2azo - Revision history

OCA at 09:14, 14 February 2024

OCA — Wed, 14 Feb 2024 09:14:54 GMT

←Older revision		Revision as of 09:14, 14 February 2024
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	<StructureSection load='2azo' size='340' side='right'caption='[[2azo]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2azo' size='340' side='right'caption='[[2azo]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2azo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Ecoli Ecoli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AZO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AZO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2azo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AZO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AZO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2azo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2azo OCA], [https://pdbe.org/2azo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2azo RCSB], [https://www.ebi.ac.uk/pdbsum/2azo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2azo ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2azo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2azo OCA], [https://pdbe.org/2azo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2azo RCSB], [https://www.ebi.ac.uk/pdbsum/2azo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2azo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MUTH_ECOLI MUTH_ECOLI]] Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair.[HAMAP-Rule:MF_00759]	+	[https://www.uniprot.org/uniprot/MUTH_ECOLI MUTH_ECOLI] Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair.[HAMAP-Rule:MF_00759]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 18:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2azo ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2azo ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	MutS, MutL and MutH are the three essential proteins for initiation of methyl-directed DNA mismatch repair to correct mistakes made during DNA replication in Escherichia coli. MutH cleaves a newly synthesized and unmethylated daughter strand 5' to the sequence d(GATC) in a hemi-methylated duplex. Activation of MutH requires the recognition of a DNA mismatch by MutS and MutL. We have crystallized MutH in two space groups and solved the structures at 1.7 and 2.3 A resolution, respectively. The active site of MutH is located at an interface between two subdomains that pivot relative to one another, as revealed by comparison of the crystal structures, and this presumably regulates the nuclease activity. The relative motion of the two subdomains in MutH correlates with the position of a protruding C-terminal helix. This helix appears to act as a molecular lever through which MutS and MutL may communicate the detection of a DNA mismatch and activate MutH. With sequence homology to Sau3AI and structural similarity to PvuII endonuclease, MutH is clearly related to these enzymes by divergent evolution, and this suggests that type II restriction endonucleases evolved from a common ancestor.

-	Structural basis for MutH activation in E.coli mismatch repair and relationship of MutH to restriction endonucleases.,Ban C, Yang W EMBO J. 1998 Mar 2;17(5):1526-34. PMID:9482749<ref>PMID:9482749</ref>	+	==See Also==
-		+	*[[DNA mismatch repair protein 3D structures\|DNA mismatch repair protein 3D structures]]
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class~~=~~"pdbe-citations 2azo" style~~=~~"background-color:#fffaf0;"></div>~~	+
-	~~== References~~ ==	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ecoli~~]]	+	[[Category: Escherichia coli K-12]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Yang, W]]	+	[[Category: Yang W]]
-	~~[[Category: Dna repair]]~~	+
-	~~[[Category: Endonuclease]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Muth~~]]	+

OCA at 14:46, 17 November 2021

OCA — Wed, 17 Nov 2021 14:46:47 GMT

←Older revision		Revision as of 14:46, 17 November 2021
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	<StructureSection load='2azo' size='340' side='right'caption='[[2azo]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2azo' size='340' side='right'caption='[[2azo]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2azo]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AZO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2AZO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2azo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AZO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AZO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2azo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2azo OCA], [~~http~~://pdbe.org/2azo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2azo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2azo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2azo ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2azo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2azo OCA], [https://pdbe.org/2azo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2azo RCSB], [https://www.ebi.ac.uk/pdbsum/2azo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2azo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MUTH_ECOLI MUTH_ECOLI]] Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair.[HAMAP-Rule:MF_00759]	+	[[https://www.uniprot.org/uniprot/MUTH_ECOLI MUTH_ECOLI]] Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair.[HAMAP-Rule:MF_00759]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 05:34, 13 February 2020

OCA — Thu, 13 Feb 2020 05:34:19 GMT

←Older revision		Revision as of 05:34, 13 February 2020
Line 1:		Line 1:

	==DNA MISMATCH REPAIR PROTEIN MUTH FROM E. COLI==		==DNA MISMATCH REPAIR PROTEIN MUTH FROM E. COLI==
-	<StructureSection load='2azo' size='340' side='right' caption='[[2azo]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='2azo' size='340' side='right'caption='[[2azo]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2azo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AZO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AZO FirstGlance]. <br>		<table><tr><td colspan='2'>[[2azo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AZO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AZO FirstGlance]. <br>
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Ecoli]]		[[Category: Ecoli]]
		+	[[Category: Large Structures]]
	[[Category: Yang, W]]		[[Category: Yang, W]]
	[[Category: Dna repair]]		[[Category: Dna repair]]

OCA at 07:28, 9 May 2018

OCA — Wed, 09 May 2018 07:28:40 GMT

←Older revision		Revision as of 07:28, 9 May 2018
Line 1:		Line 1:
		+
	==DNA MISMATCH REPAIR PROTEIN MUTH FROM E. COLI==		==DNA MISMATCH REPAIR PROTEIN MUTH FROM E. COLI==
	<StructureSection load='2azo' size='340' side='right' caption='[[2azo]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2azo' size='340' side='right' caption='[[2azo]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2azo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AZO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AZO FirstGlance]. <br>		<table><tr><td colspan='2'>[[2azo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AZO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AZO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2azo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2azo OCA], [http://pdbe.org/2azo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2azo RCSB], [http://www.ebi.ac.uk/pdbsum/2azo PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2azo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2azo OCA], [http://pdbe.org/2azo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2azo RCSB], [http://www.ebi.ac.uk/pdbsum/2azo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2azo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/az/2azo_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/az/2azo_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 19:54, 7 February 2016

