2c0p - Revision history

OCA at 14:00, 13 December 2023

OCA — Wed, 13 Dec 2023 14:00:56 GMT

←Older revision		Revision as of 14:00, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2c0p' size='340' side='right'caption='[[2c0p]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2c0p' size='340' side='right'caption='[[2c0p]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2c0p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C0P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2c0p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C0P FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ATJ:ETHYL+HYDROGEN+PHOSPHONATE'>ATJ</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1c2b\|1c2b]], [[1c2o\|1c2o]], [[1j06\|1j06]], [[1j07\|1j07]], [[1ku6\|1ku6]], [[1maa\|1maa]], [[1mah\|1mah]], [[1n5m\|1n5m]], [[1n5r\|1n5r]], [[1q83\|1q83]], [[1q84\|1q84]], [[2c0q\|2c0q]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATJ:ETHYL+HYDROGEN+PHOSPHONATE'>ATJ</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c0p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0p OCA], [https://pdbe.org/2c0p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c0p RCSB], [https://www.ebi.ac.uk/pdbsum/2c0p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c0p ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c0p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0p OCA], [https://pdbe.org/2c0p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c0p RCSB], [https://www.ebi.ac.uk/pdbsum/2c0p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c0p ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.	+	[https://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Acetylcholinesterase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Akfur, C]]	+	[[Category: Akfur C]]
-	[[Category: Ekstrom, F]]	+	[[Category: Ekstrom F]]
-	[[Category: Lundberg, S]]	+	[[Category: Lundberg S]]
-	[[Category: Tunemalm, A K]]	+	[[Category: Tunemalm A-K]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Serine esterase~~]]	+

OCA at 09:24, 12 May 2021

OCA — Wed, 12 May 2021 09:24:18 GMT

←Older revision		Revision as of 09:24, 12 May 2021
Line 1:		Line 1:

	==Aged form of mouse acetylcholinesterase inhibited by tabun==		==Aged form of mouse acetylcholinesterase inhibited by tabun==
-	<StructureSection load='2c0p' size='340' side='right' caption='[[2c0p]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='2c0p' size='340' side='right'caption='[[2c0p]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2c0p]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0P OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2C0P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2c0p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C0P FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATJ:ETHYL+HYDROGEN+PHOSPHONATE'>ATJ</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATJ:ETHYL+HYDROGEN+PHOSPHONATE'>ATJ</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c2b\|1c2b]], [[1c2o\|1c2o]], [[1j06\|1j06]], [[1j07\|1j07]], [[1ku6\|1ku6]], [[1maa\|1maa]], [[1mah\|1mah]], [[1n5m\|1n5m]], [[1n5r\|1n5r]], [[1q83\|1q83]], [[1q84\|1q84]], [[2c0q\|2c0q]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1c2b\|1c2b]], [[1c2o\|1c2o]], [[1j06\|1j06]], [[1j07\|1j07]], [[1ku6\|1ku6]], [[1maa\|1maa]], [[1mah\|1mah]], [[1n5m\|1n5m]], [[1n5r\|1n5r]], [[1q83\|1q83]], [[1q84\|1q84]], [[2c0q\|2c0q]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2c0p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0p OCA], [~~http~~://pdbe.org/2c0p PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2c0p RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2c0p PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2c0p ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c0p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0p OCA], [https://pdbe.org/2c0p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c0p RCSB], [https://www.ebi.ac.uk/pdbsum/2c0p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c0p ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.	+	[[https://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	==See Also==		==See Also==
	*[[Acetylcholinesterase 3D structures\|Acetylcholinesterase 3D structures]]		*[[Acetylcholinesterase 3D structures\|Acetylcholinesterase 3D structures]]
-	*[[3D structures of acetylcholinesterase\|3D structures of acetylcholinesterase]]
	== References ==		== References ==
	<references/>		<references/>
Line 39:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Akfur, C]]		[[Category: Akfur, C]]

OCA at 07:20, 17 January 2018

OCA — Wed, 17 Jan 2018 07:20:10 GMT

←Older revision		Revision as of 07:20, 17 January 2018
Line 1:		Line 1:
-	==~~AGED FORM OF MOUSE ACETYLCHOLINESTERASE INHIBITED BY TABUN~~==	+
		+	==Aged form of mouse acetylcholinesterase inhibited by tabun==
	<StructureSection load='2c0p' size='340' side='right' caption='[[2c0p]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2c0p' size='340' side='right' caption='[[2c0p]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c2b\|1c2b]], [[1c2o\|1c2o]], [[1j06\|1j06]], [[1j07\|1j07]], [[1ku6\|1ku6]], [[1maa\|1maa]], [[1mah\|1mah]], [[1n5m\|1n5m]], [[1n5r\|1n5r]], [[1q83\|1q83]], [[1q84\|1q84]], [[2c0q\|2c0q]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c2b\|1c2b]], [[1c2o\|1c2o]], [[1j06\|1j06]], [[1j07\|1j07]], [[1ku6\|1ku6]], [[1maa\|1maa]], [[1mah\|1mah]], [[1n5m\|1n5m]], [[1n5r\|1n5r]], [[1q83\|1q83]], [[1q84\|1q84]], [[2c0q\|2c0q]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c0p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0p OCA], [http://pdbe.org/2c0p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c0p RCSB], [http://www.ebi.ac.uk/pdbsum/2c0p PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c0p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0p OCA], [http://pdbe.org/2c0p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c0p RCSB], [http://www.ebi.ac.uk/pdbsum/2c0p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2c0p ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c0/2c0p_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c0/2c0p_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 31:		Line 32:

	==See Also==		==See Also==
		+	*[[Acetylcholinesterase 3D structures\|Acetylcholinesterase 3D structures]]
	*[[3D structures of acetylcholinesterase\|3D structures of acetylcholinesterase]]		*[[3D structures of acetylcholinesterase\|3D structures of acetylcholinesterase]]
	== References ==		== References ==

OCA at 11:17, 7 February 2016

OCA — Sun, 07 Feb 2016 11:17:42 GMT

←Older revision		Revision as of 11:17, 7 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c0p ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[~~Acetylcholinesterase~~\|~~Acetylcholinesterase~~]]	+	*[[3D structures of acetylcholinesterase\|3D structures of acetylcholinesterase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 00:59, 10 September 2015

OCA — Thu, 10 Sep 2015 00:59:03 GMT

←Older revision		Revision as of 00:59, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2c0p' size='340' side='right' caption='[[2c0p]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2c0p' size='340' side='right' caption='[[2c0p]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2c0p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C0P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2c0p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C0P FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATJ:ETHYL+HYDROGEN+PHOSPHONATE'>ATJ</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATJ:ETHYL+HYDROGEN+PHOSPHONATE'>ATJ</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c2b\|1c2b]], [[1c2o\|1c2o]], [[1j06\|1j06]], [[1j07\|1j07]], [[1ku6\|1ku6]], [[1maa\|1maa]], [[1mah\|1mah]], [[1n5m\|1n5m]], [[1n5r\|1n5r]], [[1q83\|1q83]], [[1q84\|1q84]], [[2c0q\|2c0q]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c2b\|1c2b]], [[1c2o\|1c2o]], [[1j06\|1j06]], [[1j07\|1j07]], [[1ku6\|1ku6]], [[1maa\|1maa]], [[1mah\|1mah]], [[1n5m\|1n5m]], [[1n5r\|1n5r]], [[1q83\|1q83]], [[1q84\|1q84]], [[2c0q\|2c0q]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c0p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c0p RCSB], [http://www.ebi.ac.uk/pdbsum/2c0p PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c0p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0p OCA], [http://pdbe.org/2c0p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c0p RCSB], [http://www.ebi.ac.uk/pdbsum/2c0p PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2c0p" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Akfur, C]]		[[Category: Akfur, C]]
	[[Category: Ekstrom, F]]		[[Category: Ekstrom, F]]

OCA at 14:41, 24 December 2014

OCA — Wed, 24 Dec 2014 14:41:21 GMT

←Older revision		Revision as of 14:41, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2c0p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C0P FirstGlance]. <br>		<table><tr><td colspan='2'>[[2c0p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C0P FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATJ:ETHYL+HYDROGEN+PHOSPHONATE'>ATJ</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATJ:ETHYL+HYDROGEN+PHOSPHONATE'>ATJ</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c2b\|1c2b]], [[1c2o\|1c2o]], [[1j06\|1j06]], [[1j07\|1j07]], [[1ku6\|1ku6]], [[1maa\|1maa]], [[1mah\|1mah]], [[1n5m\|1n5m]], [[1n5r\|1n5r]], [[1q83\|1q83]], [[1q84\|1q84]], [[2c0q\|2c0q]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c2b\|1c2b]], [[1c2o\|1c2o]], [[1j06\|1j06]], [[1j07\|1j07]], [[1ku6\|1ku6]], [[1maa\|1maa]], [[1mah\|1mah]], [[1n5m\|1n5m]], [[1n5r\|1n5r]], [[1q83\|1q83]], [[1q84\|1q84]], [[2c0q\|2c0q]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c0p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c0p RCSB], [http://www.ebi.ac.uk/pdbsum/2c0p PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c0p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c0p RCSB], [http://www.ebi.ac.uk/pdbsum/2c0p PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Akfur, C.]]	+	[[Category: Akfur, C]]
-	[[Category: Ekstrom, F.]]	+	[[Category: Ekstrom, F]]
-	[[Category: Lundberg, S.]]	+	[[Category: Lundberg, S]]
-	[[Category: Tunemalm, A K~~.]]~~	+	[[Category: Tunemalm, A K]]
-	~~[[Category: Acetylcholinesterase~~]]	+
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Serine esterase]]		[[Category: Serine esterase]]

