2c5n - Revision history

OCA at 14:06, 13 December 2023

OCA — Wed, 13 Dec 2023 14:06:38 GMT

←Older revision		Revision as of 14:06, 13 December 2023
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	<StructureSection load='2c5n' size='340' side='right'caption='[[2c5n]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2c5n' size='340' side='right'caption='[[2c5n]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2c5n]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C5N OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2C5N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2c5n]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C5N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C5N FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CK8:N~~-[~~4-(~~2~~,4-DIMETHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-N,N-DIMETHYL-BENZENE-~~1~~,4-DIAMINE'>CK8</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1aq1\|1aq1]], [[1b38\|1b38]], [[1b39\|1b39]], [[1buh\|1buh]], [[1ckp\|1ckp]], [[1di8\|1di8]], [[1dm2\|1dm2]], [[1e1v\|1e1v]], [[1e1x\|1e1x]], [[1e9h\|1e9h]], [[1f5q\|1f5q]], [[1fin\|1fin]], [[1fq1\|1fq1]], [[1fvt\|1fvt]], [[1fvv\|1fvv]], [[1g5s\|1g5s]], [[1gih\|1gih]], [[1gii\|1gii]], [[1gij\|1gij]], [[1gy3\|1gy3]], [[1gz8\|1gz8]], [[1h00\|1h00]], [[1h01\|1h01]], [[1h07\|1h07]], [[1h08\|1h08]], [[1h0v\|1h0v]], [[1h0w\|1h0w]], [[1h1p\|1h1p]], [[1h1q\|1h1q]], [[1h1r\|1h1r]], [[1h1s\|1h1s]], [[1h24\|1h24]], [[1h25\|1h25]], [[1h26\|1h26]], [[1h27\|1h27]], [[1h28\|1h28]], [[1hck\|1hck]], [[1hcl\|1hcl]], [[1jst\|1jst]], [[1jsu\|1jsu]], [[1jsv\|1jsv]], [[1jvp\|1jvp]], [[1ke5\|1ke5]], [[1ke6\|1ke6]], [[1ke7\|1ke7]], [[1ke8\|1ke8]], [[1ke9\|1ke9]], [[1ogu\|1ogu]], [[1oi9\|1oi9]], [[1oiq\|1oiq]], [[1oir\|1oir]], [[1oit\|1oit]], [[1oiu\|1oiu]], [[1oiy\|1oiy]], [[1oku\|1oku]], [[1okv\|1okv]], [[1okw\|1okw]], [[1ol1\|1ol1]], [[1ol2\|1ol2]], [[1p2a\|1p2a]], [[1p5e\|1p5e]], [[1pf8\|1pf8]], [[1pkd\|1pkd]], [[1pw2\|1pw2]], [[1pxi\|1pxi]], [[1pxj\|1pxj]], [[1pxk\|1pxk]], [[1pxl\|1pxl]], [[1pxm\|1pxm]], [[1pxn\|1pxn]], [[1pxo\|1pxo]], [[1pxp\|1pxp]], [[1pye\|1pye]], [[1qmz\|1qmz]], [[1r78\|1r78]], [[1urc\|1urc]], [[1urw\|1urw]], [[1v1k\|1v1k]], [[1vyw\|1vyw]], [[1vyz\|1vyz]], [[1w0x\|1w0x]], [[1w8c\|1w8c]], [[1w98\|1w98]], [[1wcc\|1wcc]], [[1y8y\|1y8y]], [[1y91\|1y91]], [[2b52\|2b52]], [[2b53\|2b53]], [[2b54\|2b54]], [[2b55\|2b55]], [[2bhe\|2bhe]], [[2bhh\|2bhh]], [[2bkz\|2bkz]], [[2bpm\|2bpm]], [[2btr\|2btr]], [[2bts\|2bts]], [[2c4g\|2c4g]], [[2c5o\|2c5o]], [[2c5p\|2c5p]], [[2c5t\|2c5t]], [[2c5x\|2c5x]], [[2c5y\|2c5y]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CK8:N-[4-(2,4-DIMETHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-N,N-DIMETHYL-BENZENE-1,4-DIAMINE'>CK8</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[http~~:~~//en.wikipedia.org/wiki/Transferase Transferase], with EC number~~ [~~http://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=~~2~~.7.11.1~~, 2~~.7.11.8~~, ~~2.7.11.9, 2.7.11.10, 2.7.11.11, 2.7.11.12, 2.7.11.13, 2.7.11.21, 2.7.11.22, 2.7.11.24, 2.7.11.25, 2.7.11.30 and 2.7.12.1 2.7.11.~~1, ~~2.7.11.8, 2.7.11.9, 2.7.11.10, 2.7.11.11, 2.7.11.12, 2.7.11.13, 2.7.11.21, 2.7.11.22, 2.7.11.24, 2.7.11.25, 2.7.11.30 and 2.7.12.1]~~ </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c5n OCA], [https://pdbe.org/2c5n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c5n RCSB], [https://www.ebi.ac.uk/pdbsum/2c5n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c5n ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2c5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c5n OCA], [~~http~~://pdbe.org/2c5n PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2c5n RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2c5n PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2c5n ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CDK2_HUMAN CDK2_HUMAN]] Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization.<ref>PMID:10499802</ref> <ref>PMID:11051553</ref> <ref>PMID:10995386</ref> <ref>PMID:10995387</ref> <ref>PMID:10884347</ref> <ref>PMID:11113184</ref> <ref>PMID:15800615</ref> <ref>PMID:18372919</ref> <ref>PMID:20147522</ref> <ref>PMID:20079829</ref> <ref>PMID:20935635</ref> <ref>PMID:20195506</ref> <ref>PMID:19966300</ref> <ref>PMID:21262353</ref> <ref>PMID:21596315</ref> <ref>PMID:21319273</ref> <ref>PMID:17495531</ref> ~~[[http://www.uniprot.org/uniprot/CCNA2_HUMAN CCNA2_HUMAN]] Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions.~~	+	[https://www.uniprot.org/uniprot/CDK2_HUMAN CDK2_HUMAN] Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization.<ref>PMID:10499802</ref> <ref>PMID:11051553</ref> <ref>PMID:10995386</ref> <ref>PMID:10995387</ref> <ref>PMID:10884347</ref> <ref>PMID:11113184</ref> <ref>PMID:15800615</ref> <ref>PMID:18372919</ref> <ref>PMID:20147522</ref> <ref>PMID:20079829</ref> <ref>PMID:20935635</ref> <ref>PMID:20195506</ref> <ref>PMID:19966300</ref> <ref>PMID:21262353</ref> <ref>PMID:21596315</ref> <ref>PMID:21319273</ref> <ref>PMID:17495531</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Transferase]]~~	+	[[Category: Fischer PM]]
-	[[Category: Fischer~~, P M~~]]	+	[[Category: Gibson D]]
-	[[Category: Gibson, D]]	+	[[Category: Kontopidis G]]
-	[[Category: Kontopidis, G]]	+	[[Category: McInnes C]]
-	[[Category: McInnes, C]]	+	[[Category: McNae I]]
-	[[Category: McNae, I]]	+	[[Category: Mezna M]]
-	[[Category: Mezna, M]]	+	[[Category: Pandalaneni SR]]
-	[[Category: Pandalaneni~~, S R~~]]	+	[[Category: Thomas M]]
-	[[Category: Thomas, M]]	+	[[Category: Walkinshaw MD]]
-	[[Category: Walkinshaw~~, M D~~]]	+	[[Category: Wang S]]
-	[[Category: Wang, S]]	+	[[Category: Wood G]]
-	[[Category: Wood, G]]	+
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Cdk2]]~~	+
-	~~[[Category: Cell cycle]]~~	+
-	~~[[Category: Cell division]]~~	+
-	~~[[Category: Cyclin]]~~	+
-	~~[[Category: Differential inhibition]]~~	+
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Mitosis]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Phosphorylation]]~~	+
-	~~[[Category: Polymorphism]]~~	+
-	~~[[Category: Serine/threonine-protein~~]]	+

