2cii - Revision history

OCA at 14:18, 13 December 2023

OCA — Wed, 13 Dec 2023 14:18:23 GMT

←Older revision		Revision as of 14:18, 13 December 2023
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	<StructureSection load='2cii' size='340' side='right'caption='[[2cii]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='2cii' size='340' side='right'caption='[[2cii]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2cii]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human ~~Human~~] and [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CII OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2CII FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2cii]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Human_respirovirus_1 Human respirovirus 1] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CII OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CII FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.55Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>[[1a1m\|1a1m]], [[1a1n\|1a1n]], [[1a1o\|1a1o]], [[1a6z\|1a6z]], [[1a9b\|1a9b]], [[1a9e\|1a9e]], [[1agb\|1agb]], [[1agc\|1agc]], [[1agd\|1agd]], [[1age\|1age]], [[1agf\|1agf]], [[1akj\|1akj]], [[1ao7\|1ao7]], [[1b0g\|1b0g]], [[1b0r\|1b0r]], [[1bd2\|1bd2]], [[1bz9\|1bz9]], [[1c16\|1c16]], [[1ce6\|1ce6]], [[1cg9\|1cg9]], [[1de4\|1de4]], [[1duy\|1duy]], [[1duz\|1duz]], [[1e27\|1e27]], [[1e28\|1e28]], [[1eey\|1eey]], [[1eez\|1eez]], [[1efx\|1efx]], [[1exu\|1exu]], [[1ffn\|1ffn]], [[1ffo\|1ffo]], [[1ffp\|1ffp]], [[1fg2\|1fg2]], [[1gzp\|1gzp]], [[1gzq\|1gzq]], [[1hoc\|1hoc]], [[1hhg\|1hhg]], [[1hhh\|1hhh]], [[1hhi\|1hhi]], [[1hhj\|1hhj]], [[1hhk\|1hhk]], [[1hla\|1hla]], [[1hsa\|1hsa]], [[1hsb\|1hsb]], [[1i1f\|1i1f]], [[1i1y\|1i1y]], [[1i4f\|1i4f]], [[1i7r\|1i7r]], [[1i7t\|1i7t]], [[1i7u\|1i7u]], [[1im3\|1im3]], [[1im9\|1im9]], [[1inq\|1inq]], [[1jf1\|1jf1]], [[1jgd\|1jgd]], [[1jge\|1jge]], [[1jht\|1jht]], [[1jnj\|1jnj]], [[1jpf\|1jpf]], [[1jpg\|1jpg]], [[1juf\|1juf]], [[1k5n\|1k5n]], [[1kpr\|1kpr]], [[1ktl\|1ktl]], [[1lds\|1lds]], [[1lp9\|1lp9]], [[1m05\|1m05]], [[1m6o\|1m6o]], [[1mhe\|1mhe]], [[1mi5\|1mi5]], [[1n2r\|1n2r]], [[1n3n\|1n3n]], [[1n5a\|1n5a]], [[1of2\|1of2]], [[1oga\|1oga]], [[1ogt\|1ogt]], [[1onq\|1onq]], [[1p7q\|1p7q]], [[1py4\|1py4]], [[1q94\|1q94]], [[1qew\|1qew]], [[1qlf\|1qlf]], [[1qqd\|1qqd]], [[1qr1\|1qr1]], [[1qrn\|1qrn]], [[1qse\|1qse]], [[1qsf\|1qsf]], [[1qvo\|1qvo]], [[1r3h\|1r3h]], [[1s7u\|1s7u]], [[1s7v\|1s7v]], [[1s7w\|1s7w]], [[1s7x\|1s7x]], [[1s9w\|1s9w]], [[1s9x\|1s9x]], [[1s9y\|1s9y]], [[1sys\|1sys]], [[1syv\|1syv]], [[1tmc\|1tmc]], [[1tvb\|1tvb]], [[1tvh\|1tvh]], [[1uqs\|1uqs]], [[1ur7\|1ur7]], [[1uxs\|1uxs]], [[1uxw\|1uxw]], [[1vgk\|1vgk]], [[1w0v\|1w0v]], [[1w0w\|1w0w]], [[1w72\|1w72]], [[1wbx\|1wbx]], [[1wby\|1wby]], [[1x7q\|1x7q]], [[1xh3\|1xh3]], [[1xr8\|1xr8]], [[1xr9\|1xr9]], [[1xz0\|1xz0]], [[1yn6\|1yn6]], [[1yn7\|1yn7]], [[1ydp\|1ydp]], [[1ypz\|1ypz]], [[1zhb\|1zhb]], [[1zs8\|1zs8]], [[1zsd\|1zsd]], [[1zt4\|1zt4]], [[2a83\|2a83]], [[2ak4\|2ak4]], [[2av7\|2av7]], [[2axf\|2axf]], [[2axg\|2axg]], [[2bck\|2bck]], [[2bnq\|2bnq]], [[2bnr\|2bnr]], [[2bsr\|2bsr]], [[2bss\|2bss]], [[2bst\|2bst]], [[2bsu\|2bsu]], [[2bsv\|2bsv]], [[2bvq\|2bvq]], [[2c7u\|2c7u]], [[2cik\|2cik]], [[2clr\|2clr]], [[2d31\|2d31]], [[2f74\|2f74]], [[2f8o\|2f8o]], [[2hla\|2hla]], [[3hla\|3hla]]</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2cii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cii OCA], [~~http~~://pdbe.org/2cii PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2cii RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2cii PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2cii ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cii OCA], [https://pdbe.org/2cii PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cii RCSB], [https://www.ebi.ac.uk/pdbsum/2cii PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cii ProSAT]</span></td></tr>
	</table>		</table>
-	== Disease ==
-	[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/HA11_MOUSE HA11_MOUSE]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/NCAP_PI1HW NCAP_PI1HW]] Encapsidates the genome in a ratio of 1 N per 6 ribonucleotides, protecting it from nucleases. The nucleocapsid (NC) has a helical structure. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. During replication, encapsidation by N is coupled to RNA synthesis and all replicative products are resistant to nucleases (By similarity). [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	+	[https://www.uniprot.org/uniprot/HA11_MOUSE HA11_MOUSE] Involved in the presentation of foreign antigens to the immune system.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]		*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
	*[[MHC 3D structures\|MHC 3D structures]]		*[[MHC 3D structures\|MHC 3D structures]]
		+	*[[MHC I 3D structures\|MHC I 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Human]]	+	[[Category: Homo sapiens]]
		+	[[Category: Human respirovirus 1]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Doering, K]]	+	[[Category: Doering K]]
-	[[Category: Elliott, T]]	+	[[Category: Elliott T]]
-	[[Category: Glithero, A]]	+	[[Category: Glithero A]]
-	[[Category: Jones~~, E Y~~]]	+	[[Category: Jones EY]]
-	[[Category: Kojima, M]]	+	[[Category: Kojima M]]
-	[[Category: Tormo, J]]	+	[[Category: Tormo J]]
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Immune response]]~~	+
-	~~[[Category: Immune system-peptide complex]]~~	+
-	~~[[Category: Immune system/peptide]]~~	+
-	~~[[Category: Immunoglobulin domain]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Mhc class i]]~~	+
-	~~[[Category: Mhc i]]~~	+
-	~~[[Category: Peptide binding]]~~	+
-	~~[[Category: Pyrrolidone carboxylic acid]]~~	+
-	~~[[Category: Sendai virus]]~~	+
-	~~[[Category: Transmembrane~~]]	+

