2cmb - Revision history

OCA at 14:22, 13 December 2023

OCA — Wed, 13 Dec 2023 14:22:30 GMT

←Older revision		Revision as of 14:22, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2cmb' size='340' side='right'caption='[[2cmb]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2cmb' size='340' side='right'caption='[[2cmb]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2cmb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CMB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CMB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2cmb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CMB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CMB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=F17:N-{[4-(1,1-DIOXIDO-3-OXO-2,3-DIHYDROISOTHIAZOL-5-YL)PHENYL]ACETYL}-L-PHENYLALANYL-4-(1,1-DIOXIDO-3-OXO-2,3-DIHYDROISOTHIAZOL-5-YL)-L-PHENYLALANINAMIDE'>F17</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1a5y\|1a5y]], [[1aax\|1aax]], [[1bzc\|1bzc]], [[1bzh\|1bzh]], [[1bzj\|1bzj]], [[1c83\|1c83]], [[1c84\|1c84]], [[1c85\|1c85]], [[1c86\|1c86]], [[1c87\|1c87]], [[1c88\|1c88]], [[1ecv\|1ecv]], [[1een\|1een]], [[1eeo\|1eeo]], [[1g1f\|1g1f]], [[1g1g\|1g1g]], [[1g1h\|1g1h]], [[1g7f\|1g7f]], [[1g7g\|1g7g]], [[1gfy\|1gfy]], [[1i57\|1i57]], [[1jf7\|1jf7]], [[1kak\|1kak]], [[1kav\|1kav]], [[1l8g\|1l8g]], [[1lqf\|1lqf]], [[1nl9\|1nl9]], [[1nny\|1nny]], [[1no6\|1no6]], [[1nwe\|1nwe]], [[1nwl\|1nwl]], [[1nz7\|1nz7]], [[1oem\|1oem]], [[1oeo\|1oeo]], [[1oes\|1oes]], [[1oet\|1oet]], [[1oeu\|1oeu]], [[1oev\|1oev]], [[1ony\|1ony]], [[1onz\|1onz]], [[1pa1\|1pa1]], [[1ph0\|1ph0]], [[1ptt\|1ptt]], [[1ptu\|1ptu]], [[1ptv\|1ptv]], [[1pty\|1pty]], [[1pxh\|1pxh]], [[1pyn\|1pyn]], [[1q1m\|1q1m]], [[1q6j\|1q6j]], [[1q6m\|1q6m]], [[1q6n\|1q6n]], [[1q6p\|1q6p]], [[1q6s\|1q6s]], [[1q6t\|1q6t]], [[1qxk\|1qxk]], [[1sug\|1sug]], [[1t48\|1t48]], [[1t49\|1t49]], [[1t4j\|1t4j]], [[1wax\|1wax]], [[1xbo\|1xbo]], [[2azr\|2azr]], [[2b07\|2b07]], [[2b4s\|2b4s]], [[2bgd\|2bgd]], [[2bge\|2bge]], [[2cm2\|2cm2]], [[2cm3\|2cm3]], [[2cm7\|2cm7]], [[2cm8\|2cm8]], [[2cma\|2cma]], [[2cmc\|2cmc]], [[2cne\|2cne]], [[2cnf\|2cnf]], [[2cng\|2cng]], [[2cnh\|2cnh]], [[2cni\|2cni]], [[2f6f\|2f6f]], [[2f6t\|2f6t]], [[2f6v\|2f6v]], [[2f6w\|2f6w]], [[2f6y\|2f6y]], [[2f6z\|2f6z]], [[2f70\|2f70]], [[2f71\|2f71]], [[2fjm\|2fjm]], [[2fjn\|2fjn]], [[2hnp\|2hnp]], [[2hnq\|2hnq]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=F17:N-{[4-(1,1-DIOXIDO-3-OXO-2,3-DIHYDROISOTHIAZOL-5-YL)PHENYL]ACETYL}-L-PHENYLALANYL-4-(1,1-DIOXIDO-3-OXO-2,3-DIHYDROISOTHIAZOL-5-YL)-L-PHENYLALANINAMIDE'>F17</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cmb OCA], [https://pdbe.org/2cmb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cmb RCSB], [https://www.ebi.ac.uk/pdbsum/2cmb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cmb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cmb OCA], [https://pdbe.org/2cmb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cmb RCSB], [https://www.ebi.ac.uk/pdbsum/2cmb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cmb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN]] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>	+	[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Protein-tyrosine-phosphatase]]~~	+	[[Category: Ala PJ]]
-	[[Category: Ala~~, P J~~]]	+	[[Category: Becker-Pasha M]]
-	[[Category: Becker-Pasha, M]]	+	[[Category: Bower M]]
-	[[Category: Bower, M]]	+	[[Category: Burn TC]]
-	[[Category: Burn~~, T C~~]]	+	[[Category: Combs AP]]
-	[[Category: Combs~~, A P~~]]	+	[[Category: Douty B]]
-	[[Category: Douty, B]]	+	[[Category: Gonneville L]]
-	[[Category: Gonneville, L]]	+	[[Category: Hillman MC]]
-	[[Category: Hillman~~, M C~~]]	+	[[Category: Hollis GF]]
-	[[Category: Hollis~~, G F~~]]	+	[[Category: Klabe R]]
-	[[Category: Klabe, R]]	+	[[Category: Polam P]]
-	[[Category: Polam, P]]	+	[[Category: Reid BG]]
-	[[Category: Reid~~, B G~~]]	+	[[Category: Wasserman Z]]
-	[[Category: Wasserman, Z]]	+	[[Category: Wayland B]]
-	[[Category: Wayland, B]]	+	[[Category: Wei M]]
-	[[Category: Wei, M]]	+	[[Category: Wynn R]]
-	[[Category: Wynn, R]]	+	[[Category: Yue EW]]
-	[[Category: Yue~~, E W]]~~	+
-	~~[[Category: Acetylation]]~~	+
-	~~[[Category: Endoplasmic reticulum]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Oxidation]]~~	+
-	~~[[Category: Phosphatase]]~~	+
-	~~[[Category: Phosphorylation]]~~	+
-	~~[[Category: Polymorphism]]~~	+
-	~~[[Category: Protein phosphatase~~]]	+

