2bz6 - Revision history

OCA at 11:24, 22 May 2024

OCA — Wed, 22 May 2024 11:24:51 GMT

←Older revision		Revision as of 11:24, 22 May 2024
Line 3:		Line 3:
	<StructureSection load='2bz6' size='340' side='right'caption='[[2bz6]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2bz6' size='340' side='right'caption='[[2bz6]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2bz6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BZ6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2bz6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BZ6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=346:(R)-(4-CARBAMIMIDOYL-PHENYLAMINO)-[5-ETHOXY-2-FLUORO-3-[(R)-TETRAHYDRO-FURAN-3-YLOXY]-PHENYL]-ACETIC+ACID'>346</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1bf9\|1bf9]], [[1cvw\|1cvw]], [[1dan\|1dan]], [[1dva\|1dva]], [[1f7e\|1f7e]], [[1f7m\|1f7m]], [[1fak\|1fak]], [[1ff7\|1ff7]], [[1ffm\|1ffm]], [[1j9c\|1j9c]], [[1jbu\|1jbu]], [[1kli\|1kli]], [[1klj\|1klj]], [[1nl8\|1nl8]], [[1o5d\|1o5d]], [[1qfk\|1qfk]], [[1w0y\|1w0y]], [[1w2k\|1w2k]], [[1w7x\|1w7x]], [[1w8b\|1w8b]], [[1ygc\|1ygc]], [[1z6j\|1z6j]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=346:(R)-(4-CARBAMIMIDOYL-PHENYLAMINO)-[5-ETHOXY-2-FLUORO-3-[(R)-TETRAHYDRO-FURAN-3-YLOXY]-PHENYL]-ACETIC+ACID'>346</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Coagulation_factor_VIIa Coagulation factor VIIa], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.21 3.4.21.21] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bz6 OCA], [https://pdbe.org/2bz6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bz6 RCSB], [https://www.ebi.ac.uk/pdbsum/2bz6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bz6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bz6 OCA], [https://pdbe.org/2bz6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bz6 RCSB], [https://www.ebi.ac.uk/pdbsum/2bz6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bz6 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/FA7_HUMAN FA7_HUMAN]] Defects in F7 are the cause of factor VII deficiency (FA7D) [MIM:[https://omim.org/entry/227500 227500]]. A hemorrhagic disease with variable presentation. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or repeated hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a surgical intervention. Finally, numerous subjects are completely asymptomatic despite very low factor VII levels.<ref>PMID:8043443</ref> <ref>PMID:2070047</ref> <ref>PMID:1634227</ref> <ref>PMID:8364544</ref> <ref>PMID:8204879</ref> <ref>PMID:7981691</ref> <ref>PMID:7974346</ref> <ref>PMID:8652821</ref> <ref>PMID:8844208</ref> <ref>PMID:8940045</ref> <ref>PMID:8883260</ref> <ref>PMID:9414278</ref> <ref>PMID:9576180</ref> <ref>PMID:9452082</ref> <ref>PMID:11091194</ref> <ref>PMID:11129332</ref> <ref>PMID:10862079</ref> <ref>PMID:12472587</ref> <ref>PMID:14717781</ref> <ref>PMID:19751712</ref> <ref>PMID:18976247</ref> <ref>PMID:19432927</ref> <ref>PMID:21206266</ref> <ref>PMID:21372693</ref>	+	[https://www.uniprot.org/uniprot/FA7_HUMAN FA7_HUMAN] Defects in F7 are the cause of factor VII deficiency (FA7D) [MIM:[https://omim.org/entry/227500 227500]. A hemorrhagic disease with variable presentation. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or repeated hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a surgical intervention. Finally, numerous subjects are completely asymptomatic despite very low factor VII levels.<ref>PMID:8043443</ref> <ref>PMID:2070047</ref> <ref>PMID:1634227</ref> <ref>PMID:8364544</ref> <ref>PMID:8204879</ref> <ref>PMID:7981691</ref> <ref>PMID:7974346</ref> <ref>PMID:8652821</ref> <ref>PMID:8844208</ref> <ref>PMID:8940045</ref> <ref>PMID:8883260</ref> <ref>PMID:9414278</ref> <ref>PMID:9576180</ref> <ref>PMID:9452082</ref> <ref>PMID:11091194</ref> <ref>PMID:11129332</ref> <ref>PMID:10862079</ref> <ref>PMID:12472587</ref> <ref>PMID:14717781</ref> <ref>PMID:19751712</ref> <ref>PMID:18976247</ref> <ref>PMID:19432927</ref> <ref>PMID:21206266</ref> <ref>PMID:21372693</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FA7_HUMAN FA7_HUMAN]] Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.	+	[https://www.uniprot.org/uniprot/FA7_HUMAN FA7_HUMAN] Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Coagulation factor VIIa]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ackermann, J]]	+	[[Category: Ackermann J]]
-	[[Category: Alig, L]]	+	[[Category: Alig L]]
-	[[Category: Banner~~, D W~~]]	+	[[Category: Banner DW]]
-	[[Category: Boehm~~, H J~~]]	+	[[Category: Boehm HJ]]
-	[[Category: Groebke-Zbinden, K]]	+	[[Category: Groebke-Zbinden K]]
-	[[Category: Hilpert, K]]	+	[[Category: Hilpert K]]
-	[[Category: Kuehne, H]]	+	[[Category: Kuehne H]]
-	[[Category: Lave, T]]	+	[[Category: Lave T]]
-	[[Category: Obst-Sander, U]]	+	[[Category: Obst-Sander U]]
-	[[Category: Riederer~~, M A~~]]	+	[[Category: Riederer MA]]
-	[[Category: Stahl, M]]	+	[[Category: Stahl M]]
-	[[Category: Tschopp~~, T B~~]]	+	[[Category: Tschopp TB]]
-	[[Category: Weber, L]]	+	[[Category: Weber L]]
-	[[Category: Wessel~~, H P]]~~	+	[[Category: Wessel HP]]
-	~~[[Category: Coagulation]]~~	+
-	~~[[Category: Enzyme complex]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Serine protease~~]]	+

