2bq6 - Revision history

OCA at 13:52, 13 December 2023

OCA — Wed, 13 Dec 2023 13:52:29 GMT

←Older revision		Revision as of 13:52, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2bq6' size='340' side='right'caption='[[2bq6]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='2bq6' size='340' side='right'caption='[[2bq6]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2bq6]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BQ6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2BQ6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2bq6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BQ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BQ6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IIB:1-{[5-(5-CHLORO-2-THIENYL)ISOXAZOL-3-YL]METHYL}-3-CYANO-N-(1-ISOPROPYLPIPERIDIN-4-YL)-7-METHYL-1H-INDOLE-2-CARBOXAMIDE'>IIB</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c5m\|1c5m]], [[1ezq\|1ezq]], [[1f0r\|1f0r]], [[1f0s\|1f0s]], [[1fax\|1fax]], [[1fjs\|1fjs]], [[1fxy\|1fxy]], [[1g2l\|1g2l]], [[1g2m\|1g2m]], [[1hcg\|1hcg]], [[1ioe\|1ioe]], [[1iqe\|1iqe]], [[1iqf\|1iqf]], [[1iqg\|1iqg]], [[1iqh\|1iqh]], [[1iqi\|1iqi]], [[1iqj\|1iqj]], [[1iqk\|1iqk]], [[1iql\|1iql]], [[1iqm\|1iqm]], [[1iqn\|1iqn]], [[1ksn\|1ksn]], [[1kye\|1kye]], [[1lpg\|1lpg]], [[1lpk\|1lpk]], [[1lpz\|1lpz]], [[1lqd\|1lqd]], [[1mq5\|1mq5]], [[1mq6\|1mq6]], [[1msx\|1msx]], [[1nfu\|1nfu]], [[1nfw\|1nfw]], [[1nfx\|1nfx]], [[1nfy\|1nfy]], [[1nl8\|1nl8]], [[1p0s\|1p0s]], [[1v3x\|1v3x]], [[1xka\|1xka]], [[1xkb\|1xkb]], [[2bmg\|2bmg]], [[2boh\|2boh]], [[2bok\|2bok]], [[2bq7\|2bq7]], [[2bqw\|2bqw]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IIB:1-{[5-(5-CHLORO-2-THIENYL)ISOXAZOL-3-YL]METHYL}-3-CYANO-N-(1-ISOPROPYLPIPERIDIN-4-YL)-7-METHYL-1H-INDOLE-2-CARBOXAMIDE'>IIB</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bq6 OCA], [https://pdbe.org/2bq6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bq6 RCSB], [https://www.ebi.ac.uk/pdbsum/2bq6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bq6 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2bq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bq6 OCA], [~~http~~://pdbe.org/2bq6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2bq6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2bq6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2bq6 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[~~http~~://omim.org/entry/227600 227600]]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref>	+	[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[https://omim.org/entry/227600 227600]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.	+	[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 39:		Line 38:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Coagulation factor Xa]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bauer, A]]	+	[[Category: Bauer A]]
-	[[Category: Czech, J]]	+	[[Category: Czech J]]
-	[[Category: Essrich, M]]	+	[[Category: Essrich M]]
-	[[Category: Laux, V]]	+	[[Category: Laux V]]
-	[[Category: Matter, H]]	+	[[Category: Matter H]]
-	[[Category: Nazare, M]]	+	[[Category: Nazare M]]
-	[[Category: Ritter, K]]	+	[[Category: Ritter K]]
-	[[Category: Schreuder, H]]	+	[[Category: Schreuder H]]
-	[[Category: Urmann, M]]	+	[[Category: Urmann M]]
-	[[Category: Wagner, M]]	+	[[Category: Wagner M]]
-	[[Category: Wehner, V]]	+	[[Category: Wehner V]]
-	[[Category: Will~~, D W]]~~	+	[[Category: Will DW]]
-	~~[[Category: Blood coagulation]]~~	+
-	~~[[Category: Blood coagulation factor]]~~	+
-	~~[[Category: Calcium-binding]]~~	+
-	~~[[Category: Egf-like domain]]~~	+
-	~~[[Category: Gamma-carboxyglutamic acid]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Hydroxylation]]~~	+
-	~~[[Category: Plasma]]~~	+
-	~~[[Category: Polymorphism]]~~	+
-	~~[[Category: Protein inhibitor complex]]~~	+
-	~~[[Category: Serine protease]]~~	+
-	~~[[Category: Serine proteinase]]~~	+
-	~~[[Category: Vitamin k]]~~	+
-	~~[[Category: Zymogen~~]]	+

