2aye - Revision history

OCA at 07:31, 23 August 2023

OCA — Wed, 23 Aug 2023 07:31:24 GMT

←Older revision		Revision as of 07:31, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='2aye' size='340' side='right'caption='[[2aye]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2aye' size='340' side='right'caption='[[2aye]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2aye]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Hpv6a Hpv6a~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AYE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AYE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2aye]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_papillomavirus_type_6a Human papillomavirus type 6a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AYE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AYE FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1r8h\|1r8h]], [[2ayb\|2ayb]], [[2ayg\|2ayg]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">E2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=37122 HPV6A])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aye OCA], [https://pdbe.org/2aye PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aye RCSB], [https://www.ebi.ac.uk/pdbsum/2aye PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aye ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aye OCA], [https://pdbe.org/2aye PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aye RCSB], [https://www.ebi.ac.uk/pdbsum/2aye PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aye ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/VE2_HPV6A VE2_HPV6A]] E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication.	+	[https://www.uniprot.org/uniprot/VE2_HPV6A VE2_HPV6A] E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</div>		</div>
	<div class="pdbe-citations 2aye" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2aye" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Regulatory protein E2\|Regulatory protein E2]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Hpv6a~~]]	+	[[Category: Human papillomavirus type 6a]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Brady~~, R L~~]]	+	[[Category: Brady RL]]
-	[[Category: Gaston, K]]	+	[[Category: Gaston K]]
-	[[Category: Hooley, E]]	+	[[Category: Hooley E]]
-	~~[[Category: Beta barrel]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 08:40, 27 January 2021

OCA — Wed, 27 Jan 2021 08:40:11 GMT

←Older revision		Revision as of 08:40, 27 January 2021
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	==Crystal structure of the unliganded E2 DNA Binding Domain from HPV6a==		==Crystal structure of the unliganded E2 DNA Binding Domain from HPV6a==
-	<StructureSection load='2aye' size='340' side='right' caption='[[2aye]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='2aye' size='340' side='right'caption='[[2aye]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2aye]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Hpv6a Hpv6a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AYE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2AYE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2aye]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Hpv6a Hpv6a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AYE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AYE FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1r8h\|1r8h]], [[2ayb\|2ayb]], [[2ayg\|2ayg]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1r8h\|1r8h]], [[2ayb\|2ayb]], [[2ayg\|2ayg]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">E2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=37122 HPV6A])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">E2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=37122 HPV6A])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2aye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aye OCA], [~~http~~://pdbe.org/2aye PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2aye RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2aye PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2aye ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aye OCA], [https://pdbe.org/2aye PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aye RCSB], [https://www.ebi.ac.uk/pdbsum/2aye PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aye ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/VE2_HPV6A VE2_HPV6A]] E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication.	+	[[https://www.uniprot.org/uniprot/VE2_HPV6A VE2_HPV6A]] E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ay/2aye_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ay/2aye_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Hpv6a]]		[[Category: Hpv6a]]
		+	[[Category: Large Structures]]
	[[Category: Brady, R L]]		[[Category: Brady, R L]]
	[[Category: Gaston, K]]		[[Category: Gaston, K]]

OCA at 15:27, 12 October 2017

OCA — Thu, 12 Oct 2017 15:27:38 GMT

←Older revision		Revision as of 15:27, 12 October 2017
Line 1:		Line 1:
		+
	==Crystal structure of the unliganded E2 DNA Binding Domain from HPV6a==		==Crystal structure of the unliganded E2 DNA Binding Domain from HPV6a==
	<StructureSection load='2aye' size='340' side='right' caption='[[2aye]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2aye' size='340' side='right' caption='[[2aye]], [[Resolution\|resolution]] 2.30Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1r8h\|1r8h]], [[2ayb\|2ayb]], [[2ayg\|2ayg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1r8h\|1r8h]], [[2ayb\|2ayb]], [[2ayg\|2ayg]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">E2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=37122 HPV6A])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">E2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=37122 HPV6A])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aye OCA], [http://pdbe.org/2aye PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2aye RCSB], [http://www.ebi.ac.uk/pdbsum/2aye PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aye OCA], [http://pdbe.org/2aye PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2aye RCSB], [http://www.ebi.ac.uk/pdbsum/2aye PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2aye ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 04:18, 9 February 2016

