2bou - Revision history

OCA at 11:22, 22 May 2024

OCA — Wed, 22 May 2024 11:22:54 GMT

←Older revision		Revision as of 11:22, 22 May 2024
Line 3:		Line 3:
	<StructureSection load='2bou' size='340' side='right'caption='[[2bou]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2bou' size='340' side='right'caption='[[2bou]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2bou]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2BOU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2bou]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BOU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bo2\|2bo2]], [[2box\|2box]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2bou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bou OCA], [~~http~~://pdbe.org/2bou PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2bou RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2bou PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2bou ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bou OCA], [https://pdbe.org/2bou PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bou RCSB], [https://www.ebi.ac.uk/pdbsum/2bou PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bou ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/AGRE2_HUMAN AGRE2_HUMAN] Vibratory urticaria. The disease is caused by variants affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~EMR2_HUMAN EMR2_HUMAN]~~] Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF.<ref>PMID:12829604</ref> <ref>PMID:17928360</ref> <ref>PMID:22310662</ref>	+	[https://www.uniprot.org/uniprot/AGRE2_HUMAN AGRE2_HUMAN] Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Is a regulator of mast cell degranulation (PubMed:26841242).<ref>PMID:12829604</ref> <ref>PMID:17928360</ref> <ref>PMID:22310662</ref> <ref>PMID:22575658</ref> <ref>PMID:26841242</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Abbott~~, R J.M~~]]	+	[[Category: Abbott RJM]]
-	[[Category: Handford~~, P A~~]]	+	[[Category: Handford PA]]
-	[[Category: Knott, V]]	+	[[Category: Knott V]]
-	[[Category: Lea~~, S M~~]]	+	[[Category: Lea SM]]
-	[[Category: McDonnell~~, J M~~]]	+	[[Category: McDonnell JM]]
-	[[Category: Roversi, P]]	+	[[Category: Roversi P]]
-	[[Category: Spendlove, I]]	+	[[Category: Spendlove I]]
-	[[Category: Teriete, P]]	+	[[Category: Teriete P]]
-	~~[[Category: Calcium-binding]]~~	+
-	~~[[Category: Cd55]]~~	+
-	~~[[Category: Cd97]]~~	+
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Egf]]~~	+
-	~~[[Category: Egf-like domain]]~~	+
-	~~[[Category: G-protein coupled receptor]]~~	+
-	~~[[Category: Immune system~~]]	+

OCA at 10:40, 16 September 2020

OCA — Wed, 16 Sep 2020 10:40:27 GMT

←Older revision		Revision as of 10:40, 16 September 2020
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	==EGF Domains 1,2,5 of human EMR2, a 7-TM immune system molecule, in complex with barium.==		==EGF Domains 1,2,5 of human EMR2, a 7-TM immune system molecule, in complex with barium.==
-	<StructureSection load='2bou' size='340' side='right' caption='[[2bou]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='2bou' size='340' side='right'caption='[[2bou]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2bou]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOU OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2BOU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2bou]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2BOU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bo2\|2bo2]], [[2box\|2box]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bo2\|2bo2]], [[2box\|2box]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2bou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bou OCA], [http://pdbe.org/2bou PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bou RCSB], [http://www.ebi.ac.uk/pdbsum/2bou PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2bou ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2bou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bou OCA], [http://pdbe.org/2bou PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bou RCSB], [http://www.ebi.ac.uk/pdbsum/2bou PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2bou ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Abbott, R J.M]]		[[Category: Abbott, R J.M]]
	[[Category: Handford, P A]]		[[Category: Handford, P A]]

OCA at 08:12, 12 December 2018

OCA — Wed, 12 Dec 2018 08:12:06 GMT

←Older revision		Revision as of 08:12, 12 December 2018
Line 3:		Line 3:
	<StructureSection load='2bou' size='340' side='right' caption='[[2bou]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2bou' size='340' side='right' caption='[[2bou]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2bou]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BOU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2bou]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BOU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bo2\|2bo2]], [[2box\|2box]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bo2\|2bo2]], [[2box\|2box]]</td></tr>
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bo/2bou_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bo/2bou_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Abbott, R J.M]]		[[Category: Abbott, R J.M]]
	[[Category: Handford, P A]]		[[Category: Handford, P A]]

