2b61 - Revision history

OCA at 11:20, 22 May 2024

OCA — Wed, 22 May 2024 11:20:13 GMT

←Older revision		Revision as of 11:20, 22 May 2024
Line 3:		Line 3:
	<StructureSection load='2b61' size='340' side='right'caption='[[2b61]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='2b61' size='340' side='right'caption='[[2b61]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2b61]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacterium_influenzae"_lehmann_and_neumann_1896 "bacterium~~ influenzae~~" lehmann and neumann 1896~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B61 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B61 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2b61]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B61 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B61 FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=MSE:SELENOMETHIONINE'>MSE</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.65Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>metX, met2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~727~~ "~~Bacterium influenzae~~" ~~Lehmann and Neumann 1896])</td~~><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Homoserine_O-acetyltransferase Homoserine O-acetyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.31 2.3.1.31]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b61 OCA], [https://pdbe.org/2b61 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b61 RCSB], [https://www.ebi.ac.uk/pdbsum/2b61 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b61 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b61 OCA], [https://pdbe.org/2b61 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b61 RCSB], [https://www.ebi.ac.uk/pdbsum/2b61 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b61 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~METX_HAEIN METX_HAEIN~~]~~] Involved in the methionine biosynthesis. Catalyzes the transfer of the~~ acetyl group from acetyl-CoA to ~~the hydroxyl group of~~ L-homoserine ~~to yield O-~~acetyl-L-homoserine.<ref>PMID:10913262</ref>	+	[https://www.uniprot.org/uniprot/METXA_HAEIN METXA_HAEIN] Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine (PubMed:10913262, PubMed:28581482). Utilizes a ping-pong kinetic mechanism in which the acetyl group of acetyl-CoA is initially transferred to the enzyme to form an acetyl-enzyme intermediate before subsequent transfer to homoserine to form the final product, O-acetylhomoserine (PubMed:10913262).<ref>PMID:10913262</ref> <ref>PMID:28581482</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacterium~~ influenzae ~~lehmann and neumann 1896]]~~	+	[[Category: Haemophilus influenzae]]
-	~~[[Category: Homoserine O-acetyltransferase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Berghuis~~, A M~~]]	+	[[Category: Berghuis AM]]
-	[[Category: Korczynska, M]]	+	[[Category: Korczynska M]]
-	[[Category: Mirza~~, I A~~]]	+	[[Category: Mirza IA]]
-	[[Category: Nazi, I]]	+	[[Category: Nazi I]]
-	[[Category: Wright~~, G D]]~~	+	[[Category: Wright GD]]
-	~~[[Category: Acyl-enzyme]]~~	+
-	~~[[Category: Alpha-beta hydrolase fold]]~~	+
-	~~[[Category: Aspartate pathway]]~~	+
-	~~[[Category: Coenzyme some]]~~	+
-	~~[[Category: Structure-function study]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 11:36, 3 February 2021

OCA — Wed, 03 Feb 2021 11:36:19 GMT

←Older revision		Revision as of 11:36, 3 February 2021
Line 1:		Line 1:

	==Crystal Structure of Homoserine Transacetylase==		==Crystal Structure of Homoserine Transacetylase==
-	<StructureSection load='2b61' size='340' side='right' caption='[[2b61]], [[Resolution\|resolution]] 1.65Å' scene=''>	+	<StructureSection load='2b61' size='340' side='right'caption='[[2b61]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2b61]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacterium_influenzae"_lehmann_and_neumann_1896 "bacterium influenzae" lehmann and neumann 1896]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B61 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2B61 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2b61]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacterium_influenzae"_lehmann_and_neumann_1896 "bacterium influenzae" lehmann and neumann 1896]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B61 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B61 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">metX, met2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 "Bacterium influenzae" Lehmann and Neumann 1896])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">metX, met2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 "Bacterium influenzae" Lehmann and Neumann 1896])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Homoserine_O-acetyltransferase Homoserine O-acetyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.31 2.3.1.31] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Homoserine_O-acetyltransferase Homoserine O-acetyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.31 2.3.1.31] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2b61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b61 OCA], [~~http~~://pdbe.org/2b61 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2b61 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2b61 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2b61 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b61 OCA], [https://pdbe.org/2b61 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b61 RCSB], [https://www.ebi.ac.uk/pdbsum/2b61 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b61 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/METX_HAEIN METX_HAEIN]] Involved in the methionine biosynthesis. Catalyzes the transfer of the acetyl group from acetyl-CoA to the hydroxyl group of L-homoserine to yield O-acetyl-L-homoserine.<ref>PMID:10913262</ref>	+	[[https://www.uniprot.org/uniprot/METX_HAEIN METX_HAEIN]] Involved in the methionine biosynthesis. Catalyzes the transfer of the acetyl group from acetyl-CoA to the hydroxyl group of L-homoserine to yield O-acetyl-L-homoserine.<ref>PMID:10913262</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	[[Category: Bacterium influenzae lehmann and neumann 1896]]		[[Category: Bacterium influenzae lehmann and neumann 1896]]
	[[Category: Homoserine O-acetyltransferase]]		[[Category: Homoserine O-acetyltransferase]]
		+	[[Category: Large Structures]]
	[[Category: Berghuis, A M]]		[[Category: Berghuis, A M]]
	[[Category: Korczynska, M]]		[[Category: Korczynska, M]]

OCA at 06:28, 7 February 2018

OCA — Wed, 07 Feb 2018 06:28:22 GMT

←Older revision		Revision as of 06:28, 7 February 2018
Line 1:		Line 1:
		+
	==Crystal Structure of Homoserine Transacetylase==		==Crystal Structure of Homoserine Transacetylase==
	<StructureSection load='2b61' size='340' side='right' caption='[[2b61]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='2b61' size='340' side='right' caption='[[2b61]], [[Resolution\|resolution]] 1.65Å' scene=''>
Line 6:		Line 7:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">metX, met2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 "Bacterium influenzae" Lehmann and Neumann 1896])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">metX, met2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 "Bacterium influenzae" Lehmann and Neumann 1896])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Homoserine_O-acetyltransferase Homoserine O-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.31 2.3.1.31] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Homoserine_O-acetyltransferase Homoserine O-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.31 2.3.1.31] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b61 OCA], [http://pdbe.org/2b61 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2b61 RCSB], [http://www.ebi.ac.uk/pdbsum/2b61 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b61 OCA], [http://pdbe.org/2b61 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2b61 RCSB], [http://www.ebi.ac.uk/pdbsum/2b61 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2b61 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b6/2b61_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b6/2b61_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b61 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:53, 11 September 2015

OCA — Fri, 11 Sep 2015 10:53:46 GMT

←Older revision		Revision as of 10:53, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2b61' size='340' side='right' caption='[[2b61]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='2b61' size='340' side='right' caption='[[2b61]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2b61]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Haemophilus_influenzae Haemophilus~~ influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B61 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B61 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2b61]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_influenzae"_lehmann_and_neumann_1896 "bacterium influenzae" lehmann and neumann 1896]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B61 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B61 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">metX, met2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 ~~Haemophilus~~ influenzae])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">metX, met2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 "Bacterium influenzae" Lehmann and Neumann 1896])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Homoserine_O-acetyltransferase Homoserine O-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.31 2.3.1.31] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Homoserine_O-acetyltransferase Homoserine O-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.31 2.3.1.31] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b61 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2b61 RCSB], [http://www.ebi.ac.uk/pdbsum/2b61 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b61 OCA], [http://pdbe.org/2b61 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2b61 RCSB], [http://www.ebi.ac.uk/pdbsum/2b61 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2b61" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Haemophilus~~ influenzae]]	+	[[Category: Bacterium influenzae lehmann and neumann 1896]]
	[[Category: Homoserine O-acetyltransferase]]		[[Category: Homoserine O-acetyltransferase]]
	[[Category: Berghuis, A M]]		[[Category: Berghuis, A M]]