OCA — Tue, 09 Feb 2016 04:18:43 GMT

←Older revision		Revision as of 04:18, 9 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2aye ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 18:33, 10 September 2015

OCA — Thu, 10 Sep 2015 18:33:47 GMT

←Older revision		Revision as of 18:33, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2aye' size='340' side='right' caption='[[2aye]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2aye' size='340' side='right' caption='[[2aye]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2aye]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Human_papillomavirus_type_6a Human papillomavirus type 6a~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AYE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AYE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2aye]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Hpv6a Hpv6a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AYE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AYE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1r8h\|1r8h]], [[2ayb\|2ayb]], [[2ayg\|2ayg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1r8h\|1r8h]], [[2ayb\|2ayb]], [[2ayg\|2ayg]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">E2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=37122 ~~Human papillomavirus type 6a~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">E2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=37122 HPV6A])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aye OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2aye RCSB], [http://www.ebi.ac.uk/pdbsum/2aye PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aye OCA], [http://pdbe.org/2aye PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2aye RCSB], [http://www.ebi.ac.uk/pdbsum/2aye PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2aye" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human papillomavirus type 6a~~]]	+	[[Category: Hpv6a]]
	[[Category: Brady, R L]]		[[Category: Brady, R L]]
	[[Category: Gaston, K]]		[[Category: Gaston, K]]

OCA at 04:22, 25 December 2014

OCA — Thu, 25 Dec 2014 04:22:53 GMT

←Older revision		Revision as of 04:22, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2aye]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_papillomavirus_type_6a Human papillomavirus type 6a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AYE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AYE FirstGlance]. <br>		<table><tr><td colspan='2'>[[2aye]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_papillomavirus_type_6a Human papillomavirus type 6a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AYE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AYE FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1r8h\|1r8h]], [[2ayb\|2ayb]], [[2ayg\|2ayg]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1r8h\|1r8h]], [[2ayb\|2ayb]], [[2ayg\|2ayg]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">E2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=37122 Human papillomavirus type 6a])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">E2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=37122 Human papillomavirus type 6a])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aye OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2aye RCSB], [http://www.ebi.ac.uk/pdbsum/2aye PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aye OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2aye RCSB], [http://www.ebi.ac.uk/pdbsum/2aye PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/VE2_HPV6A VE2_HPV6A]] E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Human papillomavirus type 6a]]		[[Category: Human papillomavirus type 6a]]
-	[[Category: Brady, R L.]]	+	[[Category: Brady, R L]]
-	[[Category: Gaston, K.]]	+	[[Category: Gaston, K]]
-	[[Category: Hooley, E.]]	+	[[Category: Hooley, E]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Transcription]]		[[Category: Transcription]]

OCA at 02:35, 30 September 2014

OCA — Tue, 30 Sep 2014 02:35:31 GMT

←Older revision		Revision as of 02:35, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2aye.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of the unliganded E2 DNA Binding Domain from HPV6a==
		+	<StructureSection load='2aye' size='340' side='right' caption='[[2aye]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2aye]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_papillomavirus_type_6a Human papillomavirus type 6a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AYE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AYE FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1r8h\|1r8h]], [[2ayb\|2ayb]], [[2ayg\|2ayg]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">E2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=37122 Human papillomavirus type 6a])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aye OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2aye RCSB], [http://www.ebi.ac.uk/pdbsum/2aye PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ay/2aye_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The E2 proteins are transcription/replication factors from papillomaviruses. Human papillomaviruses (HPVs) can be broadly divided in two groups; low-risk HPV subtypes cause benign warts while high-risk HPVs give rise to cervical cancer. Although a range of crystal structures of E2 DNA-binding domains (DBD) from both high- and low-risk HPV subtypes have been reported previously, structures of E2 DBD:DNA complexes have only been available for high-risk HPV18 and bovine papillomavirus (BPV1). In the present study we report the unliganded and DNA complex structures of the E2 DBD from the low-risk HPV6. As in the previous E2-DNA structures, complex formation results in considerable bending of the DNA, which is facilitated by sequences with A:T-rich spacers that adopt a pre-bent conformation. The low-risk HPV6 E2-DNA complex differs from the earlier structures in that minimal deformation of the protein accompanies complex formation. Stopped-flow kinetic studies confirm that both high- and low-risk E2 proteins adapt their structures on binding to DNA, although this is achieved more readily for HPV6 E2. It therefore appears that the higher selectivity of the HPV6 E2 protein may arise from its limited molecular adaptability, a property that might distinguish the behaviour of E2 proteins from high- and low-risk HPV subtypes.