OCA at 10:00, 26 May 2021

OCA — Wed, 26 May 2021 10:00:33 GMT

←Older revision		Revision as of 10:00, 26 May 2021
Line 3:		Line 3:
	<StructureSection load='2cmb' size='340' side='right'caption='[[2cmb]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2cmb' size='340' side='right'caption='[[2cmb]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2cmb]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CMB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CMB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2cmb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CMB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CMB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=F17:N-{[4-(1,1-DIOXIDO-3-OXO-2,3-DIHYDROISOTHIAZOL-5-YL)PHENYL]ACETYL}-L-PHENYLALANYL-4-(1,1-DIOXIDO-3-OXO-2,3-DIHYDROISOTHIAZOL-5-YL)-L-PHENYLALANINAMIDE'>F17</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=F17:N-{[4-(1,1-DIOXIDO-3-OXO-2,3-DIHYDROISOTHIAZOL-5-YL)PHENYL]ACETYL}-L-PHENYLALANYL-4-(1,1-DIOXIDO-3-OXO-2,3-DIHYDROISOTHIAZOL-5-YL)-L-PHENYLALANINAMIDE'>F17</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a5y\|1a5y]], [[1aax\|1aax]], [[1bzc\|1bzc]], [[1bzh\|1bzh]], [[1bzj\|1bzj]], [[1c83\|1c83]], [[1c84\|1c84]], [[1c85\|1c85]], [[1c86\|1c86]], [[1c87\|1c87]], [[1c88\|1c88]], [[1ecv\|1ecv]], [[1een\|1een]], [[1eeo\|1eeo]], [[1g1f\|1g1f]], [[1g1g\|1g1g]], [[1g1h\|1g1h]], [[1g7f\|1g7f]], [[1g7g\|1g7g]], [[1gfy\|1gfy]], [[1i57\|1i57]], [[1jf7\|1jf7]], [[1kak\|1kak]], [[1kav\|1kav]], [[1l8g\|1l8g]], [[1lqf\|1lqf]], [[1nl9\|1nl9]], [[1nny\|1nny]], [[1no6\|1no6]], [[1nwe\|1nwe]], [[1nwl\|1nwl]], [[1nz7\|1nz7]], [[1oem\|1oem]], [[1oeo\|1oeo]], [[1oes\|1oes]], [[1oet\|1oet]], [[1oeu\|1oeu]], [[1oev\|1oev]], [[1ony\|1ony]], [[1onz\|1onz]], [[1pa1\|1pa1]], [[1ph0\|1ph0]], [[1ptt\|1ptt]], [[1ptu\|1ptu]], [[1ptv\|1ptv]], [[1pty\|1pty]], [[1pxh\|1pxh]], [[1pyn\|1pyn]], [[1q1m\|1q1m]], [[1q6j\|1q6j]], [[1q6m\|1q6m]], [[1q6n\|1q6n]], [[1q6p\|1q6p]], [[1q6s\|1q6s]], [[1q6t\|1q6t]], [[1qxk\|1qxk]], [[1sug\|1sug]], [[1t48\|1t48]], [[1t49\|1t49]], [[1t4j\|1t4j]], [[1wax\|1wax]], [[1xbo\|1xbo]], [[2azr\|2azr]], [[2b07\|2b07]], [[2b4s\|2b4s]], [[2bgd\|2bgd]], [[2bge\|2bge]], [[2cm2\|2cm2]], [[2cm3\|2cm3]], [[2cm7\|2cm7]], [[2cm8\|2cm8]], [[2cma\|2cma]], [[2cmc\|2cmc]], [[2cne\|2cne]], [[2cnf\|2cnf]], [[2cng\|2cng]], [[2cnh\|2cnh]], [[2cni\|2cni]], [[2f6f\|2f6f]], [[2f6t\|2f6t]], [[2f6v\|2f6v]], [[2f6w\|2f6w]], [[2f6y\|2f6y]], [[2f6z\|2f6z]], [[2f70\|2f70]], [[2f71\|2f71]], [[2fjm\|2fjm]], [[2fjn\|2fjn]], [[2hnp\|2hnp]], [[2hnq\|2hnq]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1a5y\|1a5y]], [[1aax\|1aax]], [[1bzc\|1bzc]], [[1bzh\|1bzh]], [[1bzj\|1bzj]], [[1c83\|1c83]], [[1c84\|1c84]], [[1c85\|1c85]], [[1c86\|1c86]], [[1c87\|1c87]], [[1c88\|1c88]], [[1ecv\|1ecv]], [[1een\|1een]], [[1eeo\|1eeo]], [[1g1f\|1g1f]], [[1g1g\|1g1g]], [[1g1h\|1g1h]], [[1g7f\|1g7f]], [[1g7g\|1g7g]], [[1gfy\|1gfy]], [[1i57\|1i57]], [[1jf7\|1jf7]], [[1kak\|1kak]], [[1kav\|1kav]], [[1l8g\|1l8g]], [[1lqf\|1lqf]], [[1nl9\|1nl9]], [[1nny\|1nny]], [[1no6\|1no6]], [[1nwe\|1nwe]], [[1nwl\|1nwl]], [[1nz7\|1nz7]], [[1oem\|1oem]], [[1oeo\|1oeo]], [[1oes\|1oes]], [[1oet\|1oet]], [[1oeu\|1oeu]], [[1oev\|1oev]], [[1ony\|1ony]], [[1onz\|1onz]], [[1pa1\|1pa1]], [[1ph0\|1ph0]], [[1ptt\|1ptt]], [[1ptu\|1ptu]], [[1ptv\|1ptv]], [[1pty\|1pty]], [[1pxh\|1pxh]], [[1pyn\|1pyn]], [[1q1m\|1q1m]], [[1q6j\|1q6j]], [[1q6m\|1q6m]], [[1q6n\|1q6n]], [[1q6p\|1q6p]], [[1q6s\|1q6s]], [[1q6t\|1q6t]], [[1qxk\|1qxk]], [[1sug\|1sug]], [[1t48\|1t48]], [[1t49\|1t49]], [[1t4j\|1t4j]], [[1wax\|1wax]], [[1xbo\|1xbo]], [[2azr\|2azr]], [[2b07\|2b07]], [[2b4s\|2b4s]], [[2bgd\|2bgd]], [[2bge\|2bge]], [[2cm2\|2cm2]], [[2cm3\|2cm3]], [[2cm7\|2cm7]], [[2cm8\|2cm8]], [[2cma\|2cma]], [[2cmc\|2cmc]], [[2cne\|2cne]], [[2cnf\|2cnf]], [[2cng\|2cng]], [[2cnh\|2cnh]], [[2cni\|2cni]], [[2f6f\|2f6f]], [[2f6t\|2f6t]], [[2f6v\|2f6v]], [[2f6w\|2f6w]], [[2f6y\|2f6y]], [[2f6z\|2f6z]], [[2f70\|2f70]], [[2f71\|2f71]], [[2fjm\|2fjm]], [[2fjn\|2fjn]], [[2hnp\|2hnp]], [[2hnq\|2hnq]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2cmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cmb OCA], [~~http~~://pdbe.org/2cmb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2cmb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2cmb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2cmb ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cmb OCA], [https://pdbe.org/2cmb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cmb RCSB], [https://www.ebi.ac.uk/pdbsum/2cmb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cmb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN]] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>	+	[[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN]] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]	+	*[[Tyrosine phosphatase 3D structures\|Tyrosine phosphatase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:32, 21 August 2019