OCA at 07:52, 4 November 2020

OCA — Wed, 04 Nov 2020 07:52:28 GMT

←Older revision		Revision as of 07:52, 4 November 2020
Line 1:		Line 1:

	==Crystal structure of factor Xa in complex with 21==		==Crystal structure of factor Xa in complex with 21==
-	<StructureSection load='2bq6' size='340' side='right' caption='[[2bq6]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='2bq6' size='340' side='right'caption='[[2bq6]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2bq6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BQ6 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2BQ6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2bq6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BQ6 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2BQ6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IIB:1-{[5-(5-CHLORO-2-THIENYL)ISOXAZOL-3-YL]METHYL}-3-CYANO-N-(1-ISOPROPYLPIPERIDIN-4-YL)-7-METHYL-1H-INDOLE-2-CARBOXAMIDE'>IIB</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IIB:1-{[5-(5-CHLORO-2-THIENYL)ISOXAZOL-3-YL]METHYL}-3-CYANO-N-(1-ISOPROPYLPIPERIDIN-4-YL)-7-METHYL-1H-INDOLE-2-CARBOXAMIDE'>IIB</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c5m\|1c5m]], [[1ezq\|1ezq]], [[1f0r\|1f0r]], [[1f0s\|1f0s]], [[1fax\|1fax]], [[1fjs\|1fjs]], [[1fxy\|1fxy]], [[1g2l\|1g2l]], [[1g2m\|1g2m]], [[1hcg\|1hcg]], [[1ioe\|1ioe]], [[1iqe\|1iqe]], [[1iqf\|1iqf]], [[1iqg\|1iqg]], [[1iqh\|1iqh]], [[1iqi\|1iqi]], [[1iqj\|1iqj]], [[1iqk\|1iqk]], [[1iql\|1iql]], [[1iqm\|1iqm]], [[1iqn\|1iqn]], [[1ksn\|1ksn]], [[1kye\|1kye]], [[1lpg\|1lpg]], [[1lpk\|1lpk]], [[1lpz\|1lpz]], [[1lqd\|1lqd]], [[1mq5\|1mq5]], [[1mq6\|1mq6]], [[1msx\|1msx]], [[1nfu\|1nfu]], [[1nfw\|1nfw]], [[1nfx\|1nfx]], [[1nfy\|1nfy]], [[1nl8\|1nl8]], [[1p0s\|1p0s]], [[1v3x\|1v3x]], [[1xka\|1xka]], [[1xkb\|1xkb]], [[2bmg\|2bmg]], [[2boh\|2boh]], [[2bok\|2bok]], [[2bq7\|2bq7]], [[2bqw\|2bqw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c5m\|1c5m]], [[1ezq\|1ezq]], [[1f0r\|1f0r]], [[1f0s\|1f0s]], [[1fax\|1fax]], [[1fjs\|1fjs]], [[1fxy\|1fxy]], [[1g2l\|1g2l]], [[1g2m\|1g2m]], [[1hcg\|1hcg]], [[1ioe\|1ioe]], [[1iqe\|1iqe]], [[1iqf\|1iqf]], [[1iqg\|1iqg]], [[1iqh\|1iqh]], [[1iqi\|1iqi]], [[1iqj\|1iqj]], [[1iqk\|1iqk]], [[1iql\|1iql]], [[1iqm\|1iqm]], [[1iqn\|1iqn]], [[1ksn\|1ksn]], [[1kye\|1kye]], [[1lpg\|1lpg]], [[1lpk\|1lpk]], [[1lpz\|1lpz]], [[1lqd\|1lqd]], [[1mq5\|1mq5]], [[1mq6\|1mq6]], [[1msx\|1msx]], [[1nfu\|1nfu]], [[1nfw\|1nfw]], [[1nfx\|1nfx]], [[1nfy\|1nfy]], [[1nl8\|1nl8]], [[1p0s\|1p0s]], [[1v3x\|1v3x]], [[1xka\|1xka]], [[1xkb\|1xkb]], [[2bmg\|2bmg]], [[2boh\|2boh]], [[2bok\|2bok]], [[2bq7\|2bq7]], [[2bqw\|2bqw]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2bq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bq6 OCA], [http://pdbe.org/2bq6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bq6 RCSB], [http://www.ebi.ac.uk/pdbsum/2bq6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2bq6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2bq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bq6 OCA], [http://pdbe.org/2bq6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bq6 RCSB], [http://www.ebi.ac.uk/pdbsum/2bq6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2bq6 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	[[Category: Coagulation factor Xa]]		[[Category: Coagulation factor Xa]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
	[[Category: Bauer, A]]		[[Category: Bauer, A]]
	[[Category: Czech, J]]		[[Category: Czech, J]]

