2dt1 - Revision history

OCA at 08:29, 25 October 2023

OCA — Wed, 25 Oct 2023 08:29:41 GMT

←Older revision		Revision as of 08:29, 25 October 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2dt1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Capra_hircus Capra hircus]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2b41 2b41] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1zu7 1zu7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DT1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DT1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2dt1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Capra_hircus Capra hircus]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2b41 2b41] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1zu7 1zu7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DT1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DT1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.09Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2dpe\|2dpe]], [[2esc\|2esc]], [[2dsz\|2dsz]], [[2dt0\|2dt0]], [[2dt2\|2dt2]], [[2dt3\|2dt3]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dt1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dt1 OCA], [https://pdbe.org/2dt1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dt1 RCSB], [https://www.ebi.ac.uk/pdbsum/2dt1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dt1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dt1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dt1 OCA], [https://pdbe.org/2dt1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dt1 RCSB], [https://www.ebi.ac.uk/pdbsum/2dt1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dt1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CH3L1_CAPHI CH3L1_CAPHI]] Carbohydrate-binding lectin with a preference for chitin. May play a role in defense against pathogens, or in tissue remodeling. May play an important role in the capacity of cells to respond to and cope with changes in their environment.	+	[https://www.uniprot.org/uniprot/CH3L1_CAPHI CH3L1_CAPHI] Carbohydrate-binding lectin with a preference for chitin. May play a role in defense against pathogens, or in tissue remodeling. May play an important role in the capacity of cells to respond to and cope with changes in their environment.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 38:		Line 38:
	[[Category: Capra hircus]]		[[Category: Capra hircus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bhushan, A]]	+	[[Category: Bhushan A]]
-	[[Category: Ethayathulla~~, A S~~]]	+	[[Category: Ethayathulla AS]]
-	[[Category: Kaur, P]]	+	[[Category: Kaur P]]
-	[[Category: Kumar, J]]	+	[[Category: Kumar J]]
-	[[Category: Sharma, S]]	+	[[Category: Sharma S]]
-	[[Category: Singh, N]]	+	[[Category: Singh N]]
-	[[Category: Singh~~, T P~~]]	+	[[Category: Singh TP]]
-	[[Category: Srivastava~~, D B]]~~	+	[[Category: Srivastava DB]]
-	~~[[Category: Signaling protein]]~~	+
-	~~[[Category: Spg-40]]~~	+
-	~~[[Category: Tetrasaccharide~~]]	+

OCA at 10:35, 8 December 2021

OCA — Wed, 08 Dec 2021 10:35:56 GMT

←Older revision		Revision as of 10:35, 8 December 2021
Line 3:		Line 3:
	<StructureSection load='2dt1' size='340' side='right'caption='[[2dt1]], [[Resolution\|resolution]] 2.09Å' scene=''>		<StructureSection load='2dt1' size='340' side='right'caption='[[2dt1]], [[Resolution\|resolution]] 2.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2dt1]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Capra_hircus Capra hircus]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2b41 2b41] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1zu7 1zu7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DT1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2DT1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2dt1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Capra_hircus Capra hircus]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2b41 2b41] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1zu7 1zu7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DT1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DT1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2dpe\|2dpe]], [[2esc\|2esc]], [[2dsz\|2dsz]], [[2dt0\|2dt0]], [[2dt2\|2dt2]], [[2dt3\|2dt3]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2dpe\|2dpe]], [[2esc\|2esc]], [[2dsz\|2dsz]], [[2dt0\|2dt0]], [[2dt2\|2dt2]], [[2dt3\|2dt3]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2dt1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dt1 OCA], [~~http~~://pdbe.org/2dt1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2dt1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2dt1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2dt1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dt1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dt1 OCA], [https://pdbe.org/2dt1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dt1 RCSB], [https://www.ebi.ac.uk/pdbsum/2dt1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dt1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CH3L1_CAPHI CH3L1_CAPHI]] Carbohydrate-binding lectin with a preference for chitin. May play a role in defense against pathogens, or in tissue remodeling. May play an important role in the capacity of cells to respond to and cope with changes in their environment.	+	[[https://www.uniprot.org/uniprot/CH3L1_CAPHI CH3L1_CAPHI]] Carbohydrate-binding lectin with a preference for chitin. May play a role in defense against pathogens, or in tissue remodeling. May play an important role in the capacity of cells to respond to and cope with changes in their environment.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:58, 4 March 2020

