2bx4 - Revision history

OCA at 11:49, 1 February 2024

OCA — Thu, 01 Feb 2024 11:49:00 GMT

←Older revision		Revision as of 11:49, 1 February 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bx4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/SARS_coronavirus_Sin2774 SARS coronavirus Sin2774]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BX4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BX4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bx4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/SARS_coronavirus_Sin2774 SARS coronavirus Sin2774]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BX4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BX4 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bx4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bx4 OCA], [https://pdbe.org/2bx4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bx4 RCSB], [https://www.ebi.ac.uk/pdbsum/2bx4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bx4 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.79Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bx4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bx4 OCA], [https://pdbe.org/2bx4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bx4 RCSB], [https://www.ebi.ac.uk/pdbsum/2bx4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bx4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 08:23, 7 December 2022

OCA — Wed, 07 Dec 2022 08:23:04 GMT

←Older revision		Revision as of 08:23, 7 December 2022
Line 3:		Line 3:
	<StructureSection load='2bx4' size='340' side='right'caption='[[2bx4]], [[Resolution\|resolution]] 2.79Å' scene=''>		<StructureSection load='2bx4' size='340' side='right'caption='[[2bx4]], [[Resolution\|resolution]] 2.79Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2bx4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Sars_coronavirus_sin2774 Sars~~ coronavirus ~~sin2774~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BX4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BX4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2bx4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/SARS_coronavirus_Sin2774 SARS coronavirus Sin2774]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BX4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BX4 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1o5s\|1o5s]], [[1p4x\|1p4x]], [[1p76\|1p76]], [[1p9s\|1p9s]], [[1p9t\|1p9t]], [[1p9u\|1p9u]], [[1pa5\|1pa5]], [[1puk\|1puk]], [[1q1x\|1q1x]], [[1q2w\|1q2w]], [[1q4z\|1q4z]], [[1qz8\|1qz8]], [[1ssk\|1ssk]], [[1sxf\|1sxf]], [[1uj1\|1uj1]], [[1uk2\|1uk2]], [[1uk3\|1uk3]], [[1uk4\|1uk4]], [[1uw7\|1uw7]], [[1wnc\|1wnc]], [[1xak\|1xak]], [[1xjp\|1xjp]], [[1xjr\|1xjr]], [[2bw6\|2bw6]], [[2bx3\|2bx3]]</div></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bx4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bx4 OCA], [https://pdbe.org/2bx4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bx4 RCSB], [https://www.ebi.ac.uk/pdbsum/2bx4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bx4 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bx4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bx4 OCA], [https://pdbe.org/2bx4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bx4 RCSB], [https://www.ebi.ac.uk/pdbsum/2bx4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bx4 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~R1A_CVHSA R1A_CVHSA]~~] The ~~papain~~-~~like proteinase (PL~~-~~PRO~~) ~~is responsible~~ for the cleavages located at the N-terminus of replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host ~~IRF~~-3.<ref>PMID:~~17024178~~</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> ~~The main proteinase 3CL~~-~~PRO is responsible~~ for ~~the majority of cleavages as it cleaves~~ the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-\|-[SGACN]~~. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK (By similarity)~~. Also ~~contains~~ an ADP-ribose-1''-phosphate (ADRP)~~-binding function~~.<ref>PMID:~~17024178~~</ref> <ref>PMID:~~17692280~~</ref> <ref>PMID:~~19369340~~</ref> ~~Nsp7-~~nsp8 hexadecamer may ~~possibly confer processivity to the polymerase~~, ~~maybe~~ by binding ~~to dsRNA or by producing primers utilized~~ by the ~~latter~~.<ref>PMID:~~17024178~~</ref> <ref>PMID:~~17692280~~</ref> <ref>PMID:~~19369340~~</ref> ~~Nsp9 is a~~ ssRNA-~~binding protein~~.