2dsp - Revision history

OCA at 08:29, 25 October 2023

OCA — Wed, 25 Oct 2023 08:29:30 GMT

←Older revision		Revision as of 08:29, 25 October 2023
Line 3:		Line 3:
	<StructureSection load='2dsp' size='340' side='right'caption='[[2dsp]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2dsp' size='340' side='right'caption='[[2dsp]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2dsp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DSP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DSP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2dsp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DSP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DSP FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1wqj\|1wqj]]~~, [[~~2dsq~~\|~~2dsq~~]]~~, [[2dsr\|2dsr]]</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dsp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dsp OCA], [https://pdbe.org/2dsp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dsp RCSB], [https://www.ebi.ac.uk/pdbsum/2dsp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dsp ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dsp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dsp OCA], [https://pdbe.org/2dsp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dsp RCSB], [https://www.ebi.ac.uk/pdbsum/2dsp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dsp ProSAT]</span></td></tr>
	</table>		</table>
-	== Disease ==
-	[[https://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN]] Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:[https://omim.org/entry/608747 608747]]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/IBP4_HUMAN IBP4_HUMAN]] IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. [[https://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN]] The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.<ref>PMID:21076856</ref>	+	[https://www.uniprot.org/uniprot/IBP4_HUMAN IBP4_HUMAN] IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 39:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Holak~~, T A~~]]	+	[[Category: Holak TA]]
-	[[Category: Huber, R]]	+	[[Category: Huber R]]
-	[[Category: Popowicz~~, G M~~]]	+	[[Category: Popowicz GM]]
-	[[Category: Sitar, T]]	+	[[Category: Sitar T]]
-	[[Category: Siwanowicz, I]]	+	[[Category: Siwanowicz I]]
-	~~[[Category: Igf]]~~	+
-	~~[[Category: Igfbp]]~~	+
-	~~[[Category: Insulin]]~~	+
-	~~[[Category: Protein binding-hormone-growth factor complex~~]]	+

OCA at 10:35, 8 December 2021

OCA — Wed, 08 Dec 2021 10:35:30 GMT

←Older revision		Revision as of 10:35, 8 December 2021
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	<StructureSection load='2dsp' size='340' side='right'caption='[[2dsp]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2dsp' size='340' side='right'caption='[[2dsp]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2dsp]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DSP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2DSP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2dsp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DSP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DSP FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wqj\|1wqj]], [[2dsq\|2dsq]], [[2dsr\|2dsr]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1wqj\|1wqj]], [[2dsq\|2dsq]], [[2dsr\|2dsr]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2dsp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dsp OCA], [~~http~~://pdbe.org/2dsp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2dsp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2dsp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2dsp ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dsp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dsp OCA], [https://pdbe.org/2dsp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dsp RCSB], [https://www.ebi.ac.uk/pdbsum/2dsp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dsp ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN]] Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:[~~http~~://omim.org/entry/608747 608747]]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.	+	[[https://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN]] Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:[https://omim.org/entry/608747 608747]]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/IBP4_HUMAN IBP4_HUMAN]] IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. [[~~http~~://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN]] The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.<ref>PMID:21076856</ref>	+	[[https://www.uniprot.org/uniprot/IBP4_HUMAN IBP4_HUMAN]] IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. [[https://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN]] The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.<ref>PMID:21076856</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:38, 4 March 2020

OCA — Wed, 04 Mar 2020 07:38:26 GMT

←Older revision		Revision as of 07:38, 4 March 2020
Line 1:		Line 1:

	==Structural Basis for the Inhibition of Insulin-like Growth Factors by IGF Binding Proteins==		==Structural Basis for the Inhibition of Insulin-like Growth Factors by IGF Binding Proteins==
-	<StructureSection load='2dsp' size='340' side='right' caption='[[2dsp]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='2dsp' size='340' side='right'caption='[[2dsp]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2dsp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DSP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DSP FirstGlance]. <br>		<table><tr><td colspan='2'>[[2dsp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DSP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DSP FirstGlance]. <br>
Line 34:		Line 34:
	*[[Insulin-like growth factor\|Insulin-like growth factor]]		*[[Insulin-like growth factor\|Insulin-like growth factor]]
	*[[Insulin-like growth factor binding protein\|Insulin-like growth factor binding protein]]		*[[Insulin-like growth factor binding protein\|Insulin-like growth factor binding protein]]
		+	*[[Insulin-like growth factor binding protein 3D structures\|Insulin-like growth factor binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 39:		Line 40:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Holak, T A]]		[[Category: Holak, T A]]
	[[Category: Huber, R]]		[[Category: Huber, R]]

OCA at 06:19, 30 May 2018

OCA — Wed, 30 May 2018 06:19:58 GMT

←Older revision		Revision as of 06:19, 30 May 2018
Line 1:		Line 1:
		+
	==Structural Basis for the Inhibition of Insulin-like Growth Factors by IGF Binding Proteins==		==Structural Basis for the Inhibition of Insulin-like Growth Factors by IGF Binding Proteins==
	<StructureSection load='2dsp' size='340' side='right' caption='[[2dsp]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2dsp' size='340' side='right' caption='[[2dsp]], [[Resolution\|resolution]] 2.50Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2dsp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DSP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DSP FirstGlance]. <br>		<table><tr><td colspan='2'>[[2dsp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DSP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DSP FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wqj\|1wqj]], [[2dsq\|2dsq]], [[2dsr\|2dsr]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wqj\|1wqj]], [[2dsq\|2dsq]], [[2dsr\|2dsr]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dsp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dsp OCA], [http://pdbe.org/2dsp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dsp RCSB], [http://www.ebi.ac.uk/pdbsum/2dsp PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dsp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dsp OCA], [http://pdbe.org/2dsp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dsp RCSB], [http://www.ebi.ac.uk/pdbsum/2dsp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2dsp ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ds/2dsp_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ds/2dsp_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dsp ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 32:		Line 33:
	==See Also==		==See Also==
	*[[Insulin-like growth factor\|Insulin-like growth factor]]		*[[Insulin-like growth factor\|Insulin-like growth factor]]
		+	*[[Insulin-like growth factor binding protein\|Insulin-like growth factor binding protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:50, 11 September 2015

OCA — Fri, 11 Sep 2015 12:50:11 GMT

←Older revision		Revision as of 12:50, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2dsp' size='340' side='right' caption='[[2dsp]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2dsp' size='340' side='right' caption='[[2dsp]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2dsp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DSP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DSP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2dsp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DSP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DSP FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wqj\|1wqj]], [[2dsq\|2dsq]], [[2dsr\|2dsr]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wqj\|1wqj]], [[2dsq\|2dsq]], [[2dsr\|2dsr]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dsp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dsp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dsp RCSB], [http://www.ebi.ac.uk/pdbsum/2dsp PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dsp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dsp OCA], [http://pdbe.org/2dsp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dsp RCSB], [http://www.ebi.ac.uk/pdbsum/2dsp PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[http://www.uniprot.org/uniprot/~~IGF1B_HUMAN IGF1B_HUMAN~~]] Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:[http://omim.org/entry/608747 608747]]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.	+	[[http://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN]] Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:[http://omim.org/entry/608747 608747]]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/IBP4_HUMAN IBP4_HUMAN]] IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. [[http://www.uniprot.org/uniprot/~~IGF1B_HUMAN IGF1B_HUMAN~~]] The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.<ref>PMID:21076856</ref>	+	[[http://www.uniprot.org/uniprot/IBP4_HUMAN IBP4_HUMAN]] IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. [[http://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN]] The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.<ref>PMID:21076856</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2dsp" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Holak, T A]]		[[Category: Holak, T A]]
	[[Category: Huber, R]]		[[Category: Huber, R]]

