2c2z - Revision history

OCA at 11:25, 22 May 2024

OCA — Wed, 22 May 2024 11:25:17 GMT

←Older revision		Revision as of 11:25, 22 May 2024
Line 3:		Line 3:
	<StructureSection load='2c2z' size='340' side='right'caption='[[2c2z]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='2c2z' size='340' side='right'caption='[[2c2z]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2c2z]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C2Z OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2C2Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2c2z]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C2Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C2Z FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.95Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=MX5:{1-[4-(3,4-DIHYDROQUINOLIN-1(2H)-YL)-4-OXOBUTANOYL]HYDRAZINO}ACETIC+ACID'>MX5</scene>, <scene name='pdbligand=PHQ:BENZYL+CHLOROCARBONATE'>PHQ</scene>~~</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene>, <scene name='pdbligand=MX5:{1-[4-(3,4-DIHYDROQUINOLIN-1(2H)-YL)-4-OXOBUTANOYL]HYDRAZINO}ACETIC+ACID'>MX5</scene>, <scene name='pdbligand=PHQ:BENZYL+CHLOROCARBONATE'>PHQ</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f9e\|1f9e]], [[1i4e\|1i4e]], [[1qdu\|1qdu]], [[1qtn\|1qtn]], [[2fun\|2fun]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c2z OCA], [https://pdbe.org/2c2z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c2z RCSB], [https://www.ebi.ac.uk/pdbsum/2c2z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c2z ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2c2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c2z OCA], [~~http~~://pdbe.org/2c2z PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2c2z RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2c2z PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2c2z ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/CASP8_HUMAN CASP8_HUMAN] Defects in CASP8 are the cause of caspase-8 deficiency (CASP8D) [MIM:[https://omim.org/entry/607271 607271]. CASP8D is a disorder resembling autoimmune lymphoproliferative syndrome (ALPS). It is characterized by lymphadenopathy, splenomegaly, and defective CD95-induced apoptosis of peripheral blood lymphocytes (PBLs). It leads to defects in activation of T-lymphocytes, B-lymphocytes, and natural killer cells leading to immunodeficiency characterized by recurrent sinopulmonary and herpes simplex virus infections and poor responses to immunization.<ref>PMID:12353035</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CASP8_HUMAN CASP8_HUMAN] Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-\|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.<ref>PMID:12010809</ref> <ref>PMID:9006941</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 34:
	==See Also==		==See Also==
	*[[Caspase 3D structures\|Caspase 3D structures]]		*[[Caspase 3D structures\|Caspase 3D structures]]
-	*[[User:Christopher French\|User:Christopher French]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Asgian~~, J L~~]]	+	[[Category: Synthetic construct]]
-	[[Category: Campbell~~, A J~~]]	+	[[Category: Asgian JL]]
-	[[Category: Ekici~~, O D~~]]	+	[[Category: Campbell AJ]]
-	[[Category: Ganesan, R]]	+	[[Category: Ekici OD]]
-	[[Category: Gruetter~~, M G~~]]	+	[[Category: Ganesan R]]
-	[[Category: James~~, K E~~]]	+	[[Category: Gruetter MG]]
-	[[Category: Jelakovic, S]]	+	[[Category: James KE]]
-	[[Category: Li~~, Z Z~~]]	+	[[Category: Jelakovic S]]
-	[[Category: Mikolajczyk, J]]	+	[[Category: Li ZZ]]
-	[[Category: Powers~~, J C~~]]	+	[[Category: Mikolajczyk J]]
-	[[Category: Salvesen~~, G S]]~~	+	[[Category: Powers JC]]
-	~~[[Category: Apoptosis]]~~	+	[[Category: Salvesen GS]]
-	~~[[Category: Aza-asp]]~~	+
-	~~[[Category: Aza-peptide]]~~	+
-	~~[[Category: Clan cd]]~~	+
-	~~[[Category: Cpp32]]~~	+
-	~~[[Category: Cysteine-protease]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Ice]]~~	+
-	~~[[Category: Michael acceptor]]~~	+
-	~~[[Category: Thiol protease]]~~	+
-	~~[[Category: Yama]]~~	+
-	~~[[Category: Zymogen~~]]	+

OCA at 10:40, 16 September 2020

OCA — Wed, 16 Sep 2020 10:40:53 GMT

←Older revision		Revision as of 10:40, 16 September 2020
Line 1:		Line 1:

	==Crystal structure of caspase-8 in complex with aza-peptide Michael acceptor inhibitor==		==Crystal structure of caspase-8 in complex with aza-peptide Michael acceptor inhibitor==
-	<StructureSection load='2c2z' size='340' side='right' caption='[[2c2z]], [[Resolution\|resolution]] 1.95Å' scene=''>	+	<StructureSection load='2c2z' size='340' side='right'caption='[[2c2z]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2c2z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C2Z OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2C2Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2c2z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C2Z OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2C2Z FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MX5:{1-[4-(3,4-DIHYDROQUINOLIN-1(2H)-YL)-4-OXOBUTANOYL]HYDRAZINO}ACETIC+ACID'>MX5</scene>, <scene name='pdbligand=PHQ:BENZYL+CHLOROCARBONATE'>PHQ</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MX5:{1-[4-(3,4-DIHYDROQUINOLIN-1(2H)-YL)-4-OXOBUTANOYL]HYDRAZINO}ACETIC+ACID'>MX5</scene>, <scene name='pdbligand=PHQ:BENZYL+CHLOROCARBONATE'>PHQ</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f9e\|1f9e]], [[1i4e\|1i4e]], [[1qdu\|1qdu]], [[1qtn\|1qtn]], [[2fun\|2fun]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f9e\|1f9e]], [[1i4e\|1i4e]], [[1qdu\|1qdu]], [[1qtn\|1qtn]], [[2fun\|2fun]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2c2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c2z OCA], [http://pdbe.org/2c2z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c2z RCSB], [http://www.ebi.ac.uk/pdbsum/2c2z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2c2z ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2c2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c2z OCA], [http://pdbe.org/2c2z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c2z RCSB], [http://www.ebi.ac.uk/pdbsum/2c2z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2c2z ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Caspase\|Caspase]]	+	*[[Caspase 3D structures\|Caspase 3D structures]]
	*[[User:Christopher French\|User:Christopher French]]		*[[User:Christopher French\|User:Christopher French]]
	== References ==		== References ==
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Asgian, J L]]		[[Category: Asgian, J L]]
	[[Category: Campbell, A J]]		[[Category: Campbell, A J]]

OCA at 07:43, 12 December 2018

OCA — Wed, 12 Dec 2018 07:43:06 GMT

←Older revision		Revision as of 07:43, 12 December 2018
Line 3:		Line 3:
	<StructureSection load='2c2z' size='340' side='right' caption='[[2c2z]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='2c2z' size='340' side='right' caption='[[2c2z]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2c2z]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C2Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C2Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2c2z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C2Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C2Z FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MX5:{1-[4-(3,4-DIHYDROQUINOLIN-1(2H)-YL)-4-OXOBUTANOYL]HYDRAZINO}ACETIC+ACID'>MX5</scene>, <scene name='pdbligand=PHQ:BENZYL+CHLOROCARBONATE'>PHQ</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MX5:{1-[4-(3,4-DIHYDROQUINOLIN-1(2H)-YL)-4-OXOBUTANOYL]HYDRAZINO}ACETIC+ACID'>MX5</scene>, <scene name='pdbligand=PHQ:BENZYL+CHLOROCARBONATE'>PHQ</scene></td></tr>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c2/2c2z_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c2/2c2z_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 36:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Asgian, J L]]		[[Category: Asgian, J L]]
	[[Category: Campbell, A J]]		[[Category: Campbell, A J]]

OCA at 06:54, 9 March 2017

OCA — Thu, 09 Mar 2017 06:54:06 GMT

←Older revision		Revision as of 06:54, 9 March 2017
Line 1:		Line 1:
-	==~~CRYSTAL STRUCTURE OF CASPASE~~-8 ~~IN COMPLEX WITH AZA~~-~~PEPTIDE MICHAEL ACCEPTOR INHIBITOR~~==	+
		+	==Crystal structure of caspase-8 in complex with aza-peptide Michael acceptor inhibitor==
	<StructureSection load='2c2z' size='340' side='right' caption='[[2c2z]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='2c2z' size='340' side='right' caption='[[2c2z]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2c2z]] is a 3 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Human Human]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C2Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C2Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2c2z]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C2Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C2Z FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MX5:{1-[4-(3,4-DIHYDROQUINOLIN-1(2H)-YL)-4-OXOBUTANOYL]HYDRAZINO}ACETIC+ACID'>MX5</scene>, <scene name='pdbligand=PHQ:BENZYL+CHLOROCARBONATE'>PHQ</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MX5:{1-[4-(3,4-DIHYDROQUINOLIN-1(2H)-YL)-4-OXOBUTANOYL]HYDRAZINO}ACETIC+ACID'>MX5</scene>, <scene name='pdbligand=PHQ:BENZYL+CHLOROCARBONATE'>PHQ</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f9e\|1f9e]], [[1i4e\|1i4e]], [[1qdu\|1qdu]], [[1qtn\|1qtn]], [[2fun\|2fun]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f9e\|1f9e]], [[1i4e\|1i4e]], [[1qdu\|1qdu]], [[1qtn\|1qtn]], [[2fun\|2fun]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c2z OCA], [http://pdbe.org/2c2z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c2z RCSB], [http://www.ebi.ac.uk/pdbsum/2c2z PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c2z OCA], [http://pdbe.org/2c2z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c2z RCSB], [http://www.ebi.ac.uk/pdbsum/2c2z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2c2z ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Human]]
	[[Category: Asgian, J L]]		[[Category: Asgian, J L]]
	[[Category: Campbell, A J]]		[[Category: Campbell, A J]]

