2cct - Revision history

OCA at 09:24, 9 May 2024

OCA — Thu, 09 May 2024 09:24:21 GMT

←Older revision		Revision as of 09:24, 9 May 2024
Line 3:		Line 3:
	<StructureSection load='2cct' size='340' side='right'caption='[[2cct]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2cct' size='340' side='right'caption='[[2cct]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2cct]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CCT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2cct]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CCT FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=2E1:5-(5-CHLORO~~-2~~,4-DIHYDROXYPHENYL)-N-ETHYL-4-PIPERAZIN-1-YL-1H-PYRAZOLE-~~3~~-CARBOXAMIDE'>2E1</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>[[1byq\|1byq]], [[1osf\|1osf]], [[1uy6\|1uy6]], [[1uy7\|1uy7]], [[1uy8\|1uy8]], [[1uy9\|1uy9]], [[1uyc\|1uyc]], [[1uyd\|1uyd]], [[1uye\|1uye]], [[1uyf\|1uyf]], [[1uyg\|1uyg]], [[1uyh\|1uyh]], [[1uyi\|1uyi]], [[1uyk\|1uyk]], [[1uyl\|1uyl]], [[1yc1\|1yc1]], [[1yc3\|1yc3]], [[1yc4\|1yc4]], [[1yer\|1yer]], [[1yes\|1yes]], [[1yet\|1yet]], [[2bsm\|2bsm]], [[2bt0\|2bt0]], [[2byh\|2byh]], [[2byi\|2byi]], [[2bz5\|2bz5]], [[2c2l\|2c2l]], [[2ccs\|2ccs]], [[2ccu\|2ccu]]</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2E1:5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-PIPERAZIN-1-YL-1H-PYRAZOLE-3-CARBOXAMIDE'>2E1</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cct OCA], [https://pdbe.org/2cct PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cct RCSB], [https://www.ebi.ac.uk/pdbsum/2cct PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cct ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cct OCA], [https://pdbe.org/2cct PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cct RCSB], [https://www.ebi.ac.uk/pdbsum/2cct PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cct ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>	+	[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Barril, X]]	+	[[Category: Barril X]]
-	[[Category: Beswick~~, M C~~]]	+	[[Category: Beswick MC]]
-	[[Category: Collier, A]]	+	[[Category: Collier A]]
-	[[Category: Drysdale~~, M J~~]]	+	[[Category: Drysdale MJ]]
-	[[Category: Dymock~~, B W~~]]	+	[[Category: Dymock BW]]
-	[[Category: Fink, A]]	+	[[Category: Fink A]]
-	[[Category: Grant, K]]	+	[[Category: Grant K]]
-	[[Category: Howes, R]]	+	[[Category: Howes R]]
-	[[Category: Jordan~~, A M~~]]	+	[[Category: Jordan AM]]
-	[[Category: Massey, A]]	+	[[Category: Massey A]]
-	[[Category: Surgenor, A]]	+	[[Category: Surgenor A]]
-	[[Category: Wayne, J]]	+	[[Category: Wayne J]]
-	[[Category: Workman, P]]	+	[[Category: Workman P]]
-	[[Category: Wright, L]]	+	[[Category: Wright L]]
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Atpase]]~~	+
-	~~[[Category: Chaperone]]~~	+
-	~~[[Category: Heat shock]]~~	+
-	~~[[Category: Heat-shock protein complex]]~~	+
-	~~[[Category: Hsp90]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Phosphorylation]]~~	+
-	~~[[Category: Pyrazole~~]]	+