OCA at 13:21, 24 November 2021

OCA — Wed, 24 Nov 2021 13:21:07 GMT

OCA at 08:13, 19 February 2020

OCA — Wed, 19 Feb 2020 08:13:30 GMT

←Older revision		Revision as of 08:13, 19 February 2020
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	==Orally available Factor7a inhibitor==		==Orally available Factor7a inhibitor==
-	<StructureSection load='2bz6' size='340' side='right' caption='[[2bz6]], [[Resolution\|resolution]] 1.60Å' scene=''>	+	<StructureSection load='2bz6' size='340' side='right'caption='[[2bz6]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bz6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BZ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BZ6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bz6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BZ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BZ6 FirstGlance]. <br>
Line 34:		Line 34:

	==See Also==		==See Also==
-	*[[Factor VIIa\|Factor VIIa]]	+	*[[Factor VIIa 3D structures\|Factor VIIa 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 41:		Line 41:
	[[Category: Coagulation factor VIIa]]		[[Category: Coagulation factor VIIa]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Ackermann, J]]		[[Category: Ackermann, J]]
	[[Category: Alig, L]]		[[Category: Alig, L]]

OCA at 06:42, 16 May 2018

OCA — Wed, 16 May 2018 06:42:36 GMT

←Older revision		Revision as of 06:42, 16 May 2018
Line 1:		Line 1:
-	==~~ORALLY AVAILABLE FACTOR7A INHIBITOR~~==	+
		+	==Orally available Factor7a inhibitor==
	<StructureSection load='2bz6' size='340' side='right' caption='[[2bz6]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2bz6' size='340' side='right' caption='[[2bz6]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bf9\|1bf9]], [[1cvw\|1cvw]], [[1dan\|1dan]], [[1dva\|1dva]], [[1f7e\|1f7e]], [[1f7m\|1f7m]], [[1fak\|1fak]], [[1ff7\|1ff7]], [[1ffm\|1ffm]], [[1j9c\|1j9c]], [[1jbu\|1jbu]], [[1kli\|1kli]], [[1klj\|1klj]], [[1nl8\|1nl8]], [[1o5d\|1o5d]], [[1qfk\|1qfk]], [[1w0y\|1w0y]], [[1w2k\|1w2k]], [[1w7x\|1w7x]], [[1w8b\|1w8b]], [[1ygc\|1ygc]], [[1z6j\|1z6j]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bf9\|1bf9]], [[1cvw\|1cvw]], [[1dan\|1dan]], [[1dva\|1dva]], [[1f7e\|1f7e]], [[1f7m\|1f7m]], [[1fak\|1fak]], [[1ff7\|1ff7]], [[1ffm\|1ffm]], [[1j9c\|1j9c]], [[1jbu\|1jbu]], [[1kli\|1kli]], [[1klj\|1klj]], [[1nl8\|1nl8]], [[1o5d\|1o5d]], [[1qfk\|1qfk]], [[1w0y\|1w0y]], [[1w2k\|1w2k]], [[1w7x\|1w7x]], [[1w8b\|1w8b]], [[1ygc\|1ygc]], [[1z6j\|1z6j]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_VIIa Coagulation factor VIIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.21 3.4.21.21] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_VIIa Coagulation factor VIIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.21 3.4.21.21] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bz6 OCA], [http://pdbe.org/2bz6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bz6 RCSB], [http://www.ebi.ac.uk/pdbsum/2bz6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bz6 OCA], [http://pdbe.org/2bz6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bz6 RCSB], [http://www.ebi.ac.uk/pdbsum/2bz6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2bz6 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bz/2bz6_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bz/2bz6_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bz6 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:17, 11 September 2015

