2cut - Revision history

OCA at 11:31, 22 May 2024

OCA — Wed, 22 May 2024 11:31:26 GMT

←Older revision		Revision as of 11:31, 22 May 2024
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	<StructureSection load='2cut' size='340' side='right'caption='[[2cut]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2cut' size='340' side='right'caption='[[2cut]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2cut]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Fusso Fusso~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CUT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2cut]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Fusarium_vanettenii Fusarium vanettenii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CUT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DEP:DIETHYL+PHOSPHONATE'>DEP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DEP:DIETHYL+PHOSPHONATE'>DEP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cut OCA], [https://pdbe.org/2cut PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cut RCSB], [https://www.ebi.ac.uk/pdbsum/2cut PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cut ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cut OCA], [https://pdbe.org/2cut PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cut RCSB], [https://www.ebi.ac.uk/pdbsum/2cut PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cut ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~CUTI1_FUSSO CUTI1_FUSSO]~~] Catalyzes the hydrolysis of cutin, a ~~polyester~~ that forms the structure of plant cuticle. Allows pathogenic fungi to penetrate through the cuticular barrier into the host plant during the initial stage of ~~the~~ fungal infection.	+	[https://www.uniprot.org/uniprot/CUTI1_FUSVN CUTI1_FUSVN] Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants (PubMed:18658138, PubMed:8286366, PubMed:8555209, PubMed:19810726). Degrades cutin, a macromolecule that forms the structure of the plant cuticle (PubMed:18658138, PubMed:8286366, PubMed:8555209, PubMed:19810726). Allows pathogenic fungi to penetrate through the cuticular barrier into the host plant during the initial stage of fungal infection (Ref.4).<ref>PMID:18658138</ref> <ref>PMID:19810726</ref> <ref>PMID:8286366</ref> <ref>PMID:8555209</ref> [PROSITE-ProRule:PRU10109]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Fusso~~]]	+	[[Category: Fusarium vanettenii]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cambillau, C]]	+	[[Category: Cambillau C]]
-	[[Category: Martinez, C]]	+	[[Category: Martinez C]]

OCA at 20:37, 20 October 2021

OCA — Wed, 20 Oct 2021 20:37:20 GMT

←Older revision		Revision as of 20:37, 20 October 2021
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	<StructureSection load='2cut' size='340' side='right'caption='[[2cut]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2cut' size='340' side='right'caption='[[2cut]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2cut]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Fusso Fusso]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CUT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2cut]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Fusso Fusso]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CUT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DEP:DIETHYL+PHOSPHONATE'>DEP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DEP:DIETHYL+PHOSPHONATE'>DEP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2cut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cut OCA], [~~http~~://pdbe.org/2cut PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2cut RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2cut PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2cut ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cut OCA], [https://pdbe.org/2cut PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cut RCSB], [https://www.ebi.ac.uk/pdbsum/2cut PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cut ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CUTI1_FUSSO CUTI1_FUSSO]] Catalyzes the hydrolysis of cutin, a polyester that forms the structure of plant cuticle. Allows pathogenic fungi to penetrate through the cuticular barrier into the host plant during the initial stage of the fungal infection.	+	[[https://www.uniprot.org/uniprot/CUTI1_FUSSO CUTI1_FUSSO]] Catalyzes the hydrolysis of cutin, a polyester that forms the structure of plant cuticle. Allows pathogenic fungi to penetrate through the cuticular barrier into the host plant during the initial stage of the fungal infection.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 19:43, 11 December 2019

OCA — Wed, 11 Dec 2019 19:43:52 GMT

←Older revision		Revision as of 19:43, 11 December 2019
Line 1:		Line 1:

	==CUTINASE, A LIPOLYTIC ENZYME WITH A PREFORMED OXYANION HOLE==		==CUTINASE, A LIPOLYTIC ENZYME WITH A PREFORMED OXYANION HOLE==
-	<StructureSection load='2cut' size='340' side='right' caption='[[2cut]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='2cut' size='340' side='right'caption='[[2cut]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cut]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Fusso Fusso]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CUT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cut]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Fusso Fusso]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CUT FirstGlance]. <br>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cu/2cut_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cu/2cut_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Cutinase\|Cutinase]]	+	*[[Cutinase 3D structures\|Cutinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Fusso]]		[[Category: Fusso]]
		+	[[Category: Large Structures]]
	[[Category: Cambillau, C]]		[[Category: Cambillau, C]]
	[[Category: Martinez, C]]		[[Category: Martinez, C]]