<ref>PMID:~~17024178~~</ref> <ref>PMID:~~17692280~~</ref> <ref>PMID:~~19369340~~</ref>	+	[https://www.uniprot.org/uniprot/R1AB_SARS R1AB_SARS] Multifunctional protein involved in the transcription and replication of viral RNAs. Contains the proteinases responsible for the cleavages of the polyprotein. Inhibits host translation by interacting with the 40S ribosomal subunit. The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. Viral mRNAs are not susceptible to nsp1-mediated endonucleolytic RNA cleavage thanks to the presence of a 5'-end leader sequence and are therefore protected from degradation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response (PubMed:23035226). May disrupt nuclear pore function by binding and displacing host NUP93 (PubMed:30943371).<ref>PMID:23035226</ref> <ref>PMID:30943371</ref> May play a role in the modulation of host cell survival signaling pathway by interacting with host PHB and PHB2. Indeed, these two proteins play a role in maintaining the functional integrity of the mitochondria and protecting cells from various stresses.<ref>PMID:19640993</ref> Responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates (PubMed:17692280). Plays a role in host membrane rearrangement that leads to creation of cytoplasmic double-membrane vesicles (DMV) necessary for viral replication. Nsp3, nsp4 and nsp6 together are sufficient to form DMV (PubMed:24410069). Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF3 (PubMed:19369340, PubMed:24622840). Prevents also host NF-kappa-B signaling.<ref>PMID:16271890</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> <ref>PMID:24622840</ref> <ref>PMID:24410069</ref> Plays a role in host membrane rearrangement that leads to creation of cytoplasmic double-membrane vesicles (DMV) necessary for viral replication. Alone appears incapable to induce membrane curvature, but together with nsp3 is able to induce paired membranes. Nsp3, nsp4 and nsp6 together are sufficient to form DMV.<ref>PMID:23943763</ref> <ref>PMID:24410069</ref> Cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-\|-[SGACN]. Also able to bind an ADP-ribose-1''-phosphate (ADRP). May cleave host ATP6V1G1 thereby modifying host vacuoles intracellular pH.[PROSITE-ProRule:PRU00772]<ref>PMID:16226257</ref> Plays a role in host membrane rearrangement that leads to creation of cytoplasmic double-membrane vesicles (DMV) necessary for viral replication. Nsp3, nsp4 and nsp6 together are sufficient to form DMV (PubMed:24410069). Plays a role in the initial induction of autophagosomes from host reticulum endoplasmic. Later, limits the expansion of these phagosomes that are no longer able to deliver viral components to lysosomes (PubMed:24991833).<ref>PMID:24991833</ref> <ref>PMID:24410069</ref> Forms a hexadecamer with nsp8 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.<ref>PMID:22039154</ref> Forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.<ref>PMID:22039154</ref> May participate in viral replication by acting as a ssRNA-binding protein.<ref>PMID:19153232</ref> Plays a pivotal role in viral transcription by stimulating both nsp14 3'-5' exoribonuclease and nsp16 2'-O-methyltransferase activities. Therefore plays an essential role in viral mRNAs cap methylation.<ref>PMID:22635272</ref> Responsible for replication and transcription of the viral RNA genome.<ref>PMID:22791111</ref> Multi-functional protein with a zinc-binding domain in N-terminus displaying RNA and DNA duplex-unwinding activities with 5' to 3' polarity. Activity of helicase is dependent on magnesium.<ref>PMID:12917423</ref> <ref>PMID:22615777</ref> Enzyme possessing two different activities: an exoribonuclease activity acting on both ssRNA and dsRNA in a 3' to 5' direction and a N7-guanine methyltransferase activity (PubMed:16549795, PubMed:20421945, PubMed:22635272). Acts as a proofreading exoribonuclease for RNA replication, thereby lowering The sensitivity of the virus to RNA mutagens (PubMed:23966862, PubMed:29511076, PubMed:21593585).<ref>PMID:16549795</ref> <ref>PMID:20421945</ref> <ref>PMID:21593585</ref> <ref>PMID:22635272</ref> <ref>PMID:23966862</ref> <ref>PMID:29511076</ref> Mn(2+)-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond. Methyltransferase that mediates mRNA cap 2'-O-ribose methylation to the 5'-cap structure of viral mRNAs. N7-methyl guanosine cap is a prerequisite for binding of nsp16. Therefore plays an essential role in viral mRNAs cap methylation which is essential to evade immune system.<ref>PMID:18417574</ref> <ref>PMID:20421945</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Sars~~ coronavirus ~~sin2774~~]]	+	[[Category: SARS coronavirus Sin2774]]
-	[[Category: Bigalke, J]]	+	[[Category: Bigalke J]]
-	[[Category: Hilgenfeld, R]]	+	[[Category: Hilgenfeld R]]
-	[[Category: Mesters~~, J R~~]]	+	[[Category: Mesters JR]]
-	[[Category: Verschueren~~, K H.G]]~~	+	[[Category: Verschueren KHG]]
-	~~[[Category: Anti-parallel a- helice]]~~	+
-	~~[[Category: Anti-parallel b-barrel]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 09:44, 5 May 2021

