2cfx - Revision history

OCA at 06:38, 1 May 2024

OCA — Wed, 01 May 2024 06:38:49 GMT

←Older revision		Revision as of 06:38, 1 May 2024
Line 3:		Line 3:
	<StructureSection load='2cfx' size='340' side='right'caption='[[2cfx]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2cfx' size='340' side='right'caption='[[2cfx]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2cfx]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"vibrio_subtilis"_ehrenberg_1835 "vibrio~~ subtilis~~" ehrenberg 1835~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CFX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2cfx]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CFX FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cfx OCA], [https://pdbe.org/2cfx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cfx RCSB], [https://www.ebi.ac.uk/pdbsum/2cfx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cfx ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cfx OCA], [https://pdbe.org/2cfx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cfx RCSB], [https://www.ebi.ac.uk/pdbsum/2cfx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cfx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/LRPC_BACSU LRPC_BACSU]] Transcriptional regulator with a possible role in regulation of amino acid metabolism. Plays a role in the growth phase transition.	+	[https://www.uniprot.org/uniprot/LRPC_BACSU LRPC_BACSU] Transcriptional regulator with a possible role in regulation of amino acid metabolism. Plays a role in the growth phase transition.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cfx ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cfx ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The Lrp/AsnC family of transcriptional regulatory proteins is found in both archaea and bacteria. Members of the family influence cellular metabolism in both a global (Lrp) and specific (AsnC) manner, often in response to exogenous amino acid effectors. In the present study we have determined both the first bacterial and the highest resolution structures for members of the family. Escherichia coli AsnC is a specific gene regulator whose activity is triggered by asparagine binding. Bacillus subtilis LrpC is a global regulator involved in chromosome condensation. Our AsnC-asparagine structure is the first for a regulator-effector complex and is revealed as an octameric disc. Key ligand recognition residues are identified together with a route for ligand access. The LrpC structure reveals a stable octamer supportive of a topological role in dynamic DNA packaging. The structures yield significant clues to the functionality of Lrp/AsnC-type regulators with respect to ligand binding and oligomerization states as well as to their role in specific and global DNA regulation.
-
-	Structural insight into gene transcriptional regulation and effector binding by the Lrp/AsnC family.,Thaw P, Sedelnikova SE, Muranova T, Wiese S, Ayora S, Alonso JC, Brinkman AB, Akerboom J, van der Oost J, Rafferty JB Nucleic Acids Res. 2006 Mar 9;34(5):1439-49. Print 2006. PMID:16528101<ref>PMID:16528101</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2cfx" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Transcriptional activator 3D structures\|Transcriptional activator 3D structures]]		*[[Transcriptional activator 3D structures\|Transcriptional activator 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Vibrio~~ subtilis ~~ehrenberg 1835~~]]	+	[[Category: Bacillus subtilis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Rafferty~~, J B~~]]	+	[[Category: Rafferty JB]]
-	[[Category: Thaw, P]]	+	[[Category: Thaw P]]
-	~~[[Category: Dna binding]]~~	+
-	~~[[Category: Ffrp]]~~	+
-	~~[[Category: Lrpc]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcriptional regulation~~]]	+

OCA at 05:22, 28 April 2021

OCA — Wed, 28 Apr 2021 05:22:58 GMT

←Older revision		Revision as of 05:22, 28 April 2021
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	<StructureSection load='2cfx' size='340' side='right'caption='[[2cfx]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2cfx' size='340' side='right'caption='[[2cfx]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2cfx]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CFX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2cfx]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CFX FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2cfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cfx OCA], [~~http~~://pdbe.org/2cfx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2cfx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2cfx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2cfx ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cfx OCA], [https://pdbe.org/2cfx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cfx RCSB], [https://www.ebi.ac.uk/pdbsum/2cfx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cfx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/LRPC_BACSU LRPC_BACSU]] Transcriptional regulator with a possible role in regulation of amino acid metabolism. Plays a role in the growth phase transition.	+	[[https://www.uniprot.org/uniprot/LRPC_BACSU LRPC_BACSU]] Transcriptional regulator with a possible role in regulation of amino acid metabolism. Plays a role in the growth phase transition.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</div>		</div>
	<div class="pdbe-citations 2cfx" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2cfx" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Transcriptional activator 3D structures\|Transcriptional activator 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:47, 26 February 2020

