2di4 - Revision history

OCA at 11:39, 22 May 2024

OCA — Wed, 22 May 2024 11:39:01 GMT

←Older revision		Revision as of 11:39, 22 May 2024
Line 3:		Line 3:
	<StructureSection load='2di4' size='340' side='right'caption='[[2di4]], [[Resolution\|resolution]] 2.79Å' scene=''>		<StructureSection load='2di4' size='340' side='right'caption='[[2di4]], [[Resolution\|resolution]] 2.79Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2di4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"aquifex_aeolicus"_huber_and_stetter_2001 "aquifex~~ aeolicus~~" huber and stetter 2001~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DI4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DI4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2di4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DI4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DI4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.79Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2di4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2di4 OCA], [https://pdbe.org/2di4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2di4 RCSB], [https://www.ebi.ac.uk/pdbsum/2di4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2di4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2di4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2di4 OCA], [https://pdbe.org/2di4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2di4 RCSB], [https://www.ebi.ac.uk/pdbsum/2di4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2di4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FTSH_AQUAE FTSH_AQUAE]] Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity).[HAMAP-Rule:MF_01458]	+	[https://www.uniprot.org/uniprot/FTSH_AQUAE FTSH_AQUAE] Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity).[HAMAP-Rule:MF_01458]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Aquifex aeolicus ~~huber and stetter 2001~~]]	+	[[Category: Aquifex aeolicus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Morikawa, K]]	+	[[Category: Morikawa K]]
-	[[Category: Niwa, H]]	+	[[Category: Niwa H]]
-	[[Category: Suno, R]]	+	[[Category: Suno R]]
-	[[Category: Tsuchiya, D]]	+	[[Category: Tsuchiya D]]
-	[[Category: Yoshida, M]]	+	[[Category: Yoshida M]]
-	[[Category: Zhang, X]]	+	[[Category: Zhang X]]
-	~~[[Category: Hexamer-ring]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Metalloproteinase~~]]	+

OCA at 10:31, 8 December 2021

OCA — Wed, 08 Dec 2021 10:31:49 GMT

←Older revision		Revision as of 10:31, 8 December 2021
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	<StructureSection load='2di4' size='340' side='right'caption='[[2di4]], [[Resolution\|resolution]] 2.79Å' scene=''>		<StructureSection load='2di4' size='340' side='right'caption='[[2di4]], [[Resolution\|resolution]] 2.79Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2di4]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"aquifex_aeolicus"_huber_and_stetter_2001 "aquifex aeolicus" huber and stetter 2001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DI4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2DI4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2di4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"aquifex_aeolicus"_huber_and_stetter_2001 "aquifex aeolicus" huber and stetter 2001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DI4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DI4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2di4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2di4 OCA], [~~http~~://pdbe.org/2di4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2di4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2di4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2di4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2di4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2di4 OCA], [https://pdbe.org/2di4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2di4 RCSB], [https://www.ebi.ac.uk/pdbsum/2di4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2di4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FTSH_AQUAE FTSH_AQUAE]] Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity).[HAMAP-Rule:MF_01458]	+	[[https://www.uniprot.org/uniprot/FTSH_AQUAE FTSH_AQUAE]] Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity).[HAMAP-Rule:MF_01458]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:30, 4 March 2020

OCA — Wed, 04 Mar 2020 07:30:55 GMT

←Older revision		Revision as of 07:30, 4 March 2020
Line 1:		Line 1:

	==Crystal structure of the FtsH protease domain==		==Crystal structure of the FtsH protease domain==
-	<StructureSection load='2di4' size='340' side='right' caption='[[2di4]], [[Resolution\|resolution]] 2.79Å' scene=''>	+	<StructureSection load='2di4' size='340' side='right'caption='[[2di4]], [[Resolution\|resolution]] 2.79Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2di4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"aquifex_aeolicus"_huber_and_stetter_2001 "aquifex aeolicus" huber and stetter 2001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DI4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DI4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2di4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"aquifex_aeolicus"_huber_and_stetter_2001 "aquifex aeolicus" huber and stetter 2001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DI4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DI4 FirstGlance]. <br>
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Aquifex aeolicus huber and stetter 2001]]		[[Category: Aquifex aeolicus huber and stetter 2001]]
		+	[[Category: Large Structures]]
	[[Category: Morikawa, K]]		[[Category: Morikawa, K]]
	[[Category: Niwa, H]]		[[Category: Niwa, H]]

OCA at 06:07, 30 May 2018

OCA — Wed, 30 May 2018 06:07:31 GMT

←Older revision		Revision as of 06:07, 30 May 2018
Line 1:		Line 1:
		+
	==Crystal structure of the FtsH protease domain==		==Crystal structure of the FtsH protease domain==
	<StructureSection load='2di4' size='340' side='right' caption='[[2di4]], [[Resolution\|resolution]] 2.79Å' scene=''>		<StructureSection load='2di4' size='340' side='right' caption='[[2di4]], [[Resolution\|resolution]] 2.79Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2di4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"aquifex_aeolicus"_huber_and_stetter_2001 "aquifex aeolicus" huber and stetter 2001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DI4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DI4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2di4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"aquifex_aeolicus"_huber_and_stetter_2001 "aquifex aeolicus" huber and stetter 2001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DI4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DI4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2di4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2di4 OCA], [http://pdbe.org/2di4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2di4 RCSB], [http://www.ebi.ac.uk/pdbsum/2di4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2di4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2di4 OCA], [http://pdbe.org/2di4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2di4 RCSB], [http://www.ebi.ac.uk/pdbsum/2di4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2di4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/di/2di4_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/di/2di4_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 21:58, 7 February 2016

OCA — Sun, 07 Feb 2016 21:58:15 GMT

←Older revision		Revision as of 21:58, 7 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2di4 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 05:18, 10 September 2015

OCA — Thu, 10 Sep 2015 05:18:45 GMT

←Older revision		Revision as of 05:18, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2di4' size='340' side='right' caption='[[2di4]], [[Resolution\|resolution]] 2.79Å' scene=''>		<StructureSection load='2di4' size='340' side='right' caption='[[2di4]], [[Resolution\|resolution]] 2.79Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2di4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Aquifex_aeolicus Aquifex~~ aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DI4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DI4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2di4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"aquifex_aeolicus"_huber_and_stetter_2001 "aquifex aeolicus" huber and stetter 2001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DI4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DI4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2di4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2di4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2di4 RCSB], [http://www.ebi.ac.uk/pdbsum/2di4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2di4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2di4 OCA], [http://pdbe.org/2di4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2di4 RCSB], [http://www.ebi.ac.uk/pdbsum/2di4 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2di4" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Aquifex aeolicus]]	+	[[Category: Aquifex aeolicus huber and stetter 2001]]
	[[Category: Morikawa, K]]		[[Category: Morikawa, K]]
	[[Category: Niwa, H]]		[[Category: Niwa, H]]

OCA at 18:30, 24 December 2014

OCA — Wed, 24 Dec 2014 18:30:01 GMT

←Older revision		Revision as of 18:30, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2di4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DI4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DI4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2di4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DI4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DI4 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2di4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2di4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2di4 RCSB], [http://www.ebi.ac.uk/pdbsum/2di4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2di4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2di4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2di4 RCSB], [http://www.ebi.ac.uk/pdbsum/2di4 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FTSH_AQUAE FTSH_AQUAE]] Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity).[HAMAP-Rule:MF_01458]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Aquifex aeolicus]]		[[Category: Aquifex aeolicus]]
-	[[Category: Morikawa, K.]]	+	[[Category: Morikawa, K]]
-	[[Category: Niwa, H.]]	+	[[Category: Niwa, H]]
-	[[Category: Suno, R.]]	+	[[Category: Suno, R]]
-	[[Category: Tsuchiya, D.]]	+	[[Category: Tsuchiya, D]]
-	[[Category: Yoshida, M.]]	+	[[Category: Yoshida, M]]
-	[[Category: Zhang, X.]]	+	[[Category: Zhang, X]]
	[[Category: Hexamer-ring]]		[[Category: Hexamer-ring]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Metalloproteinase]]		[[Category: Metalloproteinase]]