OCA at 04:55, 19 November 2020

OCA — Thu, 19 Nov 2020 04:55:38 GMT

←Older revision		Revision as of 04:55, 19 November 2020
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	<StructureSection load='2cii' size='340' side='right'caption='[[2cii]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='2cii' size='340' side='right'caption='[[2cii]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2cii]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CII OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CII FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2cii]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CII OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2CII FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a1m\|1a1m]], [[1a1n\|1a1n]], [[1a1o\|1a1o]], [[1a6z\|1a6z]], [[1a9b\|1a9b]], [[1a9e\|1a9e]], [[1agb\|1agb]], [[1agc\|1agc]], [[1agd\|1agd]], [[1age\|1age]], [[1agf\|1agf]], [[1akj\|1akj]], [[1ao7\|1ao7]], [[1b0g\|1b0g]], [[1b0r\|1b0r]], [[1bd2\|1bd2]], [[1bz9\|1bz9]], [[1c16\|1c16]], [[1ce6\|1ce6]], [[1cg9\|1cg9]], [[1de4\|1de4]], [[1duy\|1duy]], [[1duz\|1duz]], [[1e27\|1e27]], [[1e28\|1e28]], [[1eey\|1eey]], [[1eez\|1eez]], [[1efx\|1efx]], [[1exu\|1exu]], [[1ffn\|1ffn]], [[1ffo\|1ffo]], [[1ffp\|1ffp]], [[1fg2\|1fg2]], [[1gzp\|1gzp]], [[1gzq\|1gzq]], [[1hoc\|1hoc]], [[1hhg\|1hhg]], [[1hhh\|1hhh]], [[1hhi\|1hhi]], [[1hhj\|1hhj]], [[1hhk\|1hhk]], [[1hla\|1hla]], [[1hsa\|1hsa]], [[1hsb\|1hsb]], [[1i1f\|1i1f]], [[1i1y\|1i1y]], [[1i4f\|1i4f]], [[1i7r\|1i7r]], [[1i7t\|1i7t]], [[1i7u\|1i7u]], [[1im3\|1im3]], [[1im9\|1im9]], [[1inq\|1inq]], [[1jf1\|1jf1]], [[1jgd\|1jgd]], [[1jge\|1jge]], [[1jht\|1jht]], [[1jnj\|1jnj]], [[1jpf\|1jpf]], [[1jpg\|1jpg]], [[1juf\|1juf]], [[1k5n\|1k5n]], [[1kpr\|1kpr]], [[1ktl\|1ktl]], [[1lds\|1lds]], [[1lp9\|1lp9]], [[1m05\|1m05]], [[1m6o\|1m6o]], [[1mhe\|1mhe]], [[1mi5\|1mi5]], [[1n2r\|1n2r]], [[1n3n\|1n3n]], [[1n5a\|1n5a]], [[1of2\|1of2]], [[1oga\|1oga]], [[1ogt\|1ogt]], [[1onq\|1onq]], [[1p7q\|1p7q]], [[1py4\|1py4]], [[1q94\|1q94]], [[1qew\|1qew]], [[1qlf\|1qlf]], [[1qqd\|1qqd]], [[1qr1\|1qr1]], [[1qrn\|1qrn]], [[1qse\|1qse]], [[1qsf\|1qsf]], [[1qvo\|1qvo]], [[1r3h\|1r3h]], [[1s7u\|1s7u]], [[1s7v\|1s7v]], [[1s7w\|1s7w]], [[1s7x\|1s7x]], [[1s9w\|1s9w]], [[1s9x\|1s9x]], [[1s9y\|1s9y]], [[1sys\|1sys]], [[1syv\|1syv]], [[1tmc\|1tmc]], [[1tvb\|1tvb]], [[1tvh\|1tvh]], [[1uqs\|1uqs]], [[1ur7\|1ur7]], [[1uxs\|1uxs]], [[1uxw\|1uxw]], [[1vgk\|1vgk]], [[1w0v\|1w0v]], [[1w0w\|1w0w]], [[1w72\|1w72]], [[1wbx\|1wbx]], [[1wby\|1wby]], [[1x7q\|1x7q]], [[1xh3\|1xh3]], [[1xr8\|1xr8]], [[1xr9\|1xr9]], [[1xz0\|1xz0]], [[1yn6\|1yn6]], [[1yn7\|1yn7]], [[1ydp\|1ydp]], [[1ypz\|1ypz]], [[1zhb\|1zhb]], [[1zs8\|1zs8]], [[1zsd\|1zsd]], [[1zt4\|1zt4]], [[2a83\|2a83]], [[2ak4\|2ak4]], [[2av7\|2av7]], [[2axf\|2axf]], [[2axg\|2axg]], [[2bck\|2bck]], [[2bnq\|2bnq]], [[2bnr\|2bnr]], [[2bsr\|2bsr]], [[2bss\|2bss]], [[2bst\|2bst]], [[2bsu\|2bsu]], [[2bsv\|2bsv]], [[2bvq\|2bvq]], [[2c7u\|2c7u]], [[2cik\|2cik]], [[2clr\|2clr]], [[2d31\|2d31]], [[2f74\|2f74]], [[2f8o\|2f8o]], [[2hla\|2hla]], [[3hla\|3hla]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1a1m\|1a1m]], [[1a1n\|1a1n]], [[1a1o\|1a1o]], [[1a6z\|1a6z]], [[1a9b\|1a9b]], [[1a9e\|1a9e]], [[1agb\|1agb]], [[1agc\|1agc]], [[1agd\|1agd]], [[1age\|1age]], [[1agf\|1agf]], [[1akj\|1akj]], [[1ao7\|1ao7]], [[1b0g\|1b0g]], [[1b0r\|1b0r]], [[1bd2\|1bd2]], [[1bz9\|1bz9]], [[1c16\|1c16]], [[1ce6\|1ce6]], [[1cg9\|1cg9]], [[1de4\|1de4]], [[1duy\|1duy]], [[1duz\|1duz]], [[1e27\|1e27]], [[1e28\|1e28]], [[1eey\|1eey]], [[1eez\|1eez]], [[1efx\|1efx]], [[1exu\|1exu]], [[1ffn\|1ffn]], [[1ffo\|1ffo]], [[1ffp\|1ffp]], [[1fg2\|1fg2]], [[1gzp\|1gzp]], [[1gzq\|1gzq]], [[1hoc\|1hoc]], [[1hhg\|1hhg]], [[1hhh\|1hhh]], [[1hhi\|1hhi]], [[1hhj\|1hhj]], [[1hhk\|1hhk]], [[1hla\|1hla]], [[1hsa\|1hsa]], [[1hsb\|1hsb]], [[1i1f\|1i1f]], [[1i1y\|1i1y]], [[1i4f\|1i4f]], [[1i7r\|1i7r]], [[1i7t\|1i7t]], [[1i7u\|1i7u]], [[1im3\|1im3]], [[1im9\|1im9]], [[1inq\|1inq]], [[1jf1\|1jf1]], [[1jgd\|1jgd]], [[1jge\|1jge]], [[1jht\|1jht]], [[1jnj\|1jnj]], [[1jpf\|1jpf]], [[1jpg\|1jpg]], [[1juf\|1juf]], [[1k5n\|1k5n]], [[1kpr\|1kpr]], [[1ktl\|1ktl]], [[1lds\|1lds]], [[1lp9\|1lp9]], [[1m05\|1m05]], [[1m6o\|1m6o]], [[1mhe\|1mhe]], [[1mi5\|1mi5]], [[1n2r\|1n2r]], [[1n3n\|1n3n]], [[1n5a\|1n5a]], [[1of2\|1of2]], [[1oga\|1oga]], [[1ogt\|1ogt]], [[1onq\|1onq]], [[1p7q\|1p7q]], [[1py4\|1py4]], [[1q94\|1q94]], [[1qew\|1qew]], [[1qlf\|1qlf]], [[1qqd\|1qqd]], [[1qr1\|1qr1]], [[1qrn\|1qrn]], [[1qse\|1qse]], [[1qsf\|1qsf]], [[1qvo\|1qvo]], [[1r3h\|1r3h]], [[1s7u\|1s7u]], [[1s7v\|1s7v]], [[1s7w\|1s7w]], [[1s7x\|1s7x]], [[1s9w\|1s9w]], [[1s9x\|1s9x]], [[1s9y\|1s9y]], [[1sys\|1sys]], [[1syv\|1syv]], [[1tmc\|1tmc]], [[1tvb\|1tvb]], [[1tvh\|1tvh]], [[1uqs\|1uqs]], [[1ur7\|1ur7]], [[1uxs\|1uxs]], [[1uxw\|1uxw]], [[1vgk\|1vgk]], [[1w0v\|1w0v]], [[1w0w\|1w0w]], [[1w72\|1w72]], [[1wbx\|1wbx]], [[1wby\|1wby]], [[1x7q\|1x7q]], [[1xh3\|1xh3]], [[1xr8\|1xr8]], [[1xr9\|1xr9]], [[1xz0\|1xz0]], [[1yn6\|1yn6]], [[1yn7\|1yn7]], [[1ydp\|1ydp]], [[1ypz\|1ypz]], [[1zhb\|1zhb]], [[1zs8\|1zs8]], [[1zsd\|1zsd]], [[1zt4\|1zt4]], [[2a83\|2a83]], [[2ak4\|2ak4]], [[2av7\|2av7]], [[2axf\|2axf]], [[2axg\|2axg]], [[2bck\|2bck]], [[2bnq\|2bnq]], [[2bnr\|2bnr]], [[2bsr\|2bsr]], [[2bss\|2bss]], [[2bst\|2bst]], [[2bsu\|2bsu]], [[2bsv\|2bsv]], [[2bvq\|2bvq]], [[2c7u\|2c7u]], [[2cik\|2cik]], [[2clr\|2clr]], [[2d31\|2d31]], [[2f74\|2f74]], [[2f8o\|2f8o]], [[2hla\|2hla]], [[3hla\|3hla]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2cii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cii OCA], [http://pdbe.org/2cii PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cii RCSB], [http://www.ebi.ac.uk/pdbsum/2cii PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cii ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2cii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cii OCA], [http://pdbe.org/2cii PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cii RCSB], [http://www.ebi.ac.uk/pdbsum/2cii PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cii ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 34:		Line 34:
	==See Also==		==See Also==
	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]		*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
-	*[[MHC 3D structures ~~of MHC~~\|MHC 3D structures ~~of MHC~~]]	+	*[[MHC 3D structures\|MHC 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 19:24, 11 December 2019

