2b7k - Revision history

OCA at 07:35, 23 August 2023

OCA — Wed, 23 Aug 2023 07:35:14 GMT

←Older revision		Revision as of 07:35, 23 August 2023
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	<StructureSection load='2b7k' size='340' side='right'caption='[[2b7k]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2b7k' size='340' side='right'caption='[[2b7k]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2b7k]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B7K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B7K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2b7k]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B7K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B7K FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[2b7j\|2b7j]]~~<~~/div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">SCO1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b7k OCA], [https://pdbe.org/2b7k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b7k RCSB], [https://www.ebi.ac.uk/pdbsum/2b7k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b7k ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b7k OCA], [https://pdbe.org/2b7k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b7k RCSB], [https://www.ebi.ac.uk/pdbsum/2b7k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b7k ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SCO1_YEAST SCO1_YEAST]] Required for the accumulation of subunits 1 and 2 of cytochrome c oxidase complex. Thought to play a role in either mitochondrial copper transport or insertion of copper into the active site of COX.<ref>PMID:16570183</ref>	+	[https://www.uniprot.org/uniprot/SCO1_YEAST SCO1_YEAST] Required for the accumulation of subunits 1 and 2 of cytochrome c oxidase complex. Thought to play a role in either mitochondrial copper transport or insertion of copper into the active site of COX.<ref>PMID:16570183</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Abajian, C~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: ~~Rosenzweig, A~~ C]]	+	[[Category: Abajian C]]
-	[[Category: ~~Cytochrome c oxidase]]~~	+	[[Category: Rosenzweig AC]]
-	~~[[Category: Metal binding protein]]~~	+
-	~~[[Category: Metallochaperone]]~~	+
-	~~[[Category: Sco]]~~	+
-	~~[[Category: Sco1~~]]	+

OCA at 11:37, 3 February 2021

OCA — Wed, 03 Feb 2021 11:37:15 GMT

←Older revision		Revision as of 11:37, 3 February 2021
Line 1:		Line 1:

	==Crystal Structure of Yeast Sco1==		==Crystal Structure of Yeast Sco1==
-	<StructureSection load='2b7k' size='340' side='right' caption='[[2b7k]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='2b7k' size='340' side='right'caption='[[2b7k]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2b7k]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B7K OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2B7K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2b7k]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B7K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B7K FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2b7j\|2b7j]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2b7j\|2b7j]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SCO1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SCO1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2b7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b7k OCA], [~~http~~://pdbe.org/2b7k PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2b7k RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2b7k PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2b7k ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b7k OCA], [https://pdbe.org/2b7k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b7k RCSB], [https://www.ebi.ac.uk/pdbsum/2b7k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b7k ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SCO1_YEAST SCO1_YEAST]] Required for the accumulation of subunits 1 and 2 of cytochrome c oxidase complex. Thought to play a role in either mitochondrial copper transport or insertion of copper into the active site of COX.<ref>PMID:16570183</ref>	+	[[https://www.uniprot.org/uniprot/SCO1_YEAST SCO1_YEAST]] Required for the accumulation of subunits 1 and 2 of cytochrome c oxidase complex. Thought to play a role in either mitochondrial copper transport or insertion of copper into the active site of COX.<ref>PMID:16570183</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
		+	[[Category: Large Structures]]
	[[Category: Abajian, C]]		[[Category: Abajian, C]]
	[[Category: Rosenzweig, A C]]		[[Category: Rosenzweig, A C]]

OCA at 06:36, 16 May 2018

OCA — Wed, 16 May 2018 06:36:09 GMT

←Older revision		Revision as of 06:36, 16 May 2018
Line 1:		Line 1:
		+
	==Crystal Structure of Yeast Sco1==		==Crystal Structure of Yeast Sco1==
	<StructureSection load='2b7k' size='340' side='right' caption='[[2b7k]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2b7k' size='340' side='right' caption='[[2b7k]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2b7j\|2b7j]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2b7j\|2b7j]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SCO1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SCO1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b7k OCA], [http://pdbe.org/2b7k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2b7k RCSB], [http://www.ebi.ac.uk/pdbsum/2b7k PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b7k OCA], [http://pdbe.org/2b7k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2b7k RCSB], [http://www.ebi.ac.uk/pdbsum/2b7k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2b7k ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b7/2b7k_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b7/2b7k_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 09:09, 7 February 2016

OCA — Sun, 07 Feb 2016 09:09:56 GMT

←Older revision		Revision as of 09:09, 7 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b7k ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:55, 9 September 2015

OCA — Wed, 09 Sep 2015 23:55:10 GMT

←Older revision		Revision as of 23:55, 9 September 2015
Line 2:		Line 2:
	<StructureSection load='2b7k' size='340' side='right' caption='[[2b7k]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2b7k' size='340' side='right' caption='[[2b7k]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2b7k]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B7K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B7K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2b7k]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B7K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B7K FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2b7j\|2b7j]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2b7j\|2b7j]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SCO1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ~~Saccharomyces cerevisiae~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SCO1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b7k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2b7k RCSB], [http://www.ebi.ac.uk/pdbsum/2b7k PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b7k OCA], [http://pdbe.org/2b7k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2b7k RCSB], [http://www.ebi.ac.uk/pdbsum/2b7k PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2b7k" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Saccharomyces cerevisiae~~]]	+	[[Category: Atcc 18824]]
	[[Category: Abajian, C]]		[[Category: Abajian, C]]
	[[Category: Rosenzweig, A C]]		[[Category: Rosenzweig, A C]]