OCA at 17:42, 15 January 2015

OCA — Thu, 15 Jan 2015 17:42:30 GMT

←Older revision		Revision as of 17:42, 15 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_2dsp\| PDB=2dsp \| SCENE= }}~~	+	==Structural Basis for the Inhibition of Insulin-like Growth Factors by IGF Binding Proteins==
-	===Structural Basis for the Inhibition of Insulin-like Growth Factors by IGF Binding Proteins===	+	<StructureSection load='2dsp' size='340' side='right' caption='[[2dsp]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~{{ABSTRACT_PUBMED_16924115}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2dsp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DSP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DSP FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wqj\|1wqj]], [[2dsq\|2dsq]], [[2dsr\|2dsr]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dsp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dsp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dsp RCSB], [http://www.ebi.ac.uk/pdbsum/2dsp PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/IGF1B_HUMAN IGF1B_HUMAN]] Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:[http://omim.org/entry/608747 608747]]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.		[[http://www.uniprot.org/uniprot/IGF1B_HUMAN IGF1B_HUMAN]] Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:[http://omim.org/entry/608747 608747]]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/IBP4_HUMAN IBP4_HUMAN]] IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. [[http://www.uniprot.org/uniprot/IGF1B_HUMAN IGF1B_HUMAN]] The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.<ref>PMID:21076856</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ds/2dsp_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Insulin-like growth factor-binding proteins (IGFBPs) control bioavailability, activity, and distribution of insulin-like growth factor (IGF)1 and -2 through high-affinity IGFBP/IGF complexes. IGF-binding sites are found on N- and C-terminal fragments of IGFBPs, the two conserved domains of IGFBPs. The relative contributions of these domains to IGFBP/IGF complexation has been difficult to analyze, in part, because of the lack of appropriate three-dimensional structures. To analyze the effects of N- and C-terminal domain interactions, we determined several x-ray structures: first, of a ternary complex of N- and C-terminal domain fragments of IGFBP4 and IGF1 and second, of a "hybrid" ternary complex using the C-terminal domain fragment of IGFBP1 instead of IGFBP4. We also solved the binary complex of the N-terminal domains of IGFBP4 and IGF1, again to analyze C- and N-terminal domain interactions by comparison with the ternary complexes. The structures reveal the mechanisms of IGF signaling regulation via IGFBP binding. This finding supports research into the design of IGFBP variants as therapeutic IGF inhibitors for diseases of IGF disregulation. In IGFBP4, residues 1-38 form a rigid disulphide bond ladder-like structure, and the first five N-terminal residues bind to IGF and partially mask IGF residues responsible for the type 1 IGF receptor binding. A high-affinity IGF1-binding site is located in a globular structure between residues 39 and 82. Although the C-terminal domains do not form stable binary complexes with either IGF1 or the N-terminal domain of IGFBP4, in the ternary complex, the C-terminal domain contacts both and contributes to blocking of the IGF1 receptor-binding region of IGF1.

-	~~==Function==~~	+	Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins.,Sitar T, Popowicz GM, Siwanowicz I, Huber R, Holak TA Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13028-33. Epub 2006 Aug 21. PMID:16924115<ref>PMID:16924115</ref>
-	~~[[http://www.uniprot.org/uniprot/IBP4_HUMAN IBP4_HUMAN]] IGF-binding proteins prolong~~ the ~~half-life~~ of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. [[http://www.uniprot.org/uniprot/IGF1B_HUMAN IGF1B_HUMAN]] The insulin-like growth factors~~, isolated from plasma, are structurally and functionally related to~~ insulin ~~but have a much higher~~ growth-~~promoting activity~~. ~~May be a physiological regulator of [1-14C]-2-deoxy-D-glucose~~ (~~2DG~~) ~~transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone~~-~~derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake~~.<ref>PMID:~~21076856~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[2dsp]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2DSP OCA].~~	+	</div>

	==See Also==		==See Also==
	*[[Insulin-like growth factor\|Insulin-like growth factor]]		*[[Insulin-like growth factor\|Insulin-like growth factor]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:016924115</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Holak, T A.]]	+	[[Category: Holak, T A]]
-	[[Category: Huber, R.]]	+	[[Category: Huber, R]]
-	[[Category: Popowicz, G M.]]	+	[[Category: Popowicz, G M]]
-	[[Category: Sitar, T.]]	+	[[Category: Sitar, T]]
-	[[Category: Siwanowicz, I.]]	+	[[Category: Siwanowicz, I]]
	[[Category: Igf]]		[[Category: Igf]]
	[[Category: Igfbp]]		[[Category: Igfbp]]
	[[Category: Insulin]]		[[Category: Insulin]]
	[[Category: Protein binding-hormone-growth factor complex]]		[[Category: Protein binding-hormone-growth factor complex]]