OCA — Wed, 21 Aug 2019 07:32:22 GMT

←Older revision		Revision as of 07:32, 21 August 2019
Line 1:		Line 1:

	==Structural Basis for Inhibition of Protein Tyrosine Phosphatase 1B by Isothiazolidinone Heterocyclic Phosphonate Mimetics==		==Structural Basis for Inhibition of Protein Tyrosine Phosphatase 1B by Isothiazolidinone Heterocyclic Phosphonate Mimetics==
-	<StructureSection load='2cmb' size='340' side='right' caption='[[2cmb]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='2cmb' size='340' side='right'caption='[[2cmb]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cmb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CMB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CMB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cmb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CMB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CMB FirstGlance]. <br>
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cm/2cmb_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cm/2cmb_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 2cmb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2cmb" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]
	== References ==		== References ==
	<references/>		<references/>
Line 35:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Protein-tyrosine-phosphatase]]		[[Category: Protein-tyrosine-phosphatase]]
	[[Category: Ala, P J]]		[[Category: Ala, P J]]

OCA at 07:16, 16 November 2017

OCA — Thu, 16 Nov 2017 07:16:31 GMT

←Older revision		Revision as of 07:16, 16 November 2017
Line 1:		Line 1:
-	==~~STRUCTURAL BASIS FOR INHIBITION OF PROTEIN TYROSINE PHOSPHATASE~~ 1B ~~BY ISOTHIAZOLIDINONE HETEROCYCLIC PHOSPHONATE MIMETICS~~==	+
		+	==Structural Basis for Inhibition of Protein Tyrosine Phosphatase 1B by Isothiazolidinone Heterocyclic Phosphonate Mimetics==
	<StructureSection load='2cmb' size='340' side='right' caption='[[2cmb]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2cmb' size='340' side='right' caption='[[2cmb]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a5y\|1a5y]], [[1aax\|1aax]], [[1bzc\|1bzc]], [[1bzh\|1bzh]], [[1bzj\|1bzj]], [[1c83\|1c83]], [[1c84\|1c84]], [[1c85\|1c85]], [[1c86\|1c86]], [[1c87\|1c87]], [[1c88\|1c88]], [[1ecv\|1ecv]], [[1een\|1een]], [[1eeo\|1eeo]], [[1g1f\|1g1f]], [[1g1g\|1g1g]], [[1g1h\|1g1h]], [[1g7f\|1g7f]], [[1g7g\|1g7g]], [[1gfy\|1gfy]], [[1i57\|1i57]], [[1jf7\|1jf7]], [[1kak\|1kak]], [[1kav\|1kav]], [[1l8g\|1l8g]], [[1lqf\|1lqf]], [[1nl9\|1nl9]], [[1nny\|1nny]], [[1no6\|1no6]], [[1nwe\|1nwe]], [[1nwl\|1nwl]], [[1nz7\|1nz7]], [[1oem\|1oem]], [[1oeo\|1oeo]], [[1oes\|1oes]], [[1oet\|1oet]], [[1oeu\|1oeu]], [[1oev\|1oev]], [[1ony\|1ony]], [[1onz\|1onz]], [[1pa1\|1pa1]], [[1ph0\|1ph0]], [[1ptt\|1ptt]], [[1ptu\|1ptu]], [[1ptv\|1ptv]], [[1pty\|1pty]], [[1pxh\|1pxh]], [[1pyn\|1pyn]], [[1q1m\|1q1m]], [[1q6j\|1q6j]], [[1q6m\|1q6m]], [[1q6n\|1q6n]], [[1q6p\|1q6p]], [[1q6s\|1q6s]], [[1q6t\|1q6t]], [[1qxk\|1qxk]], [[1sug\|1sug]], [[1t48\|1t48]], [[1t49\|1t49]], [[1t4j\|1t4j]], [[1wax\|1wax]], [[1xbo\|1xbo]], [[2azr\|2azr]], [[2b07\|2b07]], [[2b4s\|2b4s]], [[2bgd\|2bgd]], [[2bge\|2bge]], [[2cm2\|2cm2]], [[2cm3\|2cm3]], [[2cm7\|2cm7]], [[2cm8\|2cm8]], [[2cma\|2cma]], [[2cmc\|2