2bbx - Revision history

OCA at 11:20, 22 May 2024

OCA — Wed, 22 May 2024 11:20:53 GMT

←Older revision		Revision as of 11:20, 22 May 2024
Line 1:		Line 1:

	==NMR solution structure of the TSR domain of malaria TRAP protein==		==NMR solution structure of the TSR domain of malaria TRAP protein==
-	<StructureSection load='2bbx' size='340' side='right'caption='[[2bbx~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2bbx' size='340' side='right'caption='[[2bbx]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2bbx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Plafa Plafa~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BBX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2bbx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BBX FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>TRAP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~5833 PLAFA])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bbx OCA], [https://pdbe.org/2bbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bbx RCSB], [https://www.ebi.ac.uk/pdbsum/2bbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bbx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bbx OCA], [https://pdbe.org/2bbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bbx RCSB], [https://www.ebi.ac.uk/pdbsum/2bbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bbx ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TRAP_PLAFA TRAP_PLAFA]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Plafa~~]]	+	[[Category: Plasmodium falciparum]]
-	[[Category: Kilpelainen, I]]	+	[[Category: Kilpelainen I]]
-	[[Category: Permi, P]]	+	[[Category: Permi P]]
-	[[Category: Tossavainen, H]]	+	[[Category: Tossavainen H]]
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Elongated three-stranded structure~~]]	+

OCA at 11:39, 3 February 2021

OCA — Wed, 03 Feb 2021 11:39:33 GMT

←Older revision		Revision as of 11:39, 3 February 2021
Line 1:		Line 1:

	==NMR solution structure of the TSR domain of malaria TRAP protein==		==NMR solution structure of the TSR domain of malaria TRAP protein==
-	<StructureSection load='2bbx' size='340' side='right' caption='[[2bbx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2bbx' size='340' side='right'caption='[[2bbx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2bbx]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Plafa Plafa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2BBX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2bbx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plafa Plafa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BBX FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRAP ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRAP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2bbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bbx OCA], [~~http~~://pdbe.org/2bbx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2bbx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2bbx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2bbx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bbx OCA], [https://pdbe.org/2bbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bbx RCSB], [https://www.ebi.ac.uk/pdbsum/2bbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bbx ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 30:		Line 30:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Plafa]]		[[Category: Plafa]]
	[[Category: Kilpelainen, I]]		[[Category: Kilpelainen, I]]

OCA at 06:51, 16 May 2018

OCA — Wed, 16 May 2018 06:51:36 GMT

←Older revision		Revision as of 06:51, 16 May 2018
Line 1:		Line 1:
		+
	==NMR solution structure of the TSR domain of malaria TRAP protein==		==NMR solution structure of the TSR domain of malaria TRAP protein==
	<StructureSection load='2bbx' size='340' side='right' caption='[[2bbx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2bbx' size='340' side='right' caption='[[2bbx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2bbx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BBX FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bbx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BBX FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bbx OCA], [http://pdbe.org/2bbx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bbx RCSB], [http://www.ebi.ac.uk/pdbsum/2bbx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bbx OCA], [http://pdbe.org/2bbx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bbx RCSB], [http://www.ebi.ac.uk/pdbsum/2bbx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2bbx ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bb/2bbx_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bb/2bbx_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 13:54, 8 February 2016

OCA — Mon, 08 Feb 2016 13:54:55 GMT

←Older revision		Revision as of 13:54, 8 February 2016
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bbx ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 12:13, 10 September 2015

OCA — Thu, 10 Sep 2015 12:13:28 GMT

←Older revision		Revision as of 12:13, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2bbx' size='340' side='right' caption='[[2bbx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2bbx' size='340' side='right' caption='[[2bbx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2bbx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Plasmodium_falciparum Plasmodium falciparum~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BBX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2bbx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BBX FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 ~~Plasmodium falciparum~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bbx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bbx RCSB], [http://www.ebi.ac.uk/pdbsum/2bbx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bbx OCA], [http://pdbe.org/2bbx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bbx RCSB], [http://www.ebi.ac.uk/pdbsum/2bbx PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2bbx" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Plasmodium falciparum~~]]	+	[[Category: Plafa]]
	[[Category: Kilpelainen, I]]		[[Category: Kilpelainen, I]]
	[[Category: Permi, P]]		[[Category: Permi, P]]

OCA at 09:45, 8 January 2015

OCA — Thu, 08 Jan 2015 09:45:03 GMT

←Older revision		Revision as of 09:45, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bbx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BBX FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bbx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BBX FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 Plasmodium falciparum])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 Plasmodium falciparum])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bbx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bbx RCSB], [http://www.ebi.ac.uk/pdbsum/2bbx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bbx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bbx RCSB], [http://www.ebi.ac.uk/pdbsum/2bbx PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
-	[[Category: Kilpelainen, I.]]	+	[[Category: Kilpelainen, I]]
-	[[Category: Permi, P.]]	+	[[Category: Permi, P]]
-	[[Category: Tossavainen, H.]]	+	[[Category: Tossavainen, H]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: Elongated three-stranded structure]]		[[Category: Elongated three-stranded structure]]

