2b0h - Revision history

OCA at 09:23, 22 May 2024

OCA — Wed, 22 May 2024 09:23:41 GMT

←Older revision		Revision as of 09:23, 22 May 2024
Line 1:		Line 1:

	==Solution structure of VBS3 fragment of talin==		==Solution structure of VBS3 fragment of talin==
-	<StructureSection load='2b0h' size='340' side='right'caption='[[2b0h~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2b0h' size='340' side='right'caption='[[2b0h]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2b0h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B0H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B0H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2b0h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B0H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B0H FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>Tln1, Tln ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~10090 LK3 transgenic mice])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b0h OCA], [https://pdbe.org/2b0h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b0h RCSB], [https://www.ebi.ac.uk/pdbsum/2b0h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b0h ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b0h OCA], [https://pdbe.org/2b0h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b0h RCSB], [https://www.ebi.ac.uk/pdbsum/2b0h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b0h ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TLN1_MOUSE TLN1_MOUSE]] Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.	+	[https://www.uniprot.org/uniprot/TLN1_MOUSE TLN1_MOUSE] Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Talin\|Talin]]	+	*[[Talin 3D structures\|Talin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Barsukov~~, I L~~]]	+	[[Category: Barsukov IL]]
-	[[Category: Critchley~~, D R~~]]	+	[[Category: Critchley DR]]
-	[[Category: Emsley, J]]	+	[[Category: Emsley J]]
-	[[Category: Gingras~~, A R~~]]	+	[[Category: Gingras AR]]
-	[[Category: Patel, B]]	+	[[Category: Patel B]]
-	[[Category: Roberts~~, G C~~]]	+	[[Category: Roberts GC]]
-	[[Category: Steinhoff~~, H J~~]]	+	[[Category: Steinhoff HJ]]
-	[[Category: Vogel~~, K P~~]]	+	[[Category: Vogel KP]]
-	[[Category: Ziegler~~, W H]]~~	+	[[Category: Ziegler WH]]
-	~~[[Category: Helical bundle]]~~	+
-	~~[[Category: Structural protein]]~~	+
-	~~[[Category: Talin]]~~	+
-	~~[[Category: Vb]]~~	+
-	~~[[Category: Vinculin~~]]	+

OCA at 08:41, 27 January 2021

OCA — Wed, 27 Jan 2021 08:41:24 GMT

←Older revision		Revision as of 08:41, 27 January 2021
Line 1:		Line 1:

	==Solution structure of VBS3 fragment of talin==		==Solution structure of VBS3 fragment of talin==
-	<StructureSection load='2b0h' size='340' side='right' caption='[[2b0h]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2b0h' size='340' side='right'caption='[[2b0h]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2b0h]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B0H OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2B0H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2b0h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B0H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B0H FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tln1, Tln ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tln1, Tln ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2b0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b0h OCA], [~~http~~://pdbe.org/2b0h PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2b0h RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2b0h PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2b0h ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b0h OCA], [https://pdbe.org/2b0h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b0h RCSB], [https://www.ebi.ac.uk/pdbsum/2b0h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b0h ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TLN1_MOUSE TLN1_MOUSE]] Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.	+	[[https://www.uniprot.org/uniprot/TLN1_MOUSE TLN1_MOUSE]] Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Barsukov, I L]]		[[Category: Barsukov, I L]]

OCA at 06:55, 16 May 2018

OCA — Wed, 16 May 2018 06:55:18 GMT

←Older revision		Revision as of 06:55, 16 May 2018
Line 1:		Line 1:
		+
	==Solution structure of VBS3 fragment of talin==		==Solution structure of VBS3 fragment of talin==
	<StructureSection load='2b0h' size='340' side='right' caption='[[2b0h]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2b0h' size='340' side='right' caption='[[2b0h]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2b0h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B0H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B0H FirstGlance]. <br>		<table><tr><td colspan='2'>[[2b0h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B0H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B0H FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tln1, Tln ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tln1, Tln ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b0h OCA], [http://pdbe.org/2b0h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2b0h RCSB], [http://www.ebi.ac.uk/pdbsum/2b0h PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b0h OCA], [http://pdbe.org/2b0h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2b0h RCSB], [http://www.ebi.ac.uk/pdbsum/2b0h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2b0h ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b0/2b0h_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b0/2b0h_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b0h ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 11:05, 11 September 2015