OCA at 15:29, 25 December 2014

OCA — Thu, 25 Dec 2014 15:29:16 GMT

←Older revision		Revision as of 15:29, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2b61]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B61 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B61 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2b61]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B61 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B61 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">metX, met2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 Haemophilus influenzae])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">metX, met2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 Haemophilus influenzae])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Homoserine_O-acetyltransferase Homoserine O-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.31 2.3.1.31] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Homoserine_O-acetyltransferase Homoserine O-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.31 2.3.1.31] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b61 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2b61 RCSB], [http://www.ebi.ac.uk/pdbsum/2b61 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b61 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2b61 RCSB], [http://www.ebi.ac.uk/pdbsum/2b61 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/METX_HAEIN METX_HAEIN]] Involved in the methionine biosynthesis. Catalyzes the transfer of the acetyl group from acetyl-CoA to the hydroxyl group of L-homoserine to yield O-acetyl-L-homoserine.<ref>PMID:10913262</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	[[Category: Haemophilus influenzae]]		[[Category: Haemophilus influenzae]]
	[[Category: Homoserine O-acetyltransferase]]		[[Category: Homoserine O-acetyltransferase]]
-	[[Category: Berghuis, A M.]]	+	[[Category: Berghuis, A M]]
-	[[Category: Korczynska, M.]]	+	[[Category: Korczynska, M]]
-	[[Category: Mirza, I A.]]	+	[[Category: Mirza, I A]]
-	[[Category: Nazi, I.]]	+	[[Category: Nazi, I]]
-	[[Category: Wright, G D.]]	+	[[Category: Wright, G D]]
	[[Category: Acyl-enzyme]]		[[Category: Acyl-enzyme]]
	[[Category: Alpha-beta hydrolase fold]]		[[Category: Alpha-beta hydrolase fold]]

OCA at 00:22, 30 September 2014

OCA — Tue, 30 Sep 2014 00:22:29 GMT

←Older revision		Revision as of 00:22, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2b61.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of Homoserine Transacetylase==
		+	<StructureSection load='2b61' size='340' side='right' caption='[[2b61]], [[Resolution\|resolution]] 1.65Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2b61]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B61 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B61 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">metX, met2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 Haemophilus influenzae])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Homoserine_O-acetyltransferase Homoserine O-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.31 2.3.1.31] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b61 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2b61 RCSB], [http://www.ebi.ac.uk/pdbsum/2b61 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b6/2b61_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Homoserine transacetylase catalyzes one of the required steps in the biosynthesis of methionine in fungi and several bacteria. We have determined the crystal structure of homoserine transacetylase from Haemophilus influenzae to a resolution of 1.65 A. The structure identifies this enzyme to be a member of the alpha/beta-hydrolase structural superfamily. The active site of the enzyme is located near the end of a deep tunnel formed by the juxtaposition of two domains and incorporates a catalytic triad involving Ser143, His337, and Asp304. A structural basis is given for the observed double displacement kinetic mechanism of homoserine transacetylase. Furthermore, the properties of the tunnel provide a rationale for how homoserine transacetylase catalyzes a transferase reaction vs hydrolysis, despite extensive similarity in active site architecture to hydrolytic enzymes.

-	~~{{STRUCTURE_2b61\| PDB=2b61 \| SCENE= }}~~	+	Crystal structure of homoserine transacetylase from Haemophilus influenzae reveals a new family of alpha/beta-hydrolases.,Mirza IA, Nazi I, Korczynska M, Wright GD, Berghuis AM Biochemistry. 2005 Dec 6;44(48):15768-73. PMID:16313180<ref>PMID:16313180</ref>

-	~~===Crystal Structure~~ of ~~Homoserine Transacetylase===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16313180}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2b61]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Haemophilus_influenzae Haemophilus influenzae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2B61 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016313180<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Haemophilus influenzae]]		[[Category: Haemophilus influenzae]]
	[[Category: Homoserine O-acetyltransferase]]		[[Category: Homoserine O-acetyltransferase]]

OCA: Protected "2b61" [edit=sysop:move=sysop]

OCA — Sun, 06 Jan 2013 09:46:01 GMT

Protected "2b61" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:46, 6 January 2013