OCA — Fri, 11 Sep 2015 23:17:17 GMT

←Older revision		Revision as of 23:17, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2bz6' size='340' side='right' caption='[[2bz6]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2bz6' size='340' side='right' caption='[[2bz6]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2bz6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BZ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BZ6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2bz6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BZ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BZ6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=346:(R)-(4-CARBAMIMIDOYL-PHENYLAMINO)-[5-ETHOXY-2-FLUORO-3-[(R)-TETRAHYDRO-FURAN-3-YLOXY]-PHENYL]-ACETIC+ACID'>346</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=346:(R)-(4-CARBAMIMIDOYL-PHENYLAMINO)-[5-ETHOXY-2-FLUORO-3-[(R)-TETRAHYDRO-FURAN-3-YLOXY]-PHENYL]-ACETIC+ACID'>346</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bf9\|1bf9]], [[1cvw\|1cvw]], [[1dan\|1dan]], [[1dva\|1dva]], [[1f7e\|1f7e]], [[1f7m\|1f7m]], [[1fak\|1fak]], [[1ff7\|1ff7]], [[1ffm\|1ffm]], [[1j9c\|1j9c]], [[1jbu\|1jbu]], [[1kli\|1kli]], [[1klj\|1klj]], [[1nl8\|1nl8]], [[1o5d\|1o5d]], [[1qfk\|1qfk]], [[1w0y\|1w0y]], [[1w2k\|1w2k]], [[1w7x\|1w7x]], [[1w8b\|1w8b]], [[1ygc\|1ygc]], [[1z6j\|1z6j]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bf9\|1bf9]], [[1cvw\|1cvw]], [[1dan\|1dan]], [[1dva\|1dva]], [[1f7e\|1f7e]], [[1f7m\|1f7m]], [[1fak\|1fak]], [[1ff7\|1ff7]], [[1ffm\|1ffm]], [[1j9c\|1j9c]], [[1jbu\|1jbu]], [[1kli\|1kli]], [[1klj\|1klj]], [[1nl8\|1nl8]], [[1o5d\|1o5d]], [[1qfk\|1qfk]], [[1w0y\|1w0y]], [[1w2k\|1w2k]], [[1w7x\|1w7x]], [[1w8b\|1w8b]], [[1ygc\|1ygc]], [[1z6j\|1z6j]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_VIIa Coagulation factor VIIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.21 3.4.21.21] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_VIIa Coagulation factor VIIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.21 3.4.21.21] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bz6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bz6 RCSB], [http://www.ebi.ac.uk/pdbsum/2bz6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bz6 OCA], [http://pdbe.org/2bz6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bz6 RCSB], [http://www.ebi.ac.uk/pdbsum/2bz6 PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 30:		Line 30:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2bz6" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 38:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Coagulation factor VIIa]]		[[Category: Coagulation factor VIIa]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Ackermann, J]]		[[Category: Ackermann, J]]
	[[Category: Alig, L]]		[[Category: Alig, L]]

