2c21 - Revision history

OCA at 14:02, 13 December 2023

OCA — Wed, 13 Dec 2023 14:02:49 GMT

←Older revision		Revision as of 14:02, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2c21' size='340' side='right'caption='[[2c21]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2c21' size='340' side='right'caption='[[2c21]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2c21]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Leima Leima~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C21 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C21 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2c21]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C21 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C21 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c21 OCA], [https://pdbe.org/2c21 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c21 RCSB], [https://www.ebi.ac.uk/pdbsum/2c21 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c21 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c21 OCA], [https://pdbe.org/2c21 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c21 RCSB], [https://www.ebi.ac.uk/pdbsum/2c21 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c21 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q68RJ8_LEIMA Q68RJ8_LEIMA]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Leima]]
-	[[Category: Ariza, A]]
-	[[Category: Armour, K A]]
-	[[Category: Bond, C S]]
-	[[Category: Eggleston, I M]]
-	[[Category: Fairlamb, A H]]
-	[[Category: Greig, N]]
-	[[Category: Vickers, T J]]
-	[[Category: Detoxification]]
-	[[Category: Glutathionylspermidine]]
-	[[Category: Glyoxalase i]]
	[[Category: Leishmania major]]		[[Category: Leishmania major]]
-	[[Category: ~~Lyase~~]]	+	[[Category: Ariza A]]
-	[[Category: ~~Methylglyoxal~~]]	+	[[Category: Armour KA]]
-	[[Category: ~~Trypanothione~~]]	+	[[Category: Bond CS]]
		+	[[Category: Eggleston IM]]
		+	[[Category: Fairlamb AH]]
		+	[[Category: Greig N]]
		+	[[Category: Vickers TJ]]

OCA at 06:46, 1 December 2021

OCA — Wed, 01 Dec 2021 06:46:20 GMT

←Older revision		Revision as of 06:46, 1 December 2021
Line 3:		Line 3:
	<StructureSection load='2c21' size='340' side='right'caption='[[2c21]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2c21' size='340' side='right'caption='[[2c21]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2c21]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Leima Leima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C21 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2C21 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2c21]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Leima Leima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C21 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C21 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2c21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c21 OCA], [~~http~~://pdbe.org/2c21 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2c21 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2c21 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2c21 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c21 OCA], [https://pdbe.org/2c21 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c21 RCSB], [https://www.ebi.ac.uk/pdbsum/2c21 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c21 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 11:08, 26 February 2020

OCA — Wed, 26 Feb 2020 11:08:11 GMT

←Older revision		Revision as of 11:08, 26 February 2020
Line 1:		Line 1:

	==Specificity of the Trypanothione-dependednt Leishmania major Glyoxalase I: Structure and biochemical comparison with the human enzyme==		==Specificity of the Trypanothione-dependednt Leishmania major Glyoxalase I: Structure and biochemical comparison with the human enzyme==
-	<StructureSection load='2c21' size='340' side='right' caption='[[2c21]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='2c21' size='340' side='right'caption='[[2c21]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2c21]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Leima Leima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C21 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C21 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2c21]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Leima Leima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C21 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C21 FirstGlance]. <br>
Line 28:		Line 28:

	==See Also==		==See Also==
-	*[[Glyoxalase\|Glyoxalase]]	+	*[[Glyoxalase 3D structures\|Glyoxalase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Leima]]		[[Category: Leima]]
	[[Category: Ariza, A]]		[[Category: Ariza, A]]

