2des - Revision history

OCA at 09:18, 14 February 2024

OCA — Wed, 14 Feb 2024 09:18:45 GMT

←Older revision		Revision as of 09:18, 14 February 2024
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2des FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2des OCA], [https://pdbe.org/2des PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2des RCSB], [https://www.ebi.ac.uk/pdbsum/2des PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2des ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2des FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2des OCA], [https://pdbe.org/2des PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2des RCSB], [https://www.ebi.ac.uk/pdbsum/2des PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2des ProSAT]</span></td></tr>
	</table>		</table>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Anthracycline antibiotics daunomycin and adriamycin are among the most widely used in cancer chemotherapy and DNA is believed to be the primary target of their biological action. The crystal structure of a morpholino derivative of adriamycin bound to the DNA hexamer d(CGTACG) has been determined at 1.5 A resolution. The complex crystallizes in space group P1 with unit cell dimensions a = 18.01 A, b = 18.83 A, c = 27.65 A, alpha = 92.6 degrees, beta = 100.5 degrees, gamma = 94.9 degrees and there are two drug molecules bound per duplex. Morpholino derivatives differ greatly from their parent compounds in their biological and pharmacological properties. Structural comparison of this complex with the series of previously reported anthracycline-DNA complexes offers an opportunity for studying relationships between structure and function. The anthracycline chromophore intercalates at the CpG step and DNA distortions from a B-type conformation are similar to those observed in the other DNA-anthracycline complexes. Interactions between drug and DNA show no differences at the intercalation site, while in the minor groove they are significantly affected by the presence of the bulky morpholinyl moiety on the anthracycline amino sugar. The binding site involves four base-pairs and the absence of a positive charge on the amino sugar appears to influence the hydration pattern on both grooves. The two halves of the duplex are symmetrically related by a non-crystallographic 2-fold axis but they are not equivalent. In one half, one magnesium cluster bridges both drug and DNA, further stabilizing the complex.
-
-	Interactions between morpholinyl anthracyclines and DNA. The crystal structure of a morpholino doxorubicin bound to d(CGTACG).,Cirilli M, Bachechi F, Ughetto G, Colonna FP, Capobianco ML J Mol Biol. 1993 Apr 5;230(3):878-89. PMID:8478940<ref>PMID:8478940</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2des" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 18:42, 20 September 2023

OCA — Wed, 20 Sep 2023 18:42:45 GMT

←Older revision		Revision as of 18:42, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2des]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DES OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DES FirstGlance]. <br>		<table><tr><td colspan='2'>[[2des]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DES OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DES FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMM:3-DESAMINO-3-(2-METHOXY-4-MORPHOLINYL)-DOXORUBICIN'>DMM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMM:3-DESAMINO-3-(2-METHOXY-4-MORPHOLINYL)-DOXORUBICIN'>DMM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2des FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2des OCA], [https://pdbe.org/2des PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2des RCSB], [https://www.ebi.ac.uk/pdbsum/2des PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2des ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2des FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2des OCA], [https://pdbe.org/2des PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2des RCSB], [https://www.ebi.ac.uk/pdbsum/2des PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2des ProSAT]</span></td></tr>
	</table>		</table>
Line 21:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bachechi, F]]	+	[[Category: Bachechi F]]
-	[[Category: Capobianco~~, M L~~]]	+	[[Category: Capobianco ML]]
-	[[Category: Cirilli, M]]	+	[[Category: Cirilli M]]
-	[[Category: Colonna~~, F P~~]]	+	[[Category: Colonna FP]]
-	[[Category: Ughetto, G]]	+	[[Category: Ughetto G]]
-	~~[[Category: Complexed with drug]]~~	+
-	~~[[Category: Dna]]~~	+
-	~~[[Category: Double helix]]~~	+
-	~~[[Category: Right handed dna~~]]	+

OCA at 10:30, 8 December 2021

OCA — Wed, 08 Dec 2021 10:30:43 GMT

←Older revision		Revision as of 10:30, 8 December 2021
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	<StructureSection load='2des' size='340' side='right'caption='[[2des]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='2des' size='340' side='right'caption='[[2des]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2des]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DES OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2DES FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2des]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DES OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DES FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMM:3-DESAMINO-3-(2-METHOXY-4-MORPHOLINYL)-DOXORUBICIN'>DMM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMM:3-DESAMINO-3-(2-METHOXY-4-MORPHOLINYL)-DOXORUBICIN'>DMM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2des FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2des OCA], [~~http~~://pdbe.org/2des PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2des RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2des PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2des ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2des FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2des OCA], [https://pdbe.org/2des PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2des RCSB], [https://www.ebi.ac.uk/pdbsum/2des PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2des ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:53, 4 March 2020

OCA — Wed, 04 Mar 2020 07:53:57 GMT

←Older revision		Revision as of 07:53, 4 March 2020
Line 1:		Line 1:

	==INTERACTIONS BETWEEN MORPHOLINYL ANTHRACYCLINES AND DNA: THE CRYSTAL STRUCTURE OF A MORPHOLINO DOXORUBICIN BOUND TO D(CGTACG)==		==INTERACTIONS BETWEEN MORPHOLINYL ANTHRACYCLINES AND DNA: THE CRYSTAL STRUCTURE OF A MORPHOLINO DOXORUBICIN BOUND TO D(CGTACG)==
-	<StructureSection load='2des' size='340' side='right' caption='[[2des]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='2des' size='340' side='right'caption='[[2des]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2des]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DES OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DES FirstGlance]. <br>		<table><tr><td colspan='2'>[[2des]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DES OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DES FirstGlance]. <br>
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Bachechi, F]]		[[Category: Bachechi, F]]
	[[Category: Capobianco, M L]]		[[Category: Capobianco, M L]]

OCA at 06:45, 30 May 2018

OCA — Wed, 30 May 2018 06:45:41 GMT

←Older revision		Revision as of 06:45, 30 May 2018
Line 1:		Line 1:
		+
	==INTERACTIONS BETWEEN MORPHOLINYL ANTHRACYCLINES AND DNA: THE CRYSTAL STRUCTURE OF A MORPHOLINO DOXORUBICIN BOUND TO D(CGTACG)==		==INTERACTIONS BETWEEN MORPHOLINYL ANTHRACYCLINES AND DNA: THE CRYSTAL STRUCTURE OF A MORPHOLINO DOXORUBICIN BOUND TO D(CGTACG)==
	<StructureSection load='2des' size='340' side='right' caption='[[2des]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='2des' size='340' side='right' caption='[[2des]], [[Resolution\|resolution]] 1.50Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2des]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DES OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DES FirstGlance]. <br>		<table><tr><td colspan='2'>[[2des]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DES OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DES FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMM:3-DESAMINO-3-(2-METHOXY-4-MORPHOLINYL)-DOXORUBICIN'>DMM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMM:3-DESAMINO-3-(2-METHOXY-4-MORPHOLINYL)-DOXORUBICIN'>DMM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2des FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2des OCA], [http://pdbe.org/2des PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2des RCSB], [http://www.ebi.ac.uk/pdbsum/2des PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2des FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2des OCA], [http://pdbe.org/2des PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2des RCSB], [http://www.ebi.ac.uk/pdbsum/2des PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2des ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 11:39, 11 September 2015

OCA — Fri, 11 Sep 2015 11:39:02 GMT

←Older revision		Revision as of 11:39, 11 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2des]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DES OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DES FirstGlance]. <br>		<table><tr><td colspan='2'>[[2des]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DES OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DES FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMM:3-DESAMINO-3-(2-METHOXY-4-MORPHOLINYL)-DOXORUBICIN'>DMM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMM:3-DESAMINO-3-(2-METHOXY-4-MORPHOLINYL)-DOXORUBICIN'>DMM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2des FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2des OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2des RCSB], [http://www.ebi.ac.uk/pdbsum/2des PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2des FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2des OCA], [http://pdbe.org/2des PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2des RCSB], [http://www.ebi.ac.uk/pdbsum/2des PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2des" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:25, 15 January 2015

OCA — Thu, 15 Jan 2015 18:25:10 GMT

←Older revision		Revision as of 18:25, 15 January 2015
Line 18:		Line 18:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bachechi, F.]]	+	[[Category: Bachechi, F]]
-	[[Category: Capobianco, M L.]]	+	[[Category: Capobianco, M L]]
-	[[Category: Cirilli, M.]]	+	[[Category: Cirilli, M]]
-	[[Category: Colonna, F P.]]	+	[[Category: Colonna, F P]]
-	[[Category: Ughetto, G.]]	+	[[Category: Ughetto, G]]
	[[Category: Complexed with drug]]		[[Category: Complexed with drug]]
	[[Category: Dna]]		[[Category: Dna]]
	[[Category: Double helix]]		[[Category: Double helix]]
	[[Category: Right handed dna]]		[[Category: Right handed dna]]