OCA at 04:41, 19 November 2020

OCA — Thu, 19 Nov 2020 04:41:01 GMT

←Older revision		Revision as of 04:41, 19 November 2020
Line 3:		Line 3:
	<StructureSection load='2c5n' size='340' side='right'caption='[[2c5n]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2c5n' size='340' side='right'caption='[[2c5n]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2c5n]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C5N OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2C5N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2c5n]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C5N OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2C5N FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CK8:N-[4-(2,4-DIMETHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-N,N-DIMETHYL-BENZENE-1,4-DIAMINE'>CK8</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CK8:N-[4-(2,4-DIMETHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-N,N-DIMETHYL-BENZENE-1,4-DIAMINE'>CK8</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aq1\|1aq1]], [[1b38\|1b38]], [[1b39\|1b39]], [[1buh\|1buh]], [[1ckp\|1ckp]], [[1di8\|1di8]], [[1dm2\|1dm2]], [[1e1v\|1e1v]], [[1e1x\|1e1x]], [[1e9h\|1e9h]], [[1f5q\|1f5q]], [[1fin\|1fin]], [[1fq1\|1fq1]], [[1fvt\|1fvt]], [[1fvv\|1fvv]], [[1g5s\|1g5s]], [[1gih\|1gih]], [[1gii\|1gii]], [[1gij\|1gij]], [[1gy3\|1gy3]], [[1gz8\|1gz8]], [[1h00\|1h00]], [[1h01\|1h01]], [[1h07\|1h07]], [[1h08\|1h08]], [[1h0v\|1h0v]], [[1h0w\|1h0w]], [[1h1p\|1h1p]], [[1h1q\|1h1q]], [[1h1r\|1h1r]], [[1h1s\|1h1s]], [[1h24\|1h24]], [[1h25\|1h25]], [[1h26\|1h26]], [[1h27\|1h27]], [[1h28\|1h28]], [[1hck\|1hck]], [[1hcl\|1hcl]], [[1jst\|1jst]], [[1jsu\|1jsu]], [[1jsv\|1jsv]], [[1jvp\|1jvp]], [[1ke5\|1ke5]], [[1ke6\|1ke6]], [[1ke7\|1ke7]], [[1ke8\|1ke8]], [[1ke9\|1ke9]], [[1ogu\|1ogu]], [[1oi9\|1oi9]], [[1oiq\|1oiq]], [[1oir\|1oir]], [[1oit\|1oit]], [[1oiu\|1oiu]], [[1oiy\|1oiy]], [[1oku\|1oku]], [[1okv\|1okv]], [[1okw\|1okw]], [[1ol1\|1ol1]], [[1ol2\|1ol2]], [[1p2a\|1p2a]], [[1p5e\|1p5e]], [[1pf8\|1pf8]], [[1pkd\|1pkd]], [[1pw2\|1pw2]], [[1pxi\|1pxi]], [[1pxj\|1pxj]], [[1pxk\|1pxk]], [[1pxl\|1pxl]], [[1pxm\|1pxm]], [[1pxn\|1pxn]], [[1pxo\|1pxo]], [[1pxp\|1pxp]], [[1pye\|1pye]], [[1qmz\|1qmz]], [[1r78\|1r78]], [[1urc\|1urc]], [[1urw\|1urw]], [[1v1k\|1v1k]], [[1vyw\|1vyw]], [[1vyz\|1vyz]], [[1w0x\|1w0x]], [[1w8c\|1w8c]], [[1w98\|1w98]], [[1wcc\|1wcc]], [[1y8y\|1y8y]], [[1y91\|1y91]], [[2b52\|2b52]], [[2b53\|2b53]], [[2b54\|2b54]], [[2b55\|2b55]], [[2bhe\|2bhe]], [[2bhh\|2bhh]], [[2bkz\|2bkz]], [[2bpm\|2bpm]], [[2btr\|2btr]], [[2bts\|2bts]], [[2c4g\|2c4g]], [[2c5o\|2c5o]], [[2c5p\|2c5p]], [[2c5t\|2c5t]], [[2c5x\|2c5x]], [[2c5y\|2c5y]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1aq1\|1aq1]], [[1b38\|1b38]], [[1b39\|1b39]], [[1buh\|1buh]], [[1ckp\|1ckp]], [[1di8\|1di8]], [[1dm2\|1dm2]], [[1e1v\|1e1v]], [[1e1x\|1e1x]], [[1e9h\|1e9h]], [[1f5q\|1f5q]], [[1fin\|1fin]], [[1fq1\|1fq1]], [[1fvt\|1fvt]], [[1fvv\|1fvv]], [[1g5s\|1g5s]], [[1gih\|1gih]], [[1gii\|1gii]], [[1gij\|1gij]], [[1gy3\|1gy3]], [[1gz8\|1gz8]], [[1h00\|1h00]], [[1h01\|1h01]], [[1h07\|1h07]], [[1h08\|1h08]], [[1h0v\|1h0v]], [[1h0w\|1h0w]], [[1h1p\|1h1p]], [[1h1q\|1h1q]], [[1h1r\|1h1r]], [[1h1s\|1h1s]], [[1h24\|1h24]], [[1h25\|1h25]], [[1h26\|1h26]], [[1h27\|1h27]], [[1h28\|1h28]], [[1hck\|1hck]], [[1hcl\|1hcl]], [[1jst\|1jst]], [[1jsu\|1jsu]], [[1jsv\|1jsv]], [[1jvp\|1jvp]], [[1ke5\|1ke5]], [[1ke6\|1ke6]], [[1ke7\|1ke7]], [[1ke8\|1ke8]], [[1ke9\|1ke9]], [[1ogu\|1ogu]], [[1oi9\|1oi9]], [[1oiq\|1oiq]], [[1oir\|1oir]], [[1oit\|1oit]], [[1oiu\|1oiu]], [[1oiy\|1oiy]], [[1oku\|1oku]], [[1okv\|1okv]], [[1okw\|1okw]], [[1ol1\|1ol1]], [[1ol2\|1ol2]], [[1p2a\|1p2a]], [[1p5e\|1p5e]], [[1pf8\|1pf8]], [[1pkd\|1pkd]], [[1pw2\|1pw2]], [[1pxi\|1pxi]], [[1pxj\|1pxj]], [[1pxk\|1pxk]], [[1pxl\|1pxl]], [[1pxm\|1pxm]], [[1pxn\|1pxn]], [[1pxo\|1pxo]], [[1pxp\|1pxp]], [[1pye\|1pye]], [[1qmz\|1qmz]], [[1r78\|1r78]], [[1urc\|1urc]], [[1urw\|1urw]], [[1v1k\|1v1k]], [[1vyw\|1vyw]], [[1vyz\|1vyz]], [[1w0x\|1w0x]], [[1w8c\|1w8c]], [[1w98\|1w98]], [[1wcc\|1wcc]], [[1y8y\|1y8y]], [[1y91\|1y91]], [[2b52\|2b52]], [[2b53\|2b53]], [[2b54\|2b54]], [[2b55\|2b55]], [[2bhe\|2bhe]], [[2bhh\|2bhh]], [[2bkz\|2bkz]], [[2bpm\|2bpm]], [[2btr\|2btr]], [[2bts\|2bts]], [[2c4g\|2c4g]], [[2c5o\|2c5o]], [[2c5p\|2c5p]], [[2c5t\|2c5t]], [[2c5x\|2c5x]], [[2c5y\|2c5y]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1, 2.7.11.8, 2.7.11.9, 2.7.11.10, 2.7.11.11, 2.7.11.12, 2.7.11.13, 2.7.11.21, 2.7.11.22, 2.7.11.24, 2.7.11.25, 2.7.11.30 and 2.7.12.1 2.7.11.1, 2.7.11.8, 2.7.11.9, 2.7.11.10, 2.7.11.11, 2.7.11.12, 2.7.11.13, 2.7.11.21, 2.7.11.22, 2.7.11.24, 2.7.11.25, 2.7.11.30 and 2.7.12.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1, 2.7.11.8, 2.7.11.9, 2.7.11.10, 2.7.11.11, 2.7.11.12, 2.7.11.13, 2.7.11.21, 2.7.11.22, 2.7.11.24, 2.7.11.25, 2.7.11.30 and 2.7.12.1 2.7.11.1, 2.7.11.8, 2.7.11.9, 2.7.11.10, 2.7.11.11, 2.7.11.12, 2.7.11.13, 2.7.11.21, 2.7.11.22, 2.7.11.24, 2.7.11.25, 2.7.11.30 and 2.7.12.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2c5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c5n OCA], [http://pdbe.org/2c5n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c5n RCSB], [http://www.ebi.ac.uk/pdbsum/2c5n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2c5n ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2c5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c5n OCA], [http://pdbe.org/2c5n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c5n RCSB], [http://www.ebi.ac.uk/pdbsum/2c5n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2c5n ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[Cyclin\|Cyclin]]	+	*[[Cyclin 3D structures\|Cyclin 3D structures]]
-	*[[Cyclin-dependent kinase\|Cyclin-dependent kinase]]	+	*[[Cyclin-dependent kinase 3D structures\|Cyclin-dependent kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:23, 3 April 2019