OCA — Fri, 11 Sep 2015 11:05:32 GMT

←Older revision		Revision as of 11:05, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2b0h' size='340' side='right' caption='[[2b0h]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2b0h' size='340' side='right' caption='[[2b0h]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2b0h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B0H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B0H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2b0h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B0H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B0H FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tln1, Tln ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tln1, Tln ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b0h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2b0h RCSB], [http://www.ebi.ac.uk/pdbsum/2b0h PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b0h OCA], [http://pdbe.org/2b0h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2b0h RCSB], [http://www.ebi.ac.uk/pdbsum/2b0h PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2b0h" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Barsukov, I L]]		[[Category: Barsukov, I L]]
	[[Category: Critchley, D R]]		[[Category: Critchley, D R]]

OCA at 15:36, 25 December 2014

OCA — Thu, 25 Dec 2014 15:36:12 GMT

←Older revision		Revision as of 15:36, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2b0h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B0H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B0H FirstGlance]. <br>		<table><tr><td colspan='2'>[[2b0h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B0H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B0H FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tln1, Tln ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tln1, Tln ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b0h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2b0h RCSB], [http://www.ebi.ac.uk/pdbsum/2b0h PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b0h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2b0h RCSB], [http://www.ebi.ac.uk/pdbsum/2b0h PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TLN1_MOUSE TLN1_MOUSE]] Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Barsukov, I L.]]	+	[[Category: Barsukov, I L]]
-	[[Category: Critchley, D R.]]	+	[[Category: Critchley, D R]]
-	[[Category: Emsley, J.]]	+	[[Category: Emsley, J]]
-	[[Category: Gingras, A R.]]	+	[[Category: Gingras, A R]]
-	[[Category: Patel, B.]]	+	[[Category: Patel, B]]
-	[[Category: Roberts, G C.]]	+	[[Category: Roberts, G C]]
-	[[Category: Steinhoff, H J.]]	+	[[Category: Steinhoff, H J]]
-	[[Category: Vogel, K P.]]	+	[[Category: Vogel, K P]]
-	[[Category: Ziegler, W H.]]	+	[[Category: Ziegler, W H]]
	[[Category: Helical bundle]]		[[Category: Helical bundle]]
	[[Category: Structural protein]]		[[Category: Structural protein]]

OCA at 02:42, 29 September 2014

OCA — Mon, 29 Sep 2014 02:42:26 GMT

←Older revision		Revision as of 02:42, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2b0h.~~png\|left~~\|200px]]	+	==Solution structure of VBS3 fragment of talin==
		+	<StructureSection load='2b0h' size='340' side='right' caption='[[2b0h]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2b0h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B0H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B0H FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tln1, Tln ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b0h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2b0h RCSB], [http://www.ebi.ac.uk/pdbsum/2b0h PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b0/2b0h_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Talin is a key protein involved in linking integrins to the actin cytoskeleton. The long flexible talin rod domain contains a number of binding sites for vinculin, a cytoskeletal protein important in stabilizing integrin-mediated cell-matrix junctions. Here we report the solution structure of a talin rod polypeptide (residues 1843-1973) which contains a single vinculin binding site (VBS; residues 1944-1969). Like other talin rod polypeptides, it consists of a helical bundle, in this case a four-helix bundle with a right-handed topology. The residues in the VBS important for vinculin binding were identified by studying the binding of a series of VBS-related peptides to the vinculin Vd1 domain. The key binding determinants are buried in the interior of the helical bundle, suggesting that a substantial structural change in the talin polypeptide is required for vinculin binding. Direct evidence for this was obtained by NMR and EPR spectroscopy. [1H,15N]-HSQC spectra of the talin fragment indicate that vinculin binding caused approximately two-thirds of the protein to adopt a flexible random coil. For EPR spectroscopy, nitroxide spin labels were attached to the talin polypeptide via appropriately located cysteine residues. Measurements of inter-nitroxide distances in doubly spin-labeled protein showed clearly that the helical bundle is disrupted and the mobility of the helices, except for the VBS helix, is markedly increased. Binding of vinculin to talin is thus a clear example of the unusual phenomenon of protein unfolding being required for protein/protein interaction.

