2bh1 - Revision history

OCA at 13:36, 13 December 2023

OCA — Wed, 13 Dec 2023 13:36:55 GMT

←Older revision		Revision as of 13:36, 13 December 2023
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	<StructureSection load='2bh1' size='340' side='right'caption='[[2bh1]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2bh1' size='340' side='right'caption='[[2bh1]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2bh1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillo_virgola_del_koch"_trevisan_1884 "bacillo virgola del koch" trevisan 1884~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BH1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BH1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2bh1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BH1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BH1 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1w97\|1w97]], [[1p9r\|1p9r]], [[1p9w\|1p9w]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bh1 OCA], [https://pdbe.org/2bh1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bh1 RCSB], [https://www.ebi.ac.uk/pdbsum/2bh1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bh1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bh1 OCA], [https://pdbe.org/2bh1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bh1 RCSB], [https://www.ebi.ac.uk/pdbsum/2bh1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bh1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GSPL_VIBCH GSPL_VIBCH]] Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity). Required for secretion of cholera toxin through the outer membrane. [[https://www.uniprot.org/uniprot/GSPE_VIBCH GSPE_VIBCH]] Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. Required for secretion of cholera toxin through the outer membrane.	+	[https://www.uniprot.org/uniprot/GSPL_VIBCH GSPL_VIBCH] Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity). Required for secretion of cholera toxin through the outer membrane.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillo virgola del koch trevisan 1884]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Abendroth, J]]
-	[[Category: Bagdasarian, M]]
-	[[Category: Hol, W G.J]]
-	[[Category: Murphy, P M]]
-	[[Category: Mushtaq, A]]
-	[[Category: Sandkvist, M]]
-	[[Category: Atp-binding]]
-	[[Category: Ep]]
-	[[Category: Gsp]]
-	[[Category: Transmembrane]]
-	[[Category: Transport]]
-	[[Category: Transport protein]]
-	[[Category: Type ii secretion]]
	[[Category: Vibrio cholerae]]		[[Category: Vibrio cholerae]]
		+	[[Category: Abendroth J]]
		+	[[Category: Bagdasarian M]]
		+	[[Category: Hol WGJ]]
		+	[[Category: Murphy PM]]
		+	[[Category: Mushtaq A]]
		+	[[Category: Sandkvist M]]

OCA at 13:09, 24 November 2021

OCA — Wed, 24 Nov 2021 13:09:42 GMT

←Older revision		Revision as of 13:09, 24 November 2021
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	<StructureSection load='2bh1' size='340' side='right'caption='[[2bh1]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2bh1' size='340' side='right'caption='[[2bh1]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2bh1]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillo_virgola_del_koch"_trevisan_1884 "bacillo virgola del koch" trevisan 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BH1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2BH1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2bh1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillo_virgola_del_koch"_trevisan_1884 "bacillo virgola del koch" trevisan 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BH1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BH1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w97\|1w97]], [[1p9r\|1p9r]], [[1p9w\|1p9w]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1w97\|1w97]], [[1p9r\|1p9r]], [[1p9w\|1p9w]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2bh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bh1 OCA], [~~http~~://pdbe.org/2bh1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2bh1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2bh1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2bh1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bh1 OCA], [https://pdbe.org/2bh1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bh1 RCSB], [https://www.ebi.ac.uk/pdbsum/2bh1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bh1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GSPL_VIBCH GSPL_VIBCH]] Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity). Required for secretion of cholera toxin through the outer membrane. [[~~http~~://www.uniprot.org/uniprot/GSPE_VIBCH GSPE_VIBCH]] Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. Required for secretion of cholera toxin through the outer membrane.	+	[[https://www.uniprot.org/uniprot/GSPL_VIBCH GSPL_VIBCH]] Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity). Required for secretion of cholera toxin through the outer membrane. [[https://www.uniprot.org/uniprot/GSPE_VIBCH GSPE_VIBCH]] Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. Required for secretion of cholera toxin through the outer membrane.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 2bh1" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2bh1" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[General secretion pathway protein 3D structures\|General secretion pathway protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:09, 19 February 2020