OCA — Wed, 26 Feb 2020 10:47:51 GMT

←Older revision		Revision as of 10:47, 26 February 2020
Line 1:		Line 1:

	==Structure of B.subtilis LrpC==		==Structure of B.subtilis LrpC==
-	<StructureSection load='2cfx' size='340' side='right' caption='[[2cfx]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='2cfx' size='340' side='right'caption='[[2cfx]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cfx]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CFX FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cfx]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CFX FirstGlance]. <br>
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Vibrio subtilis ehrenberg 1835]]		[[Category: Vibrio subtilis ehrenberg 1835]]
		+	[[Category: Large Structures]]
	[[Category: Rafferty, J B]]		[[Category: Rafferty, J B]]
	[[Category: Thaw, P]]		[[Category: Thaw, P]]

OCA at 08:03, 23 May 2018

OCA — Wed, 23 May 2018 08:03:05 GMT

←Older revision		Revision as of 08:03, 23 May 2018
Line 1:		Line 1:
-	==~~STRUCTURE OF~~ B.~~SUBTILIS LRPC~~==	+
		+	==Structure of B.subtilis LrpC==
	<StructureSection load='2cfx' size='340' side='right' caption='[[2cfx]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2cfx' size='340' side='right' caption='[[2cfx]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2cfx]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"~~bacillus_globigii~~"~~_migula_1900~~ "~~bacillus globigii~~" ~~migula 1900~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CFX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2cfx]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CFX FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cfx OCA], [http://pdbe.org/2cfx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cfx RCSB], [http://www.ebi.ac.uk/pdbsum/2cfx PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cfx OCA], [http://pdbe.org/2cfx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cfx RCSB], [http://www.ebi.ac.uk/pdbsum/2cfx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cfx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cf/2cfx_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cf/2cfx_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cfx ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus globigii migula 1900~~]]	+	[[Category: Vibrio subtilis ehrenberg 1835]]
	[[Category: Rafferty, J B]]		[[Category: Rafferty, J B]]
	[[Category: Thaw, P]]		[[Category: Thaw, P]]

OCA at 09:02, 11 September 2015

OCA — Fri, 11 Sep 2015 09:02:19 GMT

←Older revision		Revision as of 09:02, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2cfx' size='340' side='right' caption='[[2cfx]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2cfx' size='340' side='right' caption='[[2cfx]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2cfx]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacillus_subtilis Bacillus subtilis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CFX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2cfx]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_globigii"_migula_1900 "bacillus globigii" migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CFX FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cfx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cfx RCSB], [http://www.ebi.ac.uk/pdbsum/2cfx PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cfx OCA], [http://pdbe.org/2cfx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cfx RCSB], [http://www.ebi.ac.uk/pdbsum/2cfx PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2cfx" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillus ~~subtilis~~]]	+	[[Category: Bacillus globigii migula 1900]]
	[[Category: Rafferty, J B]]		[[Category: Rafferty, J B]]
	[[Category: Thaw, P]]		[[Category: Thaw, P]]

OCA at 14:13, 25 December 2014

OCA — Thu, 25 Dec 2014 14:13:01 GMT

←Older revision		Revision as of 14:13, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cfx]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CFX FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cfx]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CFX FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cfx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cfx RCSB], [http://www.ebi.ac.uk/pdbsum/2cfx PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cfx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cfx RCSB], [http://www.ebi.ac.uk/pdbsum/2cfx PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LRPC_BACSU LRPC_BACSU]] Transcriptional regulator with a possible role in regulation of amino acid metabolism. Plays a role in the growth phase transition.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
-	[[Category: Rafferty, J B.]]	+	[[Category: Rafferty, J B]]
-	[[Category: Thaw, P.]]	+	[[Category: Thaw, P]]
	[[Category: Dna binding]]		[[Category: Dna binding]]
	[[Category: Ffrp]]		[[Category: Ffrp]]