OCA — Wed, 11 Dec 2019 19:24:47 GMT

←Older revision		Revision as of 19:24, 11 December 2019
Line 1:		Line 1:

	==The crystal structure of H-2Db complexed with a partial peptide epitope suggests an MHC Class I assembly-intermediate==		==The crystal structure of H-2Db complexed with a partial peptide epitope suggests an MHC Class I assembly-intermediate==
-	<StructureSection load='2cii' size='340' side='right' caption='[[2cii]], [[Resolution\|resolution]] 2.55Å' scene=''>	+	<StructureSection load='2cii' size='340' side='right'caption='[[2cii]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cii]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CII OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CII FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cii]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CII OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CII FirstGlance]. <br>
Line 31:		Line 31:
	</div>		</div>
	<div class="pdbe-citations 2cii" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2cii" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
		+	*[[MHC 3D structures of MHC\|MHC 3D structures of MHC]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 40:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Doering, K]]		[[Category: Doering, K]]

OCA at 06:37, 31 January 2018

OCA — Wed, 31 Jan 2018 06:37:03 GMT

←Older revision		Revision as of 06:37, 31 January 2018
Line 1:		Line 1:
-	==~~THE CRYSTAL STRUCTURE OF~~ H-~~2DB COMPLEXED WITH A PARTIAL PEPTIDE EPITOPE SUGGESTS AN~~ MHC ~~CLASS~~ I ~~ASSEMBLY~~-~~INTERMEDIATE~~==	+
		+	==The crystal structure of H-2Db complexed with a partial peptide epitope suggests an MHC Class I assembly-intermediate==
	<StructureSection load='2cii' size='340' side='right' caption='[[2cii]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='2cii' size='340' side='right' caption='[[2cii]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a1m\|1a1m]], [[1a1n\|1a1n]], [[1a1o\|1a1o]], [[1a6z\|1a6z]], [[1a9b\|1a9b]], [[1a9e\|1a9e]], [[1agb\|1agb]], [[1agc\|1agc]], [[1agd\|1agd]], [[1age\|1age]], [[1agf\|1agf]], [[1akj\|1akj]], [[1ao7\|1ao7]], [[1b0g\|1b0g]], [[1b0r\|1b0r]], [[1bd2\|1bd2]], [[1bz9\|1bz9]], [[1c16\|1c16]], [[1ce6\|1ce6]], [[1cg9\|1cg9]], [[1de4\|1de4]], [[1duy\|1duy]], [[1duz\|1duz]], [[1e27\|1e27]], [[1e28\|1e28]], [[1eey\|1eey]], [[1eez\|1eez]], [[1efx\|1efx]], [[1exu\|1exu]], [[1ffn\|1ffn]], [[1ffo\|1ffo]], [[1ffp\|1ffp]], [[1fg2\|1fg2]], [[1gzp\|1gzp]], [[1gzq\|1gzq]], [[1hoc\|1hoc]], [[1hhg\|1hhg]], [[1hhh\|1hhh]], [[1hhi\|1hhi]], [[1hhj\|1hhj]], [[1hhk\|1hhk]], [[1hla\|1hla]], [[1hsa\|1hsa]], [[1hsb\|1hsb]], [[1i1f\|1i1f]], [[1i1y\|1i1y]], [[1i4f\|1i4f]], [[1i7r\|1i7r]], [[1i7t\|1i7t]], [[1i7u\|1i7u]], [[1im3\|1im3]], [[1im9\|1im9]], [[1inq\|1inq]], [[1jf1\|1jf1]], [[1jgd\|1jgd]], [[1jge\|1jge]], [[1jht\|1jht]], [[1jnj\|1jnj]], [[1jpf\|1jpf]], [[1jpg\|1jpg]], [[1juf\|1juf]], [[1k5n\|1k5n]], [[1kpr\|1kpr]], [[1ktl\|1ktl]], [[1lds\|1lds]], [[1lp9\|1lp9]], [[1m05\|1m05]], [[1m6o\|1m6o]], [[1mhe\|1mhe]], [[1mi5\|1mi5]], [[1n2r\|1n2r]], [[1n3n\|1n3n]], [[1n5a\|1n5a]], [[1of2\|1of2]], [[1oga\|1oga]], [[1ogt\|1ogt]], [[1onq\|1onq]], [[1p7q\|1p7q]], [[1py4\|1py4]], [[1q94\|1q94]], [[1qew\|1qew]], [[1qlf\|1qlf]], [[1qqd\|1qqd]], [[1qr1\|1qr1]], [[1qrn\|1qrn]], [[1qse\|1qse]], [[1qsf\|1qsf]], [[1qvo\|1qvo]], [[1r3h\|1r3h]], [[1s7u\|1s7u]], [[1s7v\|1s7v]], [[1s7w\|1s7w]], [[1s7x\|1s7x]], [[1s9w\|1s9w]], [[1s9x\|1s9x]], [[1s9y\|1s9y]], [[1sys\|1sys]], [[1syv\|1syv]], [[1tmc\|1tmc]], [[1tvb\|1tvb]], [[1tvh\|1tvh]], [[1uqs\|1uqs]], [[1ur7\|1ur7]], [[1uxs\|1uxs]], [[1uxw\|1uxw]], [[1vgk\|1vgk]], [[1w0v\|1w0v]], [[1w0w\|1w0w]], [[1w72\|1w72]], [[1wbx\|1wbx]], [[1wby\|1wby]], [[1x7q\|1x7q]], [[1xh3\|1xh3]], [[1xr8\|1xr8]], [[1xr9\|1xr9]], [[1xz0\|1xz0]], [[1yn6\|1yn6]], [[1yn7\|1yn7]], [[1ydp\|1ydp]], [[1ypz\|1ypz]], [[1zhb\|1zhb]], [[1zs8\|1zs8]], [[1zsd\|1zsd]], [[1zt4\|1zt4]], [[2