OCA at 12:44, 9 February 2016

OCA — Tue, 09 Feb 2016 12:44:38 GMT

←Older revision		Revision as of 12:44, 9 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c2z ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:22, 10 September 2015

OCA — Thu, 10 Sep 2015 22:22:30 GMT

←Older revision		Revision as of 22:22, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2c2z' size='340' side='right' caption='[[2c2z]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='2c2z' size='340' side='right' caption='[[2c2z]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2c2z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C2Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C2Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2c2z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C2Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C2Z FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MX5:{1-[4-(3,4-DIHYDROQUINOLIN-1(2H)-YL)-4-OXOBUTANOYL]HYDRAZINO}ACETIC+ACID'>MX5</scene>, <scene name='pdbligand=PHQ:BENZYL+CHLOROCARBONATE'>PHQ</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MX5:{1-[4-(3,4-DIHYDROQUINOLIN-1(2H)-YL)-4-OXOBUTANOYL]HYDRAZINO}ACETIC+ACID'>MX5</scene>, <scene name='pdbligand=PHQ:BENZYL+CHLOROCARBONATE'>PHQ</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f9e\|1f9e]], [[1i4e\|1i4e]], [[1qdu\|1qdu]], [[1qtn\|1qtn]], [[2fun\|2fun]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f9e\|1f9e]], [[1i4e\|1i4e]], [[1qdu\|1qdu]], [[1qtn\|1qtn]], [[2fun\|2fun]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c2z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c2z RCSB], [http://www.ebi.ac.uk/pdbsum/2c2z PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c2z OCA], [http://pdbe.org/2c2z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c2z RCSB], [http://www.ebi.ac.uk/pdbsum/2c2z PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2c2z" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Asgian, J L]]		[[Category: Asgian, J L]]
	[[Category: Campbell, A J]]		[[Category: Campbell, A J]]

OCA at 16:13, 15 January 2015

OCA — Thu, 15 Jan 2015 16:13:13 GMT

←Older revision		Revision as of 16:13, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2c2z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C2Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C2Z FirstGlance]. <br>		<table><tr><td colspan='2'>[[2c2z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C2Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C2Z FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MX5:{1-[4-(3,4-DIHYDROQUINOLIN-1(2H)-YL)-4-OXOBUTANOYL]HYDRAZINO}ACETIC+ACID'>MX5</scene>, <scene name='pdbligand=PHQ:BENZYL+CHLOROCARBONATE'>PHQ</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MX5:{1-[4-(3,4-DIHYDROQUINOLIN-1(2H)-YL)-4-OXOBUTANOYL]HYDRAZINO}ACETIC+ACID'>MX5</scene>, <scene name='pdbligand=PHQ:BENZYL+CHLOROCARBONATE'>PHQ</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f9e\|1f9e]], [[1i4e\|1i4e]], [[1qdu\|1qdu]], [[1qtn\|1qtn]], [[2fun\|2fun]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f9e\|1f9e]], [[1i4e\|1i4e]], [[1qdu\|1qdu]], [[1qtn\|1qtn]], [[2fun\|2fun]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c2z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c2z RCSB], [http://www.ebi.ac.uk/pdbsum/2c2z PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c2z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c2z RCSB], [http://www.ebi.ac.uk/pdbsum/2c2z PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Asgian, J L.]]	+	[[Category: Asgian, J L]]
-	[[Category: Campbell, A J.]]	+	[[Category: Campbell, A J]]
-	[[Category: Ekici, O D.]]	+	[[Category: Ekici, O D]]
-	[[Category: Ganesan, R.]]	+	[[Category: Ganesan, R]]
-	[[Category: Gruetter, M G.]]	+	[[Category: Gruetter, M G]]
-	[[Category: James, K E.]]	+	[[Category: James, K E]]
-	[[Category: Jelakovic, S.]]	+	[[Category: Jelakovic, S]]
-	[[Category: Li, Z Z.]]	+	[[Category: Li, Z Z]]
-	[[Category: Mikolajczyk, J.]]	+	[[Category: Mikolajczyk, J]]
-	[[Category: Powers, J C.]]	+	[[Category: Powers, J C]]
-	[[Category: Salvesen, G S.]]	+	[[Category: Salvesen, G S]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]
	[[Category: Aza-asp]]		[[Category: Aza-asp]]

