2doa - Revision history

OCA at 18:45, 29 May 2024

OCA — Wed, 29 May 2024 18:45:40 GMT

←Older revision		Revision as of 18:45, 29 May 2024
Line 1:		Line 1:

	==Solution structure of the helical domain in human Eleven-nineteen lysine-rich leukemia protein ELL==		==Solution structure of the helical domain in human Eleven-nineteen lysine-rich leukemia protein ELL==
-	<StructureSection load='2doa' size='340' side='right'caption='[[2doa~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2doa' size='340' side='right'caption='[[2doa]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2doa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DOA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2doa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DOA FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>ELL, C19orf17 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2doa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2doa OCA], [https://pdbe.org/2doa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2doa RCSB], [https://www.ebi.ac.uk/pdbsum/2doa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2doa ProSAT], [https://www.topsan.org/Proteins/RSGI/2doa TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2doa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2doa OCA], [https://pdbe.org/2doa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2doa RCSB], [https://www.ebi.ac.uk/pdbsum/2doa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2doa ProSAT], [https://www.topsan.org/Proteins/RSGI/2doa TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/ELL_HUMAN ELL_HUMAN]] Note=A chromosomal aberration involving ELL is found in acute leukemias. Translocation t(11;19)(q23;p13.1) with MLL/HRX. The result is a rogue activator protein.	+	[https://www.uniprot.org/uniprot/ELL_HUMAN ELL_HUMAN] Note=A chromosomal aberration involving ELL is found in acute leukemias. Translocation t(11;19)(q23;p13.1) with MLL/HRX. The result is a rogue activator protein.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ELL_HUMAN ELL_HUMAN]] Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation.<ref>PMID:8596958</ref> <ref>PMID:16006523</ref> <ref>PMID:20471948</ref> <ref>PMID:20159561</ref> <ref>PMID:22252557</ref>	+	[https://www.uniprot.org/uniprot/ELL_HUMAN ELL_HUMAN] Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation.<ref>PMID:8596958</ref> <ref>PMID:16006523</ref> <ref>PMID:20471948</ref> <ref>PMID:20159561</ref> <ref>PMID:22252557</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Inoue, M]]	+	[[Category: Inoue M]]
-	[[Category: Kigawa, T]]	+	[[Category: Kigawa T]]
-	[[Category: Koshiba, S]]	+	[[Category: Koshiba S]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Saito K]]
-	[[Category: Saito, K]]	+	[[Category: Yokoyama S]]
-	[[Category: Yokoyama, S]]	+
-	~~[[Category: C19orf17]]~~	+
-	~~[[Category: Elongation factor]]~~	+
-	~~[[Category: National project on protein structural and functional analyse]]~~	+
-	~~[[Category: Nppsfa]]~~	+
-	~~[[Category: Rsgi]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 11:33, 10 February 2021

OCA — Wed, 10 Feb 2021 11:33:08 GMT

←Older revision		Revision as of 11:33, 10 February 2021
Line 1:		Line 1:

	==Solution structure of the helical domain in human Eleven-nineteen lysine-rich leukemia protein ELL==		==Solution structure of the helical domain in human Eleven-nineteen lysine-rich leukemia protein ELL==
-	<StructureSection load='2doa' size='340' side='right' caption='[[2doa]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2doa' size='340' side='right'caption='[[2doa]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2doa]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2DOA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2doa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DOA FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ELL, C19orf17 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ELL, C19orf17 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2doa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2doa OCA], [~~http~~://pdbe.org/2doa PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2doa RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2doa PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2doa ProSAT], [~~http~~://www.topsan.org/Proteins/RSGI/2doa TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2doa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2doa OCA], [https://pdbe.org/2doa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2doa RCSB], [https://www.ebi.ac.uk/pdbsum/2doa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2doa ProSAT], [https://www.topsan.org/Proteins/RSGI/2doa TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/ELL_HUMAN ELL_HUMAN]] Note=A chromosomal aberration involving ELL is found in acute leukemias. Translocation t(11;19)(q23;p13.1) with MLL/HRX. The result is a rogue activator protein.	+	[[https://www.uniprot.org/uniprot/ELL_HUMAN ELL_HUMAN]] Note=A chromosomal aberration involving ELL is found in acute leukemias. Translocation t(11;19)(q23;p13.1) with MLL/HRX. The result is a rogue activator protein.
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ELL_HUMAN ELL_HUMAN]] Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation.<ref>PMID:8596958</ref> <ref>PMID:16006523</ref> <ref>PMID:20471948</ref> <ref>PMID:20159561</ref> <ref>PMID:22252557</ref>	+	[[https://www.uniprot.org/uniprot/ELL_HUMAN ELL_HUMAN]] Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation.<ref>PMID:8596958</ref> <ref>PMID:16006523</ref> <ref>PMID:20471948</ref> <ref>PMID:20159561</ref> <ref>PMID:22252557</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Inoue, M]]		[[Category: Inoue, M]]
	[[Category: Kigawa, T]]		[[Category: Kigawa, T]]