OCA at 01:36, 30 September 2014

OCA — Tue, 30 Sep 2014 01:36:41 GMT

←Older revision		Revision as of 01:36, 30 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2cfx.~~png\|left~~\|200px]]	+	==STRUCTURE OF B.SUBTILIS LRPC==
		+	<StructureSection load='2cfx' size='340' side='right' caption='[[2cfx]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2cfx]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CFX FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cfx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cfx RCSB], [http://www.ebi.ac.uk/pdbsum/2cfx PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cf/2cfx_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Lrp/AsnC family of transcriptional regulatory proteins is found in both archaea and bacteria. Members of the family influence cellular metabolism in both a global (Lrp) and specific (AsnC) manner, often in response to exogenous amino acid effectors. In the present study we have determined both the first bacterial and the highest resolution structures for members of the family. Escherichia coli AsnC is a specific gene regulator whose activity is triggered by asparagine binding. Bacillus subtilis LrpC is a global regulator involved in chromosome condensation. Our AsnC-asparagine structure is the first for a regulator-effector complex and is revealed as an octameric disc. Key ligand recognition residues are identified together with a route for ligand access. The LrpC structure reveals a stable octamer supportive of a topological role in dynamic DNA packaging. The structures yield significant clues to the functionality of Lrp/AsnC-type regulators with respect to ligand binding and oligomerization states as well as to their role in specific and global DNA regulation.

-	~~{{STRUCTURE_2cfx\| PDB=2cfx \| SCENE= }}~~	+	Structural insight into gene transcriptional regulation and effector binding by the Lrp/AsnC family.,Thaw P, Sedelnikova SE, Muranova T, Wiese S, Ayora S, Alonso JC, Brinkman AB, Akerboom J, van der Oost J, Rafferty JB Nucleic Acids Res. 2006 Mar 9;34(5):1439-49. Print 2006. PMID:16528101<ref>PMID:16528101</ref>

-	~~===STRUCTURE OF B.SUBTILIS LRPC===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16528101}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2cfx]] is~~ a ~~8 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bacillus_subtilis Bacillus subtilis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2CFX OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016528101<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
	[[Category: Rafferty, J B.]]		[[Category: Rafferty, J B.]]

OCA: Protected "2cfx" [edit=sysop:move=sysop]

OCA — Sun, 06 Jan 2013 10:50:52 GMT

Protected "2cfx" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:50, 6 January 2013

OCA at 10:50, 6 January 2013

OCA — Sun, 06 Jan 2013 10:50:50 GMT

←Older revision		Revision as of 10:50, 6 January 2013
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-	{{Seed}}
	[[Image:2cfx.png\|left\|200px]]		[[Image:2cfx.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2cfx", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_2cfx\| PDB=2cfx \| SCENE= }}		{{STRUCTURE_2cfx\| PDB=2cfx \| SCENE= }}

	===STRUCTURE OF B.SUBTILIS LRPC===		===STRUCTURE OF B.SUBTILIS LRPC===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16528101}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16528101 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_16528101}}		{{ABSTRACT_PUBMED_16528101}}

	==About this Structure==		==About this Structure==
-	~~2CFX~~ is a 8 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFX OCA].	+	[[2cfx]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFX OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16528101~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016528101</ref><references group="xtra"/>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
	[[Category: Rafferty, J B.]]		[[Category: Rafferty, J B.]]
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	[[Category: Transcription]]		[[Category: Transcription]]
	[[Category: Transcriptional regulation]]		[[Category: Transcriptional regulation]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:23:20 2009''

OCA at 16:23, 17 February 2009

OCA — Tue, 17 Feb 2009 16:23:21 GMT

←Older revision		Revision as of 16:23, 17 February 2009
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	==About this Structure==		==About this Structure==
-	2CFX is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFX OCA].	+	2CFX is a 8 chains structure of sequences from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFX OCA].

	==Reference==		==Reference==
-	Structural insight into gene transcriptional regulation and effector binding by the Lrp/AsnC family., Thaw P, Sedelnikova SE, Muranova T, Wiese S, Ayora S, Alonso JC, Brinkman AB, Akerboom J, van der Oost J, Rafferty JB, Nucleic Acids Res. 2006 Mar 9;34(5):1439-49. Print 2006. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16528101 16528101]~~	+	<ref group="xtra">PMID:16528101</ref><references group="xtra"/>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
-	[[Category: Single protein]]
	[[Category: Rafferty, J B.]]		[[Category: Rafferty, J B.]]
	[[Category: Thaw, P.]]		[[Category: Thaw, P.]]
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	[[Category: Transcriptional regulation]]		[[Category: Transcriptional regulation]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 02~~:20:~~02 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:23:20 2009''