OCA at 15:34, 12 October 2014

OCA — Sun, 12 Oct 2014 15:34:24 GMT

←Older revision		Revision as of 15:34, 12 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2des.~~png~~\|~~left\|200px~~]]	+	==INTERACTIONS BETWEEN MORPHOLINYL ANTHRACYCLINES AND DNA: THE CRYSTAL STRUCTURE OF A MORPHOLINO DOXORUBICIN BOUND TO D(CGTACG)==
		+	<StructureSection load='2des' size='340' side='right' caption='[[2des]], [[Resolution\|resolution]] 1.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2des]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DES OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DES FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMM:3-DESAMINO-3-(2-METHOXY-4-MORPHOLINYL)-DOXORUBICIN'>DMM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2des FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2des OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2des RCSB], [http://www.ebi.ac.uk/pdbsum/2des PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Anthracycline antibiotics daunomycin and adriamycin are among the most widely used in cancer chemotherapy and DNA is believed to be the primary target of their biological action. The crystal structure of a morpholino derivative of adriamycin bound to the DNA hexamer d(CGTACG) has been determined at 1.5 A resolution. The complex crystallizes in space group P1 with unit cell dimensions a = 18.01 A, b = 18.83 A, c = 27.65 A, alpha = 92.6 degrees, beta = 100.5 degrees, gamma = 94.9 degrees and there are two drug molecules bound per duplex. Morpholino derivatives differ greatly from their parent compounds in their biological and pharmacological properties. Structural comparison of this complex with the series of previously reported anthracycline-DNA complexes offers an opportunity for studying relationships between structure and function. The anthracycline chromophore intercalates at the CpG step and DNA distortions from a B-type conformation are similar to those observed in the other DNA-anthracycline complexes. Interactions between drug and DNA show no differences at the intercalation site, while in the minor groove they are significantly affected by the presence of the bulky morpholinyl moiety on the anthracycline amino sugar. The binding site involves four base-pairs and the absence of a positive charge on the amino sugar appears to influence the hydration pattern on both grooves. The two halves of the duplex are symmetrically related by a non-crystallographic 2-fold axis but they are not equivalent. In one half, one magnesium cluster bridges both drug and DNA, further stabilizing the complex.

-	~~{{STRUCTURE_2des\| PDB=2des \| SCENE= }}~~	+	Interactions between morpholinyl anthracyclines and DNA. The crystal structure of a morpholino doxorubicin bound to d(CGTACG).,Cirilli M, Bachechi F, Ughetto G, Colonna FP, Capobianco ML J Mol Biol. 1993 Apr 5;230(3):878-89. PMID:8478940<ref>PMID:8478940</ref>

-	~~===INTERACTIONS BETWEEN MORPHOLINYL ANTHRACYCLINES AND DNA: THE CRYSTAL STRUCTURE OF A MORPHOLINO DOXORUBICIN BOUND TO D(CGTACG)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_8478940}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[2des]] is a 2 chain structure. Full crystallographic information is available from [http:~~//~~oca.weizmann.ac.il/oca-bin/ocashort?id=2DES OCA].~~	+	</StructureSection>
	[[Category: Bachechi, F.]]		[[Category: Bachechi, F.]]
	[[Category: Capobianco, M L.]]		[[Category: Capobianco, M L.]]

OCA: Protected "2des" [edit=sysop:move=sysop]

OCA — Sun, 06 Jan 2013 10:32:49 GMT

Protected "2des" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:32, 6 January 2013

OCA at 10:32, 6 January 2013

OCA — Sun, 06 Jan 2013 10:32:44 GMT

←Older revision		Revision as of 10:32, 6 January 2013
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-	{{Seed}}
	[[Image:2des.png\|left\|200px]]		[[Image:2des.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_2des\| PDB=2des \| SCENE= }}		{{STRUCTURE_2des\| PDB=2des \| SCENE= }}

	===INTERACTIONS BETWEEN MORPHOLINYL ANTHRACYCLINES AND DNA: THE CRYSTAL STRUCTURE OF A MORPHOLINO DOXORUBICIN BOUND TO D(CGTACG)===		===INTERACTIONS BETWEEN MORPHOLINYL ANTHRACYCLINES AND DNA: THE CRYSTAL STRUCTURE OF A MORPHOLINO DOXORUBICIN BOUND TO D(CGTACG)===

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	{{ABSTRACT_PUBMED_8478940}}		{{ABSTRACT_PUBMED_8478940}}

	==About this Structure==		==About this Structure==
-	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DES OCA].	+	[[2des]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DES OCA].
-		+
-	~~==Reference==~~	+
-	Interactions between morpholinyl anthracyclines and DNA. The crystal structure of a morpholino doxorubicin bound to d(CGTACG)., Cirilli M, Bachechi F, Ughetto G, Colonna FP, Capobianco ML, J Mol Biol. 1993 Apr 5;230(3):878-89. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8478940 8478940]	+
	[[Category: Bachechi, F.]]		[[Category: Bachechi, F.]]
	[[Category: Capobianco, M L.]]		[[Category: Capobianco, M L.]]
Line 30:		Line 15:
	[[Category: Ughetto, G.]]		[[Category: Ughetto, G.]]
	[[Category: Complexed with drug]]		[[Category: Complexed with drug]]
		+	[[Category: Dna]]
	[[Category: Double helix]]		[[Category: Double helix]]
	[[Category: Right handed dna]]		[[Category: Right handed dna]]
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-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:07:30 2008''