cmc]], [[2cne\|2cne]], [[2cnf\|2cnf]], [[2cng\|2cng]], [[2cnh\|2cnh]], [[2cni\|2cni]], [[2f6f\|2f6f]], [[2f6t\|2f6t]], [[2f6v\|2f6v]], [[2f6w\|2f6w]], [[2f6y\|2f6y]], [[2f6z\|2f6z]], [[2f70\|2f70]], [[2f71\|2f71]], [[2fjm\|2fjm]], [[2fjn\|2fjn]], [[2hnp\|2hnp]], [[2hnq\|2hnq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a5y\|1a5y]], [[1aax\|1aax]], [[1bzc\|1bzc]], [[1bzh\|1bzh]], [[1bzj\|1bzj]], [[1c83\|1c83]], [[1c84\|1c84]], [[1c85\|1c85]], [[1c86\|1c86]], [[1c87\|1c87]], [[1c88\|1c88]], [[1ecv\|1ecv]], [[1een\|1een]], [[1eeo\|1eeo]], [[1g1f\|1g1f]], [[1g1g\|1g1g]], [[1g1h\|1g1h]], [[1g7f\|1g7f]], [[1g7g\|1g7g]], [[1gfy\|1gfy]], [[1i57\|1i57]], [[1jf7\|1jf7]], [[1kak\|1kak]], [[1kav\|1kav]], [[1l8g\|1l8g]], [[1lqf\|1lqf]], [[1nl9\|1nl9]], [[1nny\|1nny]], [[1no6\|1no6]], [[1nwe\|1nwe]], [[1nwl\|1nwl]], [[1nz7\|1nz7]], [[1oem\|1oem]], [[1oeo\|1oeo]], [[1oes\|1oes]], [[1oet\|1oet]], [[1oeu\|1oeu]], [[1oev\|1oev]], [[1ony\|1ony]], [[1onz\|1onz]], [[1pa1\|1pa1]], [[1ph0\|1ph0]], [[1ptt\|1ptt]], [[1ptu\|1ptu]], [[1ptv\|1ptv]], [[1pty\|1pty]], [[1pxh\|1pxh]], [[1pyn\|1pyn]], [[1q1m\|1q1m]], [[1q6j\|1q6j]], [[1q6m\|1q6m]], [[1q6n\|1q6n]], [[1q6p\|1q6p]], [[1q6s\|1q6s]], [[1q6t\|1q6t]], [[1qxk\|1qxk]], [[1sug\|1sug]], [[1t48\|1t48]], [[1t49\|1t49]], [[1t4j\|1t4j]], [[1wax\|1wax]], [[1xbo\|1xbo]], [[2azr\|2azr]], [[2b07\|2b07]], [[2b4s\|2b4s]], [[2bgd\|2bgd]], [[2bge\|2bge]], [[2cm2\|2cm2]], [[2cm3\|2cm3]], [[2cm7\|2cm7]], [[2cm8\|2cm8]], [[2cma\|2cma]], [[2cmc\|2cmc]], [[2cne\|2cne]], [[2cnf\|2cnf]], [[2cng\|2cng]], [[2cnh\|2cnh]], [[2cni\|2cni]], [[2f6f\|2f6f]], [[2f6t\|2f6t]], [[2f6v\|2f6v]], [[2f6w\|2f6w]], [[2f6y\|2f6y]], [[2f6z\|2f6z]], [[2f70\|2f70]], [[2f71\|2f71]], [[2fjm\|2fjm]], [[2fjn\|2fjn]], [[2hnp\|2hnp]], [[2hnq\|2hnq]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cmb OCA], [http://pdbe.org/2cmb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cmb RCSB], [http://www.ebi.ac.uk/pdbsum/2cmb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cmb OCA], [http://pdbe.org/2cmb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cmb RCSB], [http://www.ebi.ac.uk/pdbsum/2cmb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cmb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 29:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 2cmb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2cmb" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]
	== References ==		== References ==
	<references/>		<references/>
Line 55:		Line 53:
	[[Category: Wynn, R]]		[[Category: Wynn, R]]
	[[Category: Yue, E W]]		[[Category: Yue, E W]]
		+	[[Category: Acetylation]]
	[[Category: Endoplasmic reticulum]]		[[Category: Endoplasmic reticulum]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
Line 60:		Line 59:
	[[Category: Phosphatase]]		[[Category: Phosphatase]]
	[[Category: Phosphorylation]]		[[Category: Phosphorylation]]
		+	[[Category: Polymorphism]]
	[[Category: Protein phosphatase]]		[[Category: Protein phosphatase]]

OCA at 00:02, 10 February 2016

OCA — Wed, 10 Feb 2016 00:02:55 GMT

←Older revision		Revision as of 00:02, 10 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cmb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 03:22, 11 September 2015