OCA — Wed, 05 May 2021 09:44:51 GMT

←Older revision		Revision as of 09:44, 5 May 2021
Line 3:		Line 3:
	<StructureSection load='2bx4' size='340' side='right'caption='[[2bx4]], [[Resolution\|resolution]] 2.79Å' scene=''>		<StructureSection load='2bx4' size='340' side='right'caption='[[2bx4]], [[Resolution\|resolution]] 2.79Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2bx4]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Sars_coronavirus_sin2774 Sars coronavirus sin2774]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BX4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2BX4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2bx4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sars_coronavirus_sin2774 Sars coronavirus sin2774]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BX4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BX4 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1o5s\|1o5s]], [[1p4x\|1p4x]], [[1p76\|1p76]], [[1p9s\|1p9s]], [[1p9t\|1p9t]], [[1p9u\|1p9u]], [[1pa5\|1pa5]], [[1puk\|1puk]], [[1q1x\|1q1x]], [[1q2w\|1q2w]], [[1q4z\|1q4z]], [[1qz8\|1qz8]], [[1ssk\|1ssk]], [[1sxf\|1sxf]], [[1uj1\|1uj1]], [[1uk2\|1uk2]], [[1uk3\|1uk3]], [[1uk4\|1uk4]], [[1uw7\|1uw7]], [[1wnc\|1wnc]], [[1xak\|1xak]], [[1xjp\|1xjp]], [[1xjr\|1xjr]], [[2bw6\|2bw6]], [[2bx3\|2bx3]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1o5s\|1o5s]], [[1p4x\|1p4x]], [[1p76\|1p76]], [[1p9s\|1p9s]], [[1p9t\|1p9t]], [[1p9u\|1p9u]], [[1pa5\|1pa5]], [[1puk\|1puk]], [[1q1x\|1q1x]], [[1q2w\|1q2w]], [[1q4z\|1q4z]], [[1qz8\|1qz8]], [[1ssk\|1ssk]], [[1sxf\|1sxf]], [[1uj1\|1uj1]], [[1uk2\|1uk2]], [[1uk3\|1uk3]], [[1uk4\|1uk4]], [[1uw7\|1uw7]], [[1wnc\|1wnc]], [[1xak\|1xak]], [[1xjp\|1xjp]], [[1xjr\|1xjr]], [[2bw6\|2bw6]], [[2bx3\|2bx3]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2bx4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bx4 OCA], [~~http~~://pdbe.org/2bx4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2bx4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2bx4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2bx4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bx4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bx4 OCA], [https://pdbe.org/2bx4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bx4 RCSB], [https://www.ebi.ac.uk/pdbsum/2bx4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bx4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/R1A_CVHSA R1A_CVHSA]] The papain-like proteinase (PL-PRO) is responsible for the cleavages located at the N-terminus of replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF-3.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-\|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK (By similarity). Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> Nsp9 is a ssRNA-binding protein.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref>	+	[[https://www.uniprot.org/uniprot/R1A_CVHSA R1A_CVHSA]] The papain-like proteinase (PL-PRO) is responsible for the cleavages located at the N-terminus of replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF-3.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-\|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK (By similarity). Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> Nsp9 is a ssRNA-binding protein.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[~~SARS Coronavirus Main Proteinase~~\|~~SARS Coronavirus Main Proteinase~~]]	+	*[[Virus protease 3D structures\|Virus protease 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:12, 24 July 2019

OCA — Wed, 24 Jul 2019 07:12:48 GMT

←Older revision		Revision as of 07:12, 24 July 2019
Line 1:		Line 1:

	==Crystal Structure of SARS Coronavirus Main Proteinase (P21212)==		==Crystal Structure of SARS Coronavirus Main Proteinase (P21212)==
-	<StructureSection load='2bx4' size='340' side='right' caption='[[2bx4]], [[Resolution\|resolution]] 2.79Å' scene=''>	+	<StructureSection load='2bx4' size='340' side='right'caption='[[2bx4]], [[Resolution\|resolution]] 2.79Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bx4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus_sin2774 Sars coronavirus sin2774]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BX4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BX4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bx4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus_sin2774 Sars coronavirus sin2774]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BX4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BX4 FirstGlance]. <br>
Line 35:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Sars coronavirus sin2774]]		[[Category: Sars coronavirus sin2774]]
	[[Category: Bigalke, J]]		[[Category: Bigalke, J]]