OCA at 13:55, 24 December 2014

OCA — Wed, 24 Dec 2014 13:55:41 GMT

←Older revision		Revision as of 13:55, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2b7k]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B7K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B7K FirstGlance]. <br>		<table><tr><td colspan='2'>[[2b7k]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B7K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B7K FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2b7j\|2b7j]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2b7j\|2b7j]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SCO1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SCO1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b7k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2b7k RCSB], [http://www.ebi.ac.uk/pdbsum/2b7k PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b7k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2b7k RCSB], [http://www.ebi.ac.uk/pdbsum/2b7k PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SCO1_YEAST SCO1_YEAST]] Required for the accumulation of subunits 1 and 2 of cytochrome c oxidase complex. Thought to play a role in either mitochondrial copper transport or insertion of copper into the active site of COX.<ref>PMID:16570183</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Abajian, C.]]	+	[[Category: Abajian, C]]
-	[[Category: Rosenzweig, A C.]]	+	[[Category: Rosenzweig, A C]]
	[[Category: Cytochrome c oxidase]]		[[Category: Cytochrome c oxidase]]
	[[Category: Metal binding protein]]		[[Category: Metal binding protein]]

OCA at 02:45, 30 September 2014

OCA — Tue, 30 Sep 2014 02:45:28 GMT

←Older revision		Revision as of 02:45, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2b7k.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of Yeast Sco1==
		+	<StructureSection load='2b7k' size='340' side='right' caption='[[2b7k]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2b7k]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B7K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B7K FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2b7j\|2b7j]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SCO1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b7k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2b7k RCSB], [http://www.ebi.ac.uk/pdbsum/2b7k PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b7/2b7k_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Sco family of proteins are involved in the assembly of the dinuclear CuA site in cytochrome c oxidase (COX), the terminal enzyme in aerobic respiration. These proteins, which are found in both eukaryotes and prokaryotes, are characterized by a conserved CXXXC sequence motif that binds copper ions and that has also been proposed to perform a thiol:disulfide oxidoreductase function. The crystal structures of Saccharomyces cerevisiae apo Sco1 (apo-ySco1) and Sco1 in the presence of copper ions (Cu-ySco1) were determined to 1.8- and 2.3-A resolutions, respectively. Yeast Sco1 exhibits a thioredoxin-like fold, similar to that observed for human Sco1 and a homolog from Bacillus subtilis. The Cu-ySco1 structure, obtained by soaking apo-ySco1 crystals in copper ions, reveals an unexpected copper-binding site involving Cys181 and Cys216, cysteine residues present in ySco1 but not in other homologs. The conserved CXXXC cysteines, Cys148 and Cys152, can undergo redox chemistry in the crystal. An essential histidine residue, His239, is located on a highly flexible loop, denoted the Sco loop, and can adopt positions proximal to both pairs of cysteines. Interactions between ySco1 and its partner proteins yeast Cox17 and yeast COX2 are likely to occur via complementary electrostatic surfaces. This high-resolution model of a eukaryotic Sco protein provides new insight into Sco copper binding and function.

-	~~{{STRUCTURE_2b7k\| PDB=2b7k \| SCENE= }}~~	+	Crystal structure of yeast Sco1.,Abajian C, Rosenzweig AC J Biol Inorg Chem. 2006 Jun;11(4):459-66. Epub 2006 Mar 29. PMID:16570183<ref>PMID:16570183</ref>

-	~~===Crystal Structure~~ of ~~Yeast Sco1===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16570183}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2b7k]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2B7K OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016570183<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Abajian, C.]]		[[Category: Abajian, C.]]

OCA: Protected "2b7k" [edit=sysop:move=sysop]

OCA — Sun, 06 Jan 2013 11:57:24 GMT

Protected "2b7k" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:57, 6 January 2013

OCA at 11:57, 6 January 2013

OCA — Sun, 06 Jan 2013 11:57:20 GMT

←Older revision		Revision as of 11:57, 6 January 2013
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-	{{Seed}}
	[[Image:2b7k.png\|left\|200px]]		[[Image:2b7k.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2b7k", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_2b7k\| PDB=2b7k \| SCENE= }}		{{STRUCTURE_2b7k\| PDB=2b7k \| SCENE= }}

	===Crystal Structure of Yeast Sco1===		===Crystal Structure of Yeast Sco1===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16570183}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16570183 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_16570183}}		{{ABSTRACT_PUBMED_16570183}}

	==About this Structure==		==About this Structure==
-	~~2B7K~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B7K OCA].	+	[[2b7k]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B7K OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16570183~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016570183</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Abajian, C.]]		[[Category: Abajian, C.]]
	[[Category: Rosenzweig, A C.]]		[[Category: Rosenzweig, A C.]]
	[[Category: Cytochrome c oxidase]]		[[Category: Cytochrome c oxidase]]
		+	[[Category: Metal binding protein]]
	[[Category: Metallochaperone]]		[[Category: Metallochaperone]]
	[[Category: Sco]]		[[Category: Sco]]
	[[Category: Sco1]]		[[Category: Sco1]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 12:47:42 2009''

OCA at 10:47, 16 February 2009

OCA — Mon, 16 Feb 2009 10:47:44 GMT

←Older revision		Revision as of 10:47, 16 February 2009
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	==About this Structure==		==About this Structure==
-	2B7K is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B7K OCA].	+	2B7K is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B7K OCA].

	==Reference==		==Reference==
-	~~Crystal structure of yeast Sco1., Abajian C, Rosenzweig AC, J Biol Inorg Chem. 2006 Jun;11(4):459-66. Epub 2006 Mar 29.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16570183 16570183]~~	+	<ref group="xtra">PMID:16570183</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Single protein]]
	[[Category: Abajian, C.]]		[[Category: Abajian, C.]]
	[[Category: Rosenzweig, A C.]]		[[Category: Rosenzweig, A C.]]
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	[[Category: Sco1]]		[[Category: Sco1]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Jul 27 15~~:04:~~57 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 12:47:42 2009''