2b8u - Revision history

OCA at 08:19, 25 October 2023

OCA — Wed, 25 Oct 2023 08:19:44 GMT

←Older revision		Revision as of 08:19, 25 October 2023
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	<StructureSection load='2b8u' size='340' side='right'caption='[[2b8u]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2b8u' size='340' side='right'caption='[[2b8u]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2b8u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B8U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2b8u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B8U FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2d48\|2d48]], [[2b8x\|2b8x]], [[2b8y\|2b8y]], [[2b8z\|2b8z]], [[2b90\|2b90]], [[2b91\|2b91]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b8u OCA], [https://pdbe.org/2b8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b8u RCSB], [https://www.ebi.ac.uk/pdbsum/2b8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b8u ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b8u OCA], [https://pdbe.org/2b8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b8u RCSB], [https://www.ebi.ac.uk/pdbsum/2b8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b8u ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/IL4_HUMAN IL4_HUMAN]] Genetic variations in IL4 may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:[https://omim.org/entry/601367 601367]]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.<ref>PMID:14681304</ref>	+	[https://www.uniprot.org/uniprot/IL4_HUMAN IL4_HUMAN] Genetic variations in IL4 may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:[https://omim.org/entry/601367 601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.<ref>PMID:14681304</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/IL4_HUMAN IL4_HUMAN]] Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.	+	[https://www.uniprot.org/uniprot/IL4_HUMAN IL4_HUMAN] Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 38:		Line 38:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Harrer, H]]	+	[[Category: Harrer H]]
-	[[Category: Klein, M]]	+	[[Category: Klein M]]
-	[[Category: Kraich, M]]	+	[[Category: Kraich M]]
-	[[Category: Mueller~~, T D~~]]	+	[[Category: Mueller TD]]
-	[[Category: Patino, E]]	+	[[Category: Patino E]]
-	[[Category: Sebald, W]]	+	[[Category: Sebald W]]
-	~~[[Category: Cytokine]]~~	+
-	~~[[Category: Four helix bundle~~]]	+

OCA at 13:06, 24 November 2021

OCA — Wed, 24 Nov 2021 13:06:34 GMT

OCA at 07:55, 19 February 2020

OCA — Wed, 19 Feb 2020 07:55:26 GMT

←Older revision		Revision as of 07:55, 19 February 2020
Line 1:		Line 1:

	==Crystal structure of wildtype human Interleukin-4==		==Crystal structure of wildtype human Interleukin-4==
-	<StructureSection load='2b8u' size='340' side='right' caption='[[2b8u]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='2b8u' size='340' side='right'caption='[[2b8u]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2b8u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B8U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B8U FirstGlance]. <br>		<table><tr><td colspan='2'>[[2b8u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B8U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B8U FirstGlance]. <br>
Line 33:		Line 33:

	==See Also==		==See Also==
-	*[[Interleukin\|Interleukin]]	+	*[[Interleukin 3D structures\|Interleukin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 39:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Harrer, H]]		[[Category: Harrer, H]]
	[[Category: Klein, M]]		[[Category: Klein, M]]

OCA at 06:14, 16 May 2018

OCA — Wed, 16 May 2018 06:14:09 GMT

←Older revision		Revision as of 06:14, 16 May 2018
Line 1:		Line 1:
		+
	==Crystal structure of wildtype human Interleukin-4==		==Crystal structure of wildtype human Interleukin-4==
	<StructureSection load='2b8u' size='340' side='right' caption='[[2b8u]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2b8u' size='340' side='right' caption='[[2b8u]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2d48\|2d48]], [[2b8x\|2b8x]], [[2b8y\|2b8y]], [[2b8z\|2b8z]], [[2b90\|2b90]], [[2b91\|2b91]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2d48\|2d48]], [[2b8x\|2b8x]], [[2b8y\|2b8y]], [[2b8z\|2b8z]], [[2b90\|2b90]], [[2b91\|2b91]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b8u OCA], [http://pdbe.org/2b8u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2b8u RCSB], [http://www.ebi.ac.uk/pdbsum/2b8u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b8u OCA], [http://pdbe.org/2b8u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2b8u RCSB], [http://www.ebi.ac.uk/pdbsum/2b8u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2b8u ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b8/2b8u_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b8/2b8u_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b8u ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:00, 11 September 2015

OCA — Fri, 11 Sep 2015 09:00:43 GMT

←Older revision		Revision as of 09:00, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2b8u' size='340' side='right' caption='[[2b8u]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2b8u' size='340' side='right' caption='[[2b8u]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2b8u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B8U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B8U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2b8u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B8U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B8U FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2d48\|2d48]], [[2b8x\|2b8x]], [[2b8y\|2b8y]], [[2b8z\|2b8z]], [[2b90\|2b90]], [[2b91\|2b91]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2d48\|2d48]], [[2b8x\|2b8x]], [[2b8y\|2b8y]], [[2b8z\|2b8z]], [[2b90\|2b90]], [[2b91\|2b91]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b8u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2b8u RCSB], [http://www.ebi.ac.uk/pdbsum/2b8u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b8u OCA], [http://pdbe.org/2b8u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2b8u RCSB], [http://www.ebi.ac.uk/pdbsum/2b8u PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2b8u" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Harrer, H]]		[[Category: Harrer, H]]
	[[Category: Klein, M]]		[[Category: Klein, M]]

