2bie - Revision history

OCA at 11:22, 22 May 2024

OCA — Wed, 22 May 2024 11:22:00 GMT

←Older revision		Revision as of 11:22, 22 May 2024
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	<StructureSection load='2bie' size='340' side='right'caption='[[2bie]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='2bie' size='340' side='right'caption='[[2bie]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2bie]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_27647 Atcc 27647~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BIE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BIE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2bie]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Alkalihalobacillus_alcalophilus Alkalihalobacillus alcalophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BIE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BIE FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.3Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1w23\|1w23]], [[2bhx\|2bhx]], [[2bi1\|2bi1]], [[2bi2\|2bi2]], [[2bi3\|2bi3]], [[2bi5\|2bi5]], [[2bi9\|2bi9]], [[2bia\|2bia]], [[2big\|2big]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phosphoserine_transaminase Phosphoserine transaminase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.52 2.6.1.52] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bie OCA], [https://pdbe.org/2bie PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bie RCSB], [https://www.ebi.ac.uk/pdbsum/2bie PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bie ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bie OCA], [https://pdbe.org/2bie PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bie RCSB], [https://www.ebi.ac.uk/pdbsum/2bie PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bie ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~SERC_BACAO SERC_BACAO]~~] Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.<ref>PMID:14646107</ref>	+	[https://www.uniprot.org/uniprot/SERC_ALKAL SERC_ALKAL] Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.<ref>PMID:14646107</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc 27647~~]]	+	[[Category: Alkalihalobacillus alcalophilus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Phosphoserine transaminase]]~~	+	[[Category: Dubnovitsky AP]]
-	[[Category: Dubnovitsky~~, A P~~]]	+	[[Category: Papageorgiou AC]]
-	[[Category: Papageorgiou~~, A C~~]]	+	[[Category: Popov AN]]
-	[[Category: Popov~~, A N~~]]	+	[[Category: Ravelli RBG]]
-	[[Category: Ravelli~~, R B.G]]~~	+
-	~~[[Category: Aminotransferase]]~~	+
-	~~[[Category: Pyridoxal-5'-phosphate]]~~	+
-	~~[[Category: Radiation damage]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 09:44, 5 May 2021

OCA — Wed, 05 May 2021 09:44:16 GMT

←Older revision		Revision as of 09:44, 5 May 2021
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	<StructureSection load='2bie' size='340' side='right'caption='[[2bie]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='2bie' size='340' side='right'caption='[[2bie]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2bie]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_27647 Atcc 27647]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BIE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2BIE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2bie]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_27647 Atcc 27647]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BIE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BIE FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w23\|1w23]], [[2bhx\|2bhx]], [[2bi1\|2bi1]], [[2bi2\|2bi2]], [[2bi3\|2bi3]], [[2bi5\|2bi5]], [[2bi9\|2bi9]], [[2bia\|2bia]], [[2big\|2big]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1w23\|1w23]], [[2bhx\|2bhx]], [[2bi1\|2bi1]], [[2bi2\|2bi2]], [[2bi3\|2bi3]], [[2bi5\|2bi5]], [[2bi9\|2bi9]], [[2bia\|2bia]], [[2big\|2big]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Phosphoserine_transaminase Phosphoserine transaminase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.52 2.6.1.52] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phosphoserine_transaminase Phosphoserine transaminase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.52 2.6.1.52] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2bie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bie OCA], [~~http~~://pdbe.org/2bie PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2bie RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2bie PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2bie ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bie OCA], [https://pdbe.org/2bie PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bie RCSB], [https://www.ebi.ac.uk/pdbsum/2bie PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bie ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SERC_BACAO SERC_BACAO]] Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.<ref>PMID:14646107</ref>	+	[[https://www.uniprot.org/uniprot/SERC_BACAO SERC_BACAO]] Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.<ref>PMID:14646107</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:10, 23 May 2019

OCA — Thu, 23 May 2019 07:10:29 GMT

←Older revision		Revision as of 07:10, 23 May 2019
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	==Radiation damage of the Schiff base in phosphoserine aminotransferase (structure H)==		==Radiation damage of the Schiff base in phosphoserine aminotransferase (structure H)==
-	<StructureSection load='2bie' size='340' side='right' caption='[[2bie]], [[Resolution\|resolution]] 1.30Å' scene=''>	+	<StructureSection load='2bie' size='340' side='right'caption='[[2bie]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bie]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_27647 Atcc 27647]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BIE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BIE FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bie]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_27647 Atcc 27647]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BIE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BIE FirstGlance]. <br>
Line 38:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 27647]]		[[Category: Atcc 27647]]
		+	[[Category: Large Structures]]
	[[Category: Phosphoserine transaminase]]		[[Category: Phosphoserine transaminase]]
	[[Category: Dubnovitsky, A P]]		[[Category: Dubnovitsky, A P]]