OCA at 04:42, 29 September 2014

OCA — Mon, 29 Sep 2014 04:42:13 GMT

←Older revision		Revision as of 04:42, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2c0p.~~png~~\|~~left~~\|200px]]	+	==AGED FORM OF MOUSE ACETYLCHOLINESTERASE INHIBITED BY TABUN==
		+	<StructureSection load='2c0p' size='340' side='right' caption='[[2c0p]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2c0p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C0P FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATJ:ETHYL+HYDROGEN+PHOSPHONATE'>ATJ</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c2b\|1c2b]], [[1c2o\|1c2o]], [[1j06\|1j06]], [[1j07\|1j07]], [[1ku6\|1ku6]], [[1maa\|1maa]], [[1mah\|1mah]], [[1n5m\|1n5m]], [[1n5r\|1n5r]], [[1q83\|1q83]], [[1q84\|1q84]], [[2c0q\|2c0q]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c0p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c0p RCSB], [http://www.ebi.ac.uk/pdbsum/2c0p PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c0/2c0p_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Organophosphorus compounds (OPs) interfere with the catalytic mechanism of acetylcholinesterase (AChE) by rapidly phosphorylating the catalytic serine residue. The inhibited enzyme can at least partly be reactivated with nucleophilic reactivators such as oximes. The covalently attached OP conjugate may undergo further intramolecular dealkylation or deamidation reactions, a process termed "aging" that results in an enzyme considered completely resistant to reactivation. Of particular interest is the inhibition and aging reaction of the OP compound tabun since tabun conjugates display an extraordinary resistance toward most reactivators of today. To investigate the structural basis for this resistance, we determined the crystal structures of Mus musculus AChE (mAChE) inhibited by tabun prior to and after the aging reaction. The nonaged tabun conjugate induces a structural change of the side chain of His447 that uncouples the catalytic triad and positions the imidazole ring of His447 in a conformation where it may form a hydrogen bond to a water molecule. Moreover, an unexpected displacement of the side chain of Phe338 narrows the active site gorge. In the crystal structure of the aged tabun conjugate, the side chains of His447 and Phe338 are reversed to the conformation found in the apo structure of mAChE. A hydrogen bond between the imidazole ring of His447 and the ethoxy oxygen of the aged tabun conjugate stabilizes the side chain of His447. The displacement of the side chain of Phe338 into the active site gorge of the nonaged tabun conjugate may interfere with the accessibility of reactivators and thereby contribute to the high resistance of tabun conjugates toward reactivation.

-	~~{{STRUCTURE_2c0p\| PDB=2c0p \| SCENE= }}~~	+	Structural changes of phenylalanine 338 and histidine 447 revealed by the crystal structures of tabun-inhibited murine acetylcholinesterase.,Ekstrom F, Akfur C, Tunemalm AK, Lundberg S Biochemistry. 2006 Jan 10;45(1):74-81. PMID:16388582<ref>PMID:16388582</ref>

-	~~===AGED FORM OF MOUSE ACETYLCHOLINESTERASE INHIBITED BY TABUN===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16388582}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2c0p]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2C0P OCA].~~	+

	==See Also==		==See Also==
	*[[Acetylcholinesterase\|Acetylcholinesterase]]		*[[Acetylcholinesterase\|Acetylcholinesterase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:016388582<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]

OCA at 06:28, 20 October 2012

OCA — Sat, 20 Oct 2012 06:28:38 GMT

←Older revision		Revision as of 06:28, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2c0p]] is a 2 chain structure ~~of [[Acetylcholinesterase]]~~ with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0P OCA].	+	[[2c0p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0P OCA].

	==See Also==		==See Also==

OCA at 13:17, 25 July 2012

OCA — Wed, 25 Jul 2012 13:17:43 GMT

←Older revision		Revision as of 13:17, 25 July 2012
Line 1:		Line 1:
	[[Image:2c0p.png\|left\|200px]]		[[Image:2c0p.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2c0p", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2c0p\| PDB=2c0p \| SCENE= }}		{{STRUCTURE_2c0p\| PDB=2c0p \| SCENE= }}

	===AGED FORM OF MOUSE ACETYLCHOLINESTERASE INHIBITED BY TABUN===		===AGED FORM OF MOUSE ACETYLCHOLINESTERASE INHIBITED BY TABUN===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16388582}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16388582 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16388582}}		{{ABSTRACT_PUBMED_16388582}}

Line 22:		Line 11:

	==See Also==		==See Also==
-	*[[Acetylcholinesterase]]	+	*[[Acetylcholinesterase\|Acetylcholinesterase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16388582~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016388582</ref><references group="xtra"/>
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]

OCA: Protected "2c0p" [edit=sysop:move=sysop]

OCA — Mon, 27 Dec 2010 00:17:42 GMT

Protected "2c0p" [edit=sysop:move=sysop]

←Older revision

Revision as of 00:17, 27 December 2010