OCA at 18:18, 15 January 2015

OCA — Thu, 15 Jan 2015 18:18:44 GMT

←Older revision		Revision as of 18:18, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bz6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BZ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BZ6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bz6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BZ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BZ6 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=346:(R)-(4-CARBAMIMIDOYL-PHENYLAMINO)-[5-ETHOXY-2-FLUORO-3-[(R)-TETRAHYDRO-FURAN-3-YLOXY]-PHENYL]-ACETIC+ACID'>346</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=346:(R)-(4-CARBAMIMIDOYL-PHENYLAMINO)-[5-ETHOXY-2-FLUORO-3-[(R)-TETRAHYDRO-FURAN-3-YLOXY]-PHENYL]-ACETIC+ACID'>346</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bf9\|1bf9]], [[1cvw\|1cvw]], [[1dan\|1dan]], [[1dva\|1dva]], [[1f7e\|1f7e]], [[1f7m\|1f7m]], [[1fak\|1fak]], [[1ff7\|1ff7]], [[1ffm\|1ffm]], [[1j9c\|1j9c]], [[1jbu\|1jbu]], [[1kli\|1kli]], [[1klj\|1klj]], [[1nl8\|1nl8]], [[1o5d\|1o5d]], [[1qfk\|1qfk]], [[1w0y\|1w0y]], [[1w2k\|1w2k]], [[1w7x\|1w7x]], [[1w8b\|1w8b]], [[1ygc\|1ygc]], [[1z6j\|1z6j]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bf9\|1bf9]], [[1cvw\|1cvw]], [[1dan\|1dan]], [[1dva\|1dva]], [[1f7e\|1f7e]], [[1f7m\|1f7m]], [[1fak\|1fak]], [[1ff7\|1ff7]], [[1ffm\|1ffm]], [[1j9c\|1j9c]], [[1jbu\|1jbu]], [[1kli\|1kli]], [[1klj\|1klj]], [[1nl8\|1nl8]], [[1o5d\|1o5d]], [[1qfk\|1qfk]], [[1w0y\|1w0y]], [[1w2k\|1w2k]], [[1w7x\|1w7x]], [[1w8b\|1w8b]], [[1ygc\|1ygc]], [[1z6j\|1z6j]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_VIIa Coagulation factor VIIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.21 3.4.21.21] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_VIIa Coagulation factor VIIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.21 3.4.21.21] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bz6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bz6 RCSB], [http://www.ebi.ac.uk/pdbsum/2bz6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bz6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bz6 RCSB], [http://www.ebi.ac.uk/pdbsum/2bz6 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/FA7_HUMAN FA7_HUMAN]] Defects in F7 are the cause of factor VII deficiency (FA7D) [MIM:[http://omim.org/entry/227500 227500]]. A hemorrhagic disease with variable presentation. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or repeated hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a surgical intervention. Finally, numerous subjects are completely asymptomatic despite very low factor VII levels.<ref>PMID:8043443</ref> <ref>PMID:2070047</ref> <ref>PMID:1634227</ref> <ref>PMID:8364544</ref> <ref>PMID:8204879</ref> <ref>PMID:7981691</ref> <ref>PMID:7974346</ref> <ref>PMID:8652821</ref> <ref>PMID:8844208</ref> <ref>PMID:8940045</ref> <ref>PMID:8883260</ref> <ref>PMID:9414278</ref> <ref>PMID:9576180</ref> <ref>PMID:9452082</ref> <ref>PMID:11091194</ref> <ref>PMID:11129332</ref> <ref>PMID:10862079</ref> <ref>PMID:12472587</ref> <ref>PMID:14717781</ref> <ref>PMID:19751712</ref> <ref>PMID:18976247</ref> <ref>PMID:19432927</ref> <ref>PMID:21206266</ref> <ref>PMID:21372693</ref>		[[http://www.uniprot.org/uniprot/FA7_HUMAN FA7_HUMAN]] Defects in F7 are the cause of factor VII deficiency (FA7D) [MIM:[http://omim.org/entry/227500 227500]]. A hemorrhagic disease with variable presentation. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or repeated hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a surgical intervention. Finally, numerous subjects are completely asymptomatic despite very low factor VII levels.<ref>PMID:8043443</ref> <ref>PMID:2070047</ref> <ref>PMID:1634227</ref> <ref>PMID:8364544</ref> <ref>PMID:8204879</ref> <ref>PMID:7981691</ref> <ref>PMID:7974346</ref> <ref>PMID:8652821</ref> <ref>PMID:8844208</ref> <ref>PMID:8940045</ref> <ref>PMID:8883260</ref> <ref>PMID:9414278</ref> <ref>PMID:9576180</ref> <ref>PMID:9452082</ref> <ref>PMID:11091194</ref> <ref>PMID:11129332</ref> <ref>PMID:10862079</ref> <ref>PMID:12472587</ref> <ref>PMID:14717781</ref> <ref>PMID:19751712</ref> <ref>PMID:18976247</ref> <ref>PMID:19432927</ref> <ref>PMID:21206266</ref> <ref>PMID:21372693</ref>
Line 39:		Line 39:
	[[Category: Coagulation factor VIIa]]		[[Category: Coagulation factor VIIa]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Ackermann, J.]]	+	[[Category: Ackermann, J]]
-	[[Category: Alig, L.]]	+	[[Category: Alig, L]]
-	[[Category: Banner, D W.]]	+	[[Category: Banner, D W]]
-	[[Category: Boehm, H J.]]	+	[[Category: Boehm, H J]]
-	[[Category: Groebke-Zbinden, K.]]	+	[[Category: Groebke-Zbinden, K]]
-	[[Category: Hilpert, K.]]	+	[[Category: Hilpert, K]]
-	[[Category: Kuehne, H.]]	+	[[Category: Kuehne, H]]
-	[[Category: Lave, T.]]	+	[[Category: Lave, T]]
-	[[Category: Obst-Sander, U.]]	+	[[Category: Obst-Sander, U]]
-	[[Category: Riederer, M A.]]	+	[[Category: Riederer, M A]]
-	[[Category: Stahl, M.]]	+	[[Category: Stahl, M]]
-	[[Category: Tschopp, T B.]]	+	[[Category: Tschopp, T B]]
-	[[Category: Weber, L.]]	+	[[Category: Weber, L]]
-	[[Category: Wessel, H P.]]	+	[[Category: Wessel, H P]]
	[[Category: Coagulation]]		[[Category: Coagulation]]
	[[Category: Enzyme complex]]		[[Category: Enzyme complex]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Serine protease]]		[[Category: Serine protease]]

