2c0b - Revision history

OCA at 14:00, 13 December 2023

OCA — Wed, 13 Dec 2023 14:00:27 GMT

←Older revision		Revision as of 14:00, 13 December 2023
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	<StructureSection load='2c0b' size='340' side='right'caption='[[2c0b]], [[Resolution\|resolution]] 3.18Å' scene=''>		<StructureSection load='2c0b' size='340' side='right'caption='[[2c0b]], [[Resolution\|resolution]] 3.18Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2c0b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C0B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2c0b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C0B FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~, ~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.18Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1slj\|1slj]]~~, ~~[[1smx\|1smx]], [[1sn8\|1sn8]], [[2bx2\|2bx2]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0b OCA], [https://pdbe.org/2c0b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c0b RCSB], [https://www.ebi.ac.uk/pdbsum/2c0b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c0b ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0b OCA], [https://pdbe.org/2c0b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c0b RCSB], [https://www.ebi.ac.uk/pdbsum/2c0b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c0b ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/RNE_ECOLI RNE_ECOLI] Matures 5S rRNA from its precursors from all the rRNA genes. It also cleaves RNA I, a molecule that controls the replication of colE1 plasmid DNA. It is the major endoribonuclease participating in mRNA turnover in E.coli. It initiates the decay of RNAs by cutting them internally near their 5'-end. It is able to remove poly(A) tails by an endonucleolytic process.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Callaghan, A J~~]]	+	[[Category: Synthetic construct]]
-	[[Category: ~~Luisi, B F~~]]	+	[[Category: Callaghan AJ]]
-	[[Category: ~~Marcaida, M J~~]]	+	[[Category: Luisi BF]]
-	[[Category: ~~Scott, W G~~]]	+	[[Category: Marcaida MJ]]
-	[[Category: ~~Endonuclease]]~~	+	[[Category: Scott WG]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Nuclease]]~~	+
-	~~[[Category: Ribonuclease]]~~	+
-	~~[[Category: Rna processing]]~~	+
-	~~[[Category: Rna turnover]]~~	+
-	~~[[Category: Rna-binding~~]]	+

OCA at 10:32, 17 February 2021

OCA — Wed, 17 Feb 2021 10:32:34 GMT

←Older revision		Revision as of 10:32, 17 February 2021
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	<StructureSection load='2c0b' size='340' side='right'caption='[[2c0b]], [[Resolution\|resolution]] 3.18Å' scene=''>		<StructureSection load='2c0b' size='340' side='right'caption='[[2c0b]], [[Resolution\|resolution]] 3.18Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2c0b]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0B OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2C0B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2c0b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C0B FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1slj\|1slj]], [[1smx\|1smx]], [[1sn8\|1sn8]], [[2bx2\|2bx2]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1slj\|1slj]], [[1smx\|1smx]], [[1sn8\|1sn8]], [[2bx2\|2bx2]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2c0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0b OCA], [~~http~~://pdbe.org/2c0b PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2c0b RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2c0b PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2c0b ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0b OCA], [https://pdbe.org/2c0b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c0b RCSB], [https://www.ebi.ac.uk/pdbsum/2c0b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c0b ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	==See Also==		==See Also==
-	*[[Ribonuclease\|Ribonuclease]]	+	*[[Ribonuclease 3D structures\|Ribonuclease 3D structures]]
-	*[[Temp\|Temp]]	+
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:54, 10 May 2019

OCA — Fri, 10 May 2019 11:54:13 GMT

←Older revision		Revision as of 11:54, 10 May 2019
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	==Catalytic domain of E. coli RNase E in complex with 13-mer RNA==		==Catalytic domain of E. coli RNase E in complex with 13-mer RNA==
-	<StructureSection load='2c0b' size='340' side='right' caption='[[2c0b]], [[Resolution\|resolution]] 3.18Å' scene=''>	+	<StructureSection load='2c0b' size='340' side='right'caption='[[2c0b]], [[Resolution\|resolution]] 3.18Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2c0b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C0B FirstGlance]. <br>		<table><tr><td colspan='2'>[[2c0b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C0B FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
		+	[[Category: Large Structures]]
	[[Category: Callaghan, A J]]		[[Category: Callaghan, A J]]
	[[Category: Luisi, B F]]		[[Category: Luisi, B F]]