OCA at 06:16, 16 May 2018

OCA — Wed, 16 May 2018 06:16:23 GMT

←Older revision		Revision as of 06:16, 16 May 2018
Line 1:		Line 1:
-	==~~CRYSTAL STRUCTURE OF FACTOR XA IN COMPLEX WITH~~ 21==	+
		+	==Crystal structure of factor Xa in complex with 21==
	<StructureSection load='2bq6' size='340' side='right' caption='[[2bq6]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='2bq6' size='340' side='right' caption='[[2bq6]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c5m\|1c5m]], [[1ezq\|1ezq]], [[1f0r\|1f0r]], [[1f0s\|1f0s]], [[1fax\|1fax]], [[1fjs\|1fjs]], [[1fxy\|1fxy]], [[1g2l\|1g2l]], [[1g2m\|1g2m]], [[1hcg\|1hcg]], [[1ioe\|1ioe]], [[1iqe\|1iqe]], [[1iqf\|1iqf]], [[1iqg\|1iqg]], [[1iqh\|1iqh]], [[1iqi\|1iqi]], [[1iqj\|1iqj]], [[1iqk\|1iqk]], [[1iql\|1iql]], [[1iqm\|1iqm]], [[1iqn\|1iqn]], [[1ksn\|1ksn]], [[1kye\|1kye]], [[1lpg\|1lpg]], [[1lpk\|1lpk]], [[1lpz\|1lpz]], [[1lqd\|1lqd]], [[1mq5\|1mq5]], [[1mq6\|1mq6]], [[1msx\|1msx]], [[1nfu\|1nfu]], [[1nfw\|1nfw]], [[1nfx\|1nfx]], [[1nfy\|1nfy]], [[1nl8\|1nl8]], [[1p0s\|1p0s]], [[1v3x\|1v3x]], [[1xka\|1xka]], [[1xkb\|1xkb]], [[2bmg\|2bmg]], [[2boh\|2boh]], [[2bok\|2bok]], [[2bq7\|2bq7]], [[2bqw\|2bqw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c5m\|1c5m]], [[1ezq\|1ezq]], [[1f0r\|1f0r]], [[1f0s\|1f0s]], [[1fax\|1fax]], [[1fjs\|1fjs]], [[1fxy\|1fxy]], [[1g2l\|1g2l]], [[1g2m\|1g2m]], [[1hcg\|1hcg]], [[1ioe\|1ioe]], [[1iqe\|1iqe]], [[1iqf\|1iqf]], [[1iqg\|1iqg]], [[1iqh\|1iqh]], [[1iqi\|1iqi]], [[1iqj\|1iqj]], [[1iqk\|1iqk]], [[1iql\|1iql]], [[1iqm\|1iqm]], [[1iqn\|1iqn]], [[1ksn\|1ksn]], [[1kye\|1kye]], [[1lpg\|1lpg]], [[1lpk\|1lpk]], [[1lpz\|1lpz]], [[1lqd\|1lqd]], [[1mq5\|1mq5]], [[1mq6\|1mq6]], [[1msx\|1msx]], [[1nfu\|1nfu]], [[1nfw\|1nfw]], [[1nfx\|1nfx]], [[1nfy\|1nfy]], [[1nl8\|1nl8]], [[1p0s\|1p0s]], [[1v3x\|1v3x]], [[1xka\|1xka]], [[1xkb\|1xkb]], [[2bmg\|2bmg]], [[2boh\|2boh]], [[2bok\|2bok]], [[2bq7\|2bq7]], [[2bqw\|2bqw]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bq6 OCA], [http://pdbe.org/2bq6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bq6 RCSB], [http://www.ebi.ac.uk/pdbsum/2bq6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bq6 OCA], [http://pdbe.org/2bq6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bq6 RCSB], [http://www.ebi.ac.uk/pdbsum/2bq6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2bq6 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 16:		Line 17:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bq/2bq6_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bq/2bq6_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 61:		Line 62:
	[[Category: Hydroxylation]]		[[Category: Hydroxylation]]
	[[Category: Plasma]]		[[Category: Plasma]]
		+	[[Category: Polymorphism]]
	[[Category: Protein inhibitor complex]]		[[Category: Protein inhibitor complex]]
	[[Category: Serine protease]]		[[Category: Serine protease]]

