2bqq - Revision history

OCA at 13:52, 13 December 2023

OCA — Wed, 13 Dec 2023 13:52:44 GMT

←Older revision		Revision as of 13:52, 13 December 2023
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	<StructureSection load='2bqq' size='340' side='right'caption='[[2bqq]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2bqq' size='340' side='right'caption='[[2bqq]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2bqq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BQQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BQQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2bqq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BQQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BQQ FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>~~[[~~1mjd~~\|~~1mjd~~]]~~</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bqq OCA], [https://pdbe.org/2bqq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bqq RCSB], [https://www.ebi.ac.uk/pdbsum/2bqq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bqq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bqq OCA], [https://pdbe.org/2bqq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bqq RCSB], [https://www.ebi.ac.uk/pdbsum/2bqq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bqq ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/DCX_HUMAN DCX_HUMAN] Defects in DCX are the cause of lissencephaly X-linked type 1 (LISX1) [MIM:[https://omim.org/entry/300067 300067]; also called X-LIS or LIS. LISX1 is a classic lissencephaly characterized by mental retardation and seizures that are more severe in male patients. Affected boys show an abnormally thick cortex with absent or severely reduced gyri. Clinical manifestations include feeding problems, abnormal muscular tone, seizures and severe to profound psychomotor retardation. Female patients display a less severe phenotype referred to as 'doublecortex'.<ref>PMID:9489699</ref> <ref>PMID:9489700</ref> <ref>PMID:9668176</ref> <ref>PMID:9817918</ref> <ref>PMID:11468322</ref> <ref>PMID:12552055</ref> Defects in DCX are the cause of subcortical band heterotopia X-linked (SBHX) [MIM:[https://omim.org/entry/300067 300067]; also known as double cortex or subcortical laminar heterotopia (SCLH). SBHX is a mild brain malformation of the lissencephaly spectrum. It is characterized by bilateral and symmetric plates or bands of gray matter found in the central white matter between the cortex and cerebral ventricles, cerebral convolutions usually appearing normal.<ref>PMID:9618162</ref> <ref>PMID:9989615</ref> <ref>PMID:10369164</ref> <ref>PMID:10441340</ref> <ref>PMID:10807542</ref> <ref>PMID:11601509</ref> <ref>PMID:11175293</ref> <ref>PMID:12390976</ref> Note=A chromosomal aberration involving DCX is found in lissencephaly. Translocation t(X;2)(q22.3;p25.1).
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/DCX_HUMAN DCX_HUMAN] Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration.<ref>PMID:22359282</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cooper~~, D R~~]]	+	[[Category: Cooper DR]]
-	[[Category: Derewenda, U]]	+	[[Category: Derewenda U]]
-	[[Category: Derewenda~~, Z S~~]]	+	[[Category: Derewenda ZS]]
-	[[Category: Kim~~, M H]]~~	+	[[Category: Kim MH]]
-	~~[[Category: Dcx domain]]~~	+
-	~~[[Category: Microtubule associated]]~~	+
-	~~[[Category: Signaling protein]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Ubiquitin-like fold~~]]	+

OCA at 10:31, 17 February 2021

OCA — Wed, 17 Feb 2021 10:31:57 GMT

←Older revision		Revision as of 10:31, 17 February 2021
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	<StructureSection load='2bqq' size='340' side='right'caption='[[2bqq]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2bqq' size='340' side='right'caption='[[2bqq]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2bqq]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BQQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2BQQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2bqq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BQQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BQQ FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mjd\|1mjd]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1mjd\|1mjd]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2bqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bqq OCA], [~~http~~://pdbe.org/2bqq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2bqq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2bqq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2bqq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bqq OCA], [https://pdbe.org/2bqq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bqq RCSB], [https://www.ebi.ac.uk/pdbsum/2bqq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bqq ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 11:52, 10 May 2019

OCA — Fri, 10 May 2019 11:52:07 GMT

←Older revision		Revision as of 11:52, 10 May 2019
Line 1:		Line 1:

	==X-ray Structure of the N-terminal Domain of Human Doublecortin==		==X-ray Structure of the N-terminal Domain of Human Doublecortin==
-	<StructureSection load='2bqq' size='340' side='right' caption='[[2bqq]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='2bqq' size='340' side='right'caption='[[2bqq]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bqq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BQQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BQQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bqq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BQQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BQQ FirstGlance]. <br>
Line 31:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Cooper, D R]]		[[Category: Cooper, D R]]
	[[Category: Derewenda, U]]		[[Category: Derewenda, U]]

OCA at 06:13, 16 May 2018

OCA — Wed, 16 May 2018 06:13:37 GMT

←Older revision		Revision as of 06:13, 16 May 2018
Line 1:		Line 1:
		+
	==X-ray Structure of the N-terminal Domain of Human Doublecortin==		==X-ray Structure of the N-terminal Domain of Human Doublecortin==
	<StructureSection load='2bqq' size='340' side='right' caption='[[2bqq]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2bqq' size='340' side='right' caption='[[2bqq]], [[Resolution\|resolution]] 2.20Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2bqq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BQQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BQQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bqq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BQQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BQQ FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mjd\|1mjd]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mjd\|1mjd]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bqq OCA], [http://pdbe.org/2bqq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bqq RCSB], [http://www.ebi.ac.uk/pdbsum/2bqq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bqq OCA], [http://pdbe.org/2bqq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bqq RCSB], [http://www.ebi.ac.uk/pdbsum/2bqq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2bqq ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bq/2bqq_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bq/2bqq_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 10:43, 8 February 2016

OCA — Mon, 08 Feb 2016 10:43:09 GMT

←Older revision		Revision as of 10:43, 8 February 2016
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2bqq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BQQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BQQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bqq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BQQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BQQ FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mjd\|1mjd]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mjd\|1mjd]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bqq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bqq RCSB], [http://www.ebi.ac.uk/pdbsum/2bqq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bqq OCA], [http://pdbe.org/2bqq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bqq RCSB], [http://www.ebi.ac.uk/pdbsum/2bqq PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bqq ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2bqq" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:05, 1 April 2015

OCA — Wed, 01 Apr 2015 07:05:35 GMT

←Older revision		Revision as of 07:05, 1 April 2015
Line 2:		Line 2:
	<StructureSection load='2bqq' size='340' side='right' caption='[[2bqq]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2bqq' size='340' side='right' caption='[[2bqq]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2bqq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BQQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BQQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2bqq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BQQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BQQ FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mjd\|1mjd]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mjd\|1mjd]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bqq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bqq RCSB], [http://www.ebi.ac.uk/pdbsum/2bqq PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bqq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bqq RCSB], [http://www.ebi.ac.uk/pdbsum/2bqq PDBsum]</span></td></tr>
Line 28:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Cooper, D R]]		[[Category: Cooper, D R]]
	[[Category: Derewenda, U]]		[[Category: Derewenda, U]]

OCA at 09:58, 8 January 2015

OCA — Thu, 08 Jan 2015 09:58:17 GMT

←Older revision		Revision as of 09:58, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bqq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BQQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BQQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bqq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BQQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BQQ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mjd\|1mjd]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mjd\|1mjd]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bqq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bqq RCSB], [http://www.ebi.ac.uk/pdbsum/2bqq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bqq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bqq RCSB], [http://www.ebi.ac.uk/pdbsum/2bqq PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Cooper, D R.]]	+	[[Category: Cooper, D R]]
-	[[Category: Derewenda, U.]]	+	[[Category: Derewenda, U]]
-	[[Category: Derewenda, Z S.]]	+	[[Category: Derewenda, Z S]]
	[[Category: Kim, M H]]		[[Category: Kim, M H]]
	[[Category: Dcx domain]]		[[Category: Dcx domain]]