OCA — Fri, 11 Sep 2015 03:22:20 GMT

←Older revision		Revision as of 03:22, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2cmb' size='340' side='right' caption='[[2cmb]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2cmb' size='340' side='right' caption='[[2cmb]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2cmb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CMB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CMB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2cmb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CMB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CMB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=F17:N-{[4-(1,1-DIOXIDO-3-OXO-2,3-DIHYDROISOTHIAZOL-5-YL)PHENYL]ACETYL}-L-PHENYLALANYL-4-(1,1-DIOXIDO-3-OXO-2,3-DIHYDROISOTHIAZOL-5-YL)-L-PHENYLALANINAMIDE'>F17</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=F17:N-{[4-(1,1-DIOXIDO-3-OXO-2,3-DIHYDROISOTHIAZOL-5-YL)PHENYL]ACETYL}-L-PHENYLALANYL-4-(1,1-DIOXIDO-3-OXO-2,3-DIHYDROISOTHIAZOL-5-YL)-L-PHENYLALANINAMIDE'>F17</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a5y\|1a5y]], [[1aax\|1aax]], [[1bzc\|1bzc]], [[1bzh\|1bzh]], [[1bzj\|1bzj]], [[1c83\|1c83]], [[1c84\|1c84]], [[1c85\|1c85]], [[1c86\|1c86]], [[1c87\|1c87]], [[1c88\|1c88]], [[1ecv\|1ecv]], [[1een\|1een]], [[1eeo\|1eeo]], [[1g1f\|1g1f]], [[1g1g\|1g1g]], [[1g1h\|1g1h]], [[1g7f\|1g7f]], [[1g7g\|1g7g]], [[1gfy\|1gfy]], [[1i57\|1i57]], [[1jf7\|1jf7]], [[1kak\|1kak]], [[1kav\|1kav]], [[1l8g\|1l8g]], [[1lqf\|1lqf]], [[1nl9\|1nl9]], [[1nny\|1nny]], [[1no6\|1no6]], [[1nwe\|1nwe]], [[1nwl\|1nwl]], [[1nz7\|1nz7]], [[1oem\|1oem]], [[1oeo\|1oeo]], [[1oes\|1oes]], [[1oet\|1oet]], [[1oeu\|1oeu]], [[1oev\|1oev]], [[1ony\|1ony]], [[1onz\|1onz]], [[1pa1\|1pa1]], [[1ph0\|1ph0]], [[1ptt\|1ptt]], [[1ptu\|1ptu]], [[1ptv\|1ptv]], [[1pty\|1pty]], [[1pxh\|1pxh]], [[1pyn\|1pyn]], [[1q1m\|1q1m]], [[1q6j\|1q6j]], [[1q6m\|1q6m]], [[1q6n\|1q6n]], [[1q6p\|1q6p]], [[1q6s\|1q6s]], [[1q6t\|1q6t]], [[1qxk\|1qxk]], [[1sug\|1sug]], [[1t48\|1t48]], [[1t49\|1t49]], [[1t4j\|1t4j]], [[1wax\|1wax]], [[1xbo\|1xbo]], [[2azr\|2azr]], [[2b07\|2b07]], [[2b4s\|2b4s]], [[2bgd\|2bgd]], [[2bge\|2bge]], [[2cm2\|2cm2]], [[2cm3\|2cm3]], [[2cm7\|2cm7]], [[2cm8\|2cm8]], [[2cma\|2cma]], [[2cmc\|2cmc]], [[2cne\|2cne]], [[2cnf\|2cnf]], [[2cng\|2cng]], [[2cnh\|2cnh]], [[2cni\|2cni]], [[2f6f\|2f6f]], [[2f6t\|2f6t]], [[2f6v\|2f6v]], [[2f6w\|2f6w]], [[2f6y\|2f6y]], [[2f6z\|2f6z]], [[2f70\|2f70]], [[2f71\|2f71]], [[2fjm\|2fjm]], [[2fjn\|2fjn]], [[2hnp\|2hnp]], [[2hnq\|2hnq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a5y\|1a5y]], [[1aax\|1aax]], [[1bzc\|1bzc]], [[1bzh\|1bzh]], [[1bzj\|1bzj]], [[1c83\|1c83]], [[1c84\|1c84]], [[1c85\|1c85]], [[1c86\|1c86]], [[1c87\|1c87]], [[1c88\|1c88]], [[1ecv\|1ecv]], [[1een\|1een]], [[1eeo\|1eeo]], [[1g1f\|1g1f]], [[1g1g\|1g1g]], [[1g1h\|1g1h]], [[1g7f\|1g7f]], [[1g7g\|1g7g]], [[1gfy\|1gfy]], [[1i57\|1i57]], [[1jf7\|1jf7]], [[1kak\|1kak]], [[1kav\|1kav]], [[1l8g\|1l8g]], [[1lqf\|1lqf]], [[1nl9\|1nl9]], [[1nny\|1nny]], [[1no6\|1no6]], [[1nwe\|1nwe]], [[1nwl\|1nwl]], [[1nz7\|1nz7]], [[1oem\|1oem]], [[1oeo\|1oeo]], [[1oes\|1oes]], [[1oet\|1oet]], [[1oeu\|1oeu]], [[1oev\|1oev]], [[1ony\|1ony]], [[1onz\|1onz]], [[1pa1\|1pa1]], [[1ph0\|1ph0]], [[1ptt\|1ptt]], [[1ptu\|1ptu]], [[1ptv\|1ptv]], [[1pty\|1pty]], [[1pxh\|1pxh]], [[1pyn\|1pyn]], [[1q1m\|1q1m]], [[1q6j\|1q6j]], [[1q6m\|1q6m]], [[1q6n\|1q6n]], [[1q6p\|1q6p]], [[1q6s\|1q6s]], [[1q6t\|1q6t]], [[1qxk\|1qxk]], [[1sug\|1sug]], [[1t48\|1t48]], [[1t49\|1t49]], [[1t4j\|1t4j]], [[1wax\|1wax]], [[1xbo\|1xbo]], [[2azr\|2azr]], [[2b07\|2b07]], [[2b4s\|2b4s]], [[2bgd\|2bgd]], [[2bge\|2bge]], [[2cm2\|2cm2]], [[2cm3\|2cm3]], [[2cm7\|2cm7]], [[2cm8\|2cm8]], [[2cma\|2cma]], [[2cmc\|2cmc]], [[2cne\|2cne]], [[2cnf\|2cnf]], [[2cng\|2cng]], [[2cnh\|2cnh]], [[2cni\|2cni]], [[2f6f\|2f6f]], [[2f6t\|2f6t]], [[2f6v\|2f6v]], [[2f6w\|2f6w]], [[2f6y\|2f6y]], [[2f6z\|2f6z]], [[2f70\|2f70]], [[2f71\|2f71]], [[2fjm\|2fjm]], [[2fjn\|2fjn]], [[2hnp\|2hnp]], [[2hnq\|2hnq]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cmb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cmb RCSB], [http://www.ebi.ac.uk/pdbsum/2cmb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cmb OCA], [http://pdbe.org/2cmb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cmb RCSB], [http://www.ebi.ac.uk/pdbsum/2cmb PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2cmb" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Protein-tyrosine-phosphatase]]		[[Category: Protein-tyrosine-phosphatase]]
	[[Category: Ala, P J]]		[[Category: Ala, P J]]