OCA at 08:37, 23 May 2018

OCA — Wed, 23 May 2018 08:37:08 GMT

←Older revision		Revision as of 08:37, 23 May 2018
Line 1:		Line 1:
-	==~~SPECIFICITY OF THE TRYPANOTHIONE~~-~~DEPENDEDNT LEISHMANIA MAJOR GLYOXALASE~~ I: ~~STRUCTURE AND BIOCHEMICAL COMPARISON WITH THE HUMAN ENZYME~~==	+
		+	==Specificity of the Trypanothione-dependednt Leishmania major Glyoxalase I: Structure and biochemical comparison with the human enzyme==
	<StructureSection load='2c21' size='340' side='right' caption='[[2c21]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2c21' size='340' side='right' caption='[[2c21]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2c21]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Leima Leima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C21 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C21 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2c21]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Leima Leima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C21 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C21 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c21 OCA], [http://pdbe.org/2c21 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c21 RCSB], [http://www.ebi.ac.uk/pdbsum/2c21 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c21 OCA], [http://pdbe.org/2c21 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c21 RCSB], [http://www.ebi.ac.uk/pdbsum/2c21 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2c21 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c2/2c21_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c2/2c21_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 01:40, 9 February 2016

OCA — Tue, 09 Feb 2016 01:40:13 GMT

←Older revision		Revision as of 01:40, 9 February 2016
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c21 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 17:22, 10 September 2015

OCA — Thu, 10 Sep 2015 17:22:14 GMT

←Older revision		Revision as of 17:22, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2c21' size='340' side='right' caption='[[2c21]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2c21' size='340' side='right' caption='[[2c21]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2c21]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Leishmania_major Leishmania major~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C21 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C21 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2c21]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Leima Leima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C21 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C21 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c21 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c21 RCSB], [http://www.ebi.ac.uk/pdbsum/2c21 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c21 OCA], [http://pdbe.org/2c21 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c21 RCSB], [http://www.ebi.ac.uk/pdbsum/2c21 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2c21" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 31:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Leishmania major~~]]	+	[[Category: Leima]]
	[[Category: Ariza, A]]		[[Category: Ariza, A]]
	[[Category: Armour, K A]]		[[Category: Armour, K A]]
Line 42:		Line 43:
	[[Category: Glutathionylspermidine]]		[[Category: Glutathionylspermidine]]
	[[Category: Glyoxalase i]]		[[Category: Glyoxalase i]]
		+	[[Category: Leishmania major]]
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Methylglyoxal]]		[[Category: Methylglyoxal]]
	[[Category: Trypanothione]]		[[Category: Trypanothione]]

OCA at 18:24, 15 January 2015

OCA — Thu, 15 Jan 2015 18:24:05 GMT

←Older revision		Revision as of 18:24, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2c21]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C21 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C21 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2c21]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C21 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C21 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c21 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c21 RCSB], [http://www.ebi.ac.uk/pdbsum/2c21 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c21 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c21 RCSB], [http://www.ebi.ac.uk/pdbsum/2c21 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Leishmania major]]		[[Category: Leishmania major]]
-	[[Category: Ariza, A.]]	+	[[Category: Ariza, A]]
-	[[Category: Armour, K A.]]	+	[[Category: Armour, K A]]
-	[[Category: Bond, C S.]]	+	[[Category: Bond, C S]]
-	[[Category: Eggleston, I M.]]	+	[[Category: Eggleston, I M]]
-	[[Category: Fairlamb, A H.]]	+	[[Category: Fairlamb, A H]]
-	[[Category: Greig, N.]]	+	[[Category: Greig, N]]
-	[[Category: Vickers, T J.]]	+	[[Category: Vickers, T J]]
	[[Category: Detoxification]]		[[Category: Detoxification]]
	[[Category: Glutathionylspermidine]]		[[Category: Glutathionylspermidine]]
	[[Category: Glyoxalase i]]		[[Category: Glyoxalase i]]
-	[[Category: Leishmania major]]
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Methylglyoxal]]		[[Category: Methylglyoxal]]
	[[Category: Trypanothione]]		[[Category: Trypanothione]]

