2bol - Revision history

OCA at 09:18, 9 May 2024

OCA — Thu, 09 May 2024 09:18:12 GMT

←Older revision		Revision as of 09:18, 9 May 2024
Line 3:		Line 3:
	<StructureSection load='2bol' size='340' side='right'caption='[[2bol]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2bol' size='340' side='right'caption='[[2bol]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2bol]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Beef_tapeworm Beef tapeworm~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BOL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2bol]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Taenia_saginata Taenia saginata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BOL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bol FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bol OCA], [https://pdbe.org/2bol PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bol RCSB], [https://www.ebi.ac.uk/pdbsum/2bol PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bol ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bol FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bol OCA], [https://pdbe.org/2bol PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bol RCSB], [https://www.ebi.ac.uk/pdbsum/2bol PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bol ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TSP36_TAESA TSP36_TAESA]] Has chaperone activity towards unfolded proteins (in vitro).<ref>PMID:15326597</ref>	+	[https://www.uniprot.org/uniprot/TSP36_TAESA TSP36_TAESA] Has chaperone activity towards unfolded proteins (in vitro).<ref>PMID:15326597</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Beef tapeworm]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Boelens, W C]]
-	[[Category: Kappe, G]]
-	[[Category: Slingsby, C]]
-	[[Category: Stamler, R J]]
-	[[Category: A-crystallin]]
-	[[Category: Heat shock protein]]
-	[[Category: Molecular chaperone]]
-	[[Category: Small heat shock protein]]
	[[Category: Taenia saginata]]		[[Category: Taenia saginata]]
		+	[[Category: Boelens WC]]
		+	[[Category: Kappe G]]
		+	[[Category: Slingsby C]]
		+	[[Category: Stamler RJ]]

OCA at 10:31, 17 February 2021

OCA — Wed, 17 Feb 2021 10:31:52 GMT

←Older revision		Revision as of 10:31, 17 February 2021
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	<StructureSection load='2bol' size='340' side='right'caption='[[2bol]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2bol' size='340' side='right'caption='[[2bol]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2bol]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Beef_tapeworm Beef tapeworm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2BOL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2bol]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Beef_tapeworm Beef tapeworm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BOL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2bol FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bol OCA], [~~http~~://pdbe.org/2bol PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2bol RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2bol PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2bol ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bol FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bol OCA], [https://pdbe.org/2bol PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bol RCSB], [https://www.ebi.ac.uk/pdbsum/2bol PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bol ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TSP36_TAESA TSP36_TAESA]] Has chaperone activity towards unfolded proteins (in vitro).<ref>PMID:15326597</ref>	+	[[https://www.uniprot.org/uniprot/TSP36_TAESA TSP36_TAESA]] Has chaperone activity towards unfolded proteins (in vitro).<ref>PMID:15326597</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Heat Shock ~~Proteins~~\|Heat Shock ~~Proteins~~]]	+	*[[Heat Shock Protein structures\|Heat Shock Protein structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:51, 10 May 2019

OCA — Fri, 10 May 2019 11:51:53 GMT

←Older revision		Revision as of 11:51, 10 May 2019
Line 1:		Line 1:

	==CRYSTAL STRUCTURE AND ASSEMBLY OF TSP36, A METAZOAN SMALL HEAT SHOCK PROTEIN==		==CRYSTAL STRUCTURE AND ASSEMBLY OF TSP36, A METAZOAN SMALL HEAT SHOCK PROTEIN==
-	<StructureSection load='2bol' size='340' side='right' caption='[[2bol]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='2bol' size='340' side='right'caption='[[2bol]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bol]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Beef_tapeworm Beef tapeworm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BOL FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bol]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Beef_tapeworm Beef tapeworm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BOL FirstGlance]. <br>
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Beef tapeworm]]		[[Category: Beef tapeworm]]
		+	[[Category: Large Structures]]
	[[Category: Boelens, W C]]		[[Category: Boelens, W C]]
	[[Category: Kappe, G]]		[[Category: Kappe, G]]