OCA at 04:04, 3 October 2014

OCA — Fri, 03 Oct 2014 04:04:21 GMT

←Older revision		Revision as of 04:04, 3 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2bqq\| PDB=2bqq \| SCENE= }}~~	+	==X-ray Structure of the N-terminal Domain of Human Doublecortin==
-	===X-ray Structure of the N-terminal Domain of Human Doublecortin===	+	<StructureSection load='2bqq' size='340' side='right' caption='[[2bqq]], [[Resolution\|resolution]] 2.20Å' scene=''>
-	~~{{ABSTRACT_PUBMED_16835924}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2bqq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BQQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BQQ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mjd\|1mjd]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bqq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bqq RCSB], [http://www.ebi.ac.uk/pdbsum/2bqq PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bq/2bqq_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The doublecortin-like (DC) domains, which usually occur in tandem, constitute novel microtubule-binding modules. They were first identified in doublecortin (DCX), a protein expressed in migrating neurons, and in the doublecortin-like kinase (DCLK). They are also found in other proteins, including the RP1 gene product which-when mutated-causes a form of inherited blindness. We previously reported an X-ray structure of the N-terminal DC domain of DCLK (N-DCLK), and a solution structure of an analogous module of human doublecortin (N-DCX). These studies showed that the DC domain has a tertiary fold closely reminiscent of ubiquitin and similar to several GTPase-binding domains. We now report an X-ray structure of a mutant of N-DCX, in which the C-terminal fragment (residues 139-147) unexpectedly shows an altered, "open" conformation. However, heteronuclear NMR data show that this C-terminal fragment is only transiently open in solution, and assumes a predominantly "closed" conformation. While the "open" conformation may be artificially stabilized by crystal packing interactions, the observed switching between the "open" and "closed" conformations, which shortens the linker between the two DC-domains by approximately 20 A, is likely to be of functional importance in the control of tubulin polymerization and microtubule bundling by doublecortin.

-	~~==About this Structure==~~	+	The DC-module of doublecortin: dynamics, domain boundaries, and functional implications.,Cierpicki T, Kim MH, Cooper DR, Derewenda U, Bushweller JH, Derewenda ZS Proteins. 2006 Sep 1;64(4):874-82. PMID:16835924<ref>PMID:16835924</ref>
-	~~[[2bqq]] is a 1 chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2BQQ OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:016835924</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Cooper, D R.]]		[[Category: Cooper, D R.]]

OCA at 06:01, 2 October 2013

OCA — Wed, 02 Oct 2013 06:01:46 GMT

←Older revision		Revision as of 06:01, 2 October 2013
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	{{STRUCTURE_2bqq\| PDB=2bqq \| SCENE= }}		{{STRUCTURE_2bqq\| PDB=2bqq \| SCENE= }}
-	===X-~~RAY STRUCURE OF THE~~ N-~~TERMINAL DOMAIN OF HUMAN DOUBLECORTIN~~===	+	===X-ray Structure of the N-terminal Domain of Human Doublecortin===
	{{ABSTRACT_PUBMED_16835924}}		{{ABSTRACT_PUBMED_16835924}}

Line 12:		Line 12:
	[[Category: Derewenda, U.]]		[[Category: Derewenda, U.]]
	[[Category: Derewenda, Z S.]]		[[Category: Derewenda, Z S.]]
-	[[Category: Kim, M H.]]	+	[[Category: Kim, M H]]
	[[Category: Dcx domain]]		[[Category: Dcx domain]]
	[[Category: Microtubule associated]]		[[Category: Microtubule associated]]

OCA at 10:41, 24 March 2013

OCA — Sun, 24 Mar 2013 10:41:05 GMT

←Older revision		Revision as of 10:41, 24 March 2013
Line 1:		Line 1:
-	[[Image:2bqq.png\|left\|200px]]
-
	{{STRUCTURE_2bqq\| PDB=2bqq \| SCENE= }}		{{STRUCTURE_2bqq\| PDB=2bqq \| SCENE= }}
-
	===X-RAY STRUCURE OF THE N-TERMINAL DOMAIN OF HUMAN DOUBLECORTIN===		===X-RAY STRUCURE OF THE N-TERMINAL DOMAIN OF HUMAN DOUBLECORTIN===
-
	{{ABSTRACT_PUBMED_16835924}}		{{ABSTRACT_PUBMED_16835924}}

Line 11:		Line 7:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:016835924</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016835924</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Cooper, D R.]]		[[Category: Cooper, D R.]]