidyl FAD==
		+	<StructureSection load='2axr' size='340' side='right' caption='[[2axr]], [[Resolution\|resolution]] 1.98Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2axr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sarocladium_strictum Sarocladium strictum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AXR FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABL:(2R,3R,4R,5R)-4,5-DIHYDROXY-2-(HYDROXYMETHYL)-6-OXOPIPERIDIN-3-YL+BETA-D-GLUCOPYRANOSIDE'>ABL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zr6\|1zr6]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2axr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2axr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2axr RCSB], [http://www.ebi.ac.uk/pdbsum/2axr PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ax/2axr_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Glucooligosaccharide oxidase from Acremonium strictum has been screened for potential applications in oligosaccharide acid production and alternative carbohydrate detection, because it catalyzes the oxidation of glucose, maltose, lactose, cellobiose and cello- and maltooligosaccharides. We report the crystal structures of the enzyme and of its complex with an inhibitor, 5-amino-5-deoxy- cellobiono-1,5-lactam at 1.55- and 1.98-A resolution, respectively. Unexpectedly, the protein structure demonstrates the first known double attachment flavinylation, 6-S-cysteinyl, 8alpha-N1-histidyl FAD. The FAD cofactor is cross-linked to the enzyme via the C(6) atom and the 8alpha-methyl group of the isoalloxazine ring with Cys(130) and His(70), respectively. This sugar oxidase possesses an open carbohydrate-binding groove, allowing the accommodation of higher oligosaccharides. The complex structure suggests that this enzyme may prefer a beta-d-glucosyl residue at the reducing end with the conserved Tyr(429) acting as a general base to abstract the OH(1) proton in concert with the H(1) hydride transfer to the flavin N(5). Finally, a detailed comparison illustrates the structural conservation as well as the divergence between this protein and its related flavoenzymes.

-	~~{{STRUCTURE_2axr\| PDB=2axr \| SCENE= }}~~	+	Crystal structure of glucooligosaccharide oxidase from Acremonium strictum: a novel flavinylation of 6-S-cysteinyl, 8alpha-N1-histidyl FAD.,Huang CH, Lai WL, Lee MH, Chen CJ, Vasella A, Tsai YC, Liaw SH J Biol Chem. 2005 Nov 18;280(46):38831-8. Epub 2005 Sep 9. PMID:16154992<ref>PMID:16154992</ref>

-	~~===Crystal structure of glucooligosaccharide oxidase from Acremonium strictum:~~ a ~~novel flavinylation~~ of 6-S~~-cysteinyl, 8alpha-N1-histidyl FAD===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16154992}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2axr]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org~~/~~wiki/Sarocladium_strictum Sarocladium strictum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXR OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016154992<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Sarocladium strictum]]		[[Category: Sarocladium strictum]]
	[[Category: Huang, C H.]]		[[Category: Huang, C H.]]

OCA: Protected "2axr" [edit=sysop:move=sysop]

OCA — Sun, 06 Jan 2013 09:35:06 GMT

Protected "2axr" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:35, 6 January 2013

OCA at 09:35, 6 January 2013

OCA — Sun, 06 Jan 2013 09:35:02 GMT

←Older revision		Revision as of 09:35, 6 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2axr.png\|left\|200px]]		[[Image:2axr.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2axr", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2axr\| PDB=2axr \| SCENE= }}		{{STRUCTURE_2axr\| PDB=2axr \| SCENE= }}

	===Crystal structure of glucooligosaccharide oxidase from Acremonium strictum: a novel flavinylation of 6-S-cysteinyl, 8alpha-N1-histidyl FAD===		===Crystal structure of glucooligosaccharide oxidase from Acremonium strictum: a novel flavinylation of 6-S-cysteinyl, 8alpha-N1-histidyl FAD===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16154992}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16154992 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16154992}}		{{ABSTRACT_PUBMED_16154992}}

	==About this Structure==		==About this Structure==
-	~~2AXR~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/~~Acremonium_strictum Acremonium~~ strictum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXR OCA].	+	[[2axr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sarocladium_strictum Sarocladium strictum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AXR OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16154992~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016154992</ref><references group="xtra"/>
-	[[Category: ~~Acremonium~~ strictum]]	+	[[Category: Sarocladium strictum]]
	[[Category: Huang, C H.]]		[[Category: Huang, C H.]]
	[[Category: Lai, W L.]]		[[Category: Lai, W L.]]
Line 32:		Line 20:
	[[Category: Alpha+beta]]		[[Category: Alpha+beta]]
	[[Category: Covalent flavoenzyme]]		[[Category: Covalent flavoenzyme]]
-		+	[[Category: Oxidoreductase]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 14:55:06 2009''~~	+