OCA at 07:05, 29 November 2017

OCA — Wed, 29 Nov 2017 07:05:48 GMT

←Older revision		Revision as of 07:05, 29 November 2017
Line 1:		Line 1:
		+
	==CUTINASE, A LIPOLYTIC ENZYME WITH A PREFORMED OXYANION HOLE==		==CUTINASE, A LIPOLYTIC ENZYME WITH A PREFORMED OXYANION HOLE==
	<StructureSection load='2cut' size='340' side='right' caption='[[2cut]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2cut' size='340' side='right' caption='[[2cut]], [[Resolution\|resolution]] 1.90Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2cut]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Fusso Fusso]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CUT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cut]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Fusso Fusso]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CUT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DEP:DIETHYL+PHOSPHONATE'>DEP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DEP:DIETHYL+PHOSPHONATE'>DEP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cut OCA], [http://pdbe.org/2cut PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cut RCSB], [http://www.ebi.ac.uk/pdbsum/2cut PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cut OCA], [http://pdbe.org/2cut PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cut RCSB], [http://www.ebi.ac.uk/pdbsum/2cut PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cut ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 03:36, 7 February 2016

OCA — Sun, 07 Feb 2016 03:36:00 GMT

←Older revision		Revision as of 03:36, 7 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cut ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 21:21, 9 September 2015

OCA — Wed, 09 Sep 2015 21:21:40 GMT

←Older revision		Revision as of 21:21, 9 September 2015
Line 2:		Line 2:
	<StructureSection load='2cut' size='340' side='right' caption='[[2cut]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2cut' size='340' side='right' caption='[[2cut]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2cut]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Fusarium_solani Fusarium solani~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CUT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2cut]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Fusso Fusso]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CUT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DEP:DIETHYL+PHOSPHONATE'>DEP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DEP:DIETHYL+PHOSPHONATE'>DEP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cut OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cut RCSB], [http://www.ebi.ac.uk/pdbsum/2cut PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cut OCA], [http://pdbe.org/2cut PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cut RCSB], [http://www.ebi.ac.uk/pdbsum/2cut PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2cut" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Fusarium solani~~]]	+	[[Category: Fusso]]
	[[Category: Cambillau, C]]		[[Category: Cambillau, C]]
	[[Category: Martinez, C]]		[[Category: Martinez, C]]

OCA at 07:33, 24 December 2014

OCA — Wed, 24 Dec 2014 07:33:28 GMT

←Older revision		Revision as of 07:33, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cut]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Fusarium_solani Fusarium solani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CUT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cut]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Fusarium_solani Fusarium solani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CUT FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DEP:DIETHYL+PHOSPHONATE'>DEP</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DEP:DIETHYL+PHOSPHONATE'>DEP</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cut OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cut RCSB], [http://www.ebi.ac.uk/pdbsum/2cut PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cut OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cut RCSB], [http://www.ebi.ac.uk/pdbsum/2cut PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CUTI1_FUSSO CUTI1_FUSSO]] Catalyzes the hydrolysis of cutin, a polyester that forms the structure of plant cuticle. Allows pathogenic fungi to penetrate through the cuticular barrier into the host plant during the initial stage of the fungal infection.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Fusarium solani]]		[[Category: Fusarium solani]]
-	[[Category: Cambillau, C.]]	+	[[Category: Cambillau, C]]
-	[[Category: Martinez, C.]]	+	[[Category: Martinez, C]]