OCA — Wed, 03 Apr 2019 07:23:35 GMT

←Older revision		Revision as of 07:23, 3 April 2019
Line 1:		Line 1:

	==Differential Binding Of Inhibitors To Active And Inactive Cdk2 Provides Insights For Drug Design==		==Differential Binding Of Inhibitors To Active And Inactive Cdk2 Provides Insights For Drug Design==
-	<StructureSection load='2c5n' size='340' side='right' caption='[[2c5n]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='2c5n' size='340' side='right'caption='[[2c5n]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2c5n]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C5N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C5N FirstGlance]. <br>		<table><tr><td colspan='2'>[[2c5n]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C5N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C5N FirstGlance]. <br>
Line 39:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Fischer, P M]]		[[Category: Fischer, P M]]

OCA at 07:58, 23 May 2018

OCA — Wed, 23 May 2018 07:58:04 GMT

←Older revision		Revision as of 07:58, 23 May 2018
Line 1:		Line 1:
-	==~~DIFFERENTIAL BINDING OF INHIBITORS TO ACTIVE AND INACTIVE CDK2 PROVIDES INSIGHTS FOR DRUG DESIGN~~==	+
		+	==Differential Binding Of Inhibitors To Active And Inactive Cdk2 Provides Insights For Drug Design==
	<StructureSection load='2c5n' size='340' side='right' caption='[[2c5n]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2c5n' size='340' side='right' caption='[[2c5n]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aq1\|1aq1]], [[1b38\|1b38]], [[1b39\|1b39]], [[1buh\|1buh]], [[1ckp\|1ckp]], [[1di8\|1di8]], [[1dm2\|1dm2]], [[1e1v\|1e1v]], [[1e1x\|1e1x]], [[1e9h\|1e9h]], [[1f5q\|1f5q]], [[1fin\|1fin]], [[1fq1\|1fq1]], [[1fvt\|1fvt]], [[1fvv\|1fvv]], [[1g5s\|1g5s]], [[1gih\|1gih]], [[1gii\|1gii]], [[1gij\|1gij]], [[1gy3\|1gy3]], [[1gz8\|1gz8]], [[1h00\|1h00]], [[1h01\|1h01]], [[1h07\|1h07]], [[1h08\|1h08]], [[1h0v\|1h0v]], [[1h0w\|1h0w]], [[1h1p\|1h1p]], [[1h1q\|1h1q]], [[1h1r\|1h1r]], [[1h1s\|1h1s]], [[1h24\|1h24]], [[1h25\|1h25]], [[1h26\|1h26]], [[1h27\|1h27]], [[1h28\|1h28]], [[1hck\|1hck]], [[1hcl\|1hcl]], [[1jst\|1jst]], [[1jsu\|1jsu]], [[1jsv\|1jsv]], [[1jvp\|1jvp]], [[1ke5\|1ke5]], [[1ke6\|1ke6]], [[1ke7\|1ke7]], [[1ke8\|1ke8]], [[1ke9\|1ke9]], [[1ogu\|1ogu]], [[1oi9\|1oi9]], [[1oiq\|1oiq]], [[1oir\|1oir]], [[1oit\|1oit]], [[1oiu\|1oiu]], [[1oiy\|1oiy]], [[1oku\|1oku]], [[1okv\|1okv]], [[1okw\|1okw]], [[1ol1\|1ol1]], [[1ol2\|1ol2]], [[1p2a\|1p2a]], [[1p5e\|1p5e]], [[1pf8\|1pf8]], [[1pkd\|1pkd]], [[1pw2\|1pw2]], [[1pxi\|1pxi]], [[1pxj\|1pxj]], [[1pxk\|1pxk]], [[1pxl\|1pxl]], [[1pxm\|1pxm]], [[1pxn\|1pxn]], [[1pxo\|1pxo]], [[1pxp\|1pxp]], [[1pye\|1pye]], [[1qmz\|1qmz]], [[1r78\|1r78]], [[1urc\|1urc]], [[1urw\|1urw]], [[1v1k\|1v1k]], [[1vyw\|1vyw]], [[1vyz\|1vyz]], [[1w0x\|1w0x]], [[1w8c\|1w8c]], [[1w98\|1w98]], [[1wcc\|1wcc]], [[1y8y\|1y8y]], [[1y91\|1y91]], [[2b52\|2b52]], [[2b53\|2b53]], [[2b54\|2b54]], [[2b55\|2b55]], [[2bhe\|2bhe]], [[2bhh\|2bhh]], [[2bkz\|2bkz]], [[2bpm\|2bpm]], [[2btr\|2btr]], [[2bts\|2bts]], [[2c4g\|2c4g]], [[2c5o\