OCA at 03:10, 29 September 2014

OCA — Mon, 29 Sep 2014 03:10:11 GMT

←Older revision		Revision as of 03:10, 29 September 2014
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-	[[~~Image~~:2c21.~~png\|left~~\|200px]]	+	==SPECIFICITY OF THE TRYPANOTHIONE-DEPENDEDNT LEISHMANIA MAJOR GLYOXALASE I: STRUCTURE AND BIOCHEMICAL COMPARISON WITH THE HUMAN ENZYME==
		+	<StructureSection load='2c21' size='340' side='right' caption='[[2c21]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2c21]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C21 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C21 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c21 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c21 RCSB], [http://www.ebi.ac.uk/pdbsum/2c21 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c2/2c21_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Trypanothione replaces glutathione in defence against cellular damage caused by oxidants, xenobiotics and methylglyoxal in the trypanosomatid parasites, which cause trypanosomiasis and leishmaniasis. In Leishmania major, the first step in methylglyoxal detoxification is performed by a trypanothione-dependent glyoxalase I (GLO1) containing a nickel cofactor; all other characterized eukaryotic glyoxalases use zinc. In kinetic studies L. major and human enzymes were active with methylglyoxal derivatives of several thiols, but showed opposite substrate selectivities: N1-glutathionylspermidine hemithioacetal is 40-fold better with L. major GLO1, whereas glutathione hemithioacetal is 300-fold better with human GLO1. Similarly, S-4-bromobenzylglutathionylspermidine is a 24-fold more potent linear competitive inhibitor of L. major than human GLO1 (Kis of 0.54 microM and 12.6 microM, respectively), whereas S-4-bromobenzylglutathione is >4000-fold more active against human than L. major GLO1 (Kis of 0.13 microM and >500 microM respectively). The crystal structure of L. major GLO1 reveals differences in active site architecture to both human GLO1 and the nickel-dependent Escherichia coli GLO1, including increased negative charge and hydrophobic character and truncation of a loop that may regulate catalysis in the human enzyme. These differences correlate with the differential binding of glutathione and trypanothione-based substrates, and thus offer a route to the rational design of L. major-specific GLO1 inhibitors.

-	~~{{STRUCTURE_2c21\| PDB=2c21 \| SCENE= }}~~	+	Specificity of the trypanothione-dependent Leishmania major glyoxalase I: structure and biochemical comparison with the human enzyme.,Ariza A, Vickers TJ, Greig N, Armour KA, Dixon MJ, Eggleston IM, Fairlamb AH, Bond CS Mol Microbiol. 2006 Feb;59(4):1239-48. PMID:16430697<ref>PMID:16430697</ref>

-	~~===SPECIFICITY OF THE TRYPANOTHIONE-DEPENDEDNT LEISHMANIA MAJOR GLYOXALASE I: STRUCTURE AND BIOCHEMICAL COMPARISON WITH THE HUMAN ENZYME===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16430697}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2c21]] is~~ a ~~6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Leishmania_major Leishmania major]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2C21 OCA].~~	+

	==See Also==		==See Also==
	*[[Glyoxalase\|Glyoxalase]]		*[[Glyoxalase\|Glyoxalase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:016430697<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Leishmania major]]		[[Category: Leishmania major]]
	[[Category: Ariza, A.]]		[[Category: Ariza, A.]]

OCA at 12:12, 20 October 2012

OCA — Sat, 20 Oct 2012 12:12:09 GMT

←Older revision		Revision as of 12:12, 20 October 2012
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	[[Image:2c21.png\|left\|200px]]		[[Image:2c21.png\|left\|200px]]

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	===SPECIFICITY OF THE TRYPANOTHIONE-DEPENDEDNT LEISHMANIA MAJOR GLYOXALASE I: STRUCTURE AND BIOCHEMICAL COMPARISON WITH THE HUMAN ENZYME===		===SPECIFICITY OF THE TRYPANOTHIONE-DEPENDEDNT LEISHMANIA MAJOR GLYOXALASE I: STRUCTURE AND BIOCHEMICAL COMPARISON WITH THE HUMAN ENZYME===

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	{{ABSTRACT_PUBMED_16430697}}		{{ABSTRACT_PUBMED_16430697}}

	==About this Structure==		==About this Structure==
	[[2c21]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C21 OCA].		[[2c21]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C21 OCA].
		+
		+	==See Also==
		+	*[[Glyoxalase\|Glyoxalase]]

	==Reference==		==Reference==

OCA: Protected "2c21" [edit=sysop:move=sysop]

OCA — Sat, 02 Jun 2012 09:33:59 GMT

Protected "2c21" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:33, 2 June 2012