OCA at 06:15, 16 May 2018

OCA — Wed, 16 May 2018 06:15:18 GMT

←Older revision		Revision as of 06:15, 16 May 2018
Line 1:		Line 1:
-	==~~CRYSTAL STRUCTURE OF~~ SARS ~~CORONAVIRUS MAIN PROTEINASE~~ (P21212)==	+
		+	==Crystal Structure of SARS Coronavirus Main Proteinase (P21212)==
	<StructureSection load='2bx4' size='340' side='right' caption='[[2bx4]], [[Resolution\|resolution]] 2.79Å' scene=''>		<StructureSection load='2bx4' size='340' side='right' caption='[[2bx4]], [[Resolution\|resolution]] 2.79Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bx4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus_sin2774 Sars coronavirus sin2774]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BX4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BX4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bx4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus_sin2774 Sars coronavirus sin2774]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BX4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BX4 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1o5s\|1o5s]], [[1p4x\|1p4x]], [[1p76\|1p76]], [[1p9s\|1p9s]], [[1p9t\|1p9t]], [[1p9u\|1p9u]], [[1pa5\|1pa5]], [[1puk\|1puk]], [[1q1x\|1q1x]], [[1q2w\|1q2w]], [[1q4z\|1q4z]], [[1qz8\|1qz8]], [[1ssk\|1ssk]], [[1sxf\|1sxf]], [[1uj1\|1uj1]], [[1uk2\|1uk2]], [[1uk3\|1uk3]], [[1uk4\|1uk4]], [[1uw7\|1uw7]], [[1wnc\|1wnc]], [[1xak\|1xak]], [[1xjp\|1xjp]], [[1xjr\|1xjr]], [[2bw6\|2bw6]], [[2bx3\|2bx3]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1o5s\|1o5s]], [[1p4x\|1p4x]], [[1p76\|1p76]], [[1p9s\|1p9s]], [[1p9t\|1p9t]], [[1p9u\|1p9u]], [[1pa5\|1pa5]], [[1puk\|1puk]], [[1q1x\|1q1x]], [[1q2w\|1q2w]], [[1q4z\|1q4z]], [[1qz8\|1qz8]], [[1ssk\|1ssk]], [[1sxf\|1sxf]], [[1uj1\|1uj1]], [[1uk2\|1uk2]], [[1uk3\|1uk3]], [[1uk4\|1uk4]], [[1uw7\|1uw7]], [[1wnc\|1wnc]], [[1xak\|1xak]], [[1xjp\|1xjp]], [[1xjr\|1xjr]], [[2bw6\|2bw6]], [[2bx3\|2bx3]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bx4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bx4 OCA], [http://pdbe.org/2bx4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bx4 RCSB], [http://www.ebi.ac.uk/pdbsum/2bx4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bx4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bx4 OCA], [http://pdbe.org/2bx4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bx4 RCSB], [http://www.ebi.ac.uk/pdbsum/2bx4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2bx4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bx/2bx4_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bx/2bx4_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 18:07, 7 February 2016

OCA — Sun, 07 Feb 2016 18:07:00 GMT

←Older revision		Revision as of 18:07, 7 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bx4 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 03:54, 10 September 2015