OCA at 08:56, 8 January 2015

OCA — Thu, 08 Jan 2015 08:56:11 GMT

←Older revision		Revision as of 08:56, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2b8u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B8U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B8U FirstGlance]. <br>		<table><tr><td colspan='2'>[[2b8u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B8U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B8U FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2d48\|2d48]], [[2b8x\|2b8x]], [[2b8y\|2b8y]], [[2b8z\|2b8z]], [[2b90\|2b90]], [[2b91\|2b91]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2d48\|2d48]], [[2b8x\|2b8x]], [[2b8y\|2b8y]], [[2b8z\|2b8z]], [[2b90\|2b90]], [[2b91\|2b91]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b8u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2b8u RCSB], [http://www.ebi.ac.uk/pdbsum/2b8u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b8u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2b8u RCSB], [http://www.ebi.ac.uk/pdbsum/2b8u PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/IL4_HUMAN IL4_HUMAN]] Genetic variations in IL4 may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:[http://omim.org/entry/601367 601367]]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.<ref>PMID:14681304</ref>		[[http://www.uniprot.org/uniprot/IL4_HUMAN IL4_HUMAN]] Genetic variations in IL4 may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:[http://omim.org/entry/601367 601367]]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.<ref>PMID:14681304</ref>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Harrer, H.]]	+	[[Category: Harrer, H]]
-	[[Category: Klein, M.]]	+	[[Category: Klein, M]]
-	[[Category: Kraich, M.]]	+	[[Category: Kraich, M]]
-	[[Category: Mueller, T D.]]	+	[[Category: Mueller, T D]]
-	[[Category: Patino, E.]]	+	[[Category: Patino, E]]
-	[[Category: Sebald, W.]]	+	[[Category: Sebald, W]]
	[[Category: Cytokine]]		[[Category: Cytokine]]
	[[Category: Four helix bundle]]		[[Category: Four helix bundle]]

OCA at 01:34, 30 September 2014

OCA — Tue, 30 Sep 2014 01:34:41 GMT

←Older revision		Revision as of 01:34, 30 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2b8u~~\| ~~PDB~~=2b8u \| ~~SCENE~~= }}	+	==Crystal structure of wildtype human Interleukin-4==
-	===~~Crystal~~ structure of ~~wildtype human Interleukin~~-4===	+	<StructureSection load='2b8u' size='340' side='right' caption='[[2b8u]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_16640778}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2b8u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B8U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B8U FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2d48\|2d48]], [[2b8x\|2b8x]], [[2b8y\|2b8y]], [[2b8z\|2b8z]], [[2b90\|2b90]], [[2b91\|2b91]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b8u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2b8u RCSB], [http://www.ebi.ac.uk/pdbsum/2b8u PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/IL4_HUMAN IL4_HUMAN]] Genetic variations in IL4 may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:[http://omim.org/entry/601367 601367]]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.<ref>PMID:14681304</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/IL4_HUMAN IL4_HUMAN]] Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b8/2b8u_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	BACKGROUND: Interleukin 4 (IL-4) is a key regulator of the immune system and an important factor in the development of allergic hypersensitivity. Together with interleukin 13 (IL-13), IL-4 plays an important role in exacerbating allergic and asthmatic symptoms. For signal transduction, both cytokines can utilise the same receptor, consisting of the IL-4Ralpha and the IL-13Ralpha1 chain, offering an explanation for their overlapping biological functions. Since both cytokine ligands share only moderate similarity on the amino acid sequence level, molecular recognition of the ligands by both receptor subunits is of great interest. IL-4 and IL-13 are interesting targets for allergy and asthma therapies. Knowledge of the binding mechanism will be important for the generation of either IL-4 or IL-13 specific drugs. RESULTS: We present a structure/function analysis of the IL-4 ligand-receptor interaction. Structural determination of a number of IL-4 variants together with in vitro binding studies show that IL-4 and its high-affinity receptor subunit IL-4Ralpha interact via a modular protein-protein interface consisting of three independently-acting interaction clusters. For high-affinity binding of wild-type IL-4 to its receptor IL-4Ralpha, only two of these clusters (i.e. cluster 1 centered around Glu9 and cluster 2 around Arg88) contribute significantly to the free binding energy. Mutating residues Thr13 or Phe82 located in cluster 3 to aspartate results in super-agonistic IL-4 variants. All three clusters are fully engaged in these variants, generating a three-fold higher binding affinity for IL-4Ralpha. Mutagenesis studies reveal that IL-13 utilizes the same main binding determinants, i.e. Glu11 (cluster 1) and Arg64 (cluster 2), suggesting that IL-13 also uses this modular protein interface architecture. CONCLUSION: The modular architecture of the IL-4-IL-4Ralpha interface suggests a possible mechanism by which proteins might be able to generate binding affinity and specificity independently. So far, affinity and specificity are often considered to co-vary, i.e. high specificity requires high affinity and vice versa. Although the binding affinities of IL-4 and IL-13 to IL-4Ralpha differ by a factor of more than 1000, the specificity remains high because the receptor subunit IL-4Ralpha binds exclusively to IL-4 and IL-13. An interface formed by several interaction clusters/binding hot-spots allows for a broad range of affinities by selecting how many of these interaction clusters will contribute to the overall binding free energy. Understanding how proteins generate affinity and specificity is essential as more and more growth factor receptor families show promiscuous binding to their respective ligands. This limited specificity is, however, not accompanied by low binding affinities.

