2bwp - Revision history

OCA at 09:20, 9 May 2024

OCA — Thu, 09 May 2024 09:20:05 GMT

←Older revision		Revision as of 09:20, 9 May 2024
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	<StructureSection load='2bwp' size='340' side='right'caption='[[2bwp]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2bwp' size='340' side='right'caption='[[2bwp]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2bwp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"rhodonostoc_capsulatum"_molisch_1907 "rhodonostoc capsulatum" molisch 1907~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BWP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BWP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2bwp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodobacter_capsulatus Rhodobacter capsulatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BWP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BWP FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>~~, ~~<scene name='pdbligand=PLG:N-GLYCINE-~~[~~3-HYDROXY-~~2~~-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE]'>PLG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2bwn\|2bwn]], [[2bwo\|2bwo]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=PLG:N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE]'>PLG</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks'>~~[~~https://en.wikipedia.org/wiki/5~~-~~aminolevulinate_synthase~~ 5-~~aminolevulinate synthase], with EC number [https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=2.3.1.37 2.3.1.37~~] </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bwp OCA], [https://pdbe.org/2bwp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bwp RCSB], [https://www.ebi.ac.uk/pdbsum/2bwp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bwp ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bwp OCA], [https://pdbe.org/2bwp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bwp RCSB], [https://www.ebi.ac.uk/pdbsum/2bwp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bwp ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/HEM1_RHOCB HEM1_RHOCB]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Rhodonostoc capsulatum molisch 1907]]
-	[[Category: 5-aminolevulinate synthase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Astner, I~~]]	+	[[Category: Rhodobacter capsulatus]]
-	[[Category: ~~Heinz, D W~~]]	+	[[Category: Astner I]]
-	[[Category: ~~Heuvel, J J.Van Den~~]]	+	[[Category: Heinz DW]]
-	[[Category: Jahn, D]]	+	[[Category: Jahn D]]
-	[[Category: Schubert, W D]]	+	[[Category: Schubert W-D]]
-	[[Category: Schulze~~, J O~~]]	+	[[Category: Schulze JO]]
-	[[Category: ~~Acyltransferase]]~~	+	[[Category: Van Den Heuvel JJ]]
-	~~[[Category: Heme biosynthesis]]~~	+
-	~~[[Category: Pyridoxal phosphate dependent]]~~	+
-	~~[[Category: Tetrapyrrole biosynthesis]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 13:19, 24 November 2021

OCA — Wed, 24 Nov 2021 13:19:30 GMT

←Older revision		Revision as of 13:19, 24 November 2021
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	<StructureSection load='2bwp' size='340' side='right'caption='[[2bwp]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2bwp' size='340' side='right'caption='[[2bwp]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2bwp]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"rhodonostoc_capsulatum"_molisch_1907 "rhodonostoc capsulatum" molisch 1907]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BWP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2BWP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2bwp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"rhodonostoc_capsulatum"_molisch_1907 "rhodonostoc capsulatum" molisch 1907]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BWP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BWP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=PLG:N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE]'>PLG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=PLG:N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE]'>PLG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bwn\|2bwn]], [[2bwo\|2bwo]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2bwn\|2bwn]], [[2bwo\|2bwo]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/5-aminolevulinate_synthase 5-aminolevulinate synthase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.37 2.3.1.37] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/5-aminolevulinate_synthase 5-aminolevulinate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.37 2.3.1.37] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2bwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bwp OCA], [~~http~~://pdbe.org/2bwp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2bwp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2bwp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2bwp ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bwp OCA], [https://pdbe.org/2bwp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bwp RCSB], [https://www.ebi.ac.uk/pdbsum/2bwp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bwp ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 08:02, 19 February 2020

OCA — Wed, 19 Feb 2020 08:02:48 GMT

←Older revision		Revision as of 08:02, 19 February 2020
Line 1:		Line 1:

	==5-Aminolevulinate Synthase from Rhodobacter capsulatus in complex with glycine==		==5-Aminolevulinate Synthase from Rhodobacter capsulatus in complex with glycine==
-	<StructureSection load='2bwp' size='340' side='right' caption='[[2bwp]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='2bwp' size='340' side='right'caption='[[2bwp]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bwp]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"rhodonostoc_capsulatum"_molisch_1907 "rhodonostoc capsulatum" molisch 1907]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BWP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BWP FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bwp]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"rhodonostoc_capsulatum"_molisch_1907 "rhodonostoc capsulatum" molisch 1907]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BWP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BWP FirstGlance]. <br>
Line 34:		Line 34:
	[[Category: Rhodonostoc capsulatum molisch 1907]]		[[Category: Rhodonostoc capsulatum molisch 1907]]
	[[Category: 5-aminolevulinate synthase]]		[[Category: 5-aminolevulinate synthase]]
		+	[[Category: Large Structures]]
	[[Category: Astner, I]]		[[Category: Astner, I]]
	[[Category: Heinz, D W]]		[[Category: Heinz, D W]]