OCA at 20:34, 20 October 2021

OCA — Wed, 20 Oct 2021 20:34:32 GMT

←Older revision		Revision as of 20:34, 20 October 2021
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	<StructureSection load='2cct' size='340' side='right'caption='[[2cct]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2cct' size='340' side='right'caption='[[2cct]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2cct]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CCT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2cct]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CCT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2E1:5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-PIPERAZIN-1-YL-1H-PYRAZOLE-3-CARBOXAMIDE'>2E1</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2E1:5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-PIPERAZIN-1-YL-1H-PYRAZOLE-3-CARBOXAMIDE'>2E1</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1byq\|1byq]], [[1osf\|1osf]], [[1uy6\|1uy6]], [[1uy7\|1uy7]], [[1uy8\|1uy8]], [[1uy9\|1uy9]], [[1uyc\|1uyc]], [[1uyd\|1uyd]], [[1uye\|1uye]], [[1uyf\|1uyf]], [[1uyg\|1uyg]], [[1uyh\|1uyh]], [[1uyi\|1uyi]], [[1uyk\|1uyk]], [[1uyl\|1uyl]], [[1yc1\|1yc1]], [[1yc3\|1yc3]], [[1yc4\|1yc4]], [[1yer\|1yer]], [[1yes\|1yes]], [[1yet\|1yet]], [[2bsm\|2bsm]], [[2bt0\|2bt0]], [[2byh\|2byh]], [[2byi\|2byi]], [[2bz5\|2bz5]], [[2c2l\|2c2l]], [[2ccs\|2ccs]], [[2ccu\|2ccu]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1byq\|1byq]], [[1osf\|1osf]], [[1uy6\|1uy6]], [[1uy7\|1uy7]], [[1uy8\|1uy8]], [[1uy9\|1uy9]], [[1uyc\|1uyc]], [[1uyd\|1uyd]], [[1uye\|1uye]], [[1uyf\|1uyf]], [[1uyg\|1uyg]], [[1uyh\|1uyh]], [[1uyi\|1uyi]], [[1uyk\|1uyk]], [[1uyl\|1uyl]], [[1yc1\|1yc1]], [[1yc3\|1yc3]], [[1yc4\|1yc4]], [[1yer\|1yer]], [[1yes\|1yes]], [[1yet\|1yet]], [[2bsm\|2bsm]], [[2bt0\|2bt0]], [[2byh\|2byh]], [[2byi\|2byi]], [[2bz5\|2bz5]], [[2c2l\|2c2l]], [[2ccs\|2ccs]], [[2ccu\|2ccu]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2cct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cct OCA], [~~http~~://pdbe.org/2cct PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2cct RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2cct PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2cct ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cct OCA], [https://pdbe.org/2cct PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cct RCSB], [https://www.ebi.ac.uk/pdbsum/2cct PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cct ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>	+	[[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 13:02, 1 January 2020

OCA — Wed, 01 Jan 2020 13:02:50 GMT

←Older revision		Revision as of 13:02, 1 January 2020
Line 1:		Line 1:

	==HUMAN HSP90 WITH 5-(5-CHLORO-2,4-DIHYDROXY-PHENYL)-4-PIPERAZIN-1-YL- 2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYLAMIDE==		==HUMAN HSP90 WITH 5-(5-CHLORO-2,4-DIHYDROXY-PHENYL)-4-PIPERAZIN-1-YL- 2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYLAMIDE==
-	<StructureSection load='2cct' size='340' side='right' caption='[[2cct]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='2cct' size='340' side='right'caption='[[2cct]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cct]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CCT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cct]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CCT FirstGlance]. <br>
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Heat Shock ~~Proteins~~\|Heat Shock ~~Proteins~~]]	+	*[[Heat Shock Protein structures\|Heat Shock Protein structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Barril, X]]		[[Category: Barril, X]]
	[[Category: Beswick, M C]]		[[Category: Beswick, M C]]

OCA at 06:52, 28 March 2018

OCA — Wed, 28 Mar 2018 06:52:13 GMT

←Older revision		Revision as of 06:52, 28 March 2018
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cc/2cct_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cc/2cct_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 2cct" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2cct" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Heat Shock Proteins\|Heat Shock Proteins]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:14, 16 November 2017