OCA — Wed, 04 Mar 2020 07:58:51 GMT

←Older revision		Revision as of 07:58, 4 March 2020
Line 1:		Line 1:

	==Crystal Structure Of The Complex Of Goat Signalling Protein With Tetrasaccharide At 2.09 A Resolution==		==Crystal Structure Of The Complex Of Goat Signalling Protein With Tetrasaccharide At 2.09 A Resolution==
-	<StructureSection load='2dt1' size='340' side='right' caption='[[2dt1]], [[Resolution\|resolution]] 2.09Å' scene=''>	+	<StructureSection load='2dt1' size='340' side='right'caption='[[2dt1]], [[Resolution\|resolution]] 2.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2dt1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Capra_hircus Capra hircus]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2b41 2b41] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1zu7 1zu7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DT1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DT1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2dt1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Capra_hircus Capra hircus]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2b41 2b41] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1zu7 1zu7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DT1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DT1 FirstGlance]. <br>
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Chitinase-3-like protein\|Chitinase-3-like protein]]	+	*[[Chitinase-3-like protein 3D structures\|Chitinase-3-like protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Capra hircus]]		[[Category: Capra hircus]]
		+	[[Category: Large Structures]]
	[[Category: Bhushan, A]]		[[Category: Bhushan, A]]
	[[Category: Ethayathulla, A S]]		[[Category: Ethayathulla, A S]]

OCA at 06:53, 30 May 2018

OCA — Wed, 30 May 2018 06:53:03 GMT

←Older revision		Revision as of 06:53, 30 May 2018
Line 1:		Line 1:
		+
	==Crystal Structure Of The Complex Of Goat Signalling Protein With Tetrasaccharide At 2.09 A Resolution==		==Crystal Structure Of The Complex Of Goat Signalling Protein With Tetrasaccharide At 2.09 A Resolution==
	<StructureSection load='2dt1' size='340' side='right' caption='[[2dt1]], [[Resolution\|resolution]] 2.09Å' scene=''>		<StructureSection load='2dt1' size='340' side='right' caption='[[2dt1]], [[Resolution\|resolution]] 2.09Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2dpe\|2dpe]], [[2esc\|2esc]], [[2dsz\|2dsz]], [[2dt0\|2dt0]], [[2dt2\|2dt2]], [[2dt3\|2dt3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2dpe\|2dpe]], [[2esc\|2esc]], [[2dsz\|2dsz]], [[2dt0\|2dt0]], [[2dt2\|2dt2]], [[2dt3\|2dt3]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dt1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dt1 OCA], [http://pdbe.org/2dt1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dt1 RCSB], [http://www.ebi.ac.uk/pdbsum/2dt1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dt1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dt1 OCA], [http://pdbe.org/2dt1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dt1 RCSB], [http://www.ebi.ac.uk/pdbsum/2dt1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2dt1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dt/2dt1_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dt/2dt1_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dt1 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 30:		Line 31:

	==See Also==		==See Also==
-	*[[Chitinase-3-like protein 1\|Chitinase-3-like protein 1]]	+	*[[Chitinase-3-like protein\|Chitinase-3-like protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:34, 11 September 2015