OCA — Thu, 10 Sep 2015 03:54:15 GMT

←Older revision		Revision as of 03:54, 10 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2bx4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus_sin2774 Sars coronavirus sin2774]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BX4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BX4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bx4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus_sin2774 Sars coronavirus sin2774]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BX4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BX4 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1o5s\|1o5s]], [[1p4x\|1p4x]], [[1p76\|1p76]], [[1p9s\|1p9s]], [[1p9t\|1p9t]], [[1p9u\|1p9u]], [[1pa5\|1pa5]], [[1puk\|1puk]], [[1q1x\|1q1x]], [[1q2w\|1q2w]], [[1q4z\|1q4z]], [[1qz8\|1qz8]], [[1ssk\|1ssk]], [[1sxf\|1sxf]], [[1uj1\|1uj1]], [[1uk2\|1uk2]], [[1uk3\|1uk3]], [[1uk4\|1uk4]], [[1uw7\|1uw7]], [[1wnc\|1wnc]], [[1xak\|1xak]], [[1xjp\|1xjp]], [[1xjr\|1xjr]], [[2bw6\|2bw6]], [[2bx3\|2bx3]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1o5s\|1o5s]], [[1p4x\|1p4x]], [[1p76\|1p76]], [[1p9s\|1p9s]], [[1p9t\|1p9t]], [[1p9u\|1p9u]], [[1pa5\|1pa5]], [[1puk\|1puk]], [[1q1x\|1q1x]], [[1q2w\|1q2w]], [[1q4z\|1q4z]], [[1qz8\|1qz8]], [[1ssk\|1ssk]], [[1sxf\|1sxf]], [[1uj1\|1uj1]], [[1uk2\|1uk2]], [[1uk3\|1uk3]], [[1uk4\|1uk4]], [[1uw7\|1uw7]], [[1wnc\|1wnc]], [[1xak\|1xak]], [[1xjp\|1xjp]], [[1xjr\|1xjr]], [[2bw6\|2bw6]], [[2bx3\|2bx3]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bx4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bx4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bx4 RCSB], [http://www.ebi.ac.uk/pdbsum/2bx4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bx4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bx4 OCA], [http://pdbe.org/2bx4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bx4 RCSB], [http://www.ebi.ac.uk/pdbsum/2bx4 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2bx4" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 17:18, 24 December 2014

OCA — Wed, 24 Dec 2014 17:18:24 GMT

←Older revision		Revision as of 17:18, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bx4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus_sin2774 Sars coronavirus sin2774]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BX4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BX4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bx4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus_sin2774 Sars coronavirus sin2774]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BX4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BX4 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1o5s\|1o5s]], [[1p4x\|1p4x]], [[1p76\|1p76]], [[1p9s\|1p9s]], [[1p9t\|1p9t]], [[1p9u\|1p9u]], [[1pa5\|1pa5]], [[1puk\|1puk]], [[1q1x\|1q1x]], [[1q2w\|1q2w]], [[1q4z\|1q4z]], [[1qz8\|1qz8]], [[1ssk\|1ssk]], [[1sxf\|1sxf]], [[1uj1\|1uj1]], [[1uk2\|1uk2]], [[1uk3\|1uk3]], [[1uk4\|1uk4]], [[1uw7\|1uw7]], [[1wnc\|1wnc]], [[1xak\|1xak]], [[1xjp\|1xjp]], [[1xjr\|1xjr]], [[2bw6\|2bw6]], [[2bx3\|2bx3]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1o5s\|1o5s]], [[1p4x\|1p4x]], [[1p76\|1p76]], [[1p9s\|1p9s]], [[1p9t\|1p9t]], [[1p9u\|1p9u]], [[1pa5\|1pa5]], [[1puk\|1puk]], [[1q1x\|1q1x]], [[1q2w\|1q2w]], [[1q4z\|1q4z]], [[1qz8\|1qz8]], [[1ssk\|1ssk]], [[1sxf\|1sxf]], [[1uj1\|1uj1]], [[1uk2\|1uk2]], [[1uk3\|1uk3]], [[1uk4\|1uk4]], [[1uw7\|1uw7]], [[1wnc\|1wnc]], [[1xak\|1xak]], [[1xjp\|1xjp]], [[1xjr\|1xjr]], [[2bw6\|2bw6]], [[2bx3\|2bx3]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bx4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bx4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bx4 RCSB], [http://www.ebi.ac.uk/pdbsum/2bx4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bx4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bx4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bx4 RCSB], [http://www.ebi.ac.uk/pdbsum/2bx4 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/R1A_CVHSA R1A_CVHSA]] The papain-like proteinase (PL-PRO) is responsible for the cleavages located at the N-terminus of replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF-3.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-\|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK (By similarity). Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref> Nsp9 is a ssRNA-binding protein.<ref>PMID:17024178</ref> <ref>PMID:17692280</ref> <ref>PMID:19369340</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Sars coronavirus sin2774]]		[[Category: Sars coronavirus sin2774]]
-	[[Category: Bigalke, J.]]	+	[[Category: Bigalke, J]]
-	[[Category: Hilgenfeld, R.]]	+	[[Category: Hilgenfeld, R]]
-	[[Category: Mesters, J R.]]	+	[[Category: Mesters, J R]]
-	[[Category: Verschueren, K H.G.]]	+	[[Category: Verschueren, K H.G]]
	[[Category: Anti-parallel a- helice]]		[[Category: Anti-parallel a- helice]]
	[[Category: Anti-parallel b-barrel]]		[[Category: Anti-parallel b-barrel]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Viral protein]]		[[Category: Viral protein]]