OCA — Thu, 16 Nov 2017 07:14:45 GMT

←Older revision		Revision as of 07:14, 16 November 2017
Line 1:		Line 1:
-	==HUMAN HSP90 WITH 5-(5-CHLORO-2,4-DIHYDROXY-PHENYL)-4-PIPERAZIN-1-YL-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYLAMIDE==	+
		+	==HUMAN HSP90 WITH 5-(5-CHLORO-2,4-DIHYDROXY-PHENYL)-4-PIPERAZIN-1-YL- 2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYLAMIDE==
	<StructureSection load='2cct' size='340' side='right' caption='[[2cct]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2cct' size='340' side='right' caption='[[2cct]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2E1:5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-PIPERAZIN-1-YL-1H-PYRAZOLE-3-CARBOXAMIDE'>2E1</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2E1:5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-PIPERAZIN-1-YL-1H-PYRAZOLE-3-CARBOXAMIDE'>2E1</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1byq\|1byq]], [[1osf\|1osf]], [[1uy6\|1uy6]], [[1uy7\|1uy7]], [[1uy8\|1uy8]], [[1uy9\|1uy9]], [[1uyc\|1uyc]], [[1uyd\|1uyd]], [[1uye\|1uye]], [[1uyf\|1uyf]], [[1uyg\|1uyg]], [[1uyh\|1uyh]], [[1uyi\|1uyi]], [[1uyk\|1uyk]], [[1uyl\|1uyl]], [[1yc1\|1yc1]], [[1yc3\|1yc3]], [[1yc4\|1yc4]], [[1yer\|1yer]], [[1yes\|1yes]], [[1yet\|1yet]], [[2bsm\|2bsm]], [[2bt0\|2bt0]], [[2byh\|2byh]], [[2byi\|2byi]], [[2bz5\|2bz5]], [[2c2l\|2c2l]], [[2ccs\|2ccs]], [[2ccu\|2ccu]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1byq\|1byq]], [[1osf\|1osf]], [[1uy6\|1uy6]], [[1uy7\|1uy7]], [[1uy8\|1uy8]], [[1uy9\|1uy9]], [[1uyc\|1uyc]], [[1uyd\|1uyd]], [[1uye\|1uye]], [[1uyf\|1uyf]], [[1uyg\|1uyg]], [[1uyh\|1uyh]], [[1uyi\|1uyi]], [[1uyk\|1uyk]], [[1uyl\|1uyl]], [[1yc1\|1yc1]], [[1yc3\|1yc3]], [[1yc4\|1yc4]], [[1yer\|1yer]], [[1yes\|1yes]], [[1yet\|1yet]], [[2bsm\|2bsm]], [[2bt0\|2bt0]], [[2byh\|2byh]], [[2byi\|2byi]], [[2bz5\|2bz5]], [[2c2l\|2c2l]], [[2ccs\|2ccs]], [[2ccu\|2ccu]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cct OCA], [http://pdbe.org/2cct PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cct RCSB], [http://www.ebi.ac.uk/pdbsum/2cct PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cct OCA], [http://pdbe.org/2cct PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cct RCSB], [http://www.ebi.ac.uk/pdbsum/2cct PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cct ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 2cct" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2cct" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Heat Shock Proteins\|Heat Shock Proteins]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 20:33, 9 February 2016

OCA — Tue, 09 Feb 2016 20:33:04 GMT

←Older revision		Revision as of 20:33, 9 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cct ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 01:47, 11 September 2015

OCA — Fri, 11 Sep 2015 01:47:56 GMT

←Older revision		Revision as of 01:47, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2cct' size='340' side='right' caption='[[2cct]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2cct' size='340' side='right' caption='[[2cct]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2cct]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CCT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2cct]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CCT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2E1:5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-PIPERAZIN-1-YL-1H-PYRAZOLE-3-CARBOXAMIDE'>2E1</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2E1:5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-PIPERAZIN-1-YL-1H-PYRAZOLE-3-CARBOXAMIDE'>2E1</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1byq\|1byq]], [[1osf\|1osf]], [[1uy6\|1uy6]], [[1uy7\|1uy7]], [[1uy8\|1uy8]], [[1uy9\|1uy9]], [[1uyc\|1uyc]], [[1uyd\|1uyd]], [[1uye\|1uye]], [[1uyf\|1uyf]], [[1uyg\|1uyg]], [[1uyh\|1uyh]], [[1uyi\|1uyi]], [[1uyk\|1uyk]], [[1uyl\|1uyl]], [[1yc1\|1yc1]], [[1yc3\|1yc3]], [[1yc4\|1yc4]], [[1yer\|1yer]], [[1yes\|1yes]], [[1yet\|1yet]], [[2bsm\|2bsm]], [[2bt0\|2bt0]], [[2byh\|2byh]], [[2byi\|2byi]], [[2bz5\|2bz5]], [[2c2l\|2c2l]], [[2ccs\|2ccs]], [[2ccu\|2ccu]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1byq\|1byq]], [[1osf\|1osf]], [[1uy6\|1uy6]], [[1uy7\|1uy7]], [[1uy8\|1uy8]], [[1uy9\|1uy9]], [[1uyc\|1uyc]], [[1uyd\|1uyd]], [[1uye\|1uye]], [[1uyf\|1uyf]], [[1uyg\|1uyg]], [[1uyh\|1uyh]], [[1uyi\|1uyi]], [[1uyk\|1uyk]], [[1uyl\|1uyl]], [[1yc1\|1yc1]], [[1yc3\|1yc3]], [[1yc4\|1yc4]], [[1yer\|1yer]], [[1yes\|1yes]], [[1yet\|1yet]], [[2bsm\|2bsm]], [[2bt0\|2bt0]], [[2byh\|2byh]], [[2byi\|2byi]], [[2bz5\|2bz5]], [[2c2l\|2c2l]], [[2ccs\|2ccs]], [[2ccu\|2ccu]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cct OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cct RCSB], [http://www.ebi.ac.uk/pdbsum/2cct PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cct OCA], [http://pdbe.org/2cct PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cct RCSB], [http://www.ebi.ac.uk/pdbsum/2cct PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2cct" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Barril, X]]		[[Category: Barril, X]]
	[[Category: Beswick, M C]]		[[Category: Beswick, M C]]