OCA at 07:43, 12 December 2018

OCA — Wed, 12 Dec 2018 07:43:03 GMT

←Older revision		Revision as of 07:43, 12 December 2018
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c0/2c0b_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c0/2c0b_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 17:25, 9 March 2017

OCA — Thu, 09 Mar 2017 17:25:16 GMT

←Older revision		Revision as of 17:25, 9 March 2017
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		+
	==Catalytic domain of E. coli RNase E in complex with 13-mer RNA==		==Catalytic domain of E. coli RNase E in complex with 13-mer RNA==
	<StructureSection load='2c0b' size='340' side='right' caption='[[2c0b]], [[Resolution\|resolution]] 3.18Å' scene=''>		<StructureSection load='2c0b' size='340' side='right' caption='[[2c0b]], [[Resolution\|resolution]] 3.18Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1slj\|1slj]], [[1smx\|1smx]], [[1sn8\|1sn8]], [[2bx2\|2bx2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1slj\|1slj]], [[1smx\|1smx]], [[1sn8\|1sn8]], [[2bx2\|2bx2]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c0b RCSB], [http://www.ebi.ac.uk/pdbsum/2c0b PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0b OCA], [http://pdbe.org/2c0b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c0b RCSB], [http://www.ebi.ac.uk/pdbsum/2c0b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2c0b ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c0b ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2c0b" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 06:35, 20 May 2015

OCA — Wed, 20 May 2015 06:35:08 GMT

←Older revision		Revision as of 06:35, 20 May 2015
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-	==~~CATALYTIC DOMAIN OF~~ E. ~~COLI RNASE~~ E ~~IN COMPLEX WITH~~ 13-~~MER~~ RNA==	+	==Catalytic domain of E. coli RNase E in complex with 13-mer RNA==
	<StructureSection load='2c0b' size='340' side='right' caption='[[2c0b]], [[Resolution\|resolution]] 3.18Å' scene=''>		<StructureSection load='2c0b' size='340' side='right' caption='[[2c0b]], [[Resolution\|resolution]] 3.18Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2c0b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C0B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2c0b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C0B FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DU:2-DEOXYURIDINE-5-MONOPHOSPHATE'>DU</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1slj\|1slj]], [[1smx\|1smx]], [[1sn8\|1sn8]], [[2bx2\|2bx2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1slj\|1slj]], [[1smx\|1smx]], [[1sn8\|1sn8]], [[2bx2\|2bx2]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c0b RCSB], [http://www.ebi.ac.uk/pdbsum/2c0b PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c0b RCSB], [http://www.ebi.ac.uk/pdbsum/2c0b PDBsum]</span></td></tr>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia~~ coli]]	+	[[Category: Bacillus coli migula 1895]]
	[[Category: Callaghan, A J]]		[[Category: Callaghan, A J]]
	[[Category: Luisi, B F]]		[[Category: Luisi, B F]]