OCA at 02:53, 30 September 2014

OCA — Tue, 30 Sep 2014 02:53:04 GMT

←Older revision		Revision as of 02:53, 30 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2bz6~~\| ~~PDB~~=2bz6 \| ~~SCENE~~= }}	+	==ORALLY AVAILABLE FACTOR7A INHIBITOR==
-	===~~ORALLY AVAILABLE FACTOR7A INHIBITOR~~===	+	<StructureSection load='2bz6' size='340' side='right' caption='[[2bz6]], [[Resolution\|resolution]] 1.60Å' scene=''>
-	~~{{ABSTRACT_PUBMED_16621574}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2bz6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BZ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BZ6 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=346:(R)-(4-CARBAMIMIDOYL-PHENYLAMINO)-[5-ETHOXY-2-FLUORO-3-[(R)-TETRAHYDRO-FURAN-3-YLOXY]-PHENYL]-ACETIC+ACID'>346</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bf9\|1bf9]], [[1cvw\|1cvw]], [[1dan\|1dan]], [[1dva\|1dva]], [[1f7e\|1f7e]], [[1f7m\|1f7m]], [[1fak\|1fak]], [[1ff7\|1ff7]], [[1ffm\|1ffm]], [[1j9c\|1j9c]], [[1jbu\|1jbu]], [[1kli\|1kli]], [[1klj\|1klj]], [[1nl8\|1nl8]], [[1o5d\|1o5d]], [[1qfk\|1qfk]], [[1w0y\|1w0y]], [[1w2k\|1w2k]], [[1w7x\|1w7x]], [[1w8b\|1w8b]], [[1ygc\|1ygc]], [[1z6j\|1z6j]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_VIIa Coagulation factor VIIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.21 3.4.21.21] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bz6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bz6 RCSB], [http://www.ebi.ac.uk/pdbsum/2bz6 PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/FA7_HUMAN FA7_HUMAN]] Defects in F7 are the cause of factor VII deficiency (FA7D) [MIM:[http://omim.org/entry/227500 227500]]. A hemorrhagic disease with variable presentation. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or repeated hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a surgical intervention. Finally, numerous subjects are completely asymptomatic despite very low factor VII levels.<ref>PMID:8043443</ref> <ref>PMID:2070047</ref> <ref>PMID:1634227</ref> <ref>PMID:8364544</ref> <ref>PMID:8204879</ref> <ref>PMID:7981691</ref> <ref>PMID:7974346</ref> <ref>PMID:8652821</ref> <ref>PMID:8844208</ref> <ref>PMID:8940045</ref> <ref>PMID:8883260</ref> <ref>PMID:9414278</ref> <ref>PMID:9576180</ref> <ref>PMID:9452082</ref> <ref>PMID:11091194</ref> <ref>PMID:11129332</ref> <ref>PMID:10862079</ref> <ref>PMID:12472587</ref> <ref>PMID:14717781</ref> <ref>PMID:19751712</ref> <ref>PMID:18976247</ref> <ref>PMID:19432927</ref> <ref>PMID:21206266</ref> <ref>PMID:21372693</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FA7_HUMAN FA7_HUMAN]] Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bz/2bz6_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The discovery of a highly potent and selective tissue factor/factor VIIa inhibitor is described. Upon oral administration of its double prodrug in the guinea pig, a dose-dependent antithrombotic effect is observed in an established model of arterial thrombosis without prolonging bleeding time. The pharmacodynamic properties of this selective inhibitor are compared to the behaviour of a mixed factor VIIa/factor Xa inhibitor.