OCA — Wed, 19 Feb 2020 08:09:38 GMT

←Older revision		Revision as of 08:09, 19 February 2020
Line 1:		Line 1:

	==X-ray structure of the general secretion pathway complex of the N- terminal domain of EpsE and the cytosolic domain of EpsL of Vibrio cholerae==		==X-ray structure of the general secretion pathway complex of the N- terminal domain of EpsE and the cytosolic domain of EpsL of Vibrio cholerae==
-	<StructureSection load='2bh1' size='340' side='right' caption='[[2bh1]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='2bh1' size='340' side='right'caption='[[2bh1]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bh1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillo_virgola_del_koch"_trevisan_1884 "bacillo virgola del koch" trevisan 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BH1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BH1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bh1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillo_virgola_del_koch"_trevisan_1884 "bacillo virgola del koch" trevisan 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BH1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BH1 FirstGlance]. <br>
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Bacillo virgola del koch trevisan 1884]]		[[Category: Bacillo virgola del koch trevisan 1884]]
		+	[[Category: Large Structures]]
	[[Category: Abendroth, J]]		[[Category: Abendroth, J]]
	[[Category: Bagdasarian, M]]		[[Category: Bagdasarian, M]]

OCA at 06:36, 16 May 2018

OCA — Wed, 16 May 2018 06:36:29 GMT

←Older revision		Revision as of 06:36, 16 May 2018
Line 1:		Line 1:
-	==X-~~RAY STRUCTURE OF THE GENERAL SECRETION PATHWAY COMPLEX OF THE~~ N-~~TERMINAL DOMAIN OF EPSE AND THE CYTOSOLIC DOMAIN OF EPSL OF VIBRIO CHOLERAE~~==	+
		+	==X-ray structure of the general secretion pathway complex of the N- terminal domain of EpsE and the cytosolic domain of EpsL of Vibrio cholerae==
	<StructureSection load='2bh1' size='340' side='right' caption='[[2bh1]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2bh1' size='340' side='right' caption='[[2bh1]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w97\|1w97]], [[1p9r\|1p9r]], [[1p9w\|1p9w]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w97\|1w97]], [[1p9r\|1p9r]], [[1p9w\|1p9w]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bh1 OCA], [http://pdbe.org/2bh1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bh1 RCSB], [http://www.ebi.ac.uk/pdbsum/2bh1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bh1 OCA], [http://pdbe.org/2bh1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bh1 RCSB], [http://www.ebi.ac.uk/pdbsum/2bh1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2bh1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bh/2bh1_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bh/2bh1_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 11:14, 7 February 2016

OCA — Sun, 07 Feb 2016 11:14:32 GMT

←Older revision		Revision as of 11:14, 7 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bh1 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 00:57, 10 September 2015

OCA — Thu, 10 Sep 2015 00:57:30 GMT

←Older revision		Revision as of 00:57, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2bh1' size='340' side='right' caption='[[2bh1]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2bh1' size='340' side='right' caption='[[2bh1]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2bh1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Vibrio_cholerae Vibrio cholerae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BH1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BH1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2bh1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillo_virgola_del_koch"_trevisan_1884 "bacillo virgola del koch" trevisan 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BH1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BH1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w97\|1w97]], [[1p9r\|1p9r]], [[1p9w\|1p9w]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w97\|1w97]], [[1p9r\|1p9r]], [[1p9w\|1p9w]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bh1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bh1 RCSB], [http://www.ebi.ac.uk/pdbsum/2bh1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bh1 OCA], [http://pdbe.org/2bh1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bh1 RCSB], [http://www.ebi.ac.uk/pdbsum/2bh1 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2bh1" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Vibrio cholerae~~]]	+	[[Category: Bacillo virgola del koch trevisan 1884]]
	[[Category: Abendroth, J]]		[[Category: Abendroth, J]]
	[[Category: Bagdasarian, M]]		[[Category: Bagdasarian, M]]
Line 45:		Line 46:
	[[Category: Transport protein]]		[[Category: Transport protein]]
	[[Category: Type ii secretion]]		[[Category: Type ii secretion]]
		+	[[Category: Vibrio cholerae]]