OCA at 01:30, 30 September 2014

OCA — Tue, 30 Sep 2014 01:30:22 GMT

←Older revision		Revision as of 01:30, 30 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2di4.~~png\|left~~\|200px]]	+	==Crystal structure of the FtsH protease domain==
		+	<StructureSection load='2di4' size='340' side='right' caption='[[2di4]], [[Resolution\|resolution]] 2.79Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2di4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DI4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DI4 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2di4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2di4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2di4 RCSB], [http://www.ebi.ac.uk/pdbsum/2di4 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/di/2di4_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	An ATP-dependent protease, FtsH, digests misassembled membrane proteins in order to maintain membrane integrity and digests short-lived soluble proteins in order to control their cellular regulation. This enzyme has an N-terminal transmembrane segment and a C-terminal cytosolic region consisting of an AAA+ ATPase domain and a protease domain. Here we present two crystal structures: the protease domain and the whole cytosolic region. The cytosolic region fully retains an ATP-dependent protease activity and adopts a three-fold-symmetric hexameric structure. The protease domains displayed a six-fold symmetry, while the AAA+ domains, each containing ADP, alternate two orientations relative to the protease domain, making "open" and "closed" interdomain contacts. Apparently, ATPase is active only in the closed form, and protease operates in the open form. The protease catalytic sites are accessible only through a tunnel following from the AAA+ domain of the adjacent subunit, raising a possibility of translocation of polypeptide substrate to the protease sites through this tunnel.

-	~~{{STRUCTURE_2di4\| PDB=2di4 \| SCENE= }}~~	+	Structure of the whole cytosolic region of ATP-dependent protease FtsH.,Suno R, Niwa H, Tsuchiya D, Zhang X, Yoshida M, Morikawa K Mol Cell. 2006 Jun 9;22(5):575-85. PMID:16762831<ref>PMID:16762831</ref>

-	~~===Crystal structure~~ of the ~~FtsH protease domain===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16762831}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2di4]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Aquifex_aeolicus Aquifex aeolicus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2DI4 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016762831<~~/~~ref~~><~~ref group="xtra">PMID:012377127</ref><references group="xtra"~~/>	+
	[[Category: Aquifex aeolicus]]		[[Category: Aquifex aeolicus]]
	[[Category: Morikawa, K.]]		[[Category: Morikawa, K.]]

OCA at 12:11, 23 January 2013

OCA — Wed, 23 Jan 2013 12:11:18 GMT

←Older revision		Revision as of 12:11, 23 January 2013
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	[[Image:2di4.png\|left\|200px]]		[[Image:2di4.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2di4", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2di4\| PDB=2di4 \| SCENE= }}		{{STRUCTURE_2di4\| PDB=2di4 \| SCENE= }}

	===Crystal structure of the FtsH protease domain===		===Crystal structure of the FtsH protease domain===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16762831}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16762831 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_16762831}}		{{ABSTRACT_PUBMED_16762831}}

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	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16762831~~</ref><ref group="xtra">PMID:~~12377127~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016762831</ref><ref group="xtra">PMID:012377127</ref><references group="xtra"/>
	[[Category: Aquifex aeolicus]]		[[Category: Aquifex aeolicus]]
	[[Category: Morikawa, K.]]		[[Category: Morikawa, K.]]

OCA: Protected "2di4" [edit=sysop:move=sysop]

OCA — Mon, 14 Mar 2011 21:19:28 GMT

Protected "2di4" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:19, 14 March 2011