2cyf - Revision history

OCA at 13:45, 13 March 2024

OCA — Wed, 13 Mar 2024 13:45:19 GMT

←Older revision		Revision as of 13:45, 13 March 2024
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	<StructureSection load='2cyf' size='340' side='right'caption='[[2cyf]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2cyf' size='340' side='right'caption='[[2cyf]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2cyf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Canavalia_maritima~~ Canavalia ~~maritima~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CYF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CYF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2cyf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Canavalia_rosea Canavalia rosea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CYF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CYF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene><~~/td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;~~'>~~[[2cwm\|2cwm]], [[2cy6\|2cy6]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PRD_900001:alpha-maltose'>PRD_900001</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cyf OCA], [https://pdbe.org/2cyf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cyf RCSB], [https://www.ebi.ac.uk/pdbsum/2cyf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cyf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cyf OCA], [https://pdbe.org/2cyf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cyf RCSB], [https://www.ebi.ac.uk/pdbsum/2cyf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cyf ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CONA_CANBR CONA_CANBR] Glucose/D-mannose specific lectin. Has anti-inflammatory activity in rats. Induces histamine release in mast cells from hamster and rat. Induces lymphocyte proliferation and IFNG production. Shows toxicity against the aquatic snail B.glabrata at concentrations higher than 20 ug/ml.<ref>PMID:1398779</ref> <ref>PMID:7524287</ref> <ref>PMID:8891754</ref> <ref>PMID:18472821</ref> <ref>PMID:9575151</ref> <ref>PMID:10747944</ref> <ref>PMID:19765980</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cyf ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cyf ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The crystal structure of Canavalia maritima lectin (ConM) complexed with trehalose and maltose revealed relevant point mutations in ConA-like lectins. ConM with the disaccharides and other ConA-like lectins complexed with carbohydrates demonstrated significant differences in the position of H-bonds. The main difference in the ConM structure is the replacement of Pro202 by Ser202, a residue that promotes the approximation of Tyr12 to the carbohydrate-binding site. The O-6' of the second glucose ring in maltose interacts with Tyr12, while in trehalose the interaction is established by the O-2' and Tyr12, explaining the higher affinity of ConM for disaccharides compared to monosaccharides.
-
-	Crystal structure of a lectin from Canavalia maritima (ConM) in complex with trehalose and maltose reveals relevant mutation in ConA-like lectins.,Delatorre P, Rocha BA, Gadelha CA, Santi-Gadelha T, Cajazeiras JB, Souza EP, Nascimento KS, Freire VN, Sampaio AH, Azevedo WF Jr, Cavada BS J Struct Biol. 2006 Jun;154(3):280-6. Epub 2006 Apr 21. PMID:16677825<ref>PMID:16677825</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2cyf" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Canavalia ~~maritima~~]]	+	[[Category: Canavalia rosea]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Azevedo~~, W F~~]]	+	[[Category: Azevedo Jr WF]]
-	[[Category: Cavada~~, B S~~]]	+	[[Category: Cavada BS]]
-	[[Category: Delatorre, P]]	+	[[Category: Delatorre P]]
-	[[Category: Gadelha~~, C A.A~~]]	+	[[Category: Gadelha CAA]]
-	[[Category: Rocha~~, B A.M~~]]	+	[[Category: Rocha BAM]]
-	[[Category: Sousa~~, E P]]~~	+	[[Category: Sousa EP]]
-	~~[[Category: Canacalia maritima]]~~	+
-	~~[[Category: Lectin]]~~	+
-	~~[[Category: Maltose]]~~	+
-	~~[[Category: Metal binding protein~~]]	+

OCA at 09:48, 5 May 2021

OCA — Wed, 05 May 2021 09:48:02 GMT

←Older revision		Revision as of 09:48, 5 May 2021
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	<StructureSection load='2cyf' size='340' side='right'caption='[[2cyf]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2cyf' size='340' side='right'caption='[[2cyf]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2cyf]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Beach_bean Beach bean~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CYF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CYF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2cyf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Canavalia_maritima Canavalia maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CYF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CYF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=~~MAL~~:~~MALTOSE~~'>~~MAL~~</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cwm\|2cwm]], [[2cy6\|2cy6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2cwm\|2cwm]], [[2cy6\|2cy6]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2cyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cyf OCA], [~~http~~://pdbe.org/2cyf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2cyf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2cyf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2cyf ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cyf OCA], [https://pdbe.org/2cyf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cyf RCSB], [https://www.ebi.ac.uk/pdbsum/2cyf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cyf ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 34:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Beach bean~~]]	+	[[Category: Canavalia maritima]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Azevedo, W F]]		[[Category: Azevedo, W F]]