OCA at 14:39, 24 December 2014

OCA — Wed, 24 Dec 2014 14:39:52 GMT

←Older revision		Revision as of 14:39, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bh1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BH1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BH1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bh1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BH1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BH1 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w97\|1w97]], [[1p9r\|1p9r]], [[1p9w\|1p9w]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w97\|1w97]], [[1p9r\|1p9r]], [[1p9w\|1p9w]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bh1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bh1 RCSB], [http://www.ebi.ac.uk/pdbsum/2bh1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bh1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bh1 RCSB], [http://www.ebi.ac.uk/pdbsum/2bh1 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GSPL_VIBCH GSPL_VIBCH]] Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity). Required for secretion of cholera toxin through the outer membrane. [[http://www.uniprot.org/uniprot/GSPE_VIBCH GSPE_VIBCH]] Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. Required for secretion of cholera toxin through the outer membrane.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Vibrio cholerae]]		[[Category: Vibrio cholerae]]
-	[[Category: Abendroth, J.]]	+	[[Category: Abendroth, J]]
-	[[Category: Bagdasarian, M.]]	+	[[Category: Bagdasarian, M]]
-	[[Category: Hol, W G.J.]]	+	[[Category: Hol, W G.J]]
-	[[Category: Murphy, P M.]]	+	[[Category: Murphy, P M]]
-	[[Category: Mushtaq, A.]]	+	[[Category: Mushtaq, A]]
-	[[Category: Sandkvist, M.]]	+	[[Category: Sandkvist, M]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Ep]]		[[Category: Ep]]
Line 43:		Line 45:
	[[Category: Transport protein]]		[[Category: Transport protein]]
	[[Category: Type ii secretion]]		[[Category: Type ii secretion]]
-	[[Category: Vibrio cholerae]]

OCA at 10:24, 3 October 2014

OCA — Fri, 03 Oct 2014 10:24:27 GMT

←Older revision		Revision as of 10:24, 3 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2bh1\| PDB=2bh1 \| SCENE= }}~~	+	==X-RAY STRUCTURE OF THE GENERAL SECRETION PATHWAY COMPLEX OF THE N-TERMINAL DOMAIN OF EPSE AND THE CYTOSOLIC DOMAIN OF EPSL OF VIBRIO CHOLERAE==
-	===X-RAY STRUCTURE OF THE GENERAL SECRETION PATHWAY COMPLEX OF THE N-TERMINAL DOMAIN OF EPSE AND THE CYTOSOLIC DOMAIN OF EPSL OF VIBRIO CHOLERAE===	+	<StructureSection load='2bh1' size='340' side='right' caption='[[2bh1]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	~~{{ABSTRACT_PUBMED_15843017}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2bh1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BH1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BH1 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w97\|1w97]], [[1p9r\|1p9r]], [[1p9w\|1p9w]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bh1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bh1 RCSB], [http://www.ebi.ac.uk/pdbsum/2bh1 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bh/2bh1_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Gram-negative bacteria use type II secretion systems for the transport of virulence factors and hydrolytic enzymes through the outer membrane. These sophisticated multi-protein complexes reach from the pore in the outer membrane via the pseudopilins in the periplasm and a multi-protein inner-membrane sub-complex, to an ATPase in the cytoplasm. The human pathogen Vibrio cholerae uses such a secretion machinery, called the Eps-system, for the export of its major virulence factor cholera toxin into the intestinal tract of the human host. Here, we describe the 2.4 A structure of the hetero-tetrameric complex of the N-terminal domain of the ATPase EpsE and the cytoplasmic domain of the inner membrane protein EpsL, which constitute the major cytoplasmic components of the Eps-system. A stable fragment of EpsE in complex with the cytoplasmic domain of EpsL was identified via limited proteolysis and facilitated the crystallization of the complex. This first structure of a complex between two different proteins of the type II secretion system reveals that the N-terminal domain of EpsE and the cytoplasmic domain of EpsL form a hetero-tetramer, in which EpsL is the central dimer and EpsE binds on the periphery. The dimer of EpsL in this complex is very similar to the dimer seen in the crystal structure of the native cytoplasmic domain of EpsL, suggesting a possible physiological relevance despite a relatively small 675 A2 buried solvent accessible surface. The N-terminal domain of EpsE, which forms a compact domain with an alpha+beta-fold, places its helix alpha2 in a mostly hydrophobic cleft between domains II and III of EpsL burying 1700 A2 solvent accessible surface. This extensive interface involves several residues whose hydrophobic or charged nature is well conserved and is therefore likely to be of general importance in type II secretion systems.