OCA at 06:49, 30 May 2018

OCA — Wed, 30 May 2018 06:49:57 GMT

←Older revision		Revision as of 06:49, 30 May 2018
Line 1:		Line 1:
		+
	==Solution structure of the helical domain in human Eleven-nineteen lysine-rich leukemia protein ELL==		==Solution structure of the helical domain in human Eleven-nineteen lysine-rich leukemia protein ELL==
	<StructureSection load='2doa' size='340' side='right' caption='[[2doa]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2doa' size='340' side='right' caption='[[2doa]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2doa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DOA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2doa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DOA FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ELL, C19orf17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ELL, C19orf17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2doa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2doa OCA], [http://pdbe.org/2doa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2doa RCSB], [http://www.ebi.ac.uk/pdbsum/2doa PDBsum], [http://www.topsan.org/Proteins/RSGI/2doa TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2doa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2doa OCA], [http://pdbe.org/2doa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2doa RCSB], [http://www.ebi.ac.uk/pdbsum/2doa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2doa ProSAT], [http://www.topsan.org/Proteins/RSGI/2doa TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/do/2doa_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/do/2doa_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2doa ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	== References ==		== References ==

OCA at 22:37, 11 September 2015

OCA — Fri, 11 Sep 2015 22:37:09 GMT

←Older revision		Revision as of 22:37, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2doa' size='340' side='right' caption='[[2doa]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2doa' size='340' side='right' caption='[[2doa]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2doa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DOA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2doa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DOA FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ELL, C19orf17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ELL, C19orf17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2doa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2doa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2doa RCSB], [http://www.ebi.ac.uk/pdbsum/2doa PDBsum], [http://www.topsan.org/Proteins/RSGI/2doa TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2doa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2doa OCA], [http://pdbe.org/2doa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2doa RCSB], [http://www.ebi.ac.uk/pdbsum/2doa PDBsum], [http://www.topsan.org/Proteins/RSGI/2doa TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 24:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Inoue, M]]		[[Category: Inoue, M]]
	[[Category: Kigawa, T]]		[[Category: Kigawa, T]]

OCA at 17:10, 15 January 2015

OCA — Thu, 15 Jan 2015 17:10:24 GMT

←Older revision		Revision as of 17:10, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2doa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DOA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2doa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DOA FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ELL, C19orf17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ELL, C19orf17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2doa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2doa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2doa RCSB], [http://www.ebi.ac.uk/pdbsum/2doa PDBsum], [http://www.topsan.org/Proteins/RSGI/2doa TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2doa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2doa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2doa RCSB], [http://www.ebi.ac.uk/pdbsum/2doa PDBsum], [http://www.topsan.org/Proteins/RSGI/2doa TOPSAN]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/ELL_HUMAN ELL_HUMAN]] Note=A chromosomal aberration involving ELL is found in acute leukemias. Translocation t(11;19)(q23;p13.1) with MLL/HRX. The result is a rogue activator protein.		[[http://www.uniprot.org/uniprot/ELL_HUMAN ELL_HUMAN]] Note=A chromosomal aberration involving ELL is found in acute leukemias. Translocation t(11;19)(q23;p13.1) with MLL/HRX. The result is a rogue activator protein.
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Inoue, M.]]	+	[[Category: Inoue, M]]
-	[[Category: Kigawa, T.]]	+	[[Category: Kigawa, T]]
-	[[Category: Koshiba, S.]]	+	[[Category: Koshiba, S]]
-	[[Category: ~~RSGI, RIKEN~~ Structural ~~Genomics/Proteomics Initiative.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Saito, K.]]	+	[[Category: Saito, K]]
-	[[Category: Yokoyama, S.]]	+	[[Category: Yokoyama, S]]
	[[Category: C19orf17]]		[[Category: C19orf17]]
	[[Category: Elongation factor]]		[[Category: Elongation factor]]
	[[Category: National project on protein structural and functional analyse]]		[[Category: National project on protein structural and functional analyse]]
	[[Category: Nppsfa]]		[[Category: Nppsfa]]
-	[[Category: Riken structural genomics/proteomics initiative]]
	[[Category: Rsgi]]		[[Category: Rsgi]]
-	[[Category: Structural genomic]]
	[[Category: Transcription]]		[[Category: Transcription]]