-	~~==Disease==~~	+	A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor.,Kraich M, Klein M, Patino E, Harrer H, Nickel J, Sebald W, Mueller TD BMC Biol. 2006 Apr 26;4:13. PMID:16640778<ref>PMID:16640778</ref>
-	[[http://www.uniprot.org/uniprot/IL4_HUMAN IL4_HUMAN]] Genetic variations in IL4 may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:[http://omim.org/entry/601367 601367]]; also known as cerebrovascular accident or cerebral infarction. A ~~stroke is an acute neurologic event leading to death of neural tissue~~ of the ~~brain and resulting in loss of motor, sensory and/or cognitive function~~. ~~Ischemic strokes~~, ~~resulting from vascular occlusion~~, ~~is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors~~.<ref>PMID:~~14681304~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~/~~/www.uniprot.org/uniprot/IL4_HUMAN IL4_HUMAN]] Participates in at least several B-cell activation processes as well as of other cell types. It is~~ a ~~costimulator~~ of ~~DNA-synthesis. It induces~~ the ~~expression of class II MHC molecules on resting B-cells~~. ~~It enhances both secretion and cell surface expression of IgE and IgG1~~. ~~It also regulates the expression~~ of ~~the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes~~.	+	</div>
-		+
-	~~==About this Structure==~~	+
-	~~[[2b8u]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B8U OCA].~~	+

	==See Also==		==See Also==
	*[[Interleukin\|Interleukin]]		*[[Interleukin\|Interleukin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:016640778</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Harrer, H.]]		[[Category: Harrer, H.]]

OCA at 05:25, 25 March 2013

OCA — Mon, 25 Mar 2013 05:25:19 GMT

←Older revision		Revision as of 05:25, 25 March 2013
Line 1:		Line 1:
-	[[Image:2b8u.png\|left\|200px]]
-
	{{STRUCTURE_2b8u\| PDB=2b8u \| SCENE= }}		{{STRUCTURE_2b8u\| PDB=2b8u \| SCENE= }}
-
	===Crystal structure of wildtype human Interleukin-4===		===Crystal structure of wildtype human Interleukin-4===
		+	{{ABSTRACT_PUBMED_16640778}}

-	~~{{ABSTRACT_PUBMED_16640778}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/IL4_HUMAN IL4_HUMAN]] Genetic variations in IL4 may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:[http://omim.org/entry/601367 601367]]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.<ref>PMID:14681304</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/IL4_HUMAN IL4_HUMAN]] Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.

	==About this Structure==		==About this Structure==
Line 14:		Line 16:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:016640778</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016640778</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Harrer, H.]]		[[Category: Harrer, H.]]

OCA at 17:40, 20 October 2012

OCA — Sat, 20 Oct 2012 17:40:30 GMT

←Older revision		Revision as of 17:40, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2b8u]] is a 1 chain structure ~~of [[Interleukin]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B8U OCA].	+	[[2b8u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B8U OCA].

	==See Also==		==See Also==

OCA: Protected "2b8u" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 01:39:35 GMT

Protected "2b8u" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:39, 27 July 2012

←Older revision		Revision as of 13:06, 24 November 2021
Line 3:		Line 3:
	<StructureSection load='2b8u' size='340' side='right'caption='[[2b8u]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2b8u' size='340' side='right'caption='[[2b8u]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2b8u]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B8U OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2B8U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2b8u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B8U FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2d48\|2d48]], [[2b8x\|2b8x]], [[2b8y\|2b8y]], [[2b8z\|2b8z]], [[2b90\|2b90]], [[2b91\|2b91]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2d48\|2d48]], [[2b8x\|2b8x]], [[2b8y\|2b8y]], [[2b8z\|2b8z]], [[2b90\|2b90]], [[2b91\|2b91]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2b8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b8u OCA], [~~http~~://pdbe.org/2b8u PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2b8u RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2b8u PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2b8u ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b8u OCA], [https://pdbe.org/2b8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b8u RCSB], [https://www.ebi.ac.uk/pdbsum/2b8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b8u ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/IL4_HUMAN IL4_HUMAN]] Genetic variations in IL4 may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:[~~http~~://omim.org/entry/601367 601367]]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.<ref>PMID:14681304</ref>	+	[[https://www.uniprot.org/uniprot/IL4_HUMAN IL4_HUMAN]] Genetic variations in IL4 may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:[https://omim.org/entry/601367 601367]]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.<ref>PMID:14681304</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/IL4_HUMAN IL4_HUMAN]] Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.	+	[[https://www.uniprot.org/uniprot/IL4_HUMAN IL4_HUMAN]] Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]