-	~~==Disease==~~	+	Dose-dependent antithrombotic activity of an orally active tissue factor/factor VIIa inhibitor without concomitant enhancement of bleeding propensity.,Groebke Zbinden K, Banner DW, Hilpert K, Himber J, Lave T, Riederer MA, Stahl M, Tschopp TB, Obst-Sander U Bioorg Med Chem. 2006 Aug 1;14(15):5357-69. Epub 2006 Apr 18. PMID:16621574<ref>PMID:16621574</ref>
-	~~[[http://www.uniprot.org/uniprot/FA7_HUMAN FA7_HUMAN]] Defects in F7 are the cause~~ of factor ~~VII deficiency (FA7D) [MIM:[http:~~/~~/omim~~.~~org/entry/227500 227500]]. A hemorrhagic disease with variable presentation. The clinical picture can be very severe~~, ~~with the early occurrence of intracerebral hemorrhages or repeated hemarthroses~~, or, ~~in contrast~~, ~~moderate with cutaneous~~-~~mucosal hemorrhages~~ (~~epistaxis, menorrhagia~~) ~~or hemorrhages provoked by a surgical intervention~~. ~~Finally, numerous subjects are completely asymptomatic despite very low factor VII levels~~.~~<ref>~~PMID:8043443</ref><ref>PMID:2070047</ref><ref>PMID:1634227</ref><ref>PMID:8364544</ref><ref>PMID:8204879</ref><ref>PMID:7981691</ref><ref>PMID:7974346</ref><ref>PMID:8652821</ref><ref>PMID:8844208</ref><ref>PMID:8940045</ref><ref>PMID:8883260</ref><ref>PMID:9414278</ref><ref>PMID:9576180</ref><ref>PMID:9452082</ref><ref>PMID:11091194</ref><ref>PMID:11129332</ref><ref>PMID:10862079</ref><ref>PMID:12472587</ref><ref>PMID:14717781</ref><ref>PMID:19751712</ref><ref>PMID:18976247</ref><ref>PMID:19432927</ref><ref>PMID:21206266</ref><ref>PMID:~~21372693~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~/~~/www.uniprot.org/uniprot/FA7_HUMAN FA7_HUMAN]] Initiates the extrinsic pathway~~ of ~~blood coagulation. Serine protease that circulates in~~ the ~~blood in a zymogen form~~. ~~Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis~~. ~~In the presence~~ of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.	+	</div>
-		+
-	~~==About this Structure==~~	+
-	~~[[2bz6]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BZ6 OCA].~~	+

	==See Also==		==See Also==
	*[[Factor VIIa\|Factor VIIa]]		*[[Factor VIIa\|Factor VIIa]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:016621574</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Coagulation factor VIIa]]		[[Category: Coagulation factor VIIa]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 02:46, 25 March 2013

OCA — Mon, 25 Mar 2013 02:46:00 GMT

←Older revision		Revision as of 02:46, 25 March 2013
Line 1:		Line 1:
-	[[Image:2bz6.png\|left\|200px]]
-
	{{STRUCTURE_2bz6\| PDB=2bz6 \| SCENE= }}		{{STRUCTURE_2bz6\| PDB=2bz6 \| SCENE= }}
-
	===ORALLY AVAILABLE FACTOR7A INHIBITOR===		===ORALLY AVAILABLE FACTOR7A INHIBITOR===
		+	{{ABSTRACT_PUBMED_16621574}}

-	~~{{ABSTRACT_PUBMED_16621574}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/FA7_HUMAN FA7_HUMAN]] Defects in F7 are the cause of factor VII deficiency (FA7D) [MIM:[http://omim.org/entry/227500 227500]]. A hemorrhagic disease with variable presentation. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or repeated hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a surgical intervention. Finally, numerous subjects are completely asymptomatic despite very low factor VII levels.<ref>PMID:8043443</ref><ref>PMID:2070047</ref><ref>PMID:1634227</ref><ref>PMID:8364544</ref><ref>PMID:8204879</ref><ref>PMID:7981691</ref><ref>PMID:7974346</ref><ref>PMID:8652821</ref><ref>PMID:8844208</ref><ref>PMID:8940045</ref><ref>PMID:8883260</ref><ref>PMID:9414278</ref><ref>PMID:9576180</ref><ref>PMID:9452082</ref><ref>PMID:11091194</ref><ref>PMID:11129332</ref><ref>PMID:10862079</ref><ref>PMID:12472587</ref><ref>PMID:14717781</ref><ref>PMID:19751712</ref><ref>PMID:18976247</ref><ref>PMID:19432927</ref><ref>PMID:21206266</ref><ref>PMID:21372693</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/FA7_HUMAN FA7_HUMAN]] Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.

	==About this Structure==		==About this Structure==
Line 14:		Line 16:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:016621574</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016621574</ref><references group="xtra"/><references/>
	[[Category: Coagulation factor VIIa]]		[[Category: Coagulation factor VIIa]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 21:25, 20 October 2012

OCA — Sat, 20 Oct 2012 21:25:01 GMT

←Older revision		Revision as of 21:25, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2bz6]] is a 2 chain structure ~~of [[Factor VIIa]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BZ6 OCA].	+	[[2bz6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BZ6 OCA].

	==See Also==		==See Also==

OCA at 13:11, 27 July 2012

OCA — Fri, 27 Jul 2012 13:11:15 GMT

←Older revision		Revision as of 13:11, 27 July 2012
Line 1:		Line 1:
	[[Image:2bz6.png\|left\|200px]]		[[Image:2bz6.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2bz6", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2bz6\| PDB=2bz6 \| SCENE= }}		{{STRUCTURE_2bz6\| PDB=2bz6 \| SCENE= }}

	===ORALLY AVAILABLE FACTOR7A INHIBITOR===		===ORALLY AVAILABLE FACTOR7A INHIBITOR===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16621574}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16621574 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16621574}}		{{ABSTRACT_PUBMED_16621574}}

Line 22:		Line 11:

	==See Also==		==See Also==
-	*[[Factor VIIa]]	+	*[[Factor VIIa\|Factor VIIa]]

