2cr8 - Revision history

OCA at 11:29, 22 May 2024

OCA — Wed, 22 May 2024 11:29:26 GMT

←Older revision		Revision as of 11:29, 22 May 2024
Line 1:		Line 1:

	==Solution structure of the zf-RanBP domain of p53-binding protein Mdm4==		==Solution structure of the zf-RanBP domain of p53-binding protein Mdm4==
-	<StructureSection load='2cr8' size='340' side='right'caption='[[2cr8~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2cr8' size='340' side='right'caption='[[2cr8]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2cr8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CR8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2cr8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CR8 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~MDM4 ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cr8 OCA], [https://pdbe.org/2cr8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cr8 RCSB], [https://www.ebi.ac.uk/pdbsum/2cr8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cr8 ProSAT], [https://www.topsan.org/Proteins/RSGI/2cr8 TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cr8 OCA], [https://pdbe.org/2cr8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cr8 RCSB], [https://www.ebi.ac.uk/pdbsum/2cr8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cr8 ProSAT], [https://www.topsan.org/Proteins/RSGI/2cr8 TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MDM4_HUMAN MDM4_HUMAN]] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.<ref>PMID:16163388</ref> <ref>PMID:16511572</ref>	+	[https://www.uniprot.org/uniprot/MDM4_HUMAN MDM4_HUMAN] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.<ref>PMID:16163388</ref> <ref>PMID:16511572</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 27:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hayashi, F]]	+	[[Category: Hayashi F]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Yokoyama S]]
-	[[Category: Yokoyama, S]]	+	[[Category: Zhang HP]]
-	[[Category: Zhang~~, H P]]~~	+
-	~~[[Category: Cell cycle]]~~	+
-	~~[[Category: Double minute 4 protein]]~~	+
-	~~[[Category: Mdm2-like p53-binding de protein]]~~	+
-	~~[[Category: Mdm4 protein]]~~	+
-	~~[[Category: Mdmx protein]]~~	+
-	~~[[Category: National project on protein structural and functional analyse]]~~	+
-	~~[[Category: Nppsfa]]~~	+
-	~~[[Category: P53-binding protein mdm4]]~~	+
-	~~[[Category: Rsgi]]~~	+
-	~~[[Category: Zf-ranbp domain~~]]	+

OCA at 11:47, 3 February 2021

OCA — Wed, 03 Feb 2021 11:47:55 GMT

←Older revision		Revision as of 11:47, 3 February 2021
Line 1:		Line 1:

	==Solution structure of the zf-RanBP domain of p53-binding protein Mdm4==		==Solution structure of the zf-RanBP domain of p53-binding protein Mdm4==
-	<StructureSection load='2cr8' size='340' side='right' caption='[[2cr8]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2cr8' size='340' side='right'caption='[[2cr8]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2cr8]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CR8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2cr8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CR8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MDM4 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MDM4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2cr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cr8 OCA], [~~http~~://pdbe.org/2cr8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2cr8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2cr8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2cr8 ProSAT], [~~http~~://www.topsan.org/Proteins/RSGI/2cr8 TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cr8 OCA], [https://pdbe.org/2cr8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cr8 RCSB], [https://www.ebi.ac.uk/pdbsum/2cr8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cr8 ProSAT], [https://www.topsan.org/Proteins/RSGI/2cr8 TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MDM4_HUMAN MDM4_HUMAN]] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.<ref>PMID:16163388</ref> <ref>PMID:16511572</ref>	+	[[https://www.uniprot.org/uniprot/MDM4_HUMAN MDM4_HUMAN]] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.<ref>PMID:16163388</ref> <ref>PMID:16511572</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[MDM2\|MDM2]]
	*[[MDM4\|MDM4]]		*[[MDM4\|MDM4]]
	== References ==		== References ==
Line 29:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Hayashi, F]]		[[Category: Hayashi, F]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]

OCA at 08:22, 23 May 2018

OCA — Wed, 23 May 2018 08:22:22 GMT

←Older revision		Revision as of 08:22, 23 May 2018
Line 1:		Line 1:
		+
	==Solution structure of the zf-RanBP domain of p53-binding protein Mdm4==		==Solution structure of the zf-RanBP domain of p53-binding protein Mdm4==
	<StructureSection load='2cr8' size='340' side='right' caption='[[2cr8]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2cr8' size='340' side='right' caption='[[2cr8]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MDM4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MDM4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cr8 OCA], [http://pdbe.org/2cr8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cr8 RCSB], [http://www.ebi.ac.uk/pdbsum/2cr8 PDBsum], [http://www.topsan.org/Proteins/RSGI/2cr8 TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cr8 OCA], [http://pdbe.org/2cr8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cr8 RCSB], [http://www.ebi.ac.uk/pdbsum/2cr8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cr8 ProSAT], [http://www.topsan.org/Proteins/RSGI/2cr8 TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cr/2cr8_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cr/2cr8_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 23:50, 9 February 2016

OCA — Tue, 09 Feb 2016 23:50:23 GMT

←Older revision		Revision as of 23:50, 9 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cr8 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