a83\|2a83]], [[2ak4\|2ak4]], [[2av7\|2av7]], [[2axf\|2axf]], [[2axg\|2axg]], [[2bck\|2bck]], [[2bnq\|2bnq]], [[2bnr\|2bnr]], [[2bsr\|2bsr]], [[2bss\|2bss]], [[2bst\|2bst]], [[2bsu\|2bsu]], [[2bsv\|2bsv]], [[2bvq\|2bvq]], [[2c7u\|2c7u]], [[2cik\|2cik]], [[2clr\|2clr]], [[2d31\|2d31]], [[2f74\|2f74]], [[2f8o\|2f8o]], [[2hla\|2hla]], [[3hla\|3hla]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a1m\|1a1m]], [[1a1n\|1a1n]], [[1a1o\|1a1o]], [[1a6z\|1a6z]], [[1a9b\|1a9b]], [[1a9e\|1a9e]], [[1agb\|1agb]], [[1agc\|1agc]], [[1agd\|1agd]], [[1age\|1age]], [[1agf\|1agf]], [[1akj\|1akj]], [[1ao7\|1ao7]], [[1b0g\|1b0g]], [[1b0r\|1b0r]], [[1bd2\|1bd2]], [[1bz9\|1bz9]], [[1c16\|1c16]], [[1ce6\|1ce6]], [[1cg9\|1cg9]], [[1de4\|1de4]], [[1duy\|1duy]], [[1duz\|1duz]], [[1e27\|1e27]], [[1e28\|1e28]], [[1eey\|1eey]], [[1eez\|1eez]], [[1efx\|1efx]], [[1exu\|1exu]], [[1ffn\|1ffn]], [[1ffo\|1ffo]], [[1ffp\|1ffp]], [[1fg2\|1fg2]], [[1gzp\|1gzp]], [[1gzq\|1gzq]], [[1hoc\|1hoc]], [[1hhg\|1hhg]], [[1hhh\|1hhh]], [[1hhi\|1hhi]], [[1hhj\|1hhj]], [[1hhk\|1hhk]], [[1hla\|1hla]], [[1hsa\|1hsa]], [[1hsb\|1hsb]], [[1i1f\|1i1f]], [[1i1y\|1i1y]], [[1i4f\|1i4f]], [[1i7r\|1i7r]], [[1i7t\|1i7t]], [[1i7u\|1i7u]], [[1im3\|1im3]], [[1im9\|1im9]], [[1inq\|1inq]], [[1jf1\|1jf1]], [[1jgd\|1jgd]], [[1jge\|1jge]], [[1jht\|1jht]], [[1jnj\|1jnj]], [[1jpf\|1jpf]], [[1jpg\|1jpg]], [[1juf\|1juf]], [[1k5n\|1k5n]], [[1kpr\|1kpr]], [[1ktl\|1ktl]], [[1lds\|1lds]], [[1lp9\|1lp9]], [[1m05\|1m05]], [[1m6o\|1m6o]], [[1mhe\|1mhe]], [[1mi5\|1mi5]], [[1n2r\|1n2r]], [[1n3n\|1n3n]], [[1n5a\|1n5a]], [[1of2\|1of2]], [[1oga\|1oga]], [[1ogt\|1ogt]], [[1onq\|1onq]], [[1p7q\|1p7q]], [[1py4\|1py4]], [[1q94\|1q94]], [[1qew\|1qew]], [[1qlf\|1qlf]], [[1qqd\|1qqd]], [[1qr1\|1qr1]], [[1qrn\|1qrn]], [[1qse\|1qse]], [[1qsf\|1qsf]], [[1qvo\|1qvo]], [[1r3h\|1r3h]], [[1s7u\|1s7u]], [[1s7v\|1s7v]], [[1s7w\|1s7w]], [[1s7x\|1s7x]], [[1s9w\|1s9w]], [[1s9x\|1s9x]], [[1s9y\|1s9y]], [[1sys\|1sys]], [[1syv\|1syv]], [[1tmc\|1tmc]], [[1tvb\|1tvb]], [[1tvh\|1tvh]], [[1uqs\|1uqs]], [[1ur7\|1ur7]], [[1uxs\|1uxs]], [[1uxw\|1uxw]], [[1vgk\|1vgk]], [[1w0v\|1w0v]], [[1w0w\|1w0w]], [[1w72\|1w72]], [[1wbx\|1wbx]], [[1wby\|1wby]], [[1x7q\|1x7q]], [[1xh3\|1xh3]], [[1xr8\|1xr8]], [[1xr9\|1xr9]], [[1xz0\|1xz0]], [[1yn6\|1yn6]], [[1yn7\|1yn7]], [[1ydp\|1ydp]], [[1ypz\|1ypz]], [[1zhb\|1zhb]], [[1zs8\|1zs8]], [[1zsd\|1zsd]], [[1zt4\|1zt4]], [[2a83\|2a83]], [[2ak4\|2ak4]], [[2av7\|2av7]], [[2axf\|2axf]], [[2axg\|2axg]], [[2bck\|2bck]], [[2bnq\|2bnq]], [[2bnr\|2bnr]], [[2bsr\|2bsr]], [[2bss\|2bss]], [[2bst\|2bst]], [[2bsu\|2bsu]], [[2bsv\|2bsv]], [[2bvq\|2bvq]], [[2c7u\|2c7u]], [[2cik\|2cik]], [[2clr\|2clr]], [[2d31\|2d31]], [[2f74\|2f74]], [[2f8o\|2f8o]], [[2hla\|2hla]], [[3hla\|3hla]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cii OCA], [http://pdbe.org/2cii PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cii RCSB], [http://www.ebi.ac.uk/pdbsum/2cii PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cii OCA], [http://pdbe.org/2cii PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cii RCSB], [http://www.ebi.ac.uk/pdbsum/2cii PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cii ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ci/2cii_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ci/2cii_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 31:
	</div>		</div>
	<div class="pdbe-citations 2cii" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2cii" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Beta-2 microglobulin\|Beta-2 microglobulin]]
-	*[[Major histocompatibility complex\|Major histocompatibility complex]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 23:50, 9 February 2016

OCA — Tue, 09 Feb 2016 23:50:09 GMT

←Older revision		Revision as of 23:50, 9 February 2016
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cii ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 03:16, 11 September 2015