OCA at 23:52, 29 September 2014

OCA — Mon, 29 Sep 2014 23:52:16 GMT

←Older revision		Revision as of 23:52, 29 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2c2z\| PDB=2c2z \| SCENE= }}~~	+	==CRYSTAL STRUCTURE OF CASPASE-8 IN COMPLEX WITH AZA-PEPTIDE MICHAEL ACCEPTOR INHIBITOR==
-	===CRYSTAL STRUCTURE OF CASPASE-8 IN COMPLEX WITH AZA-PEPTIDE MICHAEL ACCEPTOR INHIBITOR===	+	<StructureSection load='2c2z' size='340' side='right' caption='[[2c2z]], [[Resolution\|resolution]] 1.95Å' scene=''>
-	{~~{ABSTRACT_PUBMED_16970398}~~}	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2c2z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C2Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C2Z FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MX5:{1-[4-(3,4-DIHYDROQUINOLIN-1(2H)-YL)-4-OXOBUTANOYL]HYDRAZINO}ACETIC+ACID'>MX5</scene>, <scene name='pdbligand=PHQ:BENZYL+CHLOROCARBONATE'>PHQ</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f9e\|1f9e]], [[1i4e\|1i4e]], [[1qdu\|1qdu]], [[1qtn\|1qtn]], [[2fun\|2fun]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c2z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c2z RCSB], [http://www.ebi.ac.uk/pdbsum/2c2z PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c2/2c2z_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Aza-peptide Michael acceptors are a novel class of inhibitors that are potent and specific for caspases-2, -3, -6, -7, -8, -9, and -10. The second-order rate constants are in the order of 10(6) M(-1) s(-1). The aza-peptide Michael acceptor inhibitor 18t (Cbz-Asp-Glu-Val-AAsp-trans-CH=CH-CON(CH(2)-1-Naphth)(2) is the most potent compound and it inhibits caspase-3 with a k(2) value of 5620000 M(-1) s(-1). The inhibitor 18t is 13700, 190, 6.4, 594, 37500, and 173-fold more selective for caspase-3 over caspases-2, -6, -7, -8, -9, and -10, respectively. Aza-peptide Michael acceptors designed with caspase specific sequences are selective and do not show any cross reactivity with clan CA cysteine proteases such as papain, cathepsin B, and calpains. High-resolution crystal structures of caspase-3 and caspase-8 in complex with aza-peptide Michael acceptor inhibitors demonstrate the nucleophilic attack on C2 and provide insight into the selectivity and potency of the inhibitors with respect to the P1' moiety.

-	~~==About this Structure==~~	+	Design, synthesis, and evaluation of aza-peptide Michael acceptors as selective and potent inhibitors of caspases-2, -3, -6, -7, -8, -9, and -10.,Ekici OD, Li ZZ, Campbell AJ, James KE, Asgian JL, Mikolajczyk J, Salvesen GS, Ganesan R, Jelakovic S, Grutter MG, Powers JC J Med Chem. 2006 Sep 21;49(19):5728-49. PMID:16970398<ref>PMID:16970398</ref>
-	~~[[2c2z]] is a~~ 3 ~~chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=2C2Z OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Caspase\|Caspase]]		*[[Caspase\|Caspase]]
	*[[User:Christopher French\|User:Christopher French]]		*[[User:Christopher French\|User:Christopher French]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:016970398</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Asgian, J L.]]		[[Category: Asgian, J L.]]

OCA at 09:05, 24 March 2013

OCA — Sun, 24 Mar 2013 09:05:26 GMT

←Older revision		Revision as of 09:05, 24 March 2013
Line 11:		Line 11:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:016970398</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016970398</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Asgian, J L.]]		[[Category: Asgian, J L.]]

OCA at 09:11, 11 March 2013

OCA — Mon, 11 Mar 2013 09:11:37 GMT

←Older revision		Revision as of 09:11, 11 March 2013
Line 1:		Line 1:
-	[[Image:2c2z.png\|left\|200px]]
-
	{{STRUCTURE_2c2z\| PDB=2c2z \| SCENE= }}		{{STRUCTURE_2c2z\| PDB=2c2z \| SCENE= }}
-
	===CRYSTAL STRUCTURE OF CASPASE-8 IN COMPLEX WITH AZA-PEPTIDE MICHAEL ACCEPTOR INHIBITOR===		===CRYSTAL STRUCTURE OF CASPASE-8 IN COMPLEX WITH AZA-PEPTIDE MICHAEL ACCEPTOR INHIBITOR===
-
	{{ABSTRACT_PUBMED_16970398}}		{{ABSTRACT_PUBMED_16970398}}