OCA at 16:35, 25 January 2017

OCA — Wed, 25 Jan 2017 16:35:46 GMT

←Older revision		Revision as of 16:35, 25 January 2017
Line 1:		Line 1:
-	==EGF ~~DOMAINS~~ 1,2,5 ~~OF HUMAN~~ EMR2, A 7-TM ~~IMMUNE SYSTEM MOLECULE~~, ~~IN COMPLEX WITH BARIUM~~.==	+
		+	==EGF Domains 1,2,5 of human EMR2, a 7-TM immune system molecule, in complex with barium.==
	<StructureSection load='2bou' size='340' side='right' caption='[[2bou]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2bou' size='340' side='right' caption='[[2bou]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2bou]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Human Human]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BOU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2bou]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BOU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bo2\|2bo2]], [[2box\|2box]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bo2\|2bo2]], [[2box\|2box]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bou OCA], [http://pdbe.org/2bou PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bou RCSB], [http://www.ebi.ac.uk/pdbsum/2bou PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bou OCA], [http://pdbe.org/2bou PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bou RCSB], [http://www.ebi.ac.uk/pdbsum/2bou PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2bou ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Human]]
	[[Category: Abbott, R J.M]]		[[Category: Abbott, R J.M]]
	[[Category: Handford, P A]]		[[Category: Handford, P A]]
	[[Category: Knott, V]]		[[Category: Knott, V]]
	[[Category: Lea, S M]]		[[Category: Lea, S M]]
-	[[Category: ~~Mcdonnell~~, J M]]	+	[[Category: McDonnell, J M]]
	[[Category: Roversi, P]]		[[Category: Roversi, P]]
	[[Category: Spendlove, I]]		[[Category: Spendlove, I]]

OCA at 04:57, 9 February 2016

OCA — Tue, 09 Feb 2016 04:57:45 GMT

←Older revision		Revision as of 04:57, 9 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bou ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 18:50, 10 September 2015

OCA — Thu, 10 Sep 2015 18:50:55 GMT

←Older revision		Revision as of 18:50, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2bou' size='340' side='right' caption='[[2bou]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2bou' size='340' side='right' caption='[[2bou]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2bou]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BOU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2bou]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BOU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bo2\|2bo2]], [[2box\|2box]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bo2\|2bo2]], [[2box\|2box]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bou OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bou RCSB], [http://www.ebi.ac.uk/pdbsum/2bou PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bou OCA], [http://pdbe.org/2bou PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bou RCSB], [http://www.ebi.ac.uk/pdbsum/2bou PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2bou" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Abbott, R J.M]]		[[Category: Abbott, R J.M]]
	[[Category: Handford, P A]]		[[Category: Handford, P A]]

OCA at 04:35, 25 December 2014

OCA — Thu, 25 Dec 2014 04:35:29 GMT

←Older revision		Revision as of 04:35, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bou]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BOU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bou]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BOU FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bo2\|2bo2]], [[2box\|2box]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bo2\|2bo2]], [[2box\|2box]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bou OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bou RCSB], [http://www.ebi.ac.uk/pdbsum/2bou PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bou OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bou RCSB], [http://www.ebi.ac.uk/pdbsum/2bou PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/EMR2_HUMAN EMR2_HUMAN]] Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF.<ref>PMID:12829604</ref> <ref>PMID:17928360</ref> <ref>PMID:22310662</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Abbott, R J.M.]]	+	[[Category: Abbott, R J.M]]
-	[[Category: Handford, P A.]]	+	[[Category: Handford, P A]]
-	[[Category: Knott, V.]]	+	[[Category: Knott, V]]
-	[[Category: Lea, S M.]]	+	[[Category: Lea, S M]]
-	[[Category: Mcdonnell, J M.]]	+	[[Category: Mcdonnell, J M]]
-	[[Category: Roversi, P.]]	+	[[Category: Roversi, P]]
-	[[Category: Spendlove, I.]]	+	[[Category: Spendlove, I]]
-	[[Category: Teriete, P~~.]]~~	+	[[Category: Teriete, P]]
-	~~[[Category: 7tm~~]]	+
	[[Category: Calcium-binding]]		[[Category: Calcium-binding]]
	[[Category: Cd55]]		[[Category: Cd55]]

