2chk - Revision history

OCA at 10:25, 6 September 2023

OCA — Wed, 06 Sep 2023 10:25:56 GMT

←Older revision		Revision as of 10:25, 6 September 2023
Line 1:		Line 1:

	==NMR structure of TLLLLT quadruplex==		==NMR structure of TLLLLT quadruplex==
-	<StructureSection load='2chk' size='340' side='right'caption='[[2chk~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2chk' size='340' side='right'caption='[[2chk]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2chk]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CHK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CHK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2chk]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CHK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CHK FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=LCG:[(1R,3R,4R,7S)-7-HYDROXY-3-(GUANIN-9-YL)-2,5-DIOXABICYCLO[2.2.1]HEPT-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>LCG</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2chj\|2chj]]</div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LCG:[(1R,3R,4R,7S)-7-HYDROXY-3-(GUANIN-9-YL)-2,5-DIOXABICYCLO[2.2.1]HEPT-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>LCG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2chk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2chk OCA], [https://pdbe.org/2chk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2chk RCSB], [https://www.ebi.ac.uk/pdbsum/2chk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2chk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2chk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2chk OCA], [https://pdbe.org/2chk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2chk RCSB], [https://www.ebi.ac.uk/pdbsum/2chk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2chk ProSAT]</span></td></tr>
	</table>		</table>
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Nielsen~~, J T~~]]	+	[[Category: Nielsen JT]]
-	[[Category: Petersen, M]]	+	[[Category: Petersen M]]
-	~~[[Category: Lna]]~~	+
-	~~[[Category: Locked nucleic acid]]~~	+
-	~~[[Category: Nucleic acid]]~~	+
-	~~[[Category: Quadruplex~~]]	+

OCA at 06:55, 1 December 2021

OCA — Wed, 01 Dec 2021 06:55:50 GMT

←Older revision		Revision as of 06:55, 1 December 2021
Line 3:		Line 3:
	<StructureSection load='2chk' size='340' side='right'caption='[[2chk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2chk' size='340' side='right'caption='[[2chk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2chk]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CHK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CHK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2chk]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CHK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CHK FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LCG:[(1R,3R,4R,7S)-7-HYDROXY-3-(GUANIN-9-YL)-2,5-DIOXABICYCLO[2.2.1]HEPT-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>LCG</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LCG:[(1R,3R,4R,7S)-7-HYDROXY-3-(GUANIN-9-YL)-2,5-DIOXABICYCLO[2.2.1]HEPT-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>LCG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2chj\|2chj]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2chj\|2chj]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2chk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2chk OCA], [~~http~~://pdbe.org/2chk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2chk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2chk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2chk ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2chk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2chk OCA], [https://pdbe.org/2chk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2chk RCSB], [https://www.ebi.ac.uk/pdbsum/2chk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2chk ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 11:09, 26 February 2020

OCA — Wed, 26 Feb 2020 11:09:59 GMT

←Older revision		Revision as of 11:09, 26 February 2020
Line 1:		Line 1:

	==NMR structure of TLLLLT quadruplex==		==NMR structure of TLLLLT quadruplex==
-	<StructureSection load='2chk' size='340' side='right' caption='[[2chk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2chk' size='340' side='right'caption='[[2chk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2chk]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CHK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CHK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2chk]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CHK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CHK FirstGlance]. <br>
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Nielsen, J T]]		[[Category: Nielsen, J T]]
	[[Category: Petersen, M]]		[[Category: Petersen, M]]

OCA at 08:40, 23 May 2018

OCA — Wed, 23 May 2018 08:40:01 GMT

←Older revision		Revision as of 08:40, 23 May 2018
Line 1:		Line 1:
-	==NMR ~~STRUCTURE OF~~ TLLLLT ~~QUADRUPLEX~~==	+
		+	==NMR structure of TLLLLT quadruplex==
	<StructureSection load='2chk' size='340' side='right' caption='[[2chk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2chk' size='340' side='right' caption='[[2chk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LCG:[(1R,3R,4R,7S)-7-HYDROXY-3-(GUANIN-9-YL)-2,5-DIOXABICYCLO[2.2.1]HEPT-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>LCG</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LCG:[(1R,3R,4R,7S)-7-HYDROXY-3-(GUANIN-9-YL)-2,5-DIOXABICYCLO[2.2.1]HEPT-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>LCG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2chj\|2chj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2chj\|2chj]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2chk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2chk OCA], [http://pdbe.org/2chk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2chk RCSB], [http://www.ebi.ac.uk/pdbsum/2chk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2chk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2chk OCA], [http://pdbe.org/2chk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2chk RCSB], [http://www.ebi.ac.uk/pdbsum/2chk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2chk ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 03:33, 11 September 2015