OCA at 03:17, 11 September 2015

OCA — Fri, 11 Sep 2015 03:17:04 GMT

←Older revision		Revision as of 03:17, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2cr8' size='340' side='right' caption='[[2cr8]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2cr8' size='340' side='right' caption='[[2cr8]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2cr8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CR8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2cr8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CR8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MDM4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MDM4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cr8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cr8 RCSB], [http://www.ebi.ac.uk/pdbsum/2cr8 PDBsum], [http://www.topsan.org/Proteins/RSGI/2cr8 TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cr8 OCA], [http://pdbe.org/2cr8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cr8 RCSB], [http://www.ebi.ac.uk/pdbsum/2cr8 PDBsum], [http://www.topsan.org/Proteins/RSGI/2cr8 TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Hayashi, F]]		[[Category: Hayashi, F]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]

OCA at 10:22, 25 December 2014

OCA — Thu, 25 Dec 2014 10:22:24 GMT

←Older revision		Revision as of 10:22, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cr8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CR8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cr8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CR8 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MDM4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MDM4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cr8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cr8 RCSB], [http://www.ebi.ac.uk/pdbsum/2cr8 PDBsum], [http://www.topsan.org/Proteins/RSGI/2cr8 TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cr8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cr8 RCSB], [http://www.ebi.ac.uk/pdbsum/2cr8 PDBsum], [http://www.topsan.org/Proteins/RSGI/2cr8 TOPSAN]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MDM4_HUMAN MDM4_HUMAN]] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.<ref>PMID:16163388</ref> <ref>PMID:16511572</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 21:		Line 23:
	*[[MDM2\|MDM2]]		*[[MDM2\|MDM2]]
	*[[MDM4\|MDM4]]		*[[MDM4\|MDM4]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Hayashi, F.]]	+	[[Category: Hayashi, F]]
-	[[Category: ~~RSGI, RIKEN~~ Structural ~~Genomics/Proteomics Initiative.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Yokoyama, S.]]	+	[[Category: Yokoyama, S]]
-	[[Category: Zhang, H P.]]	+	[[Category: Zhang, H P]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]
	[[Category: Double minute 4 protein]]		[[Category: Double minute 4 protein]]
Line 36:		Line 40:
	[[Category: Nppsfa]]		[[Category: Nppsfa]]
	[[Category: P53-binding protein mdm4]]		[[Category: P53-binding protein mdm4]]
-	[[Category: Riken structural genomics/proteomics initiative]]
	[[Category: Rsgi]]		[[Category: Rsgi]]
-	[[Category: Structural genomic]]
	[[Category: Zf-ranbp domain]]		[[Category: Zf-ranbp domain]]

OCA at 05:43, 29 September 2014

OCA — Mon, 29 Sep 2014 05:43:58 GMT

←Older revision		Revision as of 05:43, 29 September 2014
Line 1:		Line 1:
-	~~[[Image:2cr8.png\|left\|200px]]~~	+	==Solution structure of the zf-RanBP domain of p53-binding protein Mdm4==
-		+	<StructureSection load='2cr8' size='340' side='right' caption='[[2cr8]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~{{STRUCTURE_2cr8\| PDB=2cr8 \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2cr8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CR8 FirstGlance]. <br>
-	===Solution structure of the zf-RanBP domain of p53-binding protein Mdm4===	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MDM4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cr8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cr8 RCSB], [http://www.ebi.ac.uk/pdbsum/2cr8 PDBsum], [http://www.topsan.org/Proteins/RSGI/2cr8 TOPSAN]</span></td></tr>
-	==~~About this Structure~~==	+	<table>
-	[[2cr8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR8 OCA].	+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cr/2cr8_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>

	==See Also==		==See Also==
		+	*[[MDM2\|MDM2]]
	*[[MDM4\|MDM4]]		*[[MDM4\|MDM4]]
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hayashi, F.]]		[[Category: Hayashi, F.]]

OCA at 15:34, 20 October 2012

OCA — Sat, 20 Oct 2012 15:34:30 GMT

←Older revision		Revision as of 15:34, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[2cr8]] is a 1 chain structure ~~of [[MDM4]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR8 OCA].	+	[[2cr8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR8 OCA].

	==See Also==		==See Also==

OCA: Protected "2cr8" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 18:48:44 GMT

Protected "2cr8" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:48, 26 July 2012

OCA at 18:48, 26 July 2012

OCA — Thu, 26 Jul 2012 18:48:43 GMT

←Older revision		Revision as of 18:48, 26 July 2012
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-	{{Seed}}
	[[Image:2cr8.png\|left\|200px]]		[[Image:2cr8.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2cr8", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_2cr8\| PDB=2cr8 \| SCENE= }}		{{STRUCTURE_2cr8\| PDB=2cr8 \| SCENE= }}

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	==About this Structure==		==About this Structure==
-	~~2CR8~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR8 OCA].	+	[[2cr8]] is a 1 chain structure of [[MDM4]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR8 OCA].
		+
		+	==See Also==
		+	*[[MDM4\|MDM4]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hayashi, F.]]		[[Category: Hayashi, F.]]
Line 20:		Line 16:
	[[Category: Yokoyama, S.]]		[[Category: Yokoyama, S.]]
	[[Category: Zhang, H P.]]		[[Category: Zhang, H P.]]
		+	[[Category: Cell cycle]]
	[[Category: Double minute 4 protein]]		[[Category: Double minute 4 protein]]
	[[Category: Mdm2-like p53-binding de protein]]		[[Category: Mdm2-like p53-binding de protein]]
Line 31:		Line 28:
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Zf-ranbp domain]]		[[Category: Zf-ranbp domain]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 17:15:18 2008''