OCA at 21:45, 9 February 2016

OCA — Tue, 09 Feb 2016 21:45:53 GMT

←Older revision		Revision as of 21:45, 9 February 2016
Line 20:		Line 20:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bq6 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 02:20, 11 September 2015

OCA — Fri, 11 Sep 2015 02:20:08 GMT

←Older revision		Revision as of 02:20, 11 September 2015
Line 6:		Line 6:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c5m\|1c5m]], [[1ezq\|1ezq]], [[1f0r\|1f0r]], [[1f0s\|1f0s]], [[1fax\|1fax]], [[1fjs\|1fjs]], [[1fxy\|1fxy]], [[1g2l\|1g2l]], [[1g2m\|1g2m]], [[1hcg\|1hcg]], [[1ioe\|1ioe]], [[1iqe\|1iqe]], [[1iqf\|1iqf]], [[1iqg\|1iqg]], [[1iqh\|1iqh]], [[1iqi\|1iqi]], [[1iqj\|1iqj]], [[1iqk\|1iqk]], [[1iql\|1iql]], [[1iqm\|1iqm]], [[1iqn\|1iqn]], [[1ksn\|1ksn]], [[1kye\|1kye]], [[1lpg\|1lpg]], [[1lpk\|1lpk]], [[1lpz\|1lpz]], [[1lqd\|1lqd]], [[1mq5\|1mq5]], [[1mq6\|1mq6]], [[1msx\|1msx]], [[1nfu\|1nfu]], [[1nfw\|1nfw]], [[1nfx\|1nfx]], [[1nfy\|1nfy]], [[1nl8\|1nl8]], [[1p0s\|1p0s]], [[1v3x\|1v3x]], [[1xka\|1xka]], [[1xkb\|1xkb]], [[2bmg\|2bmg]], [[2boh\|2boh]], [[2bok\|2bok]], [[2bq7\|2bq7]], [[2bqw\|2bqw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c5m\|1c5m]], [[1ezq\|1ezq]], [[1f0r\|1f0r]], [[1f0s\|1f0s]], [[1fax\|1fax]], [[1fjs\|1fjs]], [[1fxy\|1fxy]], [[1g2l\|1g2l]], [[1g2m\|1g2m]], [[1hcg\|1hcg]], [[1ioe\|1ioe]], [[1iqe\|1iqe]], [[1iqf\|1iqf]], [[1iqg\|1iqg]], [[1iqh\|1iqh]], [[1iqi\|1iqi]], [[1iqj\|1iqj]], [[1iqk\|1iqk]], [[1iql\|1iql]], [[1iqm\|1iqm]], [[1iqn\|1iqn]], [[1ksn\|1ksn]], [[1kye\|1kye]], [[1lpg\|1lpg]], [[1lpk\|1lpk]], [[1lpz\|1lpz]], [[1lqd\|1lqd]], [[1mq5\|1mq5]], [[1mq6\|1mq6]], [[1msx\|1msx]], [[1nfu\|1nfu]], [[1nfw\|1nfw]], [[1nfx\|1nfx]], [[1nfy\|1nfy]], [[1nl8\|1nl8]], [[1p0s\|1p0s]], [[1v3x\|1v3x]], [[1xka\|1xka]], [[1xkb\|1xkb]], [[2bmg\|2bmg]], [[2boh\|2boh]], [[2bok\|2bok]], [[2bq7\|2bq7]], [[2bqw\|2bqw]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bq6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bq6 RCSB], [http://www.ebi.ac.uk/pdbsum/2bq6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bq6 OCA], [http://pdbe.org/2bq6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bq6 RCSB], [http://www.ebi.ac.uk/pdbsum/2bq6 PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 30:		Line 30:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2bq6" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 10:01, 8 January 2015