OCA at 10:25, 25 December 2014

OCA — Thu, 25 Dec 2014 10:25:36 GMT

←Older revision		Revision as of 10:25, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cmb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CMB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CMB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cmb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CMB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CMB FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=F17:N-{[4-(1,1-DIOXIDO-3-OXO-2,3-DIHYDROISOTHIAZOL-5-YL)PHENYL]ACETYL}-L-PHENYLALANYL-4-(1,1-DIOXIDO-3-OXO-2,3-DIHYDROISOTHIAZOL-5-YL)-L-PHENYLALANINAMIDE'>F17</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=F17:N-{[4-(1,1-DIOXIDO-3-OXO-2,3-DIHYDROISOTHIAZOL-5-YL)PHENYL]ACETYL}-L-PHENYLALANYL-4-(1,1-DIOXIDO-3-OXO-2,3-DIHYDROISOTHIAZOL-5-YL)-L-PHENYLALANINAMIDE'>F17</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a5y\|1a5y]], [[1aax\|1aax]], [[1bzc\|1bzc]], [[1bzh\|1bzh]], [[1bzj\|1bzj]], [[1c83\|1c83]], [[1c84\|1c84]], [[1c85\|1c85]], [[1c86\|1c86]], [[1c87\|1c87]], [[1c88\|1c88]], [[1ecv\|1ecv]], [[1een\|1een]], [[1eeo\|1eeo]], [[1g1f\|1g1f]], [[1g1g\|1g1g]], [[1g1h\|1g1h]], [[1g7f\|1g7f]], [[1g7g\|1g7g]], [[1gfy\|1gfy]], [[1i57\|1i57]], [[1jf7\|1jf7]], [[1kak\|1kak]], [[1kav\|1kav]], [[1l8g\|1l8g]], [[1lqf\|1lqf]], [[1nl9\|1nl9]], [[1nny\|1nny]], [[1no6\|1no6]], [[1nwe\|1nwe]], [[1nwl\|1nwl]], [[1nz7\|1nz7]], [[1oem\|1oem]], [[1oeo\|1oeo]], [[1oes\|1oes]], [[1oet\|1oet]], [[1oeu\|1oeu]], [[1oev\|1oev]], [[1ony\|1ony]], [[1onz\|1onz]], [[1pa1\|1pa1]], [[1ph0\|1ph0]], [[1ptt\|1ptt]], [[1ptu\|1ptu]], [[1ptv\|1ptv]], [[1pty\|1pty]], [[1pxh\|1pxh]], [[1pyn\|1pyn]], [[1q1m\|1q1m]], [[1q6j\|1q6j]], [[1q6m\|1q6m]], [[1q6n\|1q6n]], [[1q6p\|1q6p]], [[1q6s\|1q6s]], [[1q6t\|1q6t]], [[1qxk\|1qxk]], [[1sug\|1sug]], [[1t48\|1t48]], [[1t49\|1t49]], [[1t4j\|1t4j]], [[1wax\|1wax]], [[1xbo\|1xbo]], [[2azr\|2azr]], [[2b07\|2b07]], [[2b4s\|2b4s]], [[2bgd\|2bgd]], [[2bge\|2bge]], [[2cm2\|2cm2]], [[2cm3\|2cm3]], [[2cm7\|2cm7]], [[2cm8\|2cm8]], [[2cma\|2cma]], [[2cmc\|2cmc]], [[2cne\|2cne]], [[2cnf\|2cnf]], [[2cng\|2cng]], [[2cnh\|2cnh]], [[2cni\|2cni]], [[2f6f\|2f6f]], [[2f6t\|2f6t]], [[2f6v\|2f6v]], [[2f6w\|2f6w]], [[2f6y\|2f6y]], [[2f6z\|2f6z]], [[2f70\|2f70]], [[2f71\|2f71]], [[2fjm\|2fjm]], [[2fjn\|2fjn]], [[2hnp\|2hnp]], [[2hnq\|2hnq]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a5y\|1a5y]], [[1aax\|1aax]], [[1bzc\|1bzc]], [[1bzh\|1bzh]], [[1bzj\|1bzj]], [[1c83\|1c83]], [[1c84\|1c84]], [[1c85\|1c85]], [[1c86\|1c86]], [[1c87\|1c87]], [[1c88\|1c88]], [[1ecv\|1ecv]], [[1een\|1een]], [[1eeo\|1eeo]], [[1g1f\|1g1f]], [[1g1g\|1g1g]], [[1g1h\|1g1h]], [[1g7f\|1g7f]], [[1g7g