-	~~==Function==~~	+	The X-ray structure of the type II secretion system complex formed by the N-terminal domain of EpsE and the cytoplasmic domain of EpsL of Vibrio cholerae.,Abendroth J, Murphy P, Sandkvist M, Bagdasarian M, Hol WG J Mol Biol. 2005 May 13;348(4):845-55. PMID:15843017<ref>PMID:15843017</ref>
-	~~[[http://www.uniprot.org/uniprot/GSPL_VIBCH GSPL_VIBCH]] Involved in a~~ type II secretion system ~~(T2SS, formerly general secretion pathway, GSP) for~~ the ~~export~~ of ~~proteins (By similarity). Required for secretion~~ of ~~cholera toxin through the outer membrane~~. ~~[[http://www~~.~~uniprot.org/uniprot/GSPE_VIBCH GSPE_VIBCH]] Involved in a type II secretion system~~ (~~T2SS, formerly general secretion pathway, GSP~~) ~~for the export of proteins. Required for secretion of cholera toxin through the outer membrane~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[2bh1]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Vibrio_cholerae Vibrio cholerae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2BH1 OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:015843017</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Vibrio cholerae]]		[[Category: Vibrio cholerae]]
	[[Category: Abendroth, J.]]		[[Category: Abendroth, J.]]

OCA at 08:16, 23 April 2014

OCA — Wed, 23 Apr 2014 08:16:34 GMT

←Older revision		Revision as of 08:16, 23 April 2014
Line 1:		Line 1:
-	[[Image:2bh1.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_2bh1", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2bh1\| PDB=2bh1 \| SCENE= }}		{{STRUCTURE_2bh1\| PDB=2bh1 \| SCENE= }}
-
	===X-RAY STRUCTURE OF THE GENERAL SECRETION PATHWAY COMPLEX OF THE N-TERMINAL DOMAIN OF EPSE AND THE CYTOSOLIC DOMAIN OF EPSL OF VIBRIO CHOLERAE===		===X-RAY STRUCTURE OF THE GENERAL SECRETION PATHWAY COMPLEX OF THE N-TERMINAL DOMAIN OF EPSE AND THE CYTOSOLIC DOMAIN OF EPSL OF VIBRIO CHOLERAE===
		+	{{ABSTRACT_PUBMED_15843017}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/GSPL_VIBCH GSPL_VIBCH]] Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity). Required for secretion of cholera toxin through the outer membrane. [[http://www.uniprot.org/uniprot/GSPE_VIBCH GSPE_VIBCH]] Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. Required for secretion of cholera toxin through the outer membrane.
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_15843017}}~~, ~~adds the Publication Abstract to~~ the ~~page~~	+
-	(~~as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov)~~, ~~where 15843017 is~~ the ~~PubMed ID number~~.	+
-	~~-->~~	+
-	~~{{ABSTRACT_PUBMED_15843017}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:015843017</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015843017</ref><references group="xtra"/><references/>
	[[Category: Vibrio cholerae]]		[[Category: Vibrio cholerae]]
	[[Category: Abendroth, J.]]		[[Category: Abendroth, J.]]

OCA: Protected "2bh1" [edit=sysop:move=sysop]

OCA — Wed, 24 Aug 2011 06:03:30 GMT

Protected "2bh1" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:03, 24 August 2011