OCA at 06:13, 16 May 2018

OCA — Wed, 16 May 2018 06:13:48 GMT

←Older revision		Revision as of 06:13, 16 May 2018
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE AND ASSEMBLY OF TSP36, A METAZOAN SMALL HEAT SHOCK PROTEIN==		==CRYSTAL STRUCTURE AND ASSEMBLY OF TSP36, A METAZOAN SMALL HEAT SHOCK PROTEIN==
	<StructureSection load='2bol' size='340' side='right' caption='[[2bol]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2bol' size='340' side='right' caption='[[2bol]], [[Resolution\|resolution]] 2.50Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2bol]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Beef_tapeworm Beef tapeworm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BOL FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bol]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Beef_tapeworm Beef tapeworm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BOL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bol FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bol OCA], [http://pdbe.org/2bol PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bol RCSB], [http://www.ebi.ac.uk/pdbsum/2bol PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bol FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bol OCA], [http://pdbe.org/2bol PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bol RCSB], [http://www.ebi.ac.uk/pdbsum/2bol PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2bol ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bo/2bol_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bo/2bol_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 10:13, 7 February 2016

OCA — Sun, 07 Feb 2016 10:13:24 GMT

←Older revision		Revision as of 10:13, 7 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bol ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 00:31, 10 September 2015

OCA — Thu, 10 Sep 2015 00:31:03 GMT

←Older revision		Revision as of 00:31, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2bol' size='340' side='right' caption='[[2bol]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2bol' size='340' side='right' caption='[[2bol]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2bol]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Taenia_saginata Taenia saginata~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BOL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2bol]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Beef_tapeworm Beef tapeworm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BOL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bol FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bol OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bol RCSB], [http://www.ebi.ac.uk/pdbsum/2bol PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bol FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bol OCA], [http://pdbe.org/2bol PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bol RCSB], [http://www.ebi.ac.uk/pdbsum/2bol PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TSP36_TAESA TSP36_TAESA]] Has chaperone activity towards unfolded proteins (in vitro).<ref>PMID:15326597</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 24:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2bol" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 31:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Taenia saginata~~]]	+	[[Category: Beef tapeworm]]
	[[Category: Boelens, W C]]		[[Category: Boelens, W C]]
	[[Category: Kappe, G]]		[[Category: Kappe, G]]
Line 40:		Line 43:
	[[Category: Molecular chaperone]]		[[Category: Molecular chaperone]]
	[[Category: Small heat shock protein]]		[[Category: Small heat shock protein]]
		+	[[Category: Taenia saginata]]

OCA at 08:55, 8 January 2015

OCA — Thu, 08 Jan 2015 08:55:31 GMT

←Older revision		Revision as of 08:55, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bol]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Taenia_saginata Taenia saginata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BOL FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bol]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Taenia_saginata Taenia saginata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BOL FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bol FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bol OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bol RCSB], [http://www.ebi.ac.uk/pdbsum/2bol PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bol FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bol OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bol RCSB], [http://www.ebi.ac.uk/pdbsum/2bol PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Taenia saginata]]		[[Category: Taenia saginata]]
-	[[Category: Boelens, W C.]]	+	[[Category: Boelens, W C]]
-	[[Category: Kappe, G.]]	+	[[Category: Kappe, G]]
-	[[Category: Slingsby, C.]]	+	[[Category: Slingsby, C]]
-	[[Category: Stamler, R J.]]	+	[[Category: Stamler, R J]]
	[[Category: A-crystallin]]		[[Category: A-crystallin]]
	[[Category: Heat shock protein]]		[[Category: Heat shock protein]]
	[[Category: Molecular chaperone]]		[[Category: Molecular chaperone]]
	[[Category: Small heat shock protein]]		[[Category: Small heat shock protein]]
-	[[Category: Taenia saginata]]