OCA at 09:12, 24 July 2019

OCA — Wed, 24 Jul 2019 09:12:27 GMT

←Older revision		Revision as of 09:12, 24 July 2019
Line 1:		Line 1:

	==The Crystal Structure of Canavalia Maritima Lectin (ConM) in Complex with Trehalose and Maltose==		==The Crystal Structure of Canavalia Maritima Lectin (ConM) in Complex with Trehalose and Maltose==
-	<StructureSection load='2cyf' size='340' side='right' caption='[[2cyf]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='2cyf' size='340' side='right'caption='[[2cyf]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cyf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Beach_bean Beach bean]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CYF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CYF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cyf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Beach_bean Beach bean]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CYF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CYF FirstGlance]. <br>
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cy/2cyf_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cy/2cyf_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 27:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 2cyf" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2cyf" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Concanavalin 3D structures\|Concanavalin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Beach bean]]		[[Category: Beach bean]]
		+	[[Category: Large Structures]]
	[[Category: Azevedo, W F]]		[[Category: Azevedo, W F]]
	[[Category: Cavada, B S]]		[[Category: Cavada, B S]]

OCA at 08:39, 12 October 2017

OCA — Thu, 12 Oct 2017 08:39:10 GMT

←Older revision		Revision as of 08:39, 12 October 2017
Line 1:		Line 1:
		+
	==The Crystal Structure of Canavalia Maritima Lectin (ConM) in Complex with Trehalose and Maltose==		==The Crystal Structure of Canavalia Maritima Lectin (ConM) in Complex with Trehalose and Maltose==
	<StructureSection load='2cyf' size='340' side='right' caption='[[2cyf]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2cyf' size='340' side='right' caption='[[2cyf]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2cyf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Canavalia_rosea Canavalia rosea~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CYF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CYF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2cyf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Beach_bean Beach bean]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CYF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CYF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cwm\|2cwm]], [[2cy6\|2cy6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cwm\|2cwm]], [[2cy6\|2cy6]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cyf OCA], [http://pdbe.org/2cyf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cyf RCSB], [http://www.ebi.ac.uk/pdbsum/2cyf PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cyf OCA], [http://pdbe.org/2cyf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cyf RCSB], [http://www.ebi.ac.uk/pdbsum/2cyf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cyf ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	</div>		</div>
	<div class="pdbe-citations 2cyf" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2cyf" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Concanavalin A\|Concanavalin A]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Canavalia rosea~~]]	+	[[Category: Beach bean]]
	[[Category: Azevedo, W F]]		[[Category: Azevedo, W F]]
	[[Category: Cavada, B S]]		[[Category: Cavada, B S]]

OCA at 10:48, 7 February 2016

OCA — Sun, 07 Feb 2016 10:48:37 GMT

←Older revision		Revision as of 10:48, 7 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cyf ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 00:47, 10 September 2015

OCA — Thu, 10 Sep 2015 00:47:53 GMT

←Older revision		Revision as of 00:47, 10 September 2015
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cwm\|2cwm]], [[2cy6\|2cy6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cwm\|2cwm]], [[2cy6\|2cy6]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cyf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cyf RCSB], [http://www.ebi.ac.uk/pdbsum/2cyf PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cyf OCA], [http://pdbe.org/2cyf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cyf RCSB], [http://www.ebi.ac.uk/pdbsum/2cyf PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2cyf" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 16:31, 15 January 2015

OCA — Thu, 15 Jan 2015 16:31:35 GMT

←Older revision		Revision as of 16:31, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cyf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_rosea Canavalia rosea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CYF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CYF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cyf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_rosea Canavalia rosea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CYF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CYF FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cwm\|2cwm]], [[2cy6\|2cy6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cwm\|2cwm]], [[2cy6\|2cy6]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cyf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cyf RCSB], [http://www.ebi.ac.uk/pdbsum/2cyf PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cyf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cyf RCSB], [http://www.ebi.ac.uk/pdbsum/2cyf PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Canavalia rosea]]		[[Category: Canavalia rosea]]
-	[[Category: Azevedo, W F.]]	+	[[Category: Azevedo, W F]]
-	[[Category: Cavada, B S.]]	+	[[Category: Cavada, B S]]
-	[[Category: Delatorre, P.]]	+	[[Category: Delatorre, P]]
-	[[Category: Gadelha, C A.A.]]	+	[[Category: Gadelha, C A.A]]
-	[[Category: Rocha, B A.M.]]	+	[[Category: Rocha, B A.M]]
-	[[Category: Sousa, E P.]]	+	[[Category: Sousa, E P]]
	[[Category: Canacalia maritima]]		[[Category: Canacalia maritima]]
	[[Category: Lectin]]		[[Category: Lectin]]
	[[Category: Maltose]]		[[Category: Maltose]]
	[[Category: Metal binding protein]]		[[Category: Metal binding protein]]

