2ckn - Revision history

OCA at 11:27, 22 May 2024

OCA — Wed, 22 May 2024 11:27:05 GMT

←Older revision		Revision as of 11:27, 22 May 2024
Line 1:		Line 1:

	==NMR Structure of the First Ig Module of mouse FGFR1==		==NMR Structure of the First Ig Module of mouse FGFR1==
-	<StructureSection load='2ckn' size='340' side='right'caption='[[2ckn~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2ckn' size='340' side='right'caption='[[2ckn]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ckn]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CKN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2CKN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ckn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CKN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CKN FirstGlance]. <br>
-	</td></tr><tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"~~><span class~~='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2ckn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ckn OCA], [~~http~~://pdbe.org/2ckn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ckn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ckn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ckn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ckn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ckn OCA], [https://pdbe.org/2ckn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ckn RCSB], [https://www.ebi.ac.uk/pdbsum/2ckn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ckn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/FGFR1_MOUSE FGFR1_MOUSE]] Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation (By similarity).<ref>PMID:10821861</ref> <ref>PMID:1309590</ref> <ref>PMID:8001822</ref> <ref>PMID:8001823</ref> <ref>PMID:10896947</ref> <ref>PMID:17086194</ref>	+	[https://www.uniprot.org/uniprot/FGFR1_MOUSE FGFR1_MOUSE] Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation (By similarity).<ref>PMID:10821861</ref> <ref>PMID:1309590</ref> <ref>PMID:8001822</ref> <ref>PMID:8001823</ref> <ref>PMID:10896947</ref> <ref>PMID:17086194</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Receptor protein-tyrosine kinase~~]]	+	[[Category: Mus musculus]]
-	[[Category: Berezin, V]]	+	[[Category: Berezin V]]
-	[[Category: Bock, E]]	+	[[Category: Bock E]]
-	[[Category: Kiselyov~~, V V~~]]	+	[[Category: Kiselyov VV]]
-	[[Category: Poulsen~~, F M]]~~	+	[[Category: Poulsen FM]]
-	~~[[Category: Alternatice splicing]]~~	+
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Heparin-binding]]~~	+
-	~~[[Category: Immunoglobulin domain]]~~	+
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Receptor]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Tyrosine-protein kinase~~]]	+

OCA at 07:53, 4 November 2020

OCA — Wed, 04 Nov 2020 07:53:47 GMT

←Older revision		Revision as of 07:53, 4 November 2020
Line 1:		Line 1:

	==NMR Structure of the First Ig Module of mouse FGFR1==		==NMR Structure of the First Ig Module of mouse FGFR1==
-	<StructureSection load='2ckn' size='340' side='right' caption='[[2ckn]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2ckn' size='340' side='right'caption='[[2ckn]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ckn]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CKN OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CKN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ckn]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CKN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2CKN FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ckn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ckn OCA], [http://pdbe.org/2ckn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ckn RCSB], [http://www.ebi.ac.uk/pdbsum/2ckn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ckn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2ckn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ckn OCA], [http://pdbe.org/2ckn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ckn RCSB], [http://www.ebi.ac.uk/pdbsum/2ckn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ckn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Fibroblast growth factor receptor\|Fibroblast growth factor receptor]]	+	*[[Fibroblast growth factor receptor 3D receptor\|Fibroblast growth factor receptor 3D receptor]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Receptor protein-tyrosine kinase]]		[[Category: Receptor protein-tyrosine kinase]]
	[[Category: Berezin, V]]		[[Category: Berezin, V]]

OCA at 10:06, 30 January 2019

OCA — Wed, 30 Jan 2019 10:06:44 GMT

←Older revision		Revision as of 10:06, 30 January 2019
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ck/2ckn_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ck/2ckn_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 06:03, 19 April 2017

OCA — Wed, 19 Apr 2017 06:03:49 GMT

←Older revision		Revision as of 06:03, 19 April 2017
Line 1:		Line 1:
-	==NMR ~~STRUCTURE OF THE FIRST IG MODULE OF MOUSE~~ FGFR1==	+
		+	==NMR Structure of the First Ig Module of mouse FGFR1==
	<StructureSection load='2ckn' size='340' side='right' caption='[[2ckn]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2ckn' size='340' side='right' caption='[[2ckn]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ckn]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CKN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CKN FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ckn]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CKN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CKN FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ckn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ckn OCA], [http://pdbe.org/2ckn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ckn RCSB], [http://www.ebi.ac.uk/pdbsum/2ckn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ckn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ckn OCA], [http://pdbe.org/2ckn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ckn RCSB], [http://www.ebi.ac.uk/pdbsum/2ckn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ckn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 11:10, 7 February 2016

OCA — Sun, 07 Feb 2016 11:10:03 GMT

←Older revision		Revision as of 11:10, 7 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ckn ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 00:55, 10 September 2015

OCA — Thu, 10 Sep 2015 00:55:50 GMT

←Older revision		Revision as of 00:55, 10 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2ckn]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CKN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CKN FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ckn]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CKN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CKN FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ckn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ckn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ckn RCSB], [http://www.ebi.ac.uk/pdbsum/2ckn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ckn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ckn OCA], [http://pdbe.org/2ckn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ckn RCSB], [http://www.ebi.ac.uk/pdbsum/2ckn PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2ckn" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 14:38, 24 December 2014