OCA at 17:32, 15 January 2015

OCA — Thu, 15 Jan 2015 17:32:31 GMT

←Older revision		Revision as of 17:32, 15 January 2015
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2c0b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C0B FirstGlance]. <br>		<table><tr><td colspan='2'>[[2c0b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C0B FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DU:2-DEOXYURIDINE-5-MONOPHOSPHATE'>DU</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DU:2-DEOXYURIDINE-5-MONOPHOSPHATE'>DU</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1slj\|1slj]], [[1smx\|1smx]], [[1sn8\|1sn8]], [[2bx2\|2bx2]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1slj\|1slj]], [[1smx\|1smx]], [[1sn8\|1sn8]], [[2bx2\|2bx2]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c0b RCSB], [http://www.ebi.ac.uk/pdbsum/2c0b PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c0b RCSB], [http://www.ebi.ac.uk/pdbsum/2c0b PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	==See Also==		==See Also==
	*[[Ribonuclease\|Ribonuclease]]		*[[Ribonuclease\|Ribonuclease]]
		+	*[[Temp\|Temp]]
	== References ==		== References ==
	<references/>		<references/>
Line 34:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Callaghan, A J.]]	+	[[Category: Callaghan, A J]]
-	[[Category: Luisi, B F.]]	+	[[Category: Luisi, B F]]
-	[[Category: Marcaida, M J.]]	+	[[Category: Marcaida, M J]]
-	[[Category: Scott, W G.]]	+	[[Category: Scott, W G]]
	[[Category: Endonuclease]]		[[Category: Endonuclease]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 06:03, 29 September 2014

OCA — Mon, 29 Sep 2014 06:03:16 GMT

←Older revision		Revision as of 06:03, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2c0b.~~png~~\|~~left~~\|200px]]	+	==CATALYTIC DOMAIN OF E. COLI RNASE E IN COMPLEX WITH 13-MER RNA==
		+	<StructureSection load='2c0b' size='340' side='right' caption='[[2c0b]], [[Resolution\|resolution]] 3.18Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2c0b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C0B FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DU:2-DEOXYURIDINE-5-MONOPHOSPHATE'>DU</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1slj\|1slj]], [[1smx\|1smx]], [[1sn8\|1sn8]], [[2bx2\|2bx2]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c0b RCSB], [http://www.ebi.ac.uk/pdbsum/2c0b PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c0/2c0b_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The coordinated regulation of gene expression is required for homeostasis, growth and development in all organisms. Such coordination may be partly achieved at the level of messenger RNA stability, in which the targeted destruction of subsets of transcripts generates the potential for cross-regulating metabolic pathways. In Escherichia coli, the balance and composition of the transcript population is affected by RNase E, an essential endoribonuclease that not only turns over RNA but also processes certain key RNA precursors. RNase E cleaves RNA internally, but its catalytic power is determined by the 5' terminus of the substrate, even if this lies at a distance from the cutting site. Here we report crystal structures of the catalytic domain of RNase E as trapped allosteric intermediates with RNA substrates. Four subunits of RNase E catalytic domain associate into an interwoven quaternary structure, explaining why the subunit organization is required for catalytic activity. The subdomain encompassing the active site is structurally congruent to a deoxyribonuclease, making an unexpected link in the evolutionary history of RNA and DNA nucleases. The structure explains how the recognition of the 5' terminus of the substrate may trigger catalysis and also sheds light on the question of how RNase E might selectively process, rather than destroy, specific RNA precursors.

-	~~{{STRUCTURE_2c0b\| PDB=2c0b \| SCENE= }}~~	+	Structure of Escherichia coli RNase E catalytic domain and implications for RNA turnover.,Callaghan AJ, Marcaida MJ, Stead JA, McDowall KJ, Scott WG, Luisi BF Nature. 2005 Oct 20;437(7062):1187-91. PMID:16237448<ref>PMID:16237448</ref>

-	~~===CATALYTIC DOMAIN OF E. COLI RNASE E IN COMPLEX WITH 13-MER RNA===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16237448}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2c0b]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2C0B OCA].~~	+

	==See Also==		==See Also==
	*[[Ribonuclease\|Ribonuclease]]		*[[Ribonuclease\|Ribonuclease]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:016237448<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Callaghan, A J.]]		[[Category: Callaghan, A J.]]

OCA at 17:56, 20 October 2012

OCA — Sat, 20 Oct 2012 17:56:06 GMT

←Older revision		Revision as of 17:56, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[2c0b]] is a 2 chain structure ~~of [[Ribonuclease]]~~ with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0B OCA].	+	[[2c0b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0B OCA].

	==See Also==		==See Also==

OCA: Protected "2c0b" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 02:27:50 GMT

Protected "2c0b" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:27, 27 July 2012