OCA at 02:11, 30 September 2014

OCA — Tue, 30 Sep 2014 02:11:55 GMT

←Older revision		Revision as of 02:11, 30 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2bbx.~~png\|left~~\|200px]]	+	==NMR solution structure of the TSR domain of malaria TRAP protein==
		+	<StructureSection load='2bbx' size='340' side='right' caption='[[2bbx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2bbx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BBX FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 Plasmodium falciparum])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bbx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bbx RCSB], [http://www.ebi.ac.uk/pdbsum/2bbx PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bb/2bbx_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Thrombospondin-related anonymous protein, TRAP, has a critical role in the hepatocyte invasion step of Plasmodium sporozoites, the transmissible form of the parasite causing malaria. The extracellular domains of this sporozoite surface protein interact with hepatocyte surface receptors whereas its intracellular domain acts as a link to the sporozoite actomyosin motor system. Liver heparan sulfate proteoglycans have been identified as potential ligands for TRAP. Proteoglycan binding has been associated with the A- and TSR domains of TRAP. We present the solution NMR structure of the TSR domain of TRAP and a chemical shift mapping study of its heparin binding epitope. The domain has an elongated structure stabilized by an array of tryptophan and arginine residues as well as disulfide bonds. The fold is very similar to those of thrombospondin type-1 (TSP-1) and F-spondin TSRs. The heparin binding site of TRAP-TSR is located in the N-terminal half of the structure, the layered side chains forming an integral part of the site. The smallest heparin fragment capable of binding to TRAP-TSR is a tetrasaccharide.

-	~~{{STRUCTURE_2bbx\| PDB=2bbx \| SCENE= }}~~	+	The layered fold of the TSR domain of P. falciparum TRAP contains a heparin binding site.,Tossavainen H, Pihlajamaa T, Huttunen TK, Raulo E, Rauvala H, Permi P, Kilpelainen I Protein Sci. 2006 Jul;15(7):1760-8. PMID:16815922<ref>PMID:16815922</ref>

-	~~===NMR solution structure~~ of the ~~TSR domain of malaria TRAP protein===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16815922}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2bbx]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Plasmodium_falciparum Plasmodium falciparum]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2BBX OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016815922<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
	[[Category: Kilpelainen, I.]]		[[Category: Kilpelainen, I.]]

OCA: Protected "2bbx" [edit=sysop:move=sysop]

OCA — Sun, 06 Jan 2013 11:25:00 GMT

Protected "2bbx" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:25, 6 January 2013

OCA at 11:24, 6 January 2013

OCA — Sun, 06 Jan 2013 11:24:56 GMT

←Older revision		Revision as of 11:24, 6 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2bbx.png\|left\|200px]]		[[Image:2bbx.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2bbx", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2bbx\| PDB=2bbx \| SCENE= }}		{{STRUCTURE_2bbx\| PDB=2bbx \| SCENE= }}

	===NMR solution structure of the TSR domain of malaria TRAP protein===		===NMR solution structure of the TSR domain of malaria TRAP protein===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16815922}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16815922 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_16815922}}		{{ABSTRACT_PUBMED_16815922}}

	==About this Structure==		==About this Structure==
-	~~2BBX~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBX OCA].	+	[[2bbx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBX OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16815922~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016815922</ref><references group="xtra"/>
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
	[[Category: Kilpelainen, I.]]		[[Category: Kilpelainen, I.]]
	[[Category: Permi, P.]]		[[Category: Permi, P.]]
	[[Category: Tossavainen, H.]]		[[Category: Tossavainen, H.]]
		+	[[Category: Cell adhesion]]
	[[Category: Elongated three-stranded structure]]		[[Category: Elongated three-stranded structure]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 23:10:31 2009''

OCA at 21:10, 16 February 2009

OCA — Mon, 16 Feb 2009 21:10:33 GMT

←Older revision		Revision as of 21:10, 16 February 2009
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	==About this Structure==		==About this Structure==
-	2BBX is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBX OCA].	+	2BBX is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBX OCA].

	==Reference==		==Reference==
-	The layered fold of the TSR domain of P. falciparum TRAP contains a heparin binding site., Tossavainen H, Pihlajamaa T, Huttunen TK, Raulo E, Rauvala H, Permi P, Kilpelainen I, Protein Sci. 2006 Jul;15(7):1760-8. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16815922 16815922]~~	+	<ref group="xtra">PMID:16815922</ref><references group="xtra"/>
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
-	[[Category: Single protein]]
	[[Category: Kilpelainen, I.]]		[[Category: Kilpelainen, I.]]
	[[Category: Permi, P.]]		[[Category: Permi, P.]]
Line 31:		Line 30:
	[[Category: Elongated three-stranded structure]]		[[Category: Elongated three-stranded structure]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon ~~Jul 28 03~~:41:~~03 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 23:10:31 2009''