OCA at 06:25, 16 May 2018

OCA — Wed, 16 May 2018 06:25:59 GMT

←Older revision		Revision as of 06:25, 16 May 2018
Line 1:		Line 1:
-	==5-~~AMINOLEVULINATE SYNTHASE FROM RHODOBACTER CAPSULATUS IN COMPLEX WITH GLYCINE~~==	+
		+	==5-Aminolevulinate Synthase from Rhodobacter capsulatus in complex with glycine==
	<StructureSection load='2bwp' size='340' side='right' caption='[[2bwp]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2bwp' size='340' side='right' caption='[[2bwp]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bwn\|2bwn]], [[2bwo\|2bwo]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bwn\|2bwn]], [[2bwo\|2bwo]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5-aminolevulinate_synthase 5-aminolevulinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.37 2.3.1.37] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5-aminolevulinate_synthase 5-aminolevulinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.37 2.3.1.37] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bwp OCA], [http://pdbe.org/2bwp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bwp RCSB], [http://www.ebi.ac.uk/pdbsum/2bwp PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bwp OCA], [http://pdbe.org/2bwp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bwp RCSB], [http://www.ebi.ac.uk/pdbsum/2bwp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2bwp ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bw/2bwp_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bw/2bwp_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 14:52, 9 February 2016

OCA — Tue, 09 Feb 2016 14:52:28 GMT

←Older revision		Revision as of 14:52, 9 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bwp ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:19, 10 September 2015

OCA — Thu, 10 Sep 2015 23:19:35 GMT

←Older revision		Revision as of 23:19, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2bwp' size='340' side='right' caption='[[2bwp]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2bwp' size='340' side='right' caption='[[2bwp]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2bwp]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rhodobacter_capsulatus Rhodobacter capsulatus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BWP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BWP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2bwp]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"rhodonostoc_capsulatum"_molisch_1907 "rhodonostoc capsulatum" molisch 1907]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BWP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BWP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=PLG:N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE]'>PLG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=PLG:N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE]'>PLG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bwn\|2bwn]], [[2bwo\|2bwo]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bwn\|2bwn]], [[2bwo\|2bwo]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5-aminolevulinate_synthase 5-aminolevulinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.37 2.3.1.37] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5-aminolevulinate_synthase 5-aminolevulinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.37 2.3.1.37] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bwp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bwp RCSB], [http://www.ebi.ac.uk/pdbsum/2bwp PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bwp OCA], [http://pdbe.org/2bwp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bwp RCSB], [http://www.ebi.ac.uk/pdbsum/2bwp PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2bwp" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Rhodonostoc capsulatum molisch 1907]]
	[[Category: 5-aminolevulinate synthase]]		[[Category: 5-aminolevulinate synthase]]
-	[[Category: Rhodobacter capsulatus]]
	[[Category: Astner, I]]		[[Category: Astner, I]]
	[[Category: Heinz, D W]]		[[Category: Heinz, D W]]

OCA at 17:49, 15 January 2015

OCA — Thu, 15 Jan 2015 17:49:13 GMT

←Older revision		Revision as of 17:49, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bwp]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodobacter_capsulatus Rhodobacter capsulatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BWP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BWP FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bwp]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodobacter_capsulatus Rhodobacter capsulatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BWP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BWP FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=PLG:N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE]'>PLG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=PLG:N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE]'>PLG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bwn\|2bwn]], [[2bwo\|2bwo]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bwn\|2bwn]], [[2bwo\|2bwo]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5-aminolevulinate_synthase 5-aminolevulinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.37 2.3.1.37] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5-aminolevulinate_synthase 5-aminolevulinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.37 2.3.1.37] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bwp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bwp RCSB], [http://www.ebi.ac.uk/pdbsum/2bwp PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bwp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bwp RCSB], [http://www.ebi.ac.uk/pdbsum/2bwp PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	[[Category: 5-aminolevulinate synthase]]		[[Category: 5-aminolevulinate synthase]]
	[[Category: Rhodobacter capsulatus]]		[[Category: Rhodobacter capsulatus]]
-	[[Category: Astner, I.]]	+	[[Category: Astner, I]]
-	[[Category: Heinz, D W.]]	+	[[Category: Heinz, D W]]
-	[[Category: Heuvel, J J.Van Den.]]	+	[[Category: Heuvel, J J.Van Den]]
-	[[Category: Jahn, D.]]	+	[[Category: Jahn, D]]
-	[[Category: Schubert, W D.]]	+	[[Category: Schubert, W D]]
-	[[Category: Schulze, J O.]]	+	[[Category: Schulze, J O]]
	[[Category: Acyltransferase]]		[[Category: Acyltransferase]]
	[[Category: Heme biosynthesis]]		[[Category: Heme biosynthesis]]