OCA — Fri, 11 Sep 2015 03:16:46 GMT

←Older revision		Revision as of 03:16, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2cii' size='340' side='right' caption='[[2cii]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='2cii' size='340' side='right' caption='[[2cii]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2cii]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~] and [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CII OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CII FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2cii]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CII OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CII FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a1m\|1a1m]], [[1a1n\|1a1n]], [[1a1o\|1a1o]], [[1a6z\|1a6z]], [[1a9b\|1a9b]], [[1a9e\|1a9e]], [[1agb\|1agb]], [[1agc\|1agc]], [[1agd\|1agd]], [[1age\|1age]], [[1agf\|1agf]], [[1akj\|1akj]], [[1ao7\|1ao7]], [[1b0g\|1b0g]], [[1b0r\|1b0r]], [[1bd2\|1bd2]], [[1bz9\|1bz9]], [[1c16\|1c16]], [[1ce6\|1ce6]], [[1cg9\|1cg9]], [[1de4\|1de4]], [[1duy\|1duy]], [[1duz\|1duz]], [[1e27\|1e27]], [[1e28\|1e28]], [[1eey\|1eey]], [[1eez\|1eez]], [[1efx\|1efx]], [[1exu\|1exu]], [[1ffn\|1ffn]], [[1ffo\|1ffo]], [[1ffp\|1ffp]], [[1fg2\|1fg2]], [[1gzp\|1gzp]], [[1gzq\|1gzq]], [[1hoc\|1hoc]], [[1hhg\|1hhg]], [[1hhh\|1hhh]], [[1hhi\|1hhi]], [[1hhj\|1hhj]], [[1hhk\|1hhk]], [[1hla\|1hla]], [[1hsa\|1hsa]], [[1hsb\|1hsb]], [[1i1f\|1i1f]], [[1i1y\|1i1y]], [[1i4f\|1i4f]], [[1i7r\|1i7r]], [[1i7t\|1i7t]], [[1i7u\|1i7u]], [[1im3\|1im3]], [[1im9\|1im9]], [[1inq\|1inq]], [[1jf1\|1jf1]], [[1jgd\|1jgd]], [[1jge\|1jge]], [[1jht\|1jht]], [[1jnj\|1jnj]], [[1jpf\|1jpf]], [[1jpg\|1jpg]], [[1juf\|1juf]], [[1k5n\|1k5n]], [[1kpr\|1kpr]], [[1ktl\|1ktl]], [[1lds\|1lds]], [[1lp9\|1lp9]], [[1m05\|1m05]], [[1m6o\|1m6o]], [[1mhe\|1mhe]], [[1mi5\|1mi5]], [[1n2r\|1n2r]], [[1n3n\|1n3n]], [[1n5a\|1n5a]], [[1of2\|1of2]], [[1oga\|1oga]], [[1ogt\|1ogt]], [[1onq\|1onq]], [[1p7q\|1p7q]], [[1py4\|1py4]], [[1q94\|1q94]], [[1qew\|1qew]], [[1qlf\|1qlf]], [[1qqd\|1qqd]], [[1qr1\|1qr1]], [[1qrn\|1qrn]], [[1qse\|1qse]], [[1qsf\|1qsf]], [[1qvo\|1qvo]], [[1r3h\|1r3h]], [[1s7u\|1s7u]], [[1s7v\|1s7v]], [[1s7w\|1s7w]], [[1s7x\|1s7x]], [[1s9w\|1s9w]], [[1s9x\|1s9x]], [[1s9y\|1s9y]], [[1sys\|1sys]], [[1syv\|1syv]], [[1tmc\|1tmc]], [[1tvb\|1tvb]], [[1tvh\|1tvh]], [[1uqs\|1uqs]], [[1ur7\|1ur7]], [[1uxs\|1uxs]], [[1uxw\|1uxw]], [[1vgk\|1vgk]], [[1w0v\|1w0v]], [[1w0w\|1w0w]], [[1w72\|1w72]], [[1wbx\|1wbx]], [[1wby\|1wby]], [[1x7q\|1x7q]], [[1xh3\|1xh3]], [[1xr8\|1xr8]], [[1xr9\|1xr9]], [[1xz0\|1xz0]], [[1yn6\|1yn6]], [[1yn7\|1yn7]], [[1ydp\|1ydp]], [[1ypz\|1ypz]], [[1zhb\|1zhb]], [[1zs8\|1zs8]], [[1zsd\|1zsd]], [[1zt4\|1zt4]], [[2a83\|2a83]], [[2ak4\|2ak4]], [[2av7\|2av7]], [[2axf\|2axf]], [[2axg\|2axg]], [[2bck\|2bck]], [[2bnq\|2bnq]], [[2bnr\|2bnr]], [[2bsr\|2bsr]], [[2bss\|2bss]], [[2bst\|2bst]], [[2bsu\|2bsu]], [[2bsv\|2bsv]], [[2bvq\|2bvq]], [[2c7u\|2c7u]], [[2cik\|2cik]], [[2clr\|2clr]], [[2d31\|2d31]], [[2f74\|2f74]], [[2f8o\|2f8o]], [[2hla\|2hla]], [[3hla\|3hla]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a1m\|1a1m]], [[1a1n\|1a1n]], [[1a1o\|1a1o]], [[1a6z\|1a6z]], [[1a9b\|1a9b]], [[1a9e\|1a9e]], [[1agb\|1agb]], [[1agc\|1agc]], [[1agd\|1agd]], [[1age\|1age]], [[1agf\|1agf]], [[1akj\|1akj]], [[1ao7\|1ao7]], [[1b0g\|1b0g]], [[1b0r\|1b0r]], [[1bd2\|1bd2]], [[1bz9\|1bz9]], [[1c16\|1c16]], [[1ce6\|1ce6]], [[1cg9\|1cg9]], [[1de4\|1de4]], [[1duy\|1duy]], [[1duz\|1duz]], [[1e27\|1e27]], [[1e28\|1e28]], [[1eey\|1eey]], [[1eez\|1eez]], [[1efx\|1efx]], [[1exu\|1exu]], [[1ffn\|1ffn]], [[1ffo\|1ffo]], [[1ffp\|1ffp]], [[1fg2\|1fg2]], [[1gzp\|1gzp]], [[1gzq\|1gzq]], [[1hoc\|1hoc]], [[1hhg\|1hhg]], [[1hhh\|1hhh]], [[1hhi\|1hhi]], [[1hhj\|1hhj]], [[1hhk\|1hhk]], [[1hla\|1hla]], [[1hsa\|1hsa]], [[1hsb\|1hsb]], [[1i1f\|1i1f]], [[1i1y\|1i1y]], [[1i4f\|1i4f]], [[1i7r\|1i7r]], [[1i7t\|1i7t]], [[1i7u\|1i7u]], [[1im3\|1im3]], [[1im9\|1im9]], [[1inq\|1inq]], [[1jf1\|1jf1]], [[1jgd\|1jgd]], [[1jge\|1jge]], [[1jht\|1jht]], [[1jnj\|1jnj]], [[1jpf\|1jpf]], [[1jpg\|1jpg]], [[1juf\|1juf]], [[1k5n\|1k5n]], [[1kpr\|1kpr]], [[1ktl\|1ktl]], [[1lds\|1lds]], [[1lp9\|1lp9]], [[1m05\|1m05]], [[1m6o\|1m6o]], [[1mhe\|1mhe]], [[1mi5\|1mi5]], [[1n2r\|1n2r]], [[1n3n\|1n3n]], [[1n5a\|1n5a]], [[1of2\|1of2]], [[1oga\|1oga]], [[1ogt\|1ogt]], [[1onq\|1onq]], [[1p7q\|1p7q]], [[1py4\|1py4]], [[1q94\|1q94]], [[1qew\|1qew]], [[1qlf\|1qlf]], [[1qqd\|1qqd]], [[1qr1\|1qr1]], [[1qrn\|1qrn]], [[1qse\|1qse]], [[1qsf\|1qsf]], [[1qvo\|1qvo]], [[1r3h\|1r3h]], [[1s7u\|1s7u]], [[1s7v\|1s7v]], [[1s7w\|1s7w]], [[1s7x\|1s7x]], [[1s9w\|1s9w]], [[1s9x\|1s9x]], [[1s9y\|1s9y]], [[1sys\|1sys]], [[1syv\|1syv]], [[1tmc\|1tmc]], [[1tvb\|1tvb]], [[1tvh\|1tvh]], [[1uqs\|1uqs]], [[1ur7\|1ur7]], [[1uxs\|1uxs]], [[1uxw\|1uxw]], [[1vgk\|1vgk]], [[1w0v\|1w0v]], [[1w0w\|1w0w]], [[1w72\|1w72]], [[1wbx\|1wbx]], [[1wby\|1wby]], [[1x7q\|1x7q]], [[1xh3\|1xh3]], [[1xr8\|1xr8]], [[1xr9\|1xr9]], [[1xz0\|1xz0]], [[1yn6\|1yn6]], [[1yn7\|1yn7]], [[1ydp\|1ydp]], [[1ypz\|1ypz]], [[1zhb\|1zhb]], [[1zs8\|1zs8]], [[1zsd\|1zsd]], [[1zt4\|1zt4]], [[2a83\|2a83]], [[2ak4\|2ak4]], [[2av7\|2av7]], [[2axf\|2axf]], [[2axg\|2axg]], [[2bck\|2bck]], [[2bnq\|2bnq]], [[2bnr\|2bnr]], [[2bsr\|2bsr]], [[2bss\|2bss]], [[2bst\|2bst]], [[2bsu\|2bsu]], [[2bsv\|2bsv]], [[2bvq\|2bvq]], [[2c7u\|2c7u]], [[2cik\|2cik]], [[2clr\|2clr]], [[2d31\|2d31]], [[2f74\|2f74]], [[2f8o\|2f8o]], [[2hla\|2hla]], [[3hla\|3hla]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cii OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cii RCSB], [http://www.ebi.ac.uk/pdbsum/2cii PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cii OCA], [http://pdbe.org/2cii PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cii RCSB], [http://www.ebi.ac.uk/pdbsum/2cii PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2cii" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 37:		Line 38:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Doering, K]]		[[Category: Doering, K]]
	[[Category: Elliott, T]]		[[Category: Elliott, T]]