OCA — Fri, 11 Sep 2015 03:33:46 GMT

←Older revision		Revision as of 03:33, 11 September 2015
Line 5:		Line 5:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LCG:[(1R,3R,4R,7S)-7-HYDROXY-3-(GUANIN-9-YL)-2,5-DIOXABICYCLO[2.2.1]HEPT-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>LCG</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LCG:[(1R,3R,4R,7S)-7-HYDROXY-3-(GUANIN-9-YL)-2,5-DIOXABICYCLO[2.2.1]HEPT-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>LCG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2chj\|2chj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2chj\|2chj]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2chk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2chk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2chk RCSB], [http://www.ebi.ac.uk/pdbsum/2chk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2chk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2chk OCA], [http://pdbe.org/2chk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2chk RCSB], [http://www.ebi.ac.uk/pdbsum/2chk PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2chk" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:06, 15 January 2015

OCA — Thu, 15 Jan 2015 17:06:46 GMT

←Older revision		Revision as of 17:06, 15 January 2015
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Nielsen, J T.]]	+	[[Category: Nielsen, J T]]
-	[[Category: Petersen, M.]]	+	[[Category: Petersen, M]]
	[[Category: Lna]]		[[Category: Lna]]
	[[Category: Locked nucleic acid]]		[[Category: Locked nucleic acid]]
	[[Category: Nucleic acid]]		[[Category: Nucleic acid]]
	[[Category: Quadruplex]]		[[Category: Quadruplex]]

OCA at 08:28, 8 October 2014

OCA — Wed, 08 Oct 2014 08:28:14 GMT

←Older revision		Revision as of 08:28, 8 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2chk.~~png~~\|~~left~~\|~~200px~~]]	+	==NMR STRUCTURE OF TLLLLT QUADRUPLEX==
		+	<StructureSection load='2chk' size='340' side='right' caption='[[2chk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2chk]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CHK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CHK FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LCG:[(1R,3R,4R,7S)-7-HYDROXY-3-(GUANIN-9-YL)-2,5-DIOXABICYCLO[2.2.1]HEPT-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>LCG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2chj\|2chj]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2chk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2chk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2chk RCSB], [http://www.ebi.ac.uk/pdbsum/2chk PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We have determined the NMR solution structures of the quadruplexes formed by d(TGLGLT) and d(TL4T), where L denotes LNA (locked nucleic acid) modified G-residues. Both structures are tetrameric, parallel and right-handed and the native global fold of the corresponding DNA quadruplex is retained upon introduction of the LNA nucleotides. However, local structural alterations are observed owing to the locked LNA sugars. In particular, a distinct change in the sugar-phosphate backbone is observed at the G2pL3 and L2pL3 base steps and sequence dependent changes in the twist between tetrads are also seen. Both the LNA modified quadruplexes have raised thermostability as compared to the DNA quadruplex. The quadruplex-forming capability of d(TGLGLT) is of particular interest as it expands the design flexibility for stable parallel LNA quadruplexes and shows that LNA nucleotides can be mixed with DNA or other modified nucleic acids. As such, LNA-based quadruplexes can be decorated by a variety of chemical modifications. Such LNA quadruplex scaffolds might find applications in the developing field of nanobiotechnology.

-	~~{{STRUCTURE_2chk\| PDB=2chk \| SCENE= }}~~	+	NMR solution structures of LNA (locked nucleic acid) modified quadruplexes.,Nielsen JT, Arar K, Petersen M Nucleic Acids Res. 2006 Apr 13;34(7):2006-14. Print 2006. PMID:16614450<ref>PMID:16614450</ref>

-	~~===NMR STRUCTURE OF TLLLLT QUADRUPLEX===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16614450}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2chk]] is~~ a ~~4 chain structure~~. ~~Full experimental information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=2CHK OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016614450<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Nielsen, J T.]]		[[Category: Nielsen, J T.]]
	[[Category: Petersen, M.]]		[[Category: Petersen, M.]]