OCA at 00:56, 30 September 2014

OCA — Tue, 30 Sep 2014 00:56:07 GMT

←Older revision		Revision as of 00:56, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2bwp.~~png~~\|~~left~~\|200px]]	+	==5-AMINOLEVULINATE SYNTHASE FROM RHODOBACTER CAPSULATUS IN COMPLEX WITH GLYCINE==
		+	<StructureSection load='2bwp' size='340' side='right' caption='[[2bwp]], [[Resolution\|resolution]] 2.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2bwp]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodobacter_capsulatus Rhodobacter capsulatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BWP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BWP FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=PLG:N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE]'>PLG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bwn\|2bwn]], [[2bwo\|2bwo]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5-aminolevulinate_synthase 5-aminolevulinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.37 2.3.1.37] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bwp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bwp RCSB], [http://www.ebi.ac.uk/pdbsum/2bwp PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bw/2bwp_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	5-Aminolevulinate synthase (ALAS) is the first and rate-limiting enzyme of heme biosynthesis in humans, animals, other non-plant eukaryotes, and alpha-proteobacteria. It catalyzes the synthesis of 5-aminolevulinic acid, the first common precursor of all tetrapyrroles, from glycine and succinyl-coenzyme A (sCoA) in a pyridoxal 5'-phosphate (PLP)-dependent manner. X-linked sideroblastic anemias (XLSAs), a group of severe disorders in humans characterized by inadequate formation of heme in erythroblast mitochondria, are caused by mutations in the gene for erythroid eALAS, one of two human genes for ALAS. We present the first crystal structure of homodimeric ALAS from Rhodobacter capsulatus (ALAS(Rc)) binding its cofactor PLP. We, furthermore, present structures of ALAS(Rc) in complex with the substrates glycine or sCoA. The sequence identity of ALAS from R. capsulatus and human eALAS is 49%. XLSA-causing mutations may thus be mapped, revealing the molecular basis of XLSA in humans. Mutations are found to obstruct substrate binding, disrupt the dimer interface, or hamper the correct folding. The structure of ALAS completes the structural analysis of enzymes in heme biosynthesis.

-	~~{{STRUCTURE_2bwp\| PDB=2bwp \| SCENE= }}~~	+	Crystal structure of 5-aminolevulinate synthase, the first enzyme of heme biosynthesis, and its link to XLSA in humans.,Astner I, Schulze JO, van den Heuvel J, Jahn D, Schubert WD, Heinz DW EMBO J. 2005 Sep 21;24(18):3166-77. Epub 2005 Aug 25. PMID:16121195<ref>PMID:16121195</ref>

-	~~===5-AMINOLEVULINATE SYNTHASE FROM RHODOBACTER CAPSULATUS IN COMPLEX WITH GLYCINE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16121195}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2bwp]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rhodobacter_capsulatus Rhodobacter capsulatus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2BWP OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016121195<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: 5-aminolevulinate synthase]]		[[Category: 5-aminolevulinate synthase]]
	[[Category: Rhodobacter capsulatus]]		[[Category: Rhodobacter capsulatus]]

OCA: Protected "2bwp" [edit=sysop:move=sysop]

OCA — Sun, 06 Jan 2013 10:14:29 GMT

Protected "2bwp" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:14, 6 January 2013

OCA at 10:14, 6 January 2013

OCA — Sun, 06 Jan 2013 10:14:26 GMT

←Older revision		Revision as of 10:14, 6 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2bwp.png\|left\|200px]]		[[Image:2bwp.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2bwp", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2bwp\| PDB=2bwp \| SCENE= }}		{{STRUCTURE_2bwp\| PDB=2bwp \| SCENE= }}

	===5-AMINOLEVULINATE SYNTHASE FROM RHODOBACTER CAPSULATUS IN COMPLEX WITH GLYCINE===		===5-AMINOLEVULINATE SYNTHASE FROM RHODOBACTER CAPSULATUS IN COMPLEX WITH GLYCINE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16121195}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16121195 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16121195}}		{{ABSTRACT_PUBMED_16121195}}

	==About this Structure==		==About this Structure==
-	~~2BWP~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Rhodobacter_capsulatus Rhodobacter capsulatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BWP OCA].	+	[[2bwp]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodobacter_capsulatus Rhodobacter capsulatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BWP OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16121195~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016121195</ref><references group="xtra"/>
	[[Category: 5-aminolevulinate synthase]]		[[Category: 5-aminolevulinate synthase]]
	[[Category: Rhodobacter capsulatus]]		[[Category: Rhodobacter capsulatus]]
Line 37:		Line 25:
	[[Category: Tetrapyrrole biosynthesis]]		[[Category: Tetrapyrrole biosynthesis]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 10:37:26 2009''