|2c5o]], [[2c5p\|2c5p]], [[2c5t\|2c5t]], [[2c5x\|2c5x]], [[2c5y\|2c5y]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aq1\|1aq1]], [[1b38\|1b38]], [[1b39\|1b39]], [[1buh\|1buh]], [[1ckp\|1ckp]], [[1di8\|1di8]], [[1dm2\|1dm2]], [[1e1v\|1e1v]], [[1e1x\|1e1x]], [[1e9h\|1e9h]], [[1f5q\|1f5q]], [[1fin\|1fin]], [[1fq1\|1fq1]], [[1fvt\|1fvt]], [[1fvv\|1fvv]], [[1g5s\|1g5s]], [[1gih\|1gih]], [[1gii\|1gii]], [[1gij\|1gij]], [[1gy3\|1gy3]], [[1gz8\|1gz8]], [[1h00\|1h00]], [[1h01\|1h01]], [[1h07\|1h07]], [[1h08\|1h08]], [[1h0v\|1h0v]], [[1h0w\|1h0w]], [[1h1p\|1h1p]], [[1h1q\|1h1q]], [[1h1r\|1h1r]], [[1h1s\|1h1s]], [[1h24\|1h24]], [[1h25\|1h25]], [[1h26\|1h26]], [[1h27\|1h27]], [[1h28\|1h28]], [[1hck\|1hck]], [[1hcl\|1hcl]], [[1jst\|1jst]], [[1jsu\|1jsu]], [[1jsv\|1jsv]], [[1jvp\|1jvp]], [[1ke5\|1ke5]], [[1ke6\|1ke6]], [[1ke7\|1ke7]], [[1ke8\|1ke8]], [[1ke9\|1ke9]], [[1ogu\|1ogu]], [[1oi9\|1oi9]], [[1oiq\|1oiq]], [[1oir\|1oir]], [[1oit\|1oit]], [[1oiu\|1oiu]], [[1oiy\|1oiy]], [[1oku\|1oku]], [[1okv\|1okv]], [[1okw\|1okw]], [[1ol1\|1ol1]], [[1ol2\|1ol2]], [[1p2a\|1p2a]], [[1p5e\|1p5e]], [[1pf8\|1pf8]], [[1pkd\|1pkd]], [[1pw2\|1pw2]], [[1pxi\|1pxi]], [[1pxj\|1pxj]], [[1pxk\|1pxk]], [[1pxl\|1pxl]], [[1pxm\|1pxm]], [[1pxn\|1pxn]], [[1pxo\|1pxo]], [[1pxp\|1pxp]], [[1pye\|1pye]], [[1qmz\|1qmz]], [[1r78\|1r78]], [[1urc\|1urc]], [[1urw\|1urw]], [[1v1k\|1v1k]], [[1vyw\|1vyw]], [[1vyz\|1vyz]], [[1w0x\|1w0x]], [[1w8c\|1w8c]], [[1w98\|1w98]], [[1wcc\|1wcc]], [[1y8y\|1y8y]], [[1y91\|1y91]], [[2b52\|2b52]], [[2b53\|2b53]], [[2b54\|2b54]], [[2b55\|2b55]], [[2bhe\|2bhe]], [[2bhh\|2bhh]], [[2bkz\|2bkz]], [[2bpm\|2bpm]], [[2btr\|2btr]], [[2bts\|2bts]], [[2c4g\|2c4g]], [[2c5o\|2c5o]], [[2c5p\|2c5p]], [[2c5t\|2c5t]], [[2c5x\|2c5x]], [[2c5y\|2c5y]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1, 2.7.11.8, 2.7.11.9, 2.7.11.10, 2.7.11.11, 2.7.11.12, 2.7.11.13, 2.7.11.21, 2.7.11.22, 2.7.11.24, 2.7.11.25, 2.7.11.30 and 2.7.12.1 2.7.11.1, 2.7.11.8, 2.7.11.9, 2.7.11.10, 2.7.11.11, 2.7.11.12, 2.7.11.13, 2.7.11.21, 2.7.11.22, 2.7.11.24, 2.7.11.25, 2.7.11.30 and 2.7.12.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1, 2.7.11.8, 2.7.11.9, 2.7.11.10, 2.7.11.11, 2.7.11.12, 2.7.11.13, 2.7.11.21, 2.7.11.22, 2.7.11.24, 2.7.11.25, 2.7.11.30 and 2.7.12.1 2.7.11.1, 2.7.11.8, 2.7.11.9, 2.7.11.10, 2.7.11.11, 2.7.11.12, 2.7.11.13, 2.7.11.21, 2.7.11.22, 2.7.11.24, 2.7.11.25, 2.7.11.30 and 2.7.12.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c5n OCA], [http://pdbe.org/2c5n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c5n RCSB], [http://www.ebi.ac.uk/pdbsum/2c5n PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c5n OCA], [http://pdbe.org/2c5n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c5n RCSB], [http://www.ebi.ac.uk/pdbsum/2c5n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2c5n ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c5/2c5n_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c5/2c5n_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c5n ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 31:		Line 32:

	==See Also==		==See Also==
-	*[[Cell division protein kinase\|Cell division protein kinase]]
	*[[Cyclin\|Cyclin]]		*[[Cyclin\|Cyclin]]
		+	*[[Cyclin-dependent kinase\|Cyclin-dependent kinase]]
	== References ==		== References ==
	<references/>		<references/>
Line 42:		Line 43:
	[[Category: Gibson, D]]		[[Category: Gibson, D]]
	[[Category: Kontopidis, G]]		[[Category: Kontopidis, G]]
-	[[Category: ~~Mcinnes~~, C]]	+	[[Category: McInnes, C]]
-	[[Category: ~~Mcnae~~, I]]	+	[[Category: McNae, I]]
	[[Category: Mezna, M]]		[[Category: Mezna, M]]
	[[Category: Pandalaneni, S R]]		[[Category: Pandalaneni, S R]]
Line 60:		Line 61:
	[[Category: Nucleotide-binding]]		[[Category: Nucleotide-binding]]
	[[Category: Phosphorylation]]		[[Category: Phosphorylation]]
		+	[[Category: Polymorphism]]
	[[Category: Serine/threonine-protein]]		[[Category: Serine/threonine-protein]]

OCA at 14:15, 11 September 2015

OCA — Fri, 11 Sep 2015 14:15:43 GMT

←Older revision		Revision as of 14:15, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2c5n' size='340' side='right' caption='[[2c5n]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2c5n' size='340' side='right' caption='[[2c5n]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2c5n]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C5N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C5N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2c5n]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C5N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C5N FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CK8:N-[4-(2,4-DIMETHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-N,N-DIMETHYL-BENZENE-1,4-DIAMINE'>CK8</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CK8:N-[4-(2,4-DIMETHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-N,N-DIMETHYL-BENZENE-1,4-DIAMINE'>CK8</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aq1\|1aq1]], [[1b38\|1b38]], [[1b39\|1b39]], [[1buh\|1buh]], [[1ckp\|1ckp]], [[1di8\|1di8]], [[1dm2\|1dm2]], [[1e1v\|1e1v]], [[1e1x\|1e1x]], [[1e9h\|1e9h]], [[1f5q\|1f5q]], [[1fin\|1fin]], [[1fq1\|1fq1]], [[1fvt\|1fvt]], [[1fvv\|1fvv]], [[1g5s\|1g5s]], [[1gih\|1gih]], [[1gii\|1gii]], [[1gij\|1gij]], [[1gy3\|1gy3]], [[1gz8\|1gz8]], [[1h00\|1h00]], [[1h01\|1h01]], [[1h07\|1h07]], [[1h08\|1h08]], [[1h0v\|1h0v]], [[1h0w\|1h0w]], [[1h1p\|1h1p]], [[1h1q\|1h1q]], [[1h1r\|1h1r]], [[1h1s\|1h1s]], [[1h24\|1h24]], [[1h25\|1h25]], [[1h26\|1h26]], [[1h27\|1h27]], [[1h28\|1h28]], [[1hck\|1hck]], [[1hcl\|1hcl]], [[1jst\|1jst]], [[1jsu\|1jsu]], [[1jsv\|1jsv]], [[1jvp\|1jvp]], [[1ke5\|1ke5]], [[1ke6\|1ke6]], [[1ke7\|1ke7]], [[1ke8\|1ke8]], [[1ke9\|1ke9]], [[1ogu\|1ogu]], [[1oi9\|1oi9]], [[1oiq\|1oiq]], [[1oir\|1oir]], [[1oit\|1oit]], [[1oiu\|1oiu]], [[1oiy\|1oiy]], [[1oku\|1oku]], [[1okv\|1okv]], [[1okw\|1okw]], [[1ol1\|1ol1]], [[1ol2\|1ol2]], [[1p2a\|1p2a]], [[1p5e\|1p5e]], [[1pf8\|1pf8]], [[1pkd\|1pkd]], [[1pw2\|1pw2]], [[1pxi\|1pxi]], [[1pxj\|1pxj]], [[1pxk\|1pxk]], [[1pxl\|1pxl]], [[1pxm\|1pxm]], [[1pxn\|1pxn]], [[1pxo\|1pxo]], [[1pxp\|1pxp]], [[1pye\|1pye]], [[1qmz\|1qmz]], [[1r78\|1r78]], [[1urc\|1urc]], [[1urw\|1urw]], [[1v1k\|1v1k]], [[1vyw\|1vyw]], [[1vyz\|1vyz]], [[1w0x\|1w0x]], [[1w8c\|1w8c]], [[1w98\|1w98]], [[1wcc\|1wcc]], [[1y8y\|1y8y]], [[1y91\|1y91]], [[2b52\|2b52]], [[2b53\|2b53]], [[2b54\|2b54]], [[2b55\|2b55]], [[2bhe\|2bhe]], [[2bhh\|2bhh]], [[2bkz\|