OCA at 09:22, 25 December 2014

OCA — Thu, 25 Dec 2014 09:22:01 GMT

←Older revision		Revision as of 09:22, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cct]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CCT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cct]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CCT FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2E1:5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-PIPERAZIN-1-YL-1H-PYRAZOLE-3-CARBOXAMIDE'>2E1</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2E1:5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-PIPERAZIN-1-YL-1H-PYRAZOLE-3-CARBOXAMIDE'>2E1</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1byq\|1byq]], [[1osf\|1osf]], [[1uy6\|1uy6]], [[1uy7\|1uy7]], [[1uy8\|1uy8]], [[1uy9\|1uy9]], [[1uyc\|1uyc]], [[1uyd\|1uyd]], [[1uye\|1uye]], [[1uyf\|1uyf]], [[1uyg\|1uyg]], [[1uyh\|1uyh]], [[1uyi\|1uyi]], [[1uyk\|1uyk]], [[1uyl\|1uyl]], [[1yc1\|1yc1]], [[1yc3\|1yc3]], [[1yc4\|1yc4]], [[1yer\|1yer]], [[1yes\|1yes]], [[1yet\|1yet]], [[2bsm\|2bsm]], [[2bt0\|2bt0]], [[2byh\|2byh]], [[2byi\|2byi]], [[2bz5\|2bz5]], [[2c2l\|2c2l]], [[2ccs\|2ccs]], [[2ccu\|2ccu]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1byq\|1byq]], [[1osf\|1osf]], [[1uy6\|1uy6]], [[1uy7\|1uy7]], [[1uy8\|1uy8]], [[1uy9\|1uy9]], [[1uyc\|1uyc]], [[1uyd\|1uyd]], [[1uye\|1uye]], [[1uyf\|1uyf]], [[1uyg\|1uyg]], [[1uyh\|1uyh]], [[1uyi\|1uyi]], [[1uyk\|1uyk]], [[1uyl\|1uyl]], [[1yc1\|1yc1]], [[1yc3\|1yc3]], [[1yc4\|1yc4]], [[1yer\|1yer]], [[1yes\|1yes]], [[1yet\|1yet]], [[2bsm\|2bsm]], [[2bt0\|2bt0]], [[2byh\|2byh]], [[2byi\|2byi]], [[2bz5\|2bz5]], [[2c2l\|2c2l]], [[2ccs\|2ccs]], [[2ccu\|2ccu]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cct OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cct RCSB], [http://www.ebi.ac.uk/pdbsum/2cct PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cct OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cct RCSB], [http://www.ebi.ac.uk/pdbsum/2cct PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Barril, X.]]	+	[[Category: Barril, X]]
-	[[Category: Beswick, M C.]]	+	[[Category: Beswick, M C]]
-	[[Category: Collier, A.]]	+	[[Category: Collier, A]]
-	[[Category: Drysdale, M J.]]	+	[[Category: Drysdale, M J]]
-	[[Category: Dymock, B W.]]	+	[[Category: Dymock, B W]]
-	[[Category: Fink, A.]]	+	[[Category: Fink, A]]
-	[[Category: Grant, K.]]	+	[[Category: Grant, K]]
-	[[Category: Howes, R.]]	+	[[Category: Howes, R]]
-	[[Category: Jordan, A M.]]	+	[[Category: Jordan, A M]]
-	[[Category: Massey, A.]]	+	[[Category: Massey, A]]
-	[[Category: Surgenor, A.]]	+	[[Category: Surgenor, A]]
-	[[Category: Wayne, J.]]	+	[[Category: Wayne, J]]
-	[[Category: Workman, P.]]	+	[[Category: Workman, P]]
-	[[Category: Wright, L.]]	+	[[Category: Wright, L]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Atpase]]		[[Category: Atpase]]