OCA — Sun, 07 Feb 2016 19:54:53 GMT

←Older revision		Revision as of 19:54, 7 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2azo ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 04:31, 10 September 2015

OCA — Thu, 10 Sep 2015 04:31:25 GMT

←Older revision		Revision as of 04:31, 10 September 2015
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	<StructureSection load='2azo' size='340' side='right' caption='[[2azo]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2azo' size='340' side='right' caption='[[2azo]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2azo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia coli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AZO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AZO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2azo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AZO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AZO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2azo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2azo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2azo RCSB], [http://www.ebi.ac.uk/pdbsum/2azo PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2azo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2azo OCA], [http://pdbe.org/2azo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2azo RCSB], [http://www.ebi.ac.uk/pdbsum/2azo PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2azo" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia coli~~]]	+	[[Category: Ecoli]]
	[[Category: Yang, W]]		[[Category: Yang, W]]
	[[Category: Dna repair]]		[[Category: Dna repair]]

OCA at 17:52, 24 December 2014

OCA — Wed, 24 Dec 2014 17:52:14 GMT

←Older revision		Revision as of 17:52, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2azo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AZO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AZO FirstGlance]. <br>		<table><tr><td colspan='2'>[[2azo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AZO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AZO FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2azo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2azo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2azo RCSB], [http://www.ebi.ac.uk/pdbsum/2azo PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2azo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2azo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2azo RCSB], [http://www.ebi.ac.uk/pdbsum/2azo PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MUTH_ECOLI MUTH_ECOLI]] Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair.[HAMAP-Rule:MF_00759]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Yang, W.]]	+	[[Category: Yang, W]]
	[[Category: Dna repair]]		[[Category: Dna repair]]
	[[Category: Endonuclease]]		[[Category: Endonuclease]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Muth]]		[[Category: Muth]]

OCA at 00:36, 30 September 2014

OCA — Tue, 30 Sep 2014 00:36:39 GMT

←Older revision		Revision as of 00:36, 30 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2azo.~~png\|left~~\|200px]]	+	==DNA MISMATCH REPAIR PROTEIN MUTH FROM E. COLI==
		+	<StructureSection load='2azo' size='340' side='right' caption='[[2azo]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2azo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AZO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AZO FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2azo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2azo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2azo RCSB], [http://www.ebi.ac.uk/pdbsum/2azo PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/az/2azo_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	MutS, MutL and MutH are the three essential proteins for initiation of methyl-directed DNA mismatch repair to correct mistakes made during DNA replication in Escherichia coli. MutH cleaves a newly synthesized and unmethylated daughter strand 5' to the sequence d(GATC) in a hemi-methylated duplex. Activation of MutH requires the recognition of a DNA mismatch by MutS and MutL. We have crystallized MutH in two space groups and solved the structures at 1.7 and 2.3 A resolution, respectively. The active site of MutH is located at an interface between two subdomains that pivot relative to one another, as revealed by comparison of the crystal structures, and this presumably regulates the nuclease activity. The relative motion of the two subdomains in MutH correlates with the position of a protruding C-terminal helix. This helix appears to act as a molecular lever through which MutS and MutL may communicate the detection of a DNA mismatch and activate MutH. With sequence homology to Sau3AI and structural similarity to PvuII endonuclease, MutH is clearly related to these enzymes by divergent evolution, and this suggests that type II restriction endonucleases evolved from a common ancestor.

-	~~{{STRUCTURE_2azo\| PDB=2azo \| SCENE= }}~~	+	Structural basis for MutH activation in E.coli mismatch repair and relationship of MutH to restriction endonucleases.,Ban C, Yang W EMBO J. 1998 Mar 2;17(5):1526-34. PMID:9482749<ref>PMID:9482749</ref>

-	~~===DNA MISMATCH REPAIR PROTEIN MUTH FROM E. COLI===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_9482749}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2azo]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2AZO OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:009482749<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Yang, W.]]		[[Category: Yang, W.]]

OCA: Protected "2azo" [edit=sysop:move=sysop]

OCA — Sun, 06 Jan 2013 09:58:32 GMT

Protected "2azo" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:58, 6 January 2013

OCA at 09:58, 6 January 2013

OCA — Sun, 06 Jan 2013 09:58:29 GMT

←Older revision		Revision as of 09:58, 6 January 2013
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-	{{Seed}}
	[[Image:2azo.png\|left\|200px]]		[[Image:2azo.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2azo", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2azo\| PDB=2azo \| SCENE= }}		{{STRUCTURE_2azo\| PDB=2azo \| SCENE= }}

	===DNA MISMATCH REPAIR PROTEIN MUTH FROM E. COLI===		===DNA MISMATCH REPAIR PROTEIN MUTH FROM E. COLI===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_9482749}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 9482749 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_9482749}}		{{ABSTRACT_PUBMED_9482749}}

	==About this Structure==		==About this Structure==
-	~~2AZO~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AZO OCA].	+	[[2azo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AZO OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~9482749~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:009482749</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Yang, W.]]		[[Category: Yang, W.]]
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	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Muth]]		[[Category: Muth]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 16:08:48 2009''