OCA at 06:49, 16 May 2018

OCA — Wed, 16 May 2018 06:49:14 GMT

←Older revision		Revision as of 06:49, 16 May 2018
Line 1:		Line 1:
-	==~~RADIATION DAMAGE OF THE SCHIFF BASE IN PHOSPHOSERINE AMINOTRANSFERASE~~ (~~STRUCTURE~~ H)==	+
		+	==Radiation damage of the Schiff base in phosphoserine aminotransferase (structure H)==
	<StructureSection load='2bie' size='340' side='right' caption='[[2bie]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='2bie' size='340' side='right' caption='[[2bie]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w23\|1w23]], [[2bhx\|2bhx]], [[2bi1\|2bi1]], [[2bi2\|2bi2]], [[2bi3\|2bi3]], [[2bi5\|2bi5]], [[2bi9\|2bi9]], [[2bia\|2bia]], [[2big\|2big]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w23\|1w23]], [[2bhx\|2bhx]], [[2bi1\|2bi1]], [[2bi2\|2bi2]], [[2bi3\|2bi3]], [[2bi5\|2bi5]], [[2bi9\|2bi9]], [[2bia\|2bia]], [[2big\|2big]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoserine_transaminase Phosphoserine transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.52 2.6.1.52] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoserine_transaminase Phosphoserine transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.52 2.6.1.52] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bie OCA], [http://pdbe.org/2bie PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bie RCSB], [http://www.ebi.ac.uk/pdbsum/2bie PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bie OCA], [http://pdbe.org/2bie PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bie RCSB], [http://www.ebi.ac.uk/pdbsum/2bie PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2bie ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SERC_BACAO SERC_BACAO]] Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.<ref>PMID:14646107</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bi/2bie_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bi/2bie_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 22:27, 8 February 2016

OCA — Mon, 08 Feb 2016 22:27:57 GMT

←Older revision		Revision as of 22:27, 8 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bie ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:57, 10 September 2015

OCA — Thu, 10 Sep 2015 15:57:33 GMT

←Older revision		Revision as of 15:57, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2bie' size='340' side='right' caption='[[2bie]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='2bie' size='340' side='right' caption='[[2bie]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2bie]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacillus_alcalophilus Bacillus alcalophilus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BIE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BIE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2bie]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_27647 Atcc 27647]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BIE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BIE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w23\|1w23]], [[2bhx\|2bhx]], [[2bi1\|2bi1]], [[2bi2\|2bi2]], [[2bi3\|2bi3]], [[2bi5\|2bi5]], [[2bi9\|2bi9]], [[2bia\|2bia]], [[2big\|2big]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w23\|1w23]], [[2bhx\|2bhx]], [[2bi1\|2bi1]], [[2bi2\|2bi2]], [[2bi3\|2bi3]], [[2bi5\|2bi5]], [[2bi9\|2bi9]], [[2bia\|2bia]], [[2big\|2big]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoserine_transaminase Phosphoserine transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.52 2.6.1.52] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoserine_transaminase Phosphoserine transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.52 2.6.1.52] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bie OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bie RCSB], [http://www.ebi.ac.uk/pdbsum/2bie PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bie OCA], [http://pdbe.org/2bie PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bie RCSB], [http://www.ebi.ac.uk/pdbsum/2bie PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2bie" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus alcalophilus~~]]	+	[[Category: Atcc 27647]]
	[[Category: Phosphoserine transaminase]]		[[Category: Phosphoserine transaminase]]
	[[Category: Dubnovitsky, A P]]		[[Category: Dubnovitsky, A P]]