OCA at 09:45, 6 January 2013

OCA — Sun, 06 Jan 2013 09:45:57 GMT

←Older revision		Revision as of 09:45, 6 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2b61.png\|left\|200px]]		[[Image:2b61.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2b61", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2b61\| PDB=2b61 \| SCENE= }}		{{STRUCTURE_2b61\| PDB=2b61 \| SCENE= }}

	===Crystal Structure of Homoserine Transacetylase===		===Crystal Structure of Homoserine Transacetylase===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16313180}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16313180 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16313180}}		{{ABSTRACT_PUBMED_16313180}}

	==About this Structure==		==About this Structure==
-	~~2B61~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B61 OCA].	+	[[2b61]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B61 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16313180~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016313180</ref><references group="xtra"/>
	[[Category: Haemophilus influenzae]]		[[Category: Haemophilus influenzae]]
	[[Category: Homoserine O-acetyltransferase]]		[[Category: Homoserine O-acetyltransferase]]
Line 36:		Line 24:
	[[Category: Coenzyme some]]		[[Category: Coenzyme some]]
	[[Category: Structure-function study]]		[[Category: Structure-function study]]
-		+	[[Category: Transferase]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 20:22:29 2009''~~	+

OCA at 18:22, 17 February 2009

OCA — Tue, 17 Feb 2009 18:22:31 GMT

←Older revision		Revision as of 18:22, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2B61 is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B61 OCA].	+	2B61 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B61 OCA].

	==Reference==		==Reference==
-	Crystal structure of homoserine transacetylase from Haemophilus influenzae reveals a new family of alpha/beta-hydrolases., Mirza IA, Nazi I, Korczynska M, Wright GD, Berghuis AM, Biochemistry. 2005 Dec 6;44(48):15768-73. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16313180 16313180]~~	+	<ref group="xtra">PMID:16313180</ref><references group="xtra"/>
	[[Category: Haemophilus influenzae]]		[[Category: Haemophilus influenzae]]
	[[Category: Homoserine O-acetyltransferase]]		[[Category: Homoserine O-acetyltransferase]]
-	[[Category: Single protein]]
	[[Category: Berghuis, A M.]]		[[Category: Berghuis, A M.]]
	[[Category: Korczynska, M.]]		[[Category: Korczynska, M.]]
Line 38:		Line 37:
	[[Category: Structure-function study]]		[[Category: Structure-function study]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 04~~:15:~~23 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 20:22:29 2009''

OCA at 01:15, 29 July 2008

OCA — Tue, 29 Jul 2008 01:15:27 GMT

←Older revision		Revision as of 01:15, 29 July 2008
Line 1:		Line 1:
-	[[Image:2b61.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2b61.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_2b61\| PDB=2b61 \| SCENE= }}		{{STRUCTURE_2b61\| PDB=2b61 \| SCENE= }}

-	~~'''~~Crystal Structure of Homoserine Transacetylase~~'''~~	+	===Crystal Structure of Homoserine Transacetylase===


-	~~==Overview==~~	+	<!--
-	Homoserine transacetylase catalyzes one of the required steps in the biosynthesis of methionine in fungi and several bacteria. We have determined the crystal structure of homoserine transacetylase from Haemophilus influenzae to a resolution of 1.65 A. The ~~structure identifies~~ this ~~enzyme~~ to ~~be a member of~~ the ~~alpha~~/~~beta-hydrolase structural superfamily~~. ~~The active site of the enzyme is located near the end of a deep tunnel formed by the juxtaposition of two domains and incorporates a catalytic triad involving Ser143~~, ~~His337, and Asp304. A structural basis~~ is ~~given for~~ the observed double displacement kinetic mechanism of homoserine transacetylase. Furthermore, the properties of the tunnel provide a rationale for how homoserine transacetylase catalyzes a transferase reaction vs hydrolysis, despite extensive similarity in active site architecture to hydrolytic enzymes.	+	The line below this paragraph, {{ABSTRACT_PUBMED_16313180}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 16313180 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_16313180}}

	==About this Structure==		==About this Structure==
Line 33:		Line 37:
	[[Category: Coenzyme some]]		[[Category: Coenzyme some]]
	[[Category: Structure-function study]]		[[Category: Structure-function study]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 19~~:54:05 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:15:23 2008''