\|1g7g]], [[1gfy\|1gfy]], [[1i57\|1i57]], [[1jf7\|1jf7]], [[1kak\|1kak]], [[1kav\|1kav]], [[1l8g\|1l8g]], [[1lqf\|1lqf]], [[1nl9\|1nl9]], [[1nny\|1nny]], [[1no6\|1no6]], [[1nwe\|1nwe]], [[1nwl\|1nwl]], [[1nz7\|1nz7]], [[1oem\|1oem]], [[1oeo\|1oeo]], [[1oes\|1oes]], [[1oet\|1oet]], [[1oeu\|1oeu]], [[1oev\|1oev]], [[1ony\|1ony]], [[1onz\|1onz]], [[1pa1\|1pa1]], [[1ph0\|1ph0]], [[1ptt\|1ptt]], [[1ptu\|1ptu]], [[1ptv\|1ptv]], [[1pty\|1pty]], [[1pxh\|1pxh]], [[1pyn\|1pyn]], [[1q1m\|1q1m]], [[1q6j\|1q6j]], [[1q6m\|1q6m]], [[1q6n\|1q6n]], [[1q6p\|1q6p]], [[1q6s\|1q6s]], [[1q6t\|1q6t]], [[1qxk\|1qxk]], [[1sug\|1sug]], [[1t48\|1t48]], [[1t49\|1t49]], [[1t4j\|1t4j]], [[1wax\|1wax]], [[1xbo\|1xbo]], [[2azr\|2azr]], [[2b07\|2b07]], [[2b4s\|2b4s]], [[2bgd\|2bgd]], [[2bge\|2bge]], [[2cm2\|2cm2]], [[2cm3\|2cm3]], [[2cm7\|2cm7]], [[2cm8\|2cm8]], [[2cma\|2cma]], [[2cmc\|2cmc]], [[2cne\|2cne]], [[2cnf\|2cnf]], [[2cng\|2cng]], [[2cnh\|2cnh]], [[2cni\|2cni]], [[2f6f\|2f6f]], [[2f6t\|2f6t]], [[2f6v\|2f6v]], [[2f6w\|2f6w]], [[2f6y\|2f6y]], [[2f6z\|2f6z]], [[2f70\|2f70]], [[2f71\|2f71]], [[2fjm\|2fjm]], [[2fjn\|2fjn]], [[2hnp\|2hnp]], [[2hnq\|2hnq]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cmb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cmb RCSB], [http://www.ebi.ac.uk/pdbsum/2cmb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cmb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cmb RCSB], [http://www.ebi.ac.uk/pdbsum/2cmb PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN]] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Protein-tyrosine-phosphatase]]		[[Category: Protein-tyrosine-phosphatase]]
-	[[Category: Ala, P J.]]	+	[[Category: Ala, P J]]
-	[[Category: Becker-Pasha, M.]]	+	[[Category: Becker-Pasha, M]]
-	[[Category: Bower, M.]]	+	[[Category: Bower, M]]
-	[[Category: Burn, T C.]]	+	[[Category: Burn, T C]]
-	[[Category: Combs, A P.]]	+	[[Category: Combs, A P]]
-	[[Category: Douty, B.]]	+	[[Category: Douty, B]]
-	[[Category: Gonneville, L.]]	+	[[Category: Gonneville, L]]
-	[[Category: Hillman, M C.]]	+	[[Category: Hillman, M C]]
-	[[Category: Hollis, G F.]]	+	[[Category: Hollis, G F]]
-	[[Category: Klabe, R.]]	+	[[Category: Klabe, R]]
-	[[Category: Polam, P.]]	+	[[Category: Polam, P]]
-	[[Category: Reid, B G.]]	+	[[Category: Reid, B G]]
-	[[Category: Wasserman, Z.]]	+	[[Category: Wasserman, Z]]
-	[[Category: Wayland, B.]]	+	[[Category: Wayland, B]]
-	[[Category: Wei, M.]]	+	[[Category: Wei, M]]
-	[[Category: Wynn, R.]]	+	[[Category: Wynn, R]]
-	[[Category: Yue, E W.]]	+	[[Category: Yue, E W]]
	[[Category: Endoplasmic reticulum]]		[[Category: Endoplasmic reticulum]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 05:47, 29 September 2014