OCA at 04:38, 29 September 2014

OCA — Mon, 29 Sep 2014 04:38:08 GMT

←Older revision		Revision as of 04:38, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2cct.~~png~~\|~~left~~\|200px]]	+	==HUMAN HSP90 WITH 5-(5-CHLORO-2,4-DIHYDROXY-PHENYL)-4-PIPERAZIN-1-YL-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYLAMIDE==
		+	<StructureSection load='2cct' size='340' side='right' caption='[[2cct]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2cct]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CCT FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2E1:5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-PIPERAZIN-1-YL-1H-PYRAZOLE-3-CARBOXAMIDE'>2E1</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1byq\|1byq]], [[1osf\|1osf]], [[1uy6\|1uy6]], [[1uy7\|1uy7]], [[1uy8\|1uy8]], [[1uy9\|1uy9]], [[1uyc\|1uyc]], [[1uyd\|1uyd]], [[1uye\|1uye]], [[1uyf\|1uyf]], [[1uyg\|1uyg]], [[1uyh\|1uyh]], [[1uyi\|1uyi]], [[1uyk\|1uyk]], [[1uyl\|1uyl]], [[1yc1\|1yc1]], [[1yc3\|1yc3]], [[1yc4\|1yc4]], [[1yer\|1yer]], [[1yes\|1yes]], [[1yet\|1yet]], [[2bsm\|2bsm]], [[2bt0\|2bt0]], [[2byh\|2byh]], [[2byi\|2byi]], [[2bz5\|2bz5]], [[2c2l\|2c2l]], [[2ccs\|2ccs]], [[2ccu\|2ccu]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cct OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cct RCSB], [http://www.ebi.ac.uk/pdbsum/2cct PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cc/2cct_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Novel piperazinyl, morpholino and piperidyl derivatives of the pyrazole-based Hsp90 inhibitor CCT018159 are described. Structure-activity relationships have been elucidated by X-ray co-crystal analysis of the new compounds bound to the N-terminal domain of human Hsp90. Key features of the binding mode are essentially identical to the recently reported potent analogue VER-49009. The most potent of the new compounds has a methylsulfonylbenzyl substituent appended to the piperazine nitrogen, possesses an IC50 of less than 600 nM binding against the enzyme and demonstrates low micromolar inhibition of tumour cell proliferation.

-	~~{{STRUCTURE_2cct\| PDB=2cct \| SCENE= }}~~	+	4-Amino derivatives of the Hsp90 inhibitor CCT018159.,Barril X, Beswick MC, Collier A, Drysdale MJ, Dymock BW, Fink A, Grant K, Howes R, Jordan AM, Massey A, Surgenor A, Wayne J, Workman P, Wright L Bioorg Med Chem Lett. 2006 May 1;16(9):2543-8. Epub 2006 Feb 9. PMID:16480864<ref>PMID:16480864</ref>

-	~~===HUMAN HSP90 WITH 5-(5-CHLORO-2~~,~~4-DIHYDROXY-PHENYL)-4-PIPERAZIN-1-YL-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYLAMIDE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16480864}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2cct]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2CCT OCA].~~	+

	==See Also==		==See Also==
	*[[Heat Shock Proteins\|Heat Shock Proteins]]		*[[Heat Shock Proteins\|Heat Shock Proteins]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:016480864<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Barril, X.]]		[[Category: Barril, X.]]

OCA at 15:03, 20 October 2012

OCA — Sat, 20 Oct 2012 15:03:03 GMT

←Older revision		Revision as of 15:03, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2cct]] is a 1 chain structure ~~of [[Heat Shock Proteins]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCT OCA].	+	[[2cct]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCT OCA].

	==See Also==		==See Also==