OCA at 00:05, 30 September 2014

OCA — Tue, 30 Sep 2014 00:05:05 GMT

←Older revision		Revision as of 00:05, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2cyf.~~png~~\|~~left~~\|200px]]	+	==The Crystal Structure of Canavalia Maritima Lectin (ConM) in Complex with Trehalose and Maltose==
		+	<StructureSection load='2cyf' size='340' side='right' caption='[[2cyf]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2cyf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_rosea Canavalia rosea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CYF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CYF FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cwm\|2cwm]], [[2cy6\|2cy6]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cyf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cyf RCSB], [http://www.ebi.ac.uk/pdbsum/2cyf PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cy/2cyf_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The crystal structure of Canavalia maritima lectin (ConM) complexed with trehalose and maltose revealed relevant point mutations in ConA-like lectins. ConM with the disaccharides and other ConA-like lectins complexed with carbohydrates demonstrated significant differences in the position of H-bonds. The main difference in the ConM structure is the replacement of Pro202 by Ser202, a residue that promotes the approximation of Tyr12 to the carbohydrate-binding site. The O-6' of the second glucose ring in maltose interacts with Tyr12, while in trehalose the interaction is established by the O-2' and Tyr12, explaining the higher affinity of ConM for disaccharides compared to monosaccharides.

-	~~{{STRUCTURE_2cyf\| PDB=2cyf \| SCENE= }}~~	+	Crystal structure of a lectin from Canavalia maritima (ConM) in complex with trehalose and maltose reveals relevant mutation in ConA-like lectins.,Delatorre P, Rocha BA, Gadelha CA, Santi-Gadelha T, Cajazeiras JB, Souza EP, Nascimento KS, Freire VN, Sampaio AH, Azevedo WF Jr, Cavada BS J Struct Biol. 2006 Jun;154(3):280-6. Epub 2006 Apr 21. PMID:16677825<ref>PMID:16677825</ref>

-	~~===The Crystal Structure~~ of ~~Canavalia Maritima Lectin (ConM) in Complex with Trehalose and Maltose===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_16677825}}~~	+	==See Also==
-		+	*[[Concanavalin A\|Concanavalin A]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~2cyf~~]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_rosea Canavalia rosea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CYF OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:016677825<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Canavalia rosea]]		[[Category: Canavalia rosea]]
	[[Category: Azevedo, W F.]]		[[Category: Azevedo, W F.]]

OCA: Protected "2cyf" [edit=sysop:move=sysop]

OCA — Sun, 06 Jan 2013 09:31:55 GMT

Protected "2cyf" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:31, 6 January 2013

OCA at 09:31, 6 January 2013

OCA — Sun, 06 Jan 2013 09:31:53 GMT

←Older revision		Revision as of 09:31, 6 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2cyf.png\|left\|200px]]		[[Image:2cyf.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2cyf", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2cyf\| PDB=2cyf \| SCENE= }}		{{STRUCTURE_2cyf\| PDB=2cyf \| SCENE= }}

	===The Crystal Structure of Canavalia Maritima Lectin (ConM) in Complex with Trehalose and Maltose===		===The Crystal Structure of Canavalia Maritima Lectin (ConM) in Complex with Trehalose and Maltose===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16677825}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16677825 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16677825}}		{{ABSTRACT_PUBMED_16677825}}

	==About this Structure==		==About this Structure==
-	~~2CYF~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/~~Canavalia_maritima~~ Canavalia ~~maritima~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CYF OCA].	+	[[2cyf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_rosea Canavalia rosea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CYF OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16677825~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016677825</ref><references group="xtra"/>
-	[[Category: Canavalia ~~maritima~~]]	+	[[Category: Canavalia rosea]]
		+	[[Category: Azevedo, W F.]]
	[[Category: Cavada, B S.]]		[[Category: Cavada, B S.]]
	[[Category: Delatorre, P.]]		[[Category: Delatorre, P.]]
	[[Category: Gadelha, C A.A.]]		[[Category: Gadelha, C A.A.]]
-	[[Category: Jr., W F.Azevedo.]]
	[[Category: Rocha, B A.M.]]		[[Category: Rocha, B A.M.]]
	[[Category: Sousa, E P.]]		[[Category: Sousa, E P.]]
	[[Category: Canacalia maritima]]		[[Category: Canacalia maritima]]
-	[[Category: Crystal structure]]
	[[Category: Lectin]]		[[Category: Lectin]]
	[[Category: Maltose]]		[[Category: Maltose]]
-		+	[[Category: Metal binding protein]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Mon Feb 16 13:17:54 2009''~~	+