2bkz]], [[2bpm\|2bpm]], [[2btr\|2btr]], [[2bts\|2bts]], [[2c4g\|2c4g]], [[2c5o\|2c5o]], [[2c5p\|2c5p]], [[2c5t\|2c5t]], [[2c5x\|2c5x]], [[2c5y\|2c5y]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aq1\|1aq1]], [[1b38\|1b38]], [[1b39\|1b39]], [[1buh\|1buh]], [[1ckp\|1ckp]], [[1di8\|1di8]], [[1dm2\|1dm2]], [[1e1v\|1e1v]], [[1e1x\|1e1x]], [[1e9h\|1e9h]], [[1f5q\|1f5q]], [[1fin\|1fin]], [[1fq1\|1fq1]], [[1fvt\|1fvt]], [[1fvv\|1fvv]], [[1g5s\|1g5s]], [[1gih\|1gih]], [[1gii\|1gii]], [[1gij\|1gij]], [[1gy3\|1gy3]], [[1gz8\|1gz8]], [[1h00\|1h00]], [[1h01\|1h01]], [[1h07\|1h07]], [[1h08\|1h08]], [[1h0v\|1h0v]], [[1h0w\|1h0w]], [[1h1p\|1h1p]], [[1h1q\|1h1q]], [[1h1r\|1h1r]], [[1h1s\|1h1s]], [[1h24\|1h24]], [[1h25\|1h25]], [[1h26\|1h26]], [[1h27\|1h27]], [[1h28\|1h28]], [[1hck\|1hck]], [[1hcl\|1hcl]], [[1jst\|1jst]], [[1jsu\|1jsu]], [[1jsv\|1jsv]], [[1jvp\|1jvp]], [[1ke5\|1ke5]], [[1ke6\|1ke6]], [[1ke7\|1ke7]], [[1ke8\|1ke8]], [[1ke9\|1ke9]], [[1ogu\|1ogu]], [[1oi9\|1oi9]], [[1oiq\|1oiq]], [[1oir\|1oir]], [[1oit\|1oit]], [[1oiu\|1oiu]], [[1oiy\|1oiy]], [[1oku\|1oku]], [[1okv\|1okv]], [[1okw\|1okw]], [[1ol1\|1ol1]], [[1ol2\|1ol2]], [[1p2a\|1p2a]], [[1p5e\|1p5e]], [[1pf8\|1pf8]], [[1pkd\|1pkd]], [[1pw2\|1pw2]], [[1pxi\|1pxi]], [[1pxj\|1pxj]], [[1pxk\|1pxk]], [[1pxl\|1pxl]], [[1pxm\|1pxm]], [[1pxn\|1pxn]], [[1pxo\|1pxo]], [[1pxp\|1pxp]], [[1pye\|1pye]], [[1qmz\|1qmz]], [[1r78\|1r78]], [[1urc\|1urc]], [[1urw\|1urw]], [[1v1k\|1v1k]], [[1vyw\|1vyw]], [[1vyz\|1vyz]], [[1w0x\|1w0x]], [[1w8c\|1w8c]], [[1w98\|1w98]], [[1wcc\|1wcc]], [[1y8y\|1y8y]], [[1y91\|1y91]], [[2b52\|2b52]], [[2b53\|2b53]], [[2b54\|2b54]], [[2b55\|2b55]], [[2bhe\|2bhe]], [[2bhh\|2bhh]], [[2bkz\|2bkz]], [[2bpm\|2bpm]], [[2btr\|2btr]], [[2bts\|2bts]], [[2c4g\|2c4g]], [[2c5o\|2c5o]], [[2c5p\|2c5p]], [[2c5t\|2c5t]], [[2c5x\|2c5x]], [[2c5y\|2c5y]]</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/~~Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase~~], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1, 2.7.11.8, 2.7.11.9, 2.7.11.10, 2.7.11.11, 2.7.11.12, 2.7.11.13, 2.7.11.21, 2.7.11.22, 2.7.11.24, 2.7.11.25, 2.7.11.30 and 2.7.12.1 2.7.11.1, 2.7.11.8, 2.7.11.9, 2.7.11.10, 2.7.11.11, 2.7.11.12, 2.7.11.13, 2.7.11.21, 2.7.11.22, 2.7.11.24, 2.7.11.25, 2.7.11.30 and 2.7.12.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c5n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c5n RCSB], [http://www.ebi.ac.uk/pdbsum/2c5n PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c5n OCA], [http://pdbe.org/2c5n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c5n RCSB], [http://www.ebi.ac.uk/pdbsum/2c5n PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2c5n" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[Cell division protein kinase 2\|Cell division protein kinase 2]]	+	*[[Cell division protein kinase\|Cell division protein kinase]]
	*[[Cyclin\|Cyclin]]		*[[Cyclin\|Cyclin]]
	== References ==		== References ==
Line 36:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
-	[[Category: ~~Non-specific serine/threonine protein kinase~~]]	+	[[Category: Transferase]]
	[[Category: Fischer, P M]]		[[Category: Fischer, P M]]
	[[Category: Gibson, D]]		[[Category: Gibson, D]]
Line 60:		Line 61:
	[[Category: Phosphorylation]]		[[Category: Phosphorylation]]
	[[Category: Serine/threonine-protein]]		[[Category: Serine/threonine-protein]]
-	[[Category: Transferase]]