OCA — Fri, 11 Sep 2015 09:34:44 GMT

←Older revision		Revision as of 09:34, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2dt1' size='340' side='right' caption='[[2dt1]], [[Resolution\|resolution]] 2.09Å' scene=''>		<StructureSection load='2dt1' size='340' side='right' caption='[[2dt1]], [[Resolution\|resolution]] 2.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2dt1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Capra_hircus Capra hircus]. This structure supersedes the now removed PDB entries and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1zu7 1zu7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DT1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DT1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2dt1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Capra_hircus Capra hircus]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2b41 2b41] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1zu7 1zu7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DT1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DT1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2dpe\|2dpe]], [[2esc\|2esc]], [[2dsz\|2dsz]], [[2dt0\|2dt0]], [[2dt2\|2dt2]], [[2dt3\|2dt3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2dpe\|2dpe]], [[2esc\|2esc]], [[2dsz\|2dsz]], [[2dt0\|2dt0]], [[2dt2\|2dt2]], [[2dt3\|2dt3]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dt1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dt1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dt1 RCSB], [http://www.ebi.ac.uk/pdbsum/2dt1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dt1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dt1 OCA], [http://pdbe.org/2dt1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dt1 RCSB], [http://www.ebi.ac.uk/pdbsum/2dt1 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2dt1" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 14:34, 25 December 2014

OCA — Thu, 25 Dec 2014 14:34:08 GMT

←Older revision		Revision as of 14:34, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2dt1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Capra_hircus Capra hircus]. This structure supersedes the now removed PDB entries and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1zu7 1zu7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DT1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DT1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2dt1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Capra_hircus Capra hircus]. This structure supersedes the now removed PDB entries and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1zu7 1zu7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DT1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DT1 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2dpe\|2dpe]], [[2esc\|2esc]], [[2dsz\|2dsz]], [[2dt0\|2dt0]], [[2dt2\|2dt2]], [[2dt3\|2dt3]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2dpe\|2dpe]], [[2esc\|2esc]], [[2dsz\|2dsz]], [[2dt0\|2dt0]], [[2dt2\|2dt2]], [[2dt3\|2dt3]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dt1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dt1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dt1 RCSB], [http://www.ebi.ac.uk/pdbsum/2dt1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dt1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dt1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dt1 RCSB], [http://www.ebi.ac.uk/pdbsum/2dt1 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CH3L1_CAPHI CH3L1_CAPHI]] Carbohydrate-binding lectin with a preference for chitin. May play a role in defense against pathogens, or in tissue remodeling. May play an important role in the capacity of cells to respond to and cope with changes in their environment.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Capra hircus]]		[[Category: Capra hircus]]
-	[[Category: Bhushan, A.]]	+	[[Category: Bhushan, A]]
-	[[Category: Ethayathulla, A S.]]	+	[[Category: Ethayathulla, A S]]
-	[[Category: Kaur, P.]]	+	[[Category: Kaur, P]]
-	[[Category: Kumar, J.]]	+	[[Category: Kumar, J]]
-	[[Category: Sharma, S.]]	+	[[Category: Sharma, S]]
-	[[Category: Singh, N.]]	+	[[Category: Singh, N]]
-	[[Category: Singh, T P.]]	+	[[Category: Singh, T P]]
-	[[Category: Srivastava, D B.]]	+	[[Category: Srivastava, D B]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]
	[[Category: Spg-40]]		[[Category: Spg-40]]
	[[Category: Tetrasaccharide]]		[[Category: Tetrasaccharide]]