OCA: Protected "2chk" [edit=sysop:move=sysop]

OCA — Sun, 06 Jan 2013 11:21:54 GMT

Protected "2chk" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:21, 6 January 2013

OCA at 11:21, 6 January 2013

OCA — Sun, 06 Jan 2013 11:21:52 GMT

←Older revision		Revision as of 11:21, 6 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2chk.png\|left\|200px]]		[[Image:2chk.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2chk", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2chk\| PDB=2chk \| SCENE= }}		{{STRUCTURE_2chk\| PDB=2chk \| SCENE= }}

	===NMR STRUCTURE OF TLLLLT QUADRUPLEX===		===NMR STRUCTURE OF TLLLLT QUADRUPLEX===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16614450}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16614450 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16614450}}		{{ABSTRACT_PUBMED_16614450}}

	==About this Structure==		==About this Structure==
-	~~2CHK is a~~ [[~~Single protein~~]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CHK OCA].	+	[[2chk]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CHK OCA].

	==Reference==		==Reference==
-	~~NMR solution structures of LNA (locked nucleic acid) modified quadruplexes., Nielsen JT, Arar K, Petersen M, Nucleic Acids Res. 2006 Apr 13;34(7):2006-14. Print 2006.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16614450 16614450]~~	+	<ref group="xtra">PMID:016614450</ref><references group="xtra"/>
-	~~[[Category: Single protein]]~~	+
	[[Category: Nielsen, J T.]]		[[Category: Nielsen, J T.]]
	[[Category: Petersen, M.]]		[[Category: Petersen, M.]]
Line 31:		Line 18:
	[[Category: Nucleic acid]]		[[Category: Nucleic acid]]
	[[Category: Quadruplex]]		[[Category: Quadruplex]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:16:15 2008''

OCA at 16:16, 28 July 2008

OCA — Mon, 28 Jul 2008 16:16:23 GMT

←Older revision		Revision as of 16:16, 28 July 2008
Line 1:		Line 1:
-	[[Image:2chk.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2chk.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_2chk\| PDB=2chk \| SCENE= }}		{{STRUCTURE_2chk\| PDB=2chk \| SCENE= }}

-	~~'''~~NMR STRUCTURE OF TLLLLT QUADRUPLEX~~'''~~	+	===NMR STRUCTURE OF TLLLLT QUADRUPLEX===


-	~~==Overview==~~	+	<!--
-	~~We have determined the NMR solution structures of the quadruplexes formed by d(TGLGLT) and d(TL4T)~~, ~~where L denotes LNA (locked nucleic acid) modified G-residues. Both structures are tetrameric~~, ~~parallel and right-handed and~~ the ~~native global fold of the corresponding DNA quadruplex is retained upon introduction of the LNA nucleotides. However, local structural alterations are observed owing~~ to the ~~locked LNA sugars. In particular, a distinct change in the sugar-phosphate backbone is observed~~ at ~~the G2pL3 and L2pL3 base steps and sequence dependent changes in the twist between tetrads are also seen~~. ~~Both the LNA modified quadruplexes have raised thermostability as compared to the DNA quadruplex~~. ~~The quadruplex-forming capability of d(TGLGLT~~) is ~~of particular interest as it expands~~ the ~~design flexibility for stable parallel LNA quadruplexes and shows that LNA nucleotides can be mixed with DNA or other modified nucleic acids~~. ~~As such, LNA~~-~~based quadruplexes can be decorated by a variety of chemical modifications. Such LNA quadruplex scaffolds might find applications in the developing field of nanobiotechnology.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_16614450}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 16614450 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_16614450}}

	==About this Structure==		==About this Structure==
-	2CHK is a [[Single protein]] structure. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CHK OCA].	+	2CHK is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CHK OCA].

	==Reference==		==Reference==
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	[[Category: Nucleic acid]]		[[Category: Nucleic acid]]
	[[Category: Quadruplex]]		[[Category: Quadruplex]]
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