OCA at 02:11, 30 September 2014

OCA — Tue, 30 Sep 2014 02:11:03 GMT

←Older revision		Revision as of 02:11, 30 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2doa\| PDB=2doa \| SCENE= }}~~	+	==Solution structure of the helical domain in human Eleven-nineteen lysine-rich leukemia protein ELL==
-	===Solution structure of the helical domain in human Eleven-nineteen lysine-rich leukemia protein ELL===	+	<StructureSection load='2doa' size='340' side='right' caption='[[2doa]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-		+	== Structural highlights ==
-	==Disease==	+	<table><tr><td colspan='2'>[[2doa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DOA FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ELL, C19orf17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2doa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2doa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2doa RCSB], [http://www.ebi.ac.uk/pdbsum/2doa PDBsum], [http://www.topsan.org/Proteins/RSGI/2doa TOPSAN]</span></td></tr>
		+	<table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/ELL_HUMAN ELL_HUMAN]] Note=A chromosomal aberration involving ELL is found in acute leukemias. Translocation t(11;19)(q23;p13.1) with MLL/HRX. The result is a rogue activator protein.		[[http://www.uniprot.org/uniprot/ELL_HUMAN ELL_HUMAN]] Note=A chromosomal aberration involving ELL is found in acute leukemias. Translocation t(11;19)(q23;p13.1) with MLL/HRX. The result is a rogue activator protein.
-		+	== Function ==
-	==Function==	+	[[http://www.uniprot.org/uniprot/ELL_HUMAN ELL_HUMAN]] Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation.<ref>PMID:8596958</ref> <ref>PMID:16006523</ref> <ref>PMID:20471948</ref> <ref>PMID:20159561</ref> <ref>PMID:22252557</ref>
-	[[http://www.uniprot.org/uniprot/ELL_HUMAN ELL_HUMAN]] Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation.<ref>PMID:8596958</ref><ref>PMID:16006523</ref><ref>PMID:20471948</ref><ref>PMID:20159561</ref><ref>PMID:22252557</ref>	+	== Evolutionary Conservation ==
-		+	[[Image:Consurf_key_small.gif\|200px\|right]]
-	==~~About this Structure~~==	+	Check<jmol>
-	[[~~2doa~~]] ~~is a 1 chain~~ structure ~~with sequence from~~ [http://en.~~wikipedia~~.~~org~~/~~wiki/Homo_sapiens Homo sapiens~~]. ~~Full experimental information is~~ available from [http://~~oca~~.~~weizmann~~.ac.il/~~oca-bin~~/~~ocashort~~?id=~~2DOA OCA~~].	+	<jmolCheckbox>
-		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/do/2doa_consurf.spt"</scriptWhenChecked>
-	==~~Reference~~==	+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-	<references ~~group="xtra"~~/><~~references~~/>	+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Inoue, M.]]		[[Category: Inoue, M.]]

OCA at 01:50, 25 March 2013

OCA — Mon, 25 Mar 2013 01:50:25 GMT

←Older revision		Revision as of 01:50, 25 March 2013
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-	[[Image:2doa.png\|left\|200px]]
-
	{{STRUCTURE_2doa\| PDB=2doa \| SCENE= }}		{{STRUCTURE_2doa\| PDB=2doa \| SCENE= }}
-
	===Solution structure of the helical domain in human Eleven-nineteen lysine-rich leukemia protein ELL===		===Solution structure of the helical domain in human Eleven-nineteen lysine-rich leukemia protein ELL===

		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/ELL_HUMAN ELL_HUMAN]] Note=A chromosomal aberration involving ELL is found in acute leukemias. Translocation t(11;19)(q23;p13.1) with MLL/HRX. The result is a rogue activator protein.
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/ELL_HUMAN ELL_HUMAN]] Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation.<ref>PMID:8596958</ref><ref>PMID:16006523</ref><ref>PMID:20471948</ref><ref>PMID:20159561</ref><ref>PMID:22252557</ref>

	==About this Structure==		==About this Structure==
	[[2doa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOA OCA].		[[2doa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOA OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Inoue, M.]]		[[Category: Inoue, M.]]

OCA: Protected "2doa" [edit=sysop:move=sysop]

OCA — Sun, 06 Jan 2013 11:23:51 GMT

Protected "2doa" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:23, 6 January 2013

OCA at 11:23, 6 January 2013

OCA — Sun, 06 Jan 2013 11:23:48 GMT

←Older revision		Revision as of 11:23, 6 January 2013
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-	{{Seed}}
	[[Image:2doa.png\|left\|200px]]		[[Image:2doa.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_2doa\| PDB=2doa \| SCENE= }}		{{STRUCTURE_2doa\| PDB=2doa \| SCENE= }}

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	==About this Structure==		==About this Structure==
-	~~2DOA~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOA OCA].	+	[[2doa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOA OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Inoue, M.]]		[[Category: Inoue, M.]]
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	[[Category: Rsgi]]		[[Category: Rsgi]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
-		+	[[Category: Transcription]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Sun Nov 16 13:03:11 2008''~~	+

OCA at 11:03, 16 November 2008

OCA — Sun, 16 Nov 2008 11:03:14 GMT

←Older revision		Revision as of 11:03, 16 November 2008
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	==About this Structure==		==About this Structure==
-	2DOA is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOA OCA].	+	2DOA is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOA OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Inoue, M.]]		[[Category: Inoue, M.]]
	[[Category: Kigawa, T.]]		[[Category: Kigawa, T.]]
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	[[Category: Structural genomic]]		[[Category: Structural genomic]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun ~~Sep 28 19~~:48:11 2008''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 13:03:11 2008''