OCA — Thu, 08 Jan 2015 10:01:36 GMT

←Older revision		Revision as of 10:01, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bq6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BQ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BQ6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bq6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BQ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BQ6 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IIB:1-{[5-(5-CHLORO-2-THIENYL)ISOXAZOL-3-YL]METHYL}-3-CYANO-N-(1-ISOPROPYLPIPERIDIN-4-YL)-7-METHYL-1H-INDOLE-2-CARBOXAMIDE'>IIB</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IIB:1-{[5-(5-CHLORO-2-THIENYL)ISOXAZOL-3-YL]METHYL}-3-CYANO-N-(1-ISOPROPYLPIPERIDIN-4-YL)-7-METHYL-1H-INDOLE-2-CARBOXAMIDE'>IIB</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c5m\|1c5m]], [[1ezq\|1ezq]], [[1f0r\|1f0r]], [[1f0s\|1f0s]], [[1fax\|1fax]], [[1fjs\|1fjs]], [[1fxy\|1fxy]], [[1g2l\|1g2l]], [[1g2m\|1g2m]], [[1hcg\|1hcg]], [[1ioe\|1ioe]], [[1iqe\|1iqe]], [[1iqf\|1iqf]], [[1iqg\|1iqg]], [[1iqh\|1iqh]], [[1iqi\|1iqi]], [[1iqj\|1iqj]], [[1iqk\|1iqk]], [[1iql\|1iql]], [[1iqm\|1iqm]], [[1iqn\|1iqn]], [[1ksn\|1ksn]], [[1kye\|1kye]], [[1lpg\|1lpg]], [[1lpk\|1lpk]], [[1lpz\|1lpz]], [[1lqd\|1lqd]], [[1mq5\|1mq5]], [[1mq6\|1mq6]], [[1msx\|1msx]], [[1nfu\|1nfu]], [[1nfw\|1nfw]], [[1nfx\|1nfx]], [[1nfy\|1nfy]], [[1nl8\|1nl8]], [[1p0s\|1p0s]], [[1v3x\|1v3x]], [[1xka\|1xka]], [[1xkb\|1xkb]], [[2bmg\|2bmg]], [[2boh\|2boh]], [[2bok\|2bok]], [[2bq7\|2bq7]], [[2bqw\|2bqw]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c5m\|1c5m]], [[1ezq\|1ezq]], [[1f0r\|1f0r]], [[1f0s\|1f0s]], [[1fax\|1fax]], [[1fjs\|1fjs]], [[1fxy\|1fxy]], [[1g2l\|1g2l]], [[1g2m\|1g2m]], [[1hcg\|1hcg]], [[1ioe\|1ioe]], [[1iqe\|1iqe]], [[1iqf\|1iqf]], [[1iqg\|1iqg]], [[1iqh\|1iqh]], [[1iqi\|1iqi]], [[1iqj\|1iqj]], [[1iqk\|1iqk]], [[1iql\|1iql]], [[1iqm\|1iqm]], [[1iqn\|1iqn]], [[1ksn\|1ksn]], [[1kye\|1kye]], [[1lpg\|1lpg]], [[1lpk\|1lpk]], [[1lpz\|1lpz]], [[1lqd\|1lqd]], [[1mq5\|1mq5]], [[1mq6\|1mq6]], [[1msx\|1msx]], [[1nfu\|1nfu]], [[1nfw\|1nfw]], [[1nfx\|1nfx]], [[1nfy\|1nfy]], [[1nl8\|1nl8]], [[1p0s\|1p0s]], [[1v3x\|1v3x]], [[1xka\|1xka]], [[1xkb\|1xkb]], [[2bmg\|2bmg]], [[2boh\|2boh]], [[2bok\|2bok]], [[2bq7\|2bq7]], [[2bqw\|2bqw]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bq6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bq6 RCSB], [http://www.ebi.ac.uk/pdbsum/2bq6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bq6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bq6 RCSB], [http://www.ebi.ac.uk/pdbsum/2bq6 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[http://omim.org/entry/227600 227600]]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref>		[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[http://omim.org/entry/227600 227600]]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref>
Line 39:		Line 39:
	[[Category: Coagulation factor Xa]]		[[Category: Coagulation factor Xa]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Bauer, A.]]	+	[[Category: Bauer, A]]
-	[[Category: Czech, J.]]	+	[[Category: Czech, J]]
-	[[Category: Essrich, M.]]	+	[[Category: Essrich, M]]
-	[[Category: Laux, V.]]	+	[[Category: Laux, V]]
-	[[Category: Matter, H.]]	+	[[Category: Matter, H]]
-	[[Category: Nazare, M.]]	+	[[Category: Nazare, M]]
-	[[Category: Ritter, K.]]	+	[[Category: Ritter, K]]
-	[[Category: Schreuder, H.]]	+	[[Category: Schreuder, H]]
-	[[Category: Urmann, M.]]	+	[[Category: Urmann, M]]
-	[[Category: Wagner, M.]]	+	[[Category: Wagner, M]]
-	[[Category: Wehner, V.]]	+	[[Category: Wehner, V]]
-	[[Category: Will, D W.]]	+	[[Category: Will, D W]]
	[[Category: Blood coagulation]]		[[Category: Blood coagulation]]
	[[Category: Blood coagulation factor]]		[[Category: Blood coagulation factor]]