OCA at 17:34, 25 December 2014

OCA — Thu, 25 Dec 2014 17:34:53 GMT

←Older revision		Revision as of 17:34, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2c5n]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C5N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C5N FirstGlance]. <br>		<table><tr><td colspan='2'>[[2c5n]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C5N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C5N FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CK8:N-[4-(2,4-DIMETHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-N,N-DIMETHYL-BENZENE-1,4-DIAMINE'>CK8</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CK8:N-[4-(2,4-DIMETHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-N,N-DIMETHYL-BENZENE-1,4-DIAMINE'>CK8</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aq1\|1aq1]], [[1b38\|1b38]], [[1b39\|1b39]], [[1buh\|1buh]], [[1ckp\|1ckp]], [[1di8\|1di8]], [[1dm2\|1dm2]], [[1e1v\|1e1v]], [[1e1x\|1e1x]], [[1e9h\|1e9h]], [[1f5q\|1f5q]], [[1fin\|1fin]], [[1fq1\|1fq1]], [[1fvt\|1fvt]], [[1fvv\|1fvv]], [[1g5s\|1g5s]], [[1gih\|1gih]], [[1gii\|1gii]], [[1gij\|1gij]], [[1gy3\|1gy3]], [[1gz8\|1gz8]], [[1h00\|1h00]], [[1h01\|1h01]], [[1h07\|1h07]], [[1h08\|1h08]], [[1h0v\|1h0v]], [[1h0w\|1h0w]], [[1h1p\|1h1p]], [[1h1q\|1h1q]], [[1h1r\|1h1r]], [[1h1s\|1h1s]], [[1h24\|1h24]], [[1h25\|1h25]], [[1h26\|1h26]], [[1h27\|1h27]], [[1h28\|1h28]], [[1hck\|1hck]], [[1hcl\|1hcl]], [[1jst\|1jst]], [[1jsu\|1jsu]], [[1jsv\|1jsv]], [[1jvp\|1jvp]], [[1ke5\|1ke5]], [[1ke6\|1ke6]], [[1ke7\|1ke7]], [[1ke8\|1ke8]], [[1ke9\|1ke9]], [[1ogu\|1ogu]], [[1oi9\|1oi9]], [[1oiq\|1oiq]], [[1oir\|1oir]], [[1oit\|1oit]], [[1oiu\|1oiu]], [[1oiy\|1oiy]], [[1oku\|1oku]], [[1okv\|1okv]], [[1okw\|1okw]], [[1ol1\|1ol1]], [[1ol2\|1ol2]], [[1p2a\|1p2a]], [[1p5e\|1p5e]], [[1pf8\|1pf8]], [[1pkd\|1pkd]], [[1pw2\|1pw2]], [[1pxi\|1pxi]], [[1pxj\|1pxj]], [[1pxk\|1pxk]], [[1pxl\|1pxl]], [[1pxm\|1pxm]], [[1pxn\|1pxn]], [[1pxo\|1pxo]], [[1pxp\|1pxp]], [[1pye\|1pye]], [[1qmz\|1qmz]], [[1r78\|1r78]], [[1urc\|1urc]], [[1urw\|1urw]], [[1v1k\|1v1k]], [[1vyw\|1vyw]], [[1vyz\|1vyz]], [[1w0x\|1w0x]], [[1w8c\|1w8c]], [[1w98\|1w98]], [[1wcc\|1wcc]], [[1y8y\|1y8y]], [[1y91\|1y91]], [[2b52\|2b52]], [[2b53\|2b53]], [[2b54\|2b54]], [[2b55\|2b55]], [[2bhe\|2bhe]], [[2bhh\|2bhh]], [[2bkz\|2bkz]], [[2bpm\|2bpm]], [[2btr\|2btr]], [[2bts\|2bts]], [[2c4g\|2c4g]], [[2c5o\|2c5o]], [[2c5p\|2c5p]], [[2c5t\|2c5t]], [[2c5x\|2c5x]], [[2c5y\|2c5y]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aq1\|1aq1]], [[1b38\|1b38]], [[1b39\|1b39]], [[1buh\|1buh]], [[1ckp\|1ckp]], [[1di8\|1di8]], [[1dm2\|1dm2]], [[1e1v\|1e1v]], [[1e1x\|1e1x]], [[1e9h\|1e9h]], [[1f5q\|1f5q]], [[1fin\|1fin]], [[1fq1\|1fq1]], [[1fvt\|1fvt]], [[1fvv\|1fvv]], [[1g5s\|1g5s]], [[1gih\|1gih]], [[1gii\|1gii]], [[1gij\|1gij]], [[1gy3\|1gy3]], [[1gz8\|1gz8]], [[1h00\|1h00]], [[1h01\|1h01]], [[1h07\|1h07]], [[1h08\|1h08]], [[1h0v\|1h0v]], [[1h0w\|1h0w]], [[1h1p\|1h1p]], [[1h1q\|1h1q]], [[1h1r\|1h1r]], [[1h1s\|1h1s]], [[1h24\|1h24]], [[1h25\|1h25]], [[1h26\|1h26]], [[1h27\|1h27]], [[1h28\|1h28]], [[1hck\|1hck]], [[1hcl\|1hcl]], [[1jst\|1jst]], [[1jsu\|1jsu]], [[1jsv\|1jsv]], [[1jvp\|1jvp]], [[1ke5\|1ke5]], [[1ke6\|1ke6]], [[1ke7\|1ke7]], [[1ke8\|1ke8]], [[1ke9\|1ke9]], [[1ogu\|1ogu]], [[1oi9\|1oi9]], [[1oiq\|1oiq]], [[1oir\|1oir]], [[1oit\|1oit]], [[1oiu\|1oiu]], [[1oiy\|1oiy]], [[1oku\|1oku]], [[1okv\|1okv]], [[1okw\|1okw]], [[1ol1\|1ol1]], [[1ol2\|1ol2]], [[1p2a\|1p2a]], [[1p5e\|1p5e]], [[1pf8\|1pf8]], [[1pkd\|1pkd]], [[1pw2\|1pw2]], [[1pxi\|1pxi]], [[1pxj\|1pxj]], [[1pxk\|1pxk]], [[1pxl\|1pxl]], [[1pxm\|1pxm]], [[1pxn\|1pxn]], [[1pxo\|1pxo]], [[1pxp\|1pxp]], [[1pye\|1pye]], [[1qmz\|1qmz]], [[1r78\|1r78]], [[1urc\|1urc]], [[1urw\|1urw]], [[1v1k\|1v1k]], [[1vyw\|1vyw]], [[1vyz\|1vyz]], [[1w0x\|1w0x]], [[1w8c\|1w8c]], [[1w98\|1w98]], [[1wcc\|1wcc]], [[1y8y\|1y8y]], [[1y91\|1y91]], [[2b52\|2b52]], [[2b53\|2b53]], [[2b54\|2b54]], [[2b55\|2b55]], [[2bhe\|2bhe]], [[2bhh\|2bhh]], [[2bkz\|2bkz]], [[2bpm\|2bpm]], [[2btr\|2btr]], [[2bts\|2bts]], [[2c4g\|2c4g]], [[2c5o\|2c5o]], [[2c5p\|2c5p]], [[2c5t\|2c5t]], [[2c5x\|2c5x]], [[2c5y\|2c5y]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c5n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c5n RCSB], [http://www.ebi.ac.uk/pdbsum/2c5n PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c5n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c5n RCSB], [http://www.ebi.ac.uk/pdbsum/2c5n PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CDK2_HUMAN CDK2_HUMAN]] Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization.<ref>PMID:10499802</ref> <ref>PMID:11051553</ref> <ref>PMID:10995386</ref> <ref>PMID:10995387</ref> <ref>PMID:10884347</ref> <ref>PMID:11113184</ref> <ref>PMID:15800615</ref> <ref>PMID:18372919</ref> <ref>PMID:20147522</ref> <ref>PMID:20079829</ref> <ref>PMID:20935635</ref> <ref>PMID:20195506</ref> <ref>PMID:19966300</ref> <ref>PMID:21262353</ref> <ref>PMID:21596315</ref> <ref>PMID:21319273</ref> <ref>PMID:17495531</ref> [[http://www.uniprot.org/uniprot/CCNA2_HUMAN CCNA2_HUMAN]] Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 38:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
-	[[Category: Fischer, P M.]]	+	[[Category: Fischer, P M]]
-	[[Category: Gibson, D.]]	+	[[Category: Gibson, D]]
-	[[Category: Kontopidis, G.]]	+	[[Category: Kontopidis, G]]
-	[[Category: Mcinnes, C.]]	+	[[Category: Mcinnes, C]]
-	[[Category: Mcnae, I.]]	+	[[Category: Mcnae, I]]
-	[[Category: Mezna, M.]]	+	[[Category: Mezna, M]]
-	[[Category: Pandalaneni, S R.]]	+	[[Category: Pandalaneni, S R]]
-	[[Category: Thomas, M.]]	+	[[Category: Thomas, M]]
-	[[Category: Walkinshaw, M D.]]	+	[[Category: Walkinshaw, M D]]
-	[[Category: Wang, S.]]	+	[[Category: Wang, S]]
-	[[Category: Wood, G.]]	+	[[Category: Wood, G]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Cdk2]]		[[Category: Cdk2]]