OCA at 02:11, 29 September 2014

OCA — Mon, 29 Sep 2014 02:11:04 GMT

←Older revision		Revision as of 02:11, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2bx4.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF SARS CORONAVIRUS MAIN PROTEINASE (P21212)==
		+	<StructureSection load='2bx4' size='340' side='right' caption='[[2bx4]], [[Resolution\|resolution]] 2.79Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2bx4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus_sin2774 Sars coronavirus sin2774]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BX4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BX4 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1o5s\|1o5s]], [[1p4x\|1p4x]], [[1p76\|1p76]], [[1p9s\|1p9s]], [[1p9t\|1p9t]], [[1p9u\|1p9u]], [[1pa5\|1pa5]], [[1puk\|1puk]], [[1q1x\|1q1x]], [[1q2w\|1q2w]], [[1q4z\|1q4z]], [[1qz8\|1qz8]], [[1ssk\|1ssk]], [[1sxf\|1sxf]], [[1uj1\|1uj1]], [[1uk2\|1uk2]], [[1uk3\|1uk3]], [[1uk4\|1uk4]], [[1uw7\|1uw7]], [[1wnc\|1wnc]], [[1xak\|1xak]], [[1xjp\|1xjp]], [[1xjr\|1xjr]], [[2bw6\|2bw6]], [[2bx3\|2bx3]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bx4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bx4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bx4 RCSB], [http://www.ebi.ac.uk/pdbsum/2bx4 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bx/2bx4_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The SARS coronavirus main proteinase (M(pro)) is a key enzyme in the processing of the viral polyproteins and thus an attractive target for the discovery of drugs directed against SARS. The enzyme has been shown by X-ray crystallography to undergo significant pH-dependent conformational changes. Here, we assess the conformational flexibility of the M(pro) by analysis of multiple crystal structures (including two new crystal forms) and by molecular dynamics (MD) calculations. The MD simulations take into account the different protonation states of two histidine residues in the substrate-binding site and explain the pH-activity profile of the enzyme. The low enzymatic activity of the M(pro) monomer and the need for dimerization are also discussed.

-	~~{{STRUCTURE_2bx4\| PDB=2bx4 \| SCENE= }}~~	+	pH-dependent conformational flexibility of the SARS-CoV main proteinase (M(pro)) dimer: molecular dynamics simulations and multiple X-ray structure analyses.,Tan J, Verschueren KH, Anand K, Shen J, Yang M, Xu Y, Rao Z, Bigalke J, Heisen B, Mesters JR, Chen K, Shen X, Jiang H, Hilgenfeld R J Mol Biol. 2005 Nov 18;354(1):25-40. Epub 2005 Sep 23. PMID:16242152<ref>PMID:16242152</ref>

-	~~===CRYSTAL STRUCTURE OF SARS CORONAVIRUS MAIN PROTEINASE (P21212)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16242152}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2bx4]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Sars_coronavirus_sin2774 Sars coronavirus sin2774]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2BX4 OCA].~~	+

	==See Also==		==See Also==
	*[[SARS Coronavirus Main Proteinase\|SARS Coronavirus Main Proteinase]]		*[[SARS Coronavirus Main Proteinase\|SARS Coronavirus Main Proteinase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:016242152<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Sars coronavirus sin2774]]		[[Category: Sars coronavirus sin2774]]
	[[Category: Bigalke, J.]]		[[Category: Bigalke, J.]]

OCA at 07:28, 20 October 2012

OCA — Sat, 20 Oct 2012 07:28:19 GMT

←Older revision		Revision as of 07:28, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2bx4]] is a 1 chain structure ~~of [[SARS Coronavirus Main Proteinase]]~~ with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus_sin2774 Sars coronavirus sin2774]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BX4 OCA].	+	[[2bx4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus_sin2774 Sars coronavirus sin2774]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BX4 OCA].

	==See Also==		==See Also==