OCA at 00:46, 30 September 2014

OCA — Tue, 30 Sep 2014 00:46:18 GMT

←Older revision		Revision as of 00:46, 30 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2bq6\| PDB=2bq6 \| SCENE= }}~~	+	==CRYSTAL STRUCTURE OF FACTOR XA IN COMPLEX WITH 21==
-	===CRYSTAL STRUCTURE OF FACTOR XA IN COMPLEX WITH 21===	+	<StructureSection load='2bq6' size='340' side='right' caption='[[2bq6]], [[Resolution\|resolution]] 3.00Å' scene=''>
-	{~~{ABSTRACT_PUBMED_15999990}~~}	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2bq6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BQ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BQ6 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IIB:1-{[5-(5-CHLORO-2-THIENYL)ISOXAZOL-3-YL]METHYL}-3-CYANO-N-(1-ISOPROPYLPIPERIDIN-4-YL)-7-METHYL-1H-INDOLE-2-CARBOXAMIDE'>IIB</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c5m\|1c5m]], [[1ezq\|1ezq]], [[1f0r\|1f0r]], [[1f0s\|1f0s]], [[1fax\|1fax]], [[1fjs\|1fjs]], [[1fxy\|1fxy]], [[1g2l\|1g2l]], [[1g2m\|1g2m]], [[1hcg\|1hcg]], [[1ioe\|1ioe]], [[1iqe\|1iqe]], [[1iqf\|1iqf]], [[1iqg\|1iqg]], [[1iqh\|1iqh]], [[1iqi\|1iqi]], [[1iqj\|1iqj]], [[1iqk\|1iqk]], [[1iql\|1iql]], [[1iqm\|1iqm]], [[1iqn\|1iqn]], [[1ksn\|1ksn]], [[1kye\|1kye]], [[1lpg\|1lpg]], [[1lpk\|1lpk]], [[1lpz\|1lpz]], [[1lqd\|1lqd]], [[1mq5\|1mq5]], [[1mq6\|1mq6]], [[1msx\|1msx]], [[1nfu\|1nfu]], [[1nfw\|1nfw]], [[1nfx\|1nfx]], [[1nfy\|1nfy]], [[1nl8\|1nl8]], [[1p0s\|1p0s]], [[1v3x\|1v3x]], [[1xka\|1xka]], [[1xkb\|1xkb]], [[2bmg\|2bmg]], [[2boh\|2boh]], [[2bok\|2bok]], [[2bq7\|2bq7]], [[2bqw\|2bqw]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bq6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bq6 RCSB], [http://www.ebi.ac.uk/pdbsum/2bq6 PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[http://omim.org/entry/227600 227600]]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bq/2bq6_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Structure-activity relationships within a series of highly potent 2-carboxyindole-based factor Xa inhibitors incorporating a neutral P1 ligand are described with particular emphasis on the structural requirements for addressing subpockets of the factor Xa enzyme. Interactions with the subpockets were probed by systematic substitution of the 2-carboxyindole scaffold, in combination with privileged P1 and P4 substituents. Combining the most favorable substituents at the indole nucleus led to the discovery of a remarkably potent factor Xa inhibitor displaying a K(i) value of 0.07 nM. X-ray crystallography of inhibitors bound to factor Xa revealed substituent-dependent switching of the inhibitor binding mode and provided a rationale for the SAR obtained. These results underscore the key role played by the P1 ligand not only in determining the binding affinity of the inhibitor by direct interaction but also in modifying the binding mode of the whole scaffold, resulting in a nonlinear SAR.