OCA — Mon, 29 Sep 2014 05:47:30 GMT

←Older revision		Revision as of 05:47, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2cmb.~~png~~\|~~left~~\|200px]]	+	==STRUCTURAL BASIS FOR INHIBITION OF PROTEIN TYROSINE PHOSPHATASE 1B BY ISOTHIAZOLIDINONE HETEROCYCLIC PHOSPHONATE MIMETICS==
		+	<StructureSection load='2cmb' size='340' side='right' caption='[[2cmb]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2cmb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CMB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CMB FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=F17:N-{[4-(1,1-DIOXIDO-3-OXO-2,3-DIHYDROISOTHIAZOL-5-YL)PHENYL]ACETYL}-L-PHENYLALANYL-4-(1,1-DIOXIDO-3-OXO-2,3-DIHYDROISOTHIAZOL-5-YL)-L-PHENYLALANINAMIDE'>F17</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a5y\|1a5y]], [[1aax\|1aax]], [[1bzc\|1bzc]], [[1bzh\|1bzh]], [[1bzj\|1bzj]], [[1c83\|1c83]], [[1c84\|1c84]], [[1c85\|1c85]], [[1c86\|1c86]], [[1c87\|1c87]], [[1c88\|1c88]], [[1ecv\|1ecv]], [[1een\|1een]], [[1eeo\|1eeo]], [[1g1f\|1g1f]], [[1g1g\|1g1g]], [[1g1h\|1g1h]], [[1g7f\|1g7f]], [[1g7g\|1g7g]], [[1gfy\|1gfy]], [[1i57\|1i57]], [[1jf7\|1jf7]], [[1kak\|1kak]], [[1kav\|1kav]], [[1l8g\|1l8g]], [[1lqf\|1lqf]], [[1nl9\|1nl9]], [[1nny\|1nny]], [[1no6\|1no6]], [[1nwe\|1nwe]], [[1nwl\|1nwl]], [[1nz7\|1nz7]], [[1oem\|1oem]], [[1oeo\|1oeo]], [[1oes\|1oes]], [[1oet\|1oet]], [[1oeu\|1oeu]], [[1oev\|1oev]], [[1ony\|1ony]], [[1onz\|1onz]], [[1pa1\|1pa1]], [[1ph0\|1ph0]], [[1ptt\|1ptt]], [[1ptu\|1ptu]], [[1ptv\|1ptv]], [[1pty\|1pty]], [[1pxh\|1pxh]], [[1pyn\|1pyn]], [[1q1m\|1q1m]], [[1q6j\|1q6j]], [[1q6m\|1q6m]], [[1q6n\|1q6n]], [[1q6p\|1q6p]], [[1q6s\|1q6s]], [[1q6t\|1q6t]], [[1qxk\|1qxk]], [[1sug\|1sug]], [[1t48\|1t48]], [[1t49\|1t49]], [[1t4j\|1t4j]], [[1wax\|1wax]], [[1xbo\|1xbo]], [[2azr\|2azr]], [[2b07\|2b07]], [[2b4s\|2b4s]], [[2bgd\|2bgd]], [[2bge\|2bge]], [[2cm2\|2cm2]], [[2cm3\|2cm3]], [[2cm7\|2cm7]], [[2cm8\|2cm8]], [[2cma\|2cma]], [[2cmc\|2cmc]], [[2cne\|2cne]], [[2cnf\|2cnf]], [[2cng\|2cng]], [[2cnh\|2cnh]], [[2cni\|2cni]], [[2f6f\|2f6f]], [[2f6t\|2f6t]], [[2f6v\|2f6v]], [[2f6w\|2f6w]], [[2f6y\|2f6y]], [[2f6z\|2f6z]], [[2f70\|2f70]], [[2f71\|2f71]], [[2fjm\|2fjm]], [[2fjn\|2fjn]], [[2hnp\|2hnp]], [[2hnq\|2hnq]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cmb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cmb RCSB], [http://www.ebi.ac.uk/pdbsum/2cmb PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cm/2cmb_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Crystal structures of protein-tyrosine phosphatase 1B in complex with compounds bearing a novel isothiazolidinone (IZD) heterocyclic phosphonate mimetic reveal that the heterocycle is highly complementary to the catalytic pocket of the protein. The heterocycle participates in an extensive network of hydrogen bonds with the backbone of the phosphate-binding loop, Phe(182) of the flap, and the side chain of Arg(221). When substituted with a phenol, the small inhibitor induces the closed conformation of the protein and displaces all waters in the catalytic pocket. Saturated IZD-containing peptides are more potent inhibitors than unsaturated analogs because the IZD heterocycle and phenyl ring directly attached to it bind in a nearly orthogonal orientation with respect to each other, a conformation that is close to the energy minimum of the saturated IZD-phenyl moiety. These results explain why the heterocycle is a potent phosphonate mimetic and an ideal starting point for designing small nonpeptidic inhibitors.

-	~~{{STRUCTURE_2cmb\| PDB=2cmb \| SCENE= }}~~	+	Structural basis for inhibition of protein-tyrosine phosphatase 1B by isothiazolidinone heterocyclic phosphonate mimetics.,Ala PJ, Gonneville L, Hillman MC, Becker-Pasha M, Wei M, Reid BG, Klabe R, Yue EW, Wayland B, Douty B, Polam P, Wasserman Z, Bower M, Combs AP, Burn TC, Hollis GF, Wynn R J Biol Chem. 2006 Oct 27;281(43):32784-95. Epub 2006 Aug 17. PMID:16916797<ref>PMID:16916797</ref>

-	~~===STRUCTURAL BASIS FOR INHIBITION OF PROTEIN TYROSINE PHOSPHATASE 1B BY ISOTHIAZOLIDINONE HETEROCYCLIC PHOSPHONATE MIMETICS===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16916797}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2cmb]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2CMB OCA].~~	+

	==See Also==		==See Also==
	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]		*[[Tyrosine phosphatase\|Tyrosine phosphatase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:016916797<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Protein-tyrosine-phosphatase]]		[[Category: Protein-tyrosine-phosphatase]]

OCA at 15:36, 20 October 2012

OCA — Sat, 20 Oct 2012 15:36:26 GMT

←Older revision		Revision as of 15:36, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2cmb]] is a 1 chain structure ~~of [[Tyrosine phosphatase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CMB OCA].	+	[[2cmb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CMB OCA].

	==See Also==		==See Also==

OCA at 11:29, 14 August 2012

OCA — Tue, 14 Aug 2012 11:29:58 GMT

←Older revision		Revision as of 11:29, 14 August 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2cmb]] is a 1 chain structure of ~~[[Proten tyrosine phosphatase]] and~~ [[Tyrosine phosphatase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CMB OCA].	+	[[2cmb]] is a 1 chain structure of [[Tyrosine phosphatase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CMB OCA].

	==See Also==		==See Also==
-	*[[Proten tyrosine phosphatase\|Proten tyrosine phosphatase]]
	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]		*[[Tyrosine phosphatase\|Tyrosine phosphatase]]