OCA at 10:37, 8 January 2015

OCA — Thu, 08 Jan 2015 10:37:35 GMT

←Older revision		Revision as of 10:37, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bie]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_alcalophilus Bacillus alcalophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BIE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BIE FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bie]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_alcalophilus Bacillus alcalophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BIE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BIE FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w23\|1w23]], [[2bhx\|2bhx]], [[2bi1\|2bi1]], [[2bi2\|2bi2]], [[2bi3\|2bi3]], [[2bi5\|2bi5]], [[2bi9\|2bi9]], [[2bia\|2bia]], [[2big\|2big]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w23\|1w23]], [[2bhx\|2bhx]], [[2bi1\|2bi1]], [[2bi2\|2bi2]], [[2bi3\|2bi3]], [[2bi5\|2bi5]], [[2bi9\|2bi9]], [[2bia\|2bia]], [[2big\|2big]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoserine_transaminase Phosphoserine transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.52 2.6.1.52] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoserine_transaminase Phosphoserine transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.52 2.6.1.52] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bie OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bie RCSB], [http://www.ebi.ac.uk/pdbsum/2bie PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bie OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bie RCSB], [http://www.ebi.ac.uk/pdbsum/2bie PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: Bacillus alcalophilus]]		[[Category: Bacillus alcalophilus]]
	[[Category: Phosphoserine transaminase]]		[[Category: Phosphoserine transaminase]]
-	[[Category: Dubnovitsky, A P.]]	+	[[Category: Dubnovitsky, A P]]
-	[[Category: Papageorgiou, A C.]]	+	[[Category: Papageorgiou, A C]]
-	[[Category: Popov, A N.]]	+	[[Category: Popov, A N]]
-	[[Category: Ravelli, R B.G.]]	+	[[Category: Ravelli, R B.G]]
	[[Category: Aminotransferase]]		[[Category: Aminotransferase]]
	[[Category: Pyridoxal-5'-phosphate]]		[[Category: Pyridoxal-5'-phosphate]]
	[[Category: Radiation damage]]		[[Category: Radiation damage]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 10:24, 29 September 2014

OCA — Mon, 29 Sep 2014 10:24:07 GMT

←Older revision		Revision as of 10:24, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2bie.~~png~~\|~~left~~\|200px]]	+	==RADIATION DAMAGE OF THE SCHIFF BASE IN PHOSPHOSERINE AMINOTRANSFERASE (STRUCTURE H)==
		+	<StructureSection load='2bie' size='340' side='right' caption='[[2bie]], [[Resolution\|resolution]] 1.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2bie]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_alcalophilus Bacillus alcalophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BIE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BIE FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w23\|1w23]], [[2bhx\|2bhx]], [[2bi1\|2bi1]], [[2bi2\|2bi2]], [[2bi3\|2bi3]], [[2bi5\|2bi5]], [[2bi9\|2bi9]], [[2bia\|2bia]], [[2big\|2big]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoserine_transaminase Phosphoserine transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.52 2.6.1.52] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bie OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bie RCSB], [http://www.ebi.ac.uk/pdbsum/2bie PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bi/2bie_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The X-ray susceptibility of the lysine-pyridoxal-5'-phosphate Schiff base in Bacillus alcalophilus phosphoserine aminotransferase has been investigated using crystallographic data collected at 100 K to 1.3 A resolution, complemented by on-line spectroscopic studies. X-rays induce deprotonation of the internal aldimine, changes in the Schiff base conformation, displacement of the cofactor molecule, and disruption of the Schiff base linkage between pyridoxal-5'-phosphate and the Lys residue. Analysis of the "undamaged" structure reveals a significant chemical strain on the internal aldimine bond that leads to a pronounced geometrical distortion of the cofactor. However, upon crystal exposure to the X-rays, the strain and distortion are relaxed and eventually diminished when the total absorbed dose has exceeded 4.7 x 10(6) Ggamma. Our data provide new insights into the enzymatic activation of pyridoxal-5'-phosphate and suggest that special care should be taken while using macromolecular crystallography to study details in strained active sites.

-	~~{{STRUCTURE_2bie\| PDB=2bie \| SCENE= }}~~	+	Strain relief at the active site of phosphoserine aminotransferase induced by radiation damage.,Dubnovitsky AP, Ravelli RB, Popov AN, Papageorgiou AC Protein Sci. 2005 Jun;14(6):1498-507. Epub 2005 May 9. PMID:15883191<ref>PMID:15883191</ref>

-	~~===RADIATION DAMAGE OF THE SCHIFF BASE IN PHOSPHOSERINE AMINOTRANSFERASE (STRUCTURE H)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15883191}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2bie]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bacillus_alcalophilus Bacillus alcalophilus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2BIE OCA].~~	+

	==See Also==		==See Also==
	*[[Phosphoserine aminotransferase\|Phosphoserine aminotransferase]]		*[[Phosphoserine aminotransferase\|Phosphoserine aminotransferase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:015883191<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Bacillus alcalophilus]]		[[Category: Bacillus alcalophilus]]
	[[Category: Phosphoserine transaminase]]		[[Category: Phosphoserine transaminase]]

OCA at 11:40, 20 October 2012

OCA — Sat, 20 Oct 2012 11:40:51 GMT

←Older revision		Revision as of 11:40, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2bie]] is a 2 chain structure ~~of [[Phosphoserine aminotransferase]]~~ with sequence from [http://en.wikipedia.org/wiki/Bacillus_alcalophilus Bacillus alcalophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BIE OCA].	+	[[2bie]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_alcalophilus Bacillus alcalophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BIE OCA].

	==See Also==		==See Also==

OCA: Protected "2bie" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 06:14:34 GMT

Protected "2bie" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:14, 26 July 2012