OCA at 05:59, 29 September 2014

OCA — Mon, 29 Sep 2014 05:59:22 GMT

←Older revision		Revision as of 05:59, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2dt1.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure Of The Complex Of Goat Signalling Protein With Tetrasaccharide At 2.09 A Resolution==
		+	<StructureSection load='2dt1' size='340' side='right' caption='[[2dt1]], [[Resolution\|resolution]] 2.09Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2dt1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Capra_hircus Capra hircus]. This structure supersedes the now removed PDB entries and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1zu7 1zu7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DT1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DT1 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2dpe\|2dpe]], [[2esc\|2esc]], [[2dsz\|2dsz]], [[2dt0\|2dt0]], [[2dt2\|2dt2]], [[2dt3\|2dt3]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dt1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dt1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dt1 RCSB], [http://www.ebi.ac.uk/pdbsum/2dt1 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dt/2dt1_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A 40 kDa glycoprotein (SPG-40) secreted during involution works as a protective signalling factor through its binding to viable cells. The crystal structure of the native protein has been determined at 2.3 A resolution. This is the first report on the carbohydrate-binding properties of SPG-40; the structure determinations of the complexes of SPG-40 with four oligosaccharides of different lengths at resolutions ranging from 2.2 to 2.8 A are described. Carbohydrate-binding studies with N-acetylglucosamines (GlcNAc(n), n = 3-6) using fluorescence spectroscopy revealed poor binding effects with GlcNAc(3) and GlcNAc(4), while GlcNAc(5) and GlcNAc(6) bound to SPG-40 with considerable strength; the dissociation constants (K(d)) were estimated to be 260 +/- 3 and 18 +/- 4 microM, respectively. SPG-40 was cocrystallized with GlcNAc(3), GlcNAc(4), GlcNAc(5) and GlcNAc(6). The overall structure of native SPG-40 was essentially similar to that reported previously at low resolution. The structures of its complexes with GlcNAc(3), GlcNAc(4), GlcNAc(5) and GlcNAc(6) revealed the positions of these oligosaccharides in the carbohydrate-binding groove and provided insights into the mechanism of binding of oligosaccharides to SPG-40, indicating that the preferred subsites in the carbohydrate-binding groove of SPG-40 were from -4 to -2. The structure of the protein remained unperturbed upon binding of GlcNAc(3) and GlcNAc(4), but the structure changed significantly upon binding of GlcNAc(5) and GlcNAc(6). Significant conformational variations were observed in the sugar-binding groove: Trp78 partially flipped out of the barrel in GlcNAc(5), while in the GlcNAc(6) complex a completely flipped-out Trp78 was observed along with several other conformational changes, including those of Asp186 and Arg242. Such changes upon binding to carbohydrates have not previously been observed in chitin-hydrolyzing chitinases and reflect less favourable binding of carbohydrates to SPG-40. As this appears to essentially be a binding protein, this loss of binding affinity might be compensated by other intermolecular interactions such as protein-protein interactions and also by the binding of its own glycan chain.

-	~~{{STRUCTURE_2dt1\| PDB=2dt1 \| SCENE= }}~~	+	Carbohydrate-binding properties of goat secretory glycoprotein (SPG-40) and its functional implications: structures of the native glycoprotein and its four complexes with chitin-like oligosaccharides.,Kumar J, Ethayathulla AS, Srivastava DB, Singh N, Sharma S, Kaur P, Srinivasan A, Singh TP Acta Crystallogr D Biol Crystallogr. 2007 Apr;63(Pt 4):437-46. Epub 2007, Mar 16. PMID:17372347<ref>PMID:17372347</ref>

-	~~===Crystal Structure Of The Complex Of Goat Signalling Protein With Tetrasaccharide At 2.09 A Resolution===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17372347}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2dt1]] is~~ a ~~1 chain structure with sequence from [http://en.wikipedia.org/wiki/Capra_hircus Capra hircus]. This structure supersedes~~ the ~~now removed PDB entries and [http://oca~~.~~weizmann~~.ac.il/~~oca-bin/send-pdb?obs=1&id=1zu7 1zu7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DT1 OCA].~~	+

	==See Also==		==See Also==
	*[[Chitinase-3-like protein 1\|Chitinase-3-like protein 1]]		*[[Chitinase-3-like protein 1\|Chitinase-3-like protein 1]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:017372347<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Capra hircus]]		[[Category: Capra hircus]]
	[[Category: Bhushan, A.]]		[[Category: Bhushan, A.]]

OCA at 17:52, 20 October 2012

OCA — Sat, 20 Oct 2012 17:52:39 GMT

←Older revision		Revision as of 17:52, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2dt1]] is a 1 chain structure ~~of [[Chitinase-3-like protein 1]]~~ with sequence from [http://en.wikipedia.org/wiki/Capra_hircus Capra hircus]. This structure supersedes the now removed PDB entries and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1zu7 1zu7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DT1 OCA].	+	[[2dt1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Capra_hircus Capra hircus]. This structure supersedes the now removed PDB entries and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1zu7 1zu7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DT1 OCA].

	==See Also==		==See Also==

OCA: Protected "2dt1" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 02:17:13 GMT

Protected "2dt1" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:17, 27 July 2012

OCA at 02:17, 27 July 2012

OCA — Fri, 27 Jul 2012 02:17:12 GMT

←Older revision		Revision as of 02:17, 27 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2dt1.png\|left\|200px]]		[[Image:