OCA at 17:16, 24 March 2013

OCA — Sun, 24 Mar 2013 17:16:58 GMT

←Older revision		Revision as of 17:16, 24 March 2013
Line 1:		Line 1:
-	[[Image:2dsp.png\|left\|200px]]
-
	{{STRUCTURE_2dsp\| PDB=2dsp \| SCENE= }}		{{STRUCTURE_2dsp\| PDB=2dsp \| SCENE= }}
-
	===Structural Basis for the Inhibition of Insulin-like Growth Factors by IGF Binding Proteins===		===Structural Basis for the Inhibition of Insulin-like Growth Factors by IGF Binding Proteins===
		+	{{ABSTRACT_PUBMED_16924115}}

-	~~{{ABSTRACT_PUBMED_16924115}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/IGF1B_HUMAN IGF1B_HUMAN]] Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:[http://omim.org/entry/608747 608747]]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/IBP4_HUMAN IBP4_HUMAN]] IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. [[http://www.uniprot.org/uniprot/IGF1B_HUMAN IGF1B_HUMAN]] The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.<ref>PMID:21076856</ref>

	==About this Structure==		==About this Structure==
Line 14:		Line 16:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:016924115</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016924115</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Holak, T A.]]		[[Category: Holak, T A.]]

OCA: Protected "2dsp" [edit=sysop:move=sysop]

OCA — Sat, 20 Oct 2012 19:01:39 GMT

Protected "2dsp" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:01, 20 October 2012

OCA at 19:01, 20 October 2012

OCA — Sat, 20 Oct 2012 19:01:37 GMT

←Older revision		Revision as of 19:01, 20 October 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2dsp.png\|left\|200px]]		[[Image:2dsp.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2dsp", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2dsp\| PDB=2dsp \| SCENE= }}		{{STRUCTURE_2dsp\| PDB=2dsp \| SCENE= }}

	===Structural Basis for the Inhibition of Insulin-like Growth Factors by IGF Binding Proteins===		===Structural Basis for the Inhibition of Insulin-like Growth Factors by IGF Binding Proteins===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16924115}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16924115 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16924115}}		{{ABSTRACT_PUBMED_16924115}}

	==About this Structure==		==About this Structure==
-	~~2DSP~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DSP OCA].	+	[[2dsp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DSP OCA].
		+
		+	==See Also==
		+	*[[Insulin-like growth factor\|Insulin-like growth factor]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16924115~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016924115</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Holak, T A.]]		[[Category: Holak, T A.]]
Line 33:		Line 24:
	[[Category: Igfbp]]		[[Category: Igfbp]]
	[[Category: Insulin]]		[[Category: Insulin]]
-		+	[[Category: Protein binding-hormone-growth factor complex]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 22:01:50 2009''~~	+

OCA at 20:01, 17 February 2009

OCA — Tue, 17 Feb 2009 20:01:52 GMT

←Older revision		Revision as of 20:01, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2DSP is a ~~[[Protein complex]]~~ structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DSP OCA].	+	2DSP is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DSP OCA].

	==Reference==		==Reference==
-	Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins., Sitar T, Popowicz GM, Siwanowicz I, Huber R, Holak TA, Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13028-33. Epub 2006 Aug 21. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16924115 16924115]~~	+	<ref group="xtra">PMID:16924115</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Protein complex]]
	[[Category: Holak, T A.]]		[[Category: Holak, T A.]]
	[[Category: Huber, R.]]		[[Category: Huber, R.]]
Line 35:		Line 34:
	[[Category: Insulin]]		[[Category: Insulin]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 06~~:15:~~49 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 22:01:50 2009''