OCA at 04:57, 29 September 2014

OCA — Mon, 29 Sep 2014 04:57:37 GMT

←Older revision		Revision as of 04:57, 29 September 2014
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-	[[~~Image:~~2c5n.~~png~~\|~~left~~\|200px]]	+	==DIFFERENTIAL BINDING OF INHIBITORS TO ACTIVE AND INACTIVE CDK2 PROVIDES INSIGHTS FOR DRUG DESIGN==
		+	<StructureSection load='2c5n' size='340' side='right' caption='[[2c5n]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2c5n]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C5N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C5N FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CK8:N-[4-(2,4-DIMETHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-N,N-DIMETHYL-BENZENE-1,4-DIAMINE'>CK8</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aq1\|1aq1]], [[1b38\|1b38]], [[1b39\|1b39]], [[1buh\|1buh]], [[1ckp\|1ckp]], [[1di8\|1di8]], [[1dm2\|1dm2]], [[1e1v\|1e1v]], [[1e1x\|1e1x]], [[1e9h\|1e9h]], [[1f5q\|1f5q]], [[1fin\|1fin]], [[1fq1\|1fq1]], [[1fvt\|1fvt]], [[1fvv\|1fvv]], [[1g5s\|1g5s]], [[1gih\|1gih]], [[1gii\|1gii]], [[1gij\|1gij]], [[1gy3\|1gy3]], [[1gz8\|1gz8]], [[1h00\|1h00]], [[1h01\|1h01]], [[1h07\|1h07]], [[1h08\|1h08]], [[1h0v\|1h0v]], [[1h0w\|1h0w]], [[1h1p\|1h1p]], [[1h1q\|1h1q]], [[1h1r\|1h1r]], [[1h1s\|1h1s]], [[1h24\|1h24]], [[1h25\|1h25]], [[1h26\|1h26]], [[1h27\|1h27]], [[1h28\|1h28]], [[1hck\|1hck]], [[1hcl\|1hcl]], [[1jst\|1jst]], [[1jsu\|1jsu]], [[1jsv\|1jsv]], [[1jvp\|1jvp]], [[1ke5\|1ke5]], [[1ke6\|1ke6]], [[1ke7\|1ke7]], [[1ke8\|1ke8]], [[1ke9\|1ke9]], [[1ogu\|1ogu]], [[1oi9\|1oi9]], [[1oiq\|1oiq]], [[1oir\|1oir]], [[1oit\|1oit]], [[1oiu\|1oiu]], [[1oiy\|1oiy]], [[1oku\|1oku]], [[1okv\|1okv]], [[1okw\|1okw]], [[1ol1\|1ol1]], [[1ol2\|1ol2]], [[1p2a\|1p2a]], [[1p5e\|1p5e]], [[1pf8\|1pf8]], [[1pkd\|1pkd]], [[1pw2\|1pw2]], [[1pxi\|1pxi]], [[1pxj\|1pxj]], [[1pxk\|1pxk]], [[1pxl\|1pxl]], [[1pxm\|1pxm]], [[1pxn\|1pxn]], [[1pxo\|1pxo]], [[1pxp\|1pxp]], [[1pye\|1pye]], [[1qmz\|1qmz]], [[1r78\|1r78]], [[1urc\|1urc]], [[1urw\|1urw]], [[1v1k\|1v1k]], [[1vyw\|1vyw]], [[1vyz\|1vyz]], [[1w0x\|1w0x]], [[1w8c\|1w8c]], [[1w98\|1w98]], [[1wcc\|1wcc]], [[1y8y\|1y8y]], [[1y91\|1y91]], [[2b52\|2b52]], [[2b53\|2b53]], [[2b54\|2b54]], [[2b55\|2b55]], [[2bhe\|2bhe]], [[2bhh\|2bhh]], [[2bkz\|2bkz]], [[2bpm\|2bpm]], [[2btr\|2btr]], [[2bts\|2bts]], [[2c4g\|2c4g]], [[2c5o\|2c5o]], [[2c5p\|2c5p]], [[2c5t\|2c5t]], [[2c5x\|2c5x]], [[2c5y\|2c5y]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c5n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c5n RCSB], [http://www.ebi.ac.uk/pdbsum/2c5n PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c5/2c5n_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The cyclin-dependent kinases (CDKs) have been characterized in complex with a variety of inhibitors, but the majority of structures solved are in the inactive form. We have solved the structures of six inhibitors in both the monomeric CDK2 and binary CDK2/cyclinA complexes and demonstrate that significant differences in ligand binding occur depending on the activation state. The binding mode of two ligands in particular varies substantially in active and inactive CDK2. Furthermore, energetic analysis of CDK2/cyclin/inhibitors demonstrates that a good correlation exists between the in vitro potency and the calculated energies of interaction, but no such relationship exists for CDK2/inhibitor structures. These results confirm that monomeric CDK2 ligand complexes do not fully reflect active conformations, revealing significant implications for inhibitor design while also suggesting that the monomeric CDK2 conformation can be selectively inhibited.

-	~~{{STRUCTURE_2c5n\| PDB=2c5n \| SCENE= }}~~	+	Differential binding of inhibitors to active and inactive CDK2 provides insights for drug design.,Kontopidis G, McInnes C, Pandalaneni SR, McNae I, Gibson D, Mezna M, Thomas M, Wood G, Wang S, Walkinshaw MD, Fischer PM Chem Biol. 2006 Feb;13(2):201-11. PMID:16492568<ref>PMID:16492568</ref>

-	~~===DIFFERENTIAL BINDING OF INHIBITORS TO ACTIVE AND INACTIVE CDK2 PROVIDES INSIGHTS FOR DRUG DESIGN===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16492568}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2c5n]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2C5N OCA].~~	+

	==See Also==		==See Also==
-	*[[Cell ~~Division Protein Kinase~~ 2\|Cell ~~Division Protein Kinase~~ 2]]	+	*[[Cell division protein kinase 2\|Cell division protein kinase 2]]
	*[[Cyclin\|Cyclin]]		*[[Cyclin\|Cyclin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:016492568<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]

OCA at 19:31, 20 October 2012

OCA — Sat, 20 Oct 2012 19:31:09 GMT

←Older revision		Revision as of 19:31, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[2c5n]] is a 4 chain structure ~~of [[Cell Division Protein Kinase 2]] and [[Cyclin]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C5N OCA].	+	[[2c5n]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C5N OCA].

	==See Also==		==See Also==

OCA: Protected "2c5n" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 07:36:38 GMT

Protected "2c5n" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:36, 27 July 2012

OCA at 07:36, 27 July 2012

OCA — Fri, 27 Jul 2012 07:36:37 GMT

←Older revision		Revision as of 07:36, 27 July 2012
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-	{{Seed}}
	[[Image:2c5n.png\|left\|200px]]		[[Image:2c5n.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2c5n", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2c5n\| PDB=2c5n \| SCENE= }}		{{STRUCTURE_2c5n\| PDB=2c5n \| SCENE= }}

	===DIFFERENTIAL BINDING OF INHIBITORS TO ACTIVE AND INACTIVE CDK2 PROVIDES INSIGHTS FOR DRUG DESIGN===		===DIFFERENTIAL BINDING OF INHIBITORS TO ACTIVE AND INACTIVE CDK2 PROVIDES INSIGHTS FOR DRUG DESIGN===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16492568}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16492568 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_16492568}}		{{ABSTRACT_PUBMED_16492568}}

	==About this Structure==		==About this Structure==
-	~~2C5N~~ is a 4 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C5N OCA].	+	[[2c5n]] is a 4 chain structure of [[Cell Division Protein Kinase 2]] and [[Cyclin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C5N OCA].
		+
		+	==See Also==
		+	*[[Cell Division Protein Kinase 2\|Cell Division Protein Kinase 2]]
		+	*[[Cyclin\|Cyclin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16492568~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016492568</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
Line 47:		Line 39:
	[[Category: Nucleotide-binding]]		[[Category: Nucleotide-binding]]
	[[Category: Phosphorylation]]		[[Category: Phosphorylation]]
-	[[Category: Polymorphism]]
	[[Category: Serine/threonine-protein]]		[[Category: Serine/threonine-protein]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 00:21:46 2009''