	==Reference==		==Reference==

←Older revision		Revision as of 13:21, 24 November 2021
Line 3:		Line 3:
	<StructureSection load='2bz6' size='340' side='right'caption='[[2bz6]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2bz6' size='340' side='right'caption='[[2bz6]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2bz6]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BZ6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2BZ6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2bz6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BZ6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=346:(R)-(4-CARBAMIMIDOYL-PHENYLAMINO)-[5-ETHOXY-2-FLUORO-3-[(R)-TETRAHYDRO-FURAN-3-YLOXY]-PHENYL]-ACETIC+ACID'>346</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=346:(R)-(4-CARBAMIMIDOYL-PHENYLAMINO)-[5-ETHOXY-2-FLUORO-3-[(R)-TETRAHYDRO-FURAN-3-YLOXY]-PHENYL]-ACETIC+ACID'>346</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bf9\|1bf9]], [[1cvw\|1cvw]], [[1dan\|1dan]], [[1dva\|1dva]], [[1f7e\|1f7e]], [[1f7m\|1f7m]], [[1fak\|1fak]], [[1ff7\|1ff7]], [[1ffm\|1ffm]], [[1j9c\|1j9c]], [[1jbu\|1jbu]], [[1kli\|1kli]], [[1klj\|1klj]], [[1nl8\|1nl8]], [[1o5d\|1o5d]], [[1qfk\|1qfk]], [[1w0y\|1w0y]], [[1w2k\|1w2k]], [[1w7x\|1w7x]], [[1w8b\|1w8b]], [[1ygc\|1ygc]], [[1z6j\|1z6j]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1bf9\|1bf9]], [[1cvw\|1cvw]], [[1dan\|1dan]], [[1dva\|1dva]], [[1f7e\|1f7e]], [[1f7m\|1f7m]], [[1fak\|1fak]], [[1ff7\|1ff7]], [[1ffm\|1ffm]], [[1j9c\|1j9c]], [[1jbu\|1jbu]], [[1kli\|1kli]], [[1klj\|1klj]], [[1nl8\|1nl8]], [[1o5d\|1o5d]], [[1qfk\|1qfk]], [[1w0y\|1w0y]], [[1w2k\|1w2k]], [[1w7x\|1w7x]], [[1w8b\|1w8b]], [[1ygc\|1ygc]], [[1z6j\|1z6j]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Coagulation_factor_VIIa Coagulation factor VIIa], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.21 3.4.21.21] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Coagulation_factor_VIIa Coagulation factor VIIa], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.21 3.4.21.21] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2bz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bz6 OCA], [~~http~~://pdbe.org/2bz6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2bz6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2bz6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2bz6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bz6 OCA], [https://pdbe.org/2bz6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bz6 RCSB], [https://www.ebi.ac.uk/pdbsum/2bz6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bz6 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/FA7_HUMAN FA7_HUMAN]] Defects in F7 are the cause of factor VII deficiency (FA7D) [MIM:[~~http~~://omim.org/entry/227500 227500]]. A hemorrhagic disease with variable presentation. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or repeated hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a surgical intervention. Finally, numerous subjects are completely asymptomatic despite very low factor VII levels.<ref>PMID:8043443</ref> <ref>PMID:2070047</ref> <ref>PMID:1634227</ref> <ref>PMID:8364544</ref> <ref>PMID:8204879</ref> <ref>PMID:7981691</ref> <ref>PMID:7974346</ref> <ref>PMID:8652821</ref> <ref>PMID:8844208</ref> <ref>PMID:8940045</ref> <ref>PMID:8883260</ref> <ref>PMID:9414278</ref> <ref>PMID:9576180</ref> <ref>PMID:9452082</ref> <ref>PMID:11091194</ref> <ref>PMID:11129332</ref> <ref>PMID:10862079</ref> <ref>PMID:12472587</ref> <ref>PMID:14717781</ref> <ref>PMID:19751712</ref> <ref>PMID:18976247</ref> <ref>PMID:19432927</ref> <ref>PMID:21206266</ref> <ref>PMID:21372693</ref>	+	[[https://www.uniprot.org/uniprot/FA7_HUMAN FA7_HUMAN]] Defects in F7 are the cause of factor VII deficiency (FA7D) [MIM:[https://omim.org/entry/227500 227500]]. A hemorrhagic disease with variable presentation. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or repeated hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a surgical intervention. Finally, numerous subjects are completely asymptomatic despite very low factor VII levels.<ref>PMID:8043443</ref> <ref>PMID:2070047</ref> <ref>PMID:1634227</ref> <ref>PMID:8364544</ref> <ref>PMID:8204879</ref> <ref>PMID:7981691</ref> <ref>PMID:7974346</ref> <ref>PMID:8652821</ref> <ref>PMID:8844208</ref> <ref>PMID:8940045</ref> <ref>PMID:8883260</ref> <ref>PMID:9414278</ref> <ref>PMID:9576180</ref> <ref>PMID:9452082</ref> <ref>PMID:11091194</ref> <ref>PMID:11129332</ref> <ref>PMID:10862079</ref> <ref>PMID:12472587</ref> <ref>PMID:14717781</ref> <ref>PMID:19751712</ref> <ref>PMID:18976247</ref> <ref>PMID:19432927</ref> <ref>PMID:21206266</ref> <ref>PMID:21372693</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FA7_HUMAN FA7_HUMAN]] Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.	+	[[https://www.uniprot.org/uniprot/FA7_HUMAN FA7_HUMAN]] Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]