-	~~==Disease==~~	+	Probing the subpockets of factor Xa reveals two binding modes for inhibitors based on a 2-carboxyindole scaffold: a study combining structure-activity relationship and X-ray crystallography.,Nazare M, Will DW, Matter H, Schreuder H, Ritter K, Urmann M, Essrich M, Bauer A, Wagner M, Czech J, Lorenz M, Laux V, Wehner V J Med Chem. 2005 Jul 14;48(14):4511-25. PMID:15999990<ref>PMID:15999990</ref>
-	~~[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Defects in F10 are~~ the ~~cause~~ of factor X ~~deficiency (FA10D) [MIM:[http://omim.org/entry/227600 227600]]~~. A ~~hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage~~, ~~menorrhagia~~, ~~hematuria~~, ~~and occasionally hemarthrosis~~. ~~Some patients do not have clinical bleeding diathesis~~.~~<ref>~~PMID:2790181</ref><ref>PMID:1973167</ref><ref>PMID:1985698</ref><ref>PMID:7669671</ref><ref>PMID:8529633</ref><ref>PMID:7860069</ref><ref>PMID:8845463</ref><ref>PMID:8910490</ref><ref>PMID:10468877</ref><ref>PMID:10746568</ref><ref>PMID:10739379</ref><ref>PMID:11248282</ref><ref>PMID:11728527</ref><ref>PMID:12945883</ref><ref>PMID:15650540</ref><ref>PMID:17393015</ref><ref>PMID:~~19135706~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~/~~/www~~.~~uniprot~~.~~org/uniprot/FA10_HUMAN FA10_HUMAN]] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence~~ of ~~factor Va, calcium and phospholipid during blood clotting~~.	+	</div>
-		+
-	~~==About this Structure==~~	+
-	~~[[2bq6]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BQ6 OCA].~~	+

	==See Also==		==See Also==
	*[[Factor Xa\|Factor Xa]]		*[[Factor Xa\|Factor Xa]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:015999990</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Coagulation factor Xa]]		[[Category: Coagulation factor Xa]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 19:27, 24 March 2013

OCA — Sun, 24 Mar 2013 19:27:47 GMT

←Older revision		Revision as of 19:27, 24 March 2013
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-	[[Image:2bq6.png\|left\|200px]]
-
	{{STRUCTURE_2bq6\| PDB=2bq6 \| SCENE= }}		{{STRUCTURE_2bq6\| PDB=2bq6 \| SCENE= }}
-
	===CRYSTAL STRUCTURE OF FACTOR XA IN COMPLEX WITH 21===		===CRYSTAL STRUCTURE OF FACTOR XA IN COMPLEX WITH 21===
		+	{{ABSTRACT_PUBMED_15999990}}

-	~~{{ABSTRACT_PUBMED_15999990}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[http://omim.org/entry/227600 227600]]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref><ref>PMID:1973167</ref><ref>PMID:1985698</ref><ref>PMID:7669671</ref><ref>PMID:8529633</ref><ref>PMID:7860069</ref><ref>PMID:8845463</ref><ref>PMID:8910490</ref><ref>PMID:10468877</ref><ref>PMID:10746568</ref><ref>PMID:10739379</ref><ref>PMID:11248282</ref><ref>PMID:11728527</ref><ref>PMID:12945883</ref><ref>PMID:15650540</ref><ref>PMID:17393015</ref><ref>PMID:19135706</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.

	==About this Structure==		==About this Structure==
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	==Reference==		==Reference==
-	<ref group="xtra">PMID:015999990</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015999990</ref><references group="xtra"/><references/>
	[[Category: Coagulation factor Xa]]		[[Category: Coagulation factor Xa]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 15:14, 20 October 2012

OCA — Sat, 20 Oct 2012 15:14:58 GMT

←Older revision		Revision as of 15:14, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[2bq6]] is a 2 chain structure ~~of [[Factor Xa]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BQ6 OCA].	+	[[2bq6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BQ6 OCA].

	==See Also==		==See Also==

OCA: Protected "2bq6" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 17:46:03 GMT

Protected "2bq6" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:46, 26 July 2012