-	~~{{STRUCTURE_2b0h\| PDB=2b0h \| SCENE= }}~~	+	Structural and dynamic characterization of a vinculin binding site in the talin rod.,Gingras AR, Vogel KP, Steinhoff HJ, Ziegler WH, Patel B, Emsley J, Critchley DR, Roberts GC, Barsukov IL Biochemistry. 2006 Feb 14;45(6):1805-17. PMID:16460027<ref>PMID:16460027</ref>

-	~~===Solution structure~~ of ~~VBS3 fragment of talin===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16460027}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2b0h]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2B0H OCA].~~	+

	==See Also==		==See Also==
	*[[Talin\|Talin]]		*[[Talin\|Talin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:016460027<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Barsukov, I L.]]		[[Category: Barsukov, I L.]]

OCA at 18:25, 20 October 2012

OCA — Sat, 20 Oct 2012 18:25:23 GMT

←Older revision		Revision as of 18:25, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[2b0h]] is a 1 chain structure ~~of [[Talin]]~~ with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B0H OCA].	+	[[2b0h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B0H OCA].

	==See Also==		==See Also==

OCA at 04:02, 27 July 2012

OCA — Fri, 27 Jul 2012 04:02:02 GMT

←Older revision		Revision as of 04:02, 27 July 2012
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	[[Image:2b0h.png\|left\|200px]]		[[Image:2b0h.png\|left\|200px]]

-	<!--
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-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_2b0h\| PDB=2b0h \| SCENE= }}		{{STRUCTURE_2b0h\| PDB=2b0h \| SCENE= }}

	===Solution structure of VBS3 fragment of talin===		===Solution structure of VBS3 fragment of talin===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16460027}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16460027 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_16460027}}		{{ABSTRACT_PUBMED_16460027}}

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	==See Also==		==See Also==
-	*[[Talin]]	+	*[[Talin\|Talin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16460027~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016460027</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Barsukov, I L.]]		[[Category: Barsukov, I L.]]

OCA: Protected "2b0h" [edit=sysop:move=sysop]

OCA — Sun, 26 Dec 2010 09:32:26 GMT

Protected "2b0h" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:32, 26 December 2010

OCA at 09:32, 26 December 2010

OCA — Sun, 26 Dec 2010 09:32:24 GMT

←Older revision		Revision as of 09:32, 26 December 2010
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-	{{Seed}}
	[[Image:2b0h.png\|left\|200px]]		[[Image:2b0h.png\|left\|200px]]

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	==About this Structure==		==About this Structure==
-	~~2B0H~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B0H OCA].	+	[[2b0h]] is a 1 chain structure of [[Talin]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B0H OCA].
		+
		+	==See Also==
		+	*[[Talin]]

	==Reference==		==Reference==
Line 35:		Line 37:
	[[Category: Ziegler, W H.]]		[[Category: Ziegler, W H.]]
	[[Category: Helical bundle]]		[[Category: Helical bundle]]
		+	[[Category: Structural protein]]
	[[Category: Talin]]		[[Category: Talin]]
	[[Category: Vb]]		[[Category: Vb]]
	[[Category: Vinculin]]		[[Category: Vinculin]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 20:35:07 2009''