-	~~{{STRUCTURE_2aye\| PDB=2aye \| SCENE= }}~~	+	The recognition of local DNA conformation by the human papillomavirus type 6 E2 protein.,Hooley E, Fairweather V, Clarke AR, Gaston K, Brady RL Nucleic Acids Res. 2006;34(14):3897-908. Epub 2006 Aug 12. PMID:16914454<ref>PMID:16914454</ref>

-	~~===Crystal structure~~ of the ~~unliganded E2 DNA Binding Domain from HPV6a===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16914454}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2aye]] is a 6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Human_papillomavirus_type_6a Human papillomavirus type 6a]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2AYE OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016914454<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Human papillomavirus type 6a]]		[[Category: Human papillomavirus type 6a]]
	[[Category: Brady, R L.]]		[[Category: Brady, R L.]]

OCA: Protected "2aye" [edit=sysop:move=sysop]

OCA — Sun, 06 Jan 2013 11:47:57 GMT

Protected "2aye" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:47, 6 January 2013

OCA at 11:47, 6 January 2013

OCA — Sun, 06 Jan 2013 11:47:55 GMT

←Older revision		Revision as of 11:47, 6 January 2013
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-	{{Seed}}
	[[Image:2aye.png\|left\|200px]]		[[Image:2aye.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2aye", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2aye\| PDB=2aye \| SCENE= }}		{{STRUCTURE_2aye\| PDB=2aye \| SCENE= }}

	===Crystal structure of the unliganded E2 DNA Binding Domain from HPV6a===		===Crystal structure of the unliganded E2 DNA Binding Domain from HPV6a===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16914454}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16914454 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16914454}}		{{ABSTRACT_PUBMED_16914454}}

	==About this Structure==		==About this Structure==
-	~~2AYE~~ is a 6 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Human_papillomavirus_type_6a Human papillomavirus type 6a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AYE OCA].	+	[[2aye]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_papillomavirus_type_6a Human papillomavirus type 6a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AYE OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16914454~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016914454</ref><references group="xtra"/>
	[[Category: Human papillomavirus type 6a]]		[[Category: Human papillomavirus type 6a]]
	[[Category: Brady, R L.]]		[[Category: Brady, R L.]]
Line 29:		Line 17:
	[[Category: Hooley, E.]]		[[Category: Hooley, E.]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
-		+	[[Category: Transcription]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 06:25:04 2009''~~	+

OCA at 04:25, 17 February 2009

OCA — Tue, 17 Feb 2009 04:25:05 GMT

←Older revision		Revision as of 04:25, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2AYE is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Human_papillomavirus_type_6a Human papillomavirus type 6a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AYE OCA].	+	2AYE is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Human_papillomavirus_type_6a Human papillomavirus type 6a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AYE OCA].

	==Reference==		==Reference==
-	The recognition of local DNA conformation by the human papillomavirus type 6 E2 protein., Hooley E, Fairweather V, Clarke AR, Gaston K, Brady RL, Nucleic Acids Res. 2006;34(14):3897-908. Epub 2006 Aug 12. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16914454 16914454]~~	+	<ref group="xtra">PMID:16914454</ref><references group="xtra"/>
	[[Category: Human papillomavirus type 6a]]		[[Category: Human papillomavirus type 6a]]
-	[[Category: Single protein]]
	[[Category: Brady, R L.]]		[[Category: Brady, R L.]]
	[[Category: Gaston, K.]]		[[Category: Gaston, K.]]
Line 31:		Line 30:
	[[Category: Beta barrel]]		[[Category: Beta barrel]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28 09~~:58:~~40 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 06:25:04 2009''