OCA at 00:32, 30 September 2014

OCA — Tue, 30 Sep 2014 00:32:05 GMT

←Older revision		Revision as of 00:32, 30 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2cut.~~png\|left~~\|200px]]	+	==CUTINASE, A LIPOLYTIC ENZYME WITH A PREFORMED OXYANION HOLE==
		+	<StructureSection load='2cut' size='340' side='right' caption='[[2cut]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2cut]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Fusarium_solani Fusarium solani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CUT FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DEP:DIETHYL+PHOSPHONATE'>DEP</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cut OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cut RCSB], [http://www.ebi.ac.uk/pdbsum/2cut PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cu/2cut_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cutinases, a group of cutin degrading enzymes with molecular masses of around 22-25 kDa (Kolattukudy, 1984), are also able to efficiently hydrolyse triglycerides (De Geus et al., 1989; Lauwereys et al., 1991), but without exhibiting the interfacial activation phenomenom (Sarda et al., 1958). They belong to a class of proteins with a common structural framework, called the alpha/beta hydrolase fold (Martinez et al., 1992; Ollis et al., 1992). We describe herein the structure of cutinase covalently inhibited by diethyl-p-nitrophenyl phosphate (E600) and refined at 1.9-A resolution. Contrary to what has previously been reported with lipases (Brzozowski et al., 1991; Derewenda et al., 1992; Van Tilbeurgh et al., 1993), no significant structural rearrangement was observed here in cutinase upon the inhibitor binding. Moreover, the structure of the active site machinery, consisting of a catalytic triad (S120, H188, D175) and an oxyanion hole (Q121 and S42), was found to be identical to that of the native enzyme, whereas the oxyanion hole of Rhizomucor lipase (Brzozowski et al., 1991; Derewenda et al., 1992), like that of pancreatic lipase (van Tilbeurgh et al., 1993), is formed only upon enzyme-ligand complex formation. The fact that cutinase does not display interfacial activation cannot therefore only be due to the absence of a lid but might also be attributable to the presence of a preformed oxyanion hole.

-	~~{{STRUCTURE_2cut\| PDB=2cut \| SCENE= }}~~	+	Cutinase, a lipolytic enzyme with a preformed oxyanion hole.,Martinez C, Nicolas A, van Tilbeurgh H, Egloff MP, Cudrey C, Verger R, Cambillau C Biochemistry. 1994 Jan 11;33(1):83-9. PMID:8286366<ref>PMID:8286366</ref>

-	~~===CUTINASE~~, ~~A LIPOLYTIC ENZYME WITH A PREFORMED OXYANION HOLE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_8286366}}~~	+	==See Also==
-		+	*[[Cutinase\|Cutinase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~2cut~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Fusarium_solani Fusarium solani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUT OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:008286366<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Fusarium solani]]		[[Category: Fusarium solani]]
	[[Category: Cambillau, C.]]		[[Category: Cambillau, C.]]
	[[Category: Martinez, C.]]		[[Category: Martinez, C.]]

OCA: Protected "2cut" [edit=sysop:move=sysop]

OCA — Sun, 06 Jan 2013 09:54:26 GMT

Protected "2cut" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:54, 6 January 2013

OCA at 09:54, 6 January 2013

OCA — Sun, 06 Jan 2013 09:54:23 GMT

←Older revision		Revision as of 09:54, 6 January 2013
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	[[Image:2cut.png\|left\|200px]]		[[Image:2cut.png\|left\|200px]]

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	{{STRUCTURE_2cut\| PDB=2cut \| SCENE= }}		{{STRUCTURE_2cut\| PDB=2cut \| SCENE= }}

	===CUTINASE, A LIPOLYTIC ENZYME WITH A PREFORMED OXYANION HOLE===		===CUTINASE, A LIPOLYTIC ENZYME WITH A PREFORMED OXYANION HOLE===

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	{{ABSTRACT_PUBMED_8286366}}		{{ABSTRACT_PUBMED_8286366}}

	==About this Structure==		==About this Structure==
-	~~2CUT~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Fusarium_solani Fusarium solani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUT OCA].	+	[[2cut]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Fusarium_solani Fusarium solani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUT OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~8286366~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:008286366</ref><references group="xtra"/>
	[[Category: Fusarium solani]]		[[Category: Fusarium solani]]
	[[Category: Cambillau, C.]]		[[Category: Cambillau, C.]]
	[[Category: Martinez, C.]]		[[Category: Martinez, C.]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 10:52:38 2009''