OCA at 16:39, 15 January 2015

OCA — Thu, 15 Jan 2015 16:39:15 GMT

←Older revision		Revision as of 16:39, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cii]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CII OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CII FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cii]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CII OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CII FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a1m\|1a1m]], [[1a1n\|1a1n]], [[1a1o\|1a1o]], [[1a6z\|1a6z]], [[1a9b\|1a9b]], [[1a9e\|1a9e]], [[1agb\|1agb]], [[1agc\|1agc]], [[1agd\|1agd]], [[1age\|1age]], [[1agf\|1agf]], [[1akj\|1akj]], [[1ao7\|1ao7]], [[1b0g\|1b0g]], [[1b0r\|1b0r]], [[1bd2\|1bd2]], [[1bz9\|1bz9]], [[1c16\|1c16]], [[1ce6\|1ce6]], [[1cg9\|1cg9]], [[1de4\|1de4]], [[1duy\|1duy]], [[1duz\|1duz]], [[1e27\|1e27]], [[1e28\|1e28]], [[1eey\|1eey]], [[1eez\|1eez]], [[1efx\|1efx]], [[1exu\|1exu]], [[1ffn\|1ffn]], [[1ffo\|1ffo]], [[1ffp\|1ffp]], [[1fg2\|1fg2]], [[1gzp\|1gzp]], [[1gzq\|1gzq]], [[1hoc\|1hoc]], [[1hhg\|1hhg]], [[1hhh\|1hhh]], [[1hhi\|1hhi]], [[1hhj\|1hhj]], [[1hhk\|1hhk]], [[1hla\|1hla]], [[1hsa\|1hsa]], [[1hsb\|1hsb]], [[1i1f\|1i1f]], [[1i1y\|1i1y]], [[1i4f\|1i4f]], [[1i7r\|1i7r]], [[1i7t\|1i7t]], [[1i7u\|1i7u]], [[1im3\|1im3]], [[1im9\|1im9]], [[1inq\|1inq]], [[1jf1\|1jf1]], [[1jgd\|1jgd]], [[1jge\|1jge]], [[1jht\|1jht]], [[1jnj\|1jnj]], [[1jpf\|1jpf]], [[1jpg\|1jpg]], [[1juf\|1juf]], [[1k5n\|1k5n]], [[1kpr\|1kpr]], [[1ktl\|1ktl]], [[1lds\|1lds]], [[1lp9\|1lp9]], [[1m05\|1m05]], [[1m6o\|1m6o]], [[1mhe\|1mhe]], [[1mi5\|1mi5]], [[1n2r\|1n2r]], [[1n3n\|1n3n]], [[1n5a\|1n5a]], [[1of2\|1of2]], [[1oga\|1oga]], [[1ogt\|1ogt]], [[1onq\|1onq]], [[1p7q\|1p7q]], [[1py4\|1py4]], [[1q94\|1q94]], [[1qew\|1qew]], [[1qlf\|1qlf]], [[1qqd\|1qqd]], [[1qr1\|1qr1]], [[1qrn\|1qrn]], [[1qse\|1qse]], [[1qsf\|1qsf]], [[1qvo\|1qvo]], [[1r3h\|1r3h]], [[1s7u\|1s7u]], [[1s7v\|1s7v]], [[1s7w\|1s7w]], [[1s7x\|1s7x]], [[1s9w\|1s9w]], [[1s9x\|1s9x]], [[1s9y\|1s9y]], [[1sys\|1sys]], [[1syv\|1syv]], [[1tmc\|1tmc]], [[1tvb\|1tvb]], [[1tvh\|1tvh]], [[1uqs\|1uqs]], [[1ur7\|1ur7]], [[1uxs\|1uxs]], [[1uxw\|1uxw]], [[1vgk\|1vgk]], [[1w0v\|1w0v]], [[1w0w\|1w0w]], [[1w72\|1w72]], [[1wbx\|1wbx]], [[1wby\|1wby]], [[1x7q\|1x7q]], [[1xh3\|1xh3]], [[1xr8\|1xr8]], [[1xr9\|1xr9]], [[1xz0\|1xz0]], [[1yn6\|1yn6]], [[1yn7\|1yn7]], [[1ydp\|1ydp]], [[1ypz\|1ypz]], [[1zhb\|1zhb]], [[1zs8\|1zs8]], [[1zsd\|1zsd]], [[1zt4\|1zt4]], [[2a83\|2a83]], [[2ak4\|2ak4]], [[2av7\|2av7]], [[2axf\|2axf]], [[2axg\|2axg]], [[2bck\|2bck]], [[2bnq\|2bnq]], [[2bnr\|2bnr]], [[2bsr\|2bsr]], [[2bss\|2bss]], [[2bst\|2bst]], [[2bsu\|2bsu]], [[2bsv\|2bsv]], [[2bvq\|2bvq]], [[2c7u\|2c7u]], [[2cik\|2cik]], [[2clr\|2clr]], [[2d31\|2d31]], [[2f74\|2f74]], [[2f8o\|2f8o]], [[2hla\|2hla]], [[3hla\|3hla]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a1m\|1a1m]], [[1a1n\|1a1n]], [[1a1o\|1a1o]], [[1a6z\|1a6z]], [[1a9b\|1a9b]], [[1a9e\|1a9e]], [[1agb\|1agb]], [[1agc\|1agc]], [[1agd\|1agd]], [[1age\|1age]], [[1agf\|1agf]], [[1akj\|1akj]], [[1ao7\|1ao7]], [[1b0g\|1b0g]], [[1b0r\|1b0r]], [[1bd2\|1bd2]], [[1bz9\|1bz9]], [[1c16\|1c16]], [[1ce6\|1ce6]], [[1cg9\|1cg9]], [[1de4\|1de4]], [[1duy\|1duy]], [[1duz\|1duz]], [[1e27\|1e27]], [[1e28\|1e28]], [[1eey\|1eey]], [[1eez\|1eez]], [[1efx\|1efx]], [[1exu\|1exu]], [[1ffn\|1ffn]], [[1ffo\|1ffo]], [[1ffp\|1ffp]], [[1fg2\|1fg2]], [[1gzp\|1gzp]], [[1gzq\|1gzq]], [[1hoc\|1hoc]], [[1hhg\|1hhg]], [[1hhh\|1hhh]], [[1hhi\|1hhi]], [[1hhj\|1hhj]], [[1hhk\|1hhk]], [[1hla\|1hla]], [[1hsa\|1hsa]], [[1hsb\|1hsb]], [[1i1f\|1i1f]], [[1i1y\|1i1y]], [[1i4f\|1i4f]], [[1i7r\|1i7r]], [[1i7t\|1i7t]], [[1i7u\|1i7u]], [[1im3\|1im3]], [[1im9\|1im9]], [[1inq\|1inq]], [[1jf1\|1jf1]], [[1jgd\|1jgd]], [[1jge\|1jge]], [[1jht\|1jht]], [[1jnj\|1jnj]], [[1jpf\|1jpf]], [[1jpg\|1jpg]], [[1juf\|1juf]], [[1k5n\|1k5n]], [[1kpr\|1kpr]], [[1ktl\|1ktl]], [[1lds\|1lds]], [[1lp9\|1lp9]], [[1m05\|1m05]], [[1m6o\|1m6o]], [[1mhe\|1mhe]], [[1mi5\|1mi5]], [[1n2r\|1n2r]], [[1n3n\|1n3n]], [[1n5a\|1n5a]], [[1of2\|1of2]], [[1oga\|1oga]], [[1ogt\|1ogt]], [[1onq\|1onq]], [[1p7q\|1p7q]], [[1py4\|1py4]], [[1q94\|1q94]], [[1qew\|1qew]], [[1qlf\|1qlf]], [[1qqd\|1qqd]], [[1qr1\|1qr1]], [[1qrn\|1qrn]], [[1qse\|1qse]], [[1qsf\|1qsf]], [[1qvo\|1qvo]], [[1r3h\|1r3h]], [[1s7u\|1s7u]], [[1s7v\|1s7v]], [[1s7w\|1s7w]], [[1s7x\|1s7x]], [[1s9w\|1s9w]], [[1s9x\|1s9x]], [[1s9y\|1s9y]], [[1sys\|1sys]], [[1syv\|1syv]], [[1tmc\|1tmc]], [[1tvb\|1tvb]], [[1tvh\|1tvh]], [[1uqs\|1uqs]], [[1ur7\|1ur7]], [[1uxs\|1uxs]], [[1uxw\|1uxw]], [[1vgk\|1vgk]], [[1w0v\|1w0v]], [[1w0w\|1w0w]], [[1w72\|1w72]], [[1wbx\|1wbx]], [[1wby\|1wby]], [[1x7q\|1x7q]], [[1xh3\|1xh3]], [[1xr8\|1xr8]], [[1xr9\|1xr9]], [[1xz0\|1xz0]], [[1yn6\|1yn6]], [[1yn7\|1yn7]], [[1ydp\|1ydp]], [[1ypz\|1ypz]], [[1zhb\|1zhb]], [[1zs8\|1zs8]], [[1zsd\|1zsd]], [[1zt4\|1zt4]], [[2a83\|2a83]], [[2ak4\|2ak4]], [[2av7\|2av7]], [[2axf\|2axf]], [[2axg\|2axg]], [[2bck\|2bck]], [[2bnq\|2bnq]], [[2bnr\|2bnr]], [[2bsr\|2bsr]], [[2bss\|2bss]], [[2bst\|2bst]], [[2bsu\|2bsu]], [[2bsv\|2bsv]], [[2bvq\|2bvq]], [[2c7u\|2c7u]], [[2cik\|2cik]], [[2clr\|2clr]], [[2d31\|2d31]], [[2f74\|2f74]], [[2f8o\|2f8o]], [[2hla\|2hla]], [[3hla\|3hla]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cii OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cii RCSB], [http://www.ebi.ac.uk/pdbsum/2cii PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cii OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cii RCSB], [http://www.ebi.ac.uk/pdbsum/2cii PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>		[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
Line 39:		Line 39:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Doering, K.]]	+	[[Category: Doering, K]]
-	[[Category: Elliott, T.]]	+	[[Category: Elliott, T]]
-	[[Category: Glithero, A.]]	+	[[Category: Glithero, A]]
-	[[Category: Jones, E Y.]]	+	[[Category: Jones, E Y]]
-	[[Category: Kojima, M.]]	+	[[Category: Kojima, M]]
-	[[Category: Tormo, J.]]	+	[[Category: Tormo, J]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]
	[[Category: Immune response]]		[[Category: Immune response]]

OCA at 01:52, 30 September 2014

OCA — Tue, 30 Sep 2014 01:52:45 GMT

←Older revision		Revision as of 01:52, 30 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2cii\| PDB=2cii \| SCENE= }}~~	+	==THE CRYSTAL STRUCTURE OF H-2DB COMPLEXED WITH A PARTIAL PEPTIDE EPITOPE SUGGESTS AN MHC CLASS I ASSEMBLY-INTERMEDIATE==
-	===THE CRYSTAL STRUCTURE OF H-2DB COMPLEXED WITH A PARTIAL PEPTIDE EPITOPE SUGGESTS AN MHC CLASS I ASSEMBLY-INTERMEDIATE===	+	<StructureSection load='2cii' size='340' side='right' caption='[[2cii]], [[Resolution\|resolution]] 2.55Å' scene=''>
-	~~{{ABSTRACT_PUBMED_16478731}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2cii]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CII OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CII FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a1m\|1a1m]], [[1a1n\|1a1n]], [[1a1o\|1a1o]], [[1a6z\|1a6z]], [[1a9b\|1a9b]], [[1a9e\|1a9e]], [[1agb\|1agb]], [[1agc\|1agc]], [[1agd\|1agd]], [[1age\|1age]], [[1agf\|1agf]], [[1akj\|1akj]], [[1ao7\|1ao7]], [[1b0g\|1b0g]], [[1b0r\|1b0r]], [[1bd2\|1bd2]], [[1bz9\|1bz9]], [[1c16\|1c16]], [[1ce6\|1ce6]], [[1cg9\|1cg9]], [[1de4\|1de4]], [[1duy\|1duy]], [[1duz\|1duz]], [[1e27\|1e27]], [[1e28\|1e28]], [[1eey\|1eey]], [[1eez\|1eez]], [[1efx\|1efx]], [[1exu\|1exu]], [[1ffn\|1ffn]], [[1ffo\|1ffo]], [[1ffp\|1ffp]], [[1fg2\|1fg2]], [[1gzp\|1gzp]], [[1gzq\|1gzq]], [[1hoc\|1hoc]], [[1hhg\|1hhg]], [[1hhh\|1hhh]], [[1hhi\|1hhi]], [[1hhj\|1hhj]], [[1hhk\|1hhk]], [[1hla\|1hla]], [[1hsa\|1hsa]], [[1hsb\|1hsb]], [[1i1f\|1i1f]], [[1i1y\|1i1y]], [[1i4f\|1i4f]], [[1i7r\|1i7r]], [[1i7t\|1i7t]], [[1i7u\|1i7u]], [[1im3\|1im3]], [[1im9\|1im9]], [[1inq\|1inq]], [[1jf1\|1jf1]], [[1jgd\|1jgd]], [[1jge\|1jge]], [[1jht\|1jht]], [[1jnj\|1jnj]], [[1jpf\|1jpf]], [[1jpg\|1jpg]], [[1juf\|1juf]], [[1k5n\|1k5n]], [[1kpr\|1kpr]], [[1ktl\|1ktl]], [[1lds\|1lds]], [[1lp9\|1lp9]], [[1m05\|1m05]], [[1m6o\|1m6o]], [[1mhe\|1mhe]], [[1mi5\|1mi5]], [[1n2r\|1n2r]], [[1n3n\|1n3n]], [[1n5a\|1n5a]], [[1of2\|1of2]], [[1oga\|1oga]], [[1ogt\|1ogt]], [[1onq\|1onq]], [[1p7q\|1p7q]], [[1py4\|1py4]], [[1q94\|1q94]], [[1qew\|1qew]], [[1qlf\|1qlf]], [[1qqd\|1qqd]], [[1qr1\|1qr1]], [[1qrn\|1qrn]], [[1qse\|1qse]], [[1qsf\|1qsf]], [[1qvo\|1qvo]], [[1r3h\|1r3h]], [[1s7u\|1s7u]], [[1s7v\|1s7v]], [[1s7w\|1s7w]], [[1s7x\|1s7x]], [[1s9w\|1s9w]], [[1s9x\|1s9x]], [[1s9y\|1s9y]], [[1sys\|1sys]], [[1syv\|1syv]], [[1tmc\|1tmc]], [[1tvb\|1tvb]], [[1tvh\|1tvh]], [[1uqs\|1uqs]], [[1ur7\|1ur7]], [[1uxs\|1uxs]], [[1uxw\|1uxw]], [[1vgk\|1vgk]], [[1w0v\|1w0v]], [[1w0w\|1w0w]], [[1w72\|1w72]], [[1wbx\|1wbx]], [[1wby\|1wby]], [[1x7q\|1x7q]], [[1xh3\|1xh3]], [[1xr8\|1xr8]], [[1xr9\|1xr9]], [[1xz0\|1xz0]], [[1yn6\|1yn6]], [[1yn7\|1yn7]], [[1ydp\|1ydp]], [[1ypz\|1ypz]], [[1zhb\|1zhb]], [[1zs8\|1zs8]], [[1zsd\|1zsd]], [[1zt4\|1zt4]], [[2a83\|2a83]], [[2ak4\|2ak4]], [[2av7\|2av7]], [[2axf\|2axf]], [[2axg\|2axg]], [[2bck\|2bck]], [[2bnq\|2bnq]], [[2bnr\|2bnr]], [[2bsr\|2bsr]], [[2bss\|2bss]], [[2bst\|2bst]], [[2bsu\|2bsu]], [[2bsv\|2bsv]], [[2bvq\|2bvq]], [[2c7u\|2c7u]], [[2cik\|2cik]], [[2clr\|2clr]], [[2d31\|2d31]], [[2f74\|2f74]], [[2f8o\|2f8o]], [[2hla\|2hla]], [[3hla\|3hla]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cii OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cii RCSB], [http://www.ebi.ac.uk/pdbsum/2cii PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HA11_MOUSE HA11_MOUSE]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/NCAP_PI1HW NCAP_PI1HW]] Encapsidates the genome in a ratio of 1 N per 6 ribonucleotides, protecting it from nucleases. The nucleocapsid (NC) has a helical structure. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. During replication, encapsidation by N is coupled to RNA synthesis and all replicative products are resistant to nucleases (By similarity). [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ci/2cii_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In the absence of bound peptide ligands, major histocompatibility complex (MHC) class I molecules are unstable. In an attempt to determine the minimum requirement for peptide-dependent MHC class I stabilization, we have used short synthetic peptides derived from the Sendai virus nucleoprotein epitope (residues 324-332, 1FAPGNYPAL9) to promote its folding in vitro of H-2D(b). We found that H-2D(b) can be stabilized by the pentapeptide 5NYPAL9, which is equivalent to the C-terminal portion of the optimal nonapeptide and includes both the P5 and P9 anchor residues. We have crystallized the complex of the H-2D(b) molecule with the pentamer and determined the structure to show how a quasi-stable MHC class I molecule can be formed by occupancy of a single binding pocket in the peptide-binding groove.

-	~~==Disease==~~	+	The crystal structure of H-2D(b) complexed with a partial peptide epitope suggests a major histocompatibility complex class I assembly intermediate.,Glithero A, Tormo J, Doering K, Kojima M, Jones EY, Elliott T J Biol Chem. 2006 May 5;281(18):12699-704. Epub 2006 Feb 14. PMID:16478731<ref>PMID:16478731</ref>
-	~~[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause~~ of ~~hypercatabolic hypoproteinemia~~ (~~HYCATHYP~~) ~~[MIM:[http://omim~~.~~org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin~~, ~~probably due to rapid degradation~~.~~<ref>PMID~~:~~16549777</ref> Note=Beta~~-~~2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states~~. ~~The capacity to assemble into amyloid fibrils is concentration dependent~~. ~~Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>~~PMID:3532124</ref><ref>PMID:1336137</ref><ref>PMID:7554280</ref><ref>PMID:4586824</ref><ref>PMID:8084451</ref><ref>PMID:12119416</ref><ref>PMID:12796775</ref><ref>PMID:16901902</ref><ref>PMID:16491088</ref><ref>PMID:17646174</ref><ref>PMID:18835253</ref><ref>PMID:18395224</ref><ref>PMID:~~19284997~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~//www.uniprot.org/uniprot/HA11_MOUSE HA11_MOUSE]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/NCAP_PI1HW NCAP_PI1HW]] Encapsidates the genome in a ~~ratio~~ of ~~1 N per 6 ribonucleotides, protecting it from nucleases. The nucleocapsid (NC) has a helical structure. The encapsidated genomic RNA is termed~~ the ~~NC and serves as template for transcription and replication~~. ~~During replication, encapsidation by N is coupled to RNA synthesis and all replicative products are resistant to nucleases (By similarity)~~. ~~[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component~~ of ~~the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system~~.	+	</div>
-		+
-	~~==About this Structure==~~	+
-	~~[[2cii]] is a 3 chain structure with sequence from [http:~~//en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CII OCA].	+

	==See Also==		==See Also==
	*[[Beta-2 microglobulin\|Beta-2 microglobulin]]		*[[Beta-2 microglobulin\|Beta-2 microglobulin]]
	*[[Major histocompatibility complex\|Major histocompatibility complex]]		*[[Major histocompatibility complex\|Major histocompatibility complex]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:016478731</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]

OCA at 20:58, 24 March 2013

OCA — Sun, 24 Mar 2013 20:58:33 GMT

←Older revision		Revision as of 20:58, 24 March 2013
Line 1:		Line 1:
-	[[Image:2cii.png\|left\|200px]]
-
	{{STRUCTURE_2cii\| PDB=2cii \| SCENE= }}		{{STRUCTURE_2cii\| PDB=2cii \| SCENE= }}
-
	===THE CRYSTAL STRUCTURE OF H-2DB COMPLEXED WITH A PARTIAL PEPTIDE EPITOPE SUGGESTS AN MHC CLASS I ASSEMBLY-INTERMEDIATE===		===THE CRYSTAL STRUCTURE OF H-2DB COMPLEXED WITH A PARTIAL PEPTIDE EPITOPE SUGGESTS AN MHC CLASS I ASSEMBLY-INTERMEDIATE===
		+	{{ABSTRACT_PUBMED_16478731}}

-	~~{{ABSTRACT_PUBMED_16478731}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref><ref>PMID:1336137</ref><ref>PMID:7554280</ref><ref>PMID:4586824</ref><ref>PMID:8084451</ref><ref>PMID:12119416</ref><ref>PMID:12796775</ref><ref>PMID:16901902</ref><ref>PMID:16491088</ref><ref>PMID:17646174</ref><ref>PMID:18835253</ref><ref>PMID:18395224</ref><ref>PMID:19284997</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/HA11_MOUSE HA11_MOUSE]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/NCAP_PI1HW NCAP_PI1HW]] Encapsidates the genome in a ratio of 1 N per 6 ribonucleotides, protecting it from nucleases. The nucleocapsid (NC) has a helical structure. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. During replication, encapsidation by N is coupled to RNA synthesis and all replicative products are resistant to nucleases (By similarity). [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

	==About this Structure==		==About this Structure==
Line 15:		Line 17:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:016478731</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016478731</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]

OCA at 15:34, 20 October 2012

OCA — Sat, 20 Oct 2012 15:34:28 GMT

←Older revision		Revision as of 15:34, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2cii]] is a 3 chain structure ~~of [[Beta-2 microglobulin]] and [[Major histocompatibility complex]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CII OCA].	+	[[2cii]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CII OCA].

	==See Also==		==See Also==