OCA at 04:22, 3 October 2014

OCA — Fri, 03 Oct 2014 04:22:37 GMT

←Older revision		Revision as of 04:22, 3 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2bou\| PDB=2bou \| SCENE= }}~~	+	==EGF DOMAINS 1,2,5 OF HUMAN EMR2, A 7-TM IMMUNE SYSTEM MOLECULE, IN COMPLEX WITH BARIUM.==
-	===EGF DOMAINS 1,2,5 OF HUMAN EMR2, A 7-TM IMMUNE SYSTEM MOLECULE, IN COMPLEX WITH BARIUM.===	+	<StructureSection load='2bou' size='340' side='right' caption='[[2bou]], [[Resolution\|resolution]] 1.90Å' scene=''>
-	~~{{ABSTRACT_PUBMED_17449467}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2bou]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BOU FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bo2\|2bo2]], [[2box\|2box]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bou OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bou RCSB], [http://www.ebi.ac.uk/pdbsum/2bou PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bo/2bou_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	CD97, the archetypal member of the EGF-TM7 protein family, is constitutively expressed on granulocytes and monocytes and rapidly up-regulated on T and B cells following activation. The key isoform of CD97 expressed on leukocytes binds the complement regulatory protein CD55 (also termed decay-accelerating factor). CD97 has been shown recently to mediate co-stimulation of T cells via CD55. Here, we demonstrate that blocking the interaction between CD55 on monocytes and CD97 on T cells leads to inhibition of proliferation and interferon-gamma secretion. This implies that bidirectional interactions between CD97 and CD55 are involved in T cell regulation. Structural studies presented here reveal the molecular basis for this activity. We have solved the structure of EMR2, a very close homolog of CD97, using x-ray crystallography. NMR-based chemical shift mapping of the EMR2-CD55 interaction has allowed us to generate a model for the CD97-CD55 complex. The structure of the complex reveals that the T cell and complement regulatory activities of CD55 occur on opposite faces of the molecule. This suggests that CD55 might simultaneously regulate both the innate and adaptive immune responses, and we have shown that CD55 can still regulate complement when bound to CD97.

-	~~==Function==~~	+	Structural and functional characterization of a novel T cell receptor co-regulatory protein complex, CD97-CD55.,Abbott RJ, Spendlove I, Roversi P, Fitzgibbon H, Knott V, Teriete P, McDonnell JM, Handford PA, Lea SM J Biol Chem. 2007 Jul 27;282(30):22023-32. Epub 2007 Apr 20. PMID:17449467<ref>PMID:17449467</ref>
-	~~[[http://www.uniprot.org/uniprot/EMR2_HUMAN EMR2_HUMAN]] Cell surface receptor that binds to the chondroitin sulfate moiety~~ of ~~glycosaminoglycan chains and promotes~~ cell ~~attachment. Promotes granulocyte chemotaxis~~, ~~degranulation and adhesion~~. ~~In macrophages~~, ~~promotes the release of inflammatory cytokines~~, ~~including IL8 and TNF~~.~~<ref>PMID~~:~~12829604</ref> <ref>~~PMID:~~17928360</ref>~~ <ref>PMID:~~22310662~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[2bou]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2BOU OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:017449467</ref><ref group="xtra">PMID:015103144</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Abbott, R J.M.]]		[[Category: Abbott, R J.M.]]

OCA at 02:26, 4 April 2013

OCA — Thu, 04 Apr 2013 02:26:09 GMT

←Older revision		Revision as of 02:26, 4 April 2013
Line 1:		Line 1:
-	[[Image:2bou.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_2bou", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2bou\| PDB=2bou \| SCENE= }}		{{STRUCTURE_2bou\| PDB=2bou \| SCENE= }}
-
	===EGF DOMAINS 1,2,5 OF HUMAN EMR2, A 7-TM IMMUNE SYSTEM MOLECULE, IN COMPLEX WITH BARIUM.===		===EGF DOMAINS 1,2,5 OF HUMAN EMR2, A 7-TM IMMUNE SYSTEM MOLECULE, IN COMPLEX WITH BARIUM.===
		+	{{ABSTRACT_PUBMED_17449467}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/EMR2_HUMAN EMR2_HUMAN]] Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF.<ref>PMID:12829604</ref> <ref>PMID:17928360</ref> <ref>PMID:22310662</ref>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_17449467}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov)~~, ~~where 17449467 is~~ the ~~PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_17449467}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:017449467</ref><ref group="xtra">PMID:015103144</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017449467</ref><ref group="xtra">PMID:015103144</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Abbott, R J.M.]]		[[Category: Abbott, R J.M.]]
Line 32:		Line 20:
	[[Category: Spendlove, I.]]		[[Category: Spendlove, I.]]
	[[Category: Teriete, P.]]		[[Category: Teriete, P.]]
		+	[[Category: 7tm]]
		+	[[Category: Calcium-binding]]
		+	[[Category: Cd55]]
		+	[[Category: Cd97]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Egf]]
		+	[[Category: Egf-like domain]]
		+	[[Category: G-protein coupled receptor]]
		+	[[Category: Immune system]]

OCA: Protected "2bou" [edit=sysop:move=sysop]

OCA — Wed, 25 May 2011 05:39:09 GMT

Protected "2bou" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:39, 25 May 2011