OCA at 04:27, 29 September 2014

OCA — Mon, 29 Sep 2014 04:27:13 GMT

←Older revision		Revision as of 04:27, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2bol.~~png\|left~~\|200px]]	+	==CRYSTAL STRUCTURE AND ASSEMBLY OF TSP36, A METAZOAN SMALL HEAT SHOCK PROTEIN==
		+	<StructureSection load='2bol' size='340' side='right' caption='[[2bol]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2bol]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Taenia_saginata Taenia saginata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BOL FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bol FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bol OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bol RCSB], [http://www.ebi.ac.uk/pdbsum/2bol PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bo/2bol_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Small heat shock proteins (sHsps) are oligomers that perform a protective function by binding denatured proteins. Although ubiquitous, they are of variable sequence except for a C-terminal approximately 90-residue "alpha-crystallin domain". Unlike larger stress response chaperones, sHsps are ATP-independent and generally form polydisperse assemblies. One proposed mechanism of action involves these assemblies breaking into smaller subunits in response to stress, before binding unfolding substrate and reforming into larger complexes. Two previously solved non-metazoan sHsp multimers are built from dimers formed by domain swapping between the alpha-crystallin domains, adding to evidence that the smaller subunits are dimers. Here, the 2.5A resolution structure of an sHsp from the parasitic flatworm Taenia saginata Tsp36, the first metazoan crystal structure, shows a new mode of dimerization involving N-terminal regions, which differs from that seen for non-metazoan sHsps. Sequence differences in the alpha-crystallin domains between metazoans and non-metazoans are critical to the different mechanism of dimerization, suggesting that some structural features seen for Tsp36 may be generalized to other metazoan sHsps. The structure also indicates scope for flexible assembly of subunits, supporting the proposed process of oligomer breakdown, substrate binding and reassembly as the chaperone mechanism. It further shows how sHsps can bind coil and secondary structural elements by wrapping them around the alpha-crystallin domain. The structure also illustrates possible roles for conserved residues associated with disease, and suggests a mechanism for the sHsp-related pathogenicity of some flatworm infections. Tsp36, like other flatworm sHsps, possesses two divergent sHsp repeats per monomer. Together with the two previously solved structures, a total of four alpha-crystallin domain structures are now available, giving a better definition of domain boundaries for sHsps.

-	~~{{STRUCTURE_2bol\| PDB=2bol \| SCENE= }}~~	+	Wrapping the alpha-crystallin domain fold in a chaperone assembly.,Stamler R, Kappe G, Boelens W, Slingsby C J Mol Biol. 2005 Oct 14;353(1):68-79. PMID:16165157<ref>PMID:16165157</ref>

-	~~===CRYSTAL STRUCTURE AND ASSEMBLY OF TSP36~~, ~~A METAZOAN SMALL HEAT SHOCK PROTEIN===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16165157}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2bol]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Taenia_saginata Taenia saginata]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2BOL OCA].~~	+

	==See Also==		==See Also==
	*[[Heat Shock Proteins\|Heat Shock Proteins]]		*[[Heat Shock Proteins\|Heat Shock Proteins]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:016165157<~~/~~ref~~><~~ref group="xtra">PMID:016488888</ref><ref group="xtra">PMID:019140694</ref><references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Taenia saginata]]		[[Category: Taenia saginata]]
	[[Category: Boelens, W C.]]		[[Category: Boelens, W C.]]

OCA at 06:20, 20 October 2012

OCA — Sat, 20 Oct 2012 06:20:38 GMT

←Older revision		Revision as of 06:20, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[2bol]] is a 2 chain structure ~~of [[Heat Shock Proteins]]~~ with sequence from [http://en.wikipedia.org/wiki/Taenia_saginata Taenia saginata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOL OCA].	+	[[2bol]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Taenia_saginata Taenia saginata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOL OCA].

	==See Also==		==See Also==

OCA at 12:52, 25 July 2012

OCA — Wed, 25 Jul 2012 12:52:29 GMT

←Older revision		Revision as of 12:52, 25 July 2012
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	[[Image:2bol.png\|left\|200px]]		[[Image:2bol.png\|left\|200px]]

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	{{STRUCTURE_2bol\| PDB=2bol \| SCENE= }}		{{STRUCTURE_2bol\| PDB=2bol \| SCENE= }}

	===CRYSTAL STRUCTURE AND ASSEMBLY OF TSP36, A METAZOAN SMALL HEAT SHOCK PROTEIN===		===CRYSTAL STRUCTURE AND ASSEMBLY OF TSP36, A METAZOAN SMALL HEAT SHOCK PROTEIN===

-
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	==See Also==		==See Also==
-	*[[Heat Shock Proteins]]	+	*[[Heat Shock Proteins\|Heat Shock Proteins]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16165157~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016165157</ref><ref group="xtra">PMID:016488888</ref><ref group="xtra">PMID:019140694</ref><references group="xtra"/>
	[[Category: Taenia saginata]]		[[Category: Taenia saginata]]
	[[Category: Boelens, W C.]]		[[Category: Boelens, W C.]]