OCA — Wed, 24 Dec 2014 14:38:17 GMT

←Older revision		Revision as of 14:38, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ckn]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CKN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CKN FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ckn]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CKN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CKN FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ckn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ckn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ckn RCSB], [http://www.ebi.ac.uk/pdbsum/2ckn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ckn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ckn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ckn RCSB], [http://www.ebi.ac.uk/pdbsum/2ckn PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FGFR1_MOUSE FGFR1_MOUSE]] Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation (By similarity).<ref>PMID:10821861</ref> <ref>PMID:1309590</ref> <ref>PMID:8001822</ref> <ref>PMID:8001823</ref> <ref>PMID:10896947</ref> <ref>PMID:17086194</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Receptor protein-tyrosine kinase]]		[[Category: Receptor protein-tyrosine kinase]]
-	[[Category: Berezin, V.]]	+	[[Category: Berezin, V]]
-	[[Category: Bock, E.]]	+	[[Category: Bock, E]]
-	[[Category: Kiselyov, V V.]]	+	[[Category: Kiselyov, V V]]
-	[[Category: Poulsen, F M.]]	+	[[Category: Poulsen, F M]]
	[[Category: Alternatice splicing]]		[[Category: Alternatice splicing]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]

OCA at 00:14, 30 September 2014

OCA — Tue, 30 Sep 2014 00:14:19 GMT

←Older revision		Revision as of 00:14, 30 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2ckn.~~png\|left~~\|200px]]	+	==NMR STRUCTURE OF THE FIRST IG MODULE OF MOUSE FGFR1==
		+	<StructureSection load='2ckn' size='340' side='right' caption='[[2ckn]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2ckn]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CKN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CKN FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ckn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ckn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ckn RCSB], [http://www.ebi.ac.uk/pdbsum/2ckn PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ck/2ckn_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Fibroblast growth factor (FGF) receptors (FGFRs) regulate a multitude of cellular processes during embryogenesis and in the adult. The extracellular part of the prototypical FGFR consists of three Ig modules (Ig1 - Ig3), in which Ig2 and Ig3 determine affinity and specificity for FGF and heparin, while the Ig1 module is thought to have a regulatory function. The crystal structures of the Ig2 and Ig3 modules alone and in complex with FGF have previously been reported. The structure of the Ig1 module is unknown, and very little is known about the structural determinants for the regulatory function of this module. We describe here the NMR structure of the Ig1 module of mouse FGFR1. The three-dimensional fold of the module belongs to the intermediate Ig subgroup and can be described as a beta-barrel consisting of two beta-sheets. One sheet is formed by A', G, F, C, and C', and the other by A, B, B', E, and D beta-strands. The overall strand topology of the Ig1 module is similar to that of the Ig2 and Ig3 modules. However, the A/A' loop of the Ig1 module is much longer than that of the Ig2 and Ig3 modules. It contains eight extra residues compared to the Ig3 module, and five extra residues compared to Ig2.

-	~~{{STRUCTURE_2ckn\| PDB=2ckn \| SCENE= }}~~	+	NMR structure of the first Ig module of mouse FGFR1.,Kiselyov VV, Bock E, Berezin V, Poulsen FM Protein Sci. 2006 Jun;15(6):1512-5. PMID:16731982<ref>PMID:16731982</ref>

-	~~===NMR STRUCTURE OF THE FIRST IG MODULE OF MOUSE FGFR1===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_16731982}}~~	+	==See Also==
-		+	*[[Fibroblast growth factor receptor\|Fibroblast growth factor receptor]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~2ckn~~]] ~~is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CKN OCA].~~	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:016731982<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Receptor protein-tyrosine kinase]]		[[Category: Receptor protein-tyrosine kinase]]
	[[Category: Berezin, V.]]		[[Category: Berezin, V.]]

OCA: Protected "2ckn" [edit=sysop:move=sysop]

OCA — Sun, 06 Jan 2013 09:39:19 GMT

Protected "2ckn" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:39, 6 January 2013

OCA at 09:39, 6 January 2013

OCA — Sun, 06 Jan 2013 09:39:15 GMT

←Older revision		Revision as of 09:39, 6 January 2013
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-	{{Seed}}
	[[Image:2ckn.png\|left\|200px]]		[[Image:2ckn.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_2ckn\| PDB=2ckn \| SCENE= }}		{{STRUCTURE_2ckn\| PDB=2ckn \| SCENE= }}

	===NMR STRUCTURE OF THE FIRST IG MODULE OF MOUSE FGFR1===		===NMR STRUCTURE OF THE FIRST IG MODULE OF MOUSE FGFR1===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16731982}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16731982 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_16731982}}		{{ABSTRACT_PUBMED_16731982}}

	==About this Structure==		==About this Structure==
-	~~2CKN~~ is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CKN OCA].	+	[[2ckn]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CKN OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16731982~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016731982</ref><references group="xtra"/>
	[[Category: Receptor protein-tyrosine kinase]]		[[Category: Receptor protein-tyrosine kinase]]
	[[Category: Berezin, V.]]		[[Category: Berezin, V.]]
Line 39:		Line 27:
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Tyrosine-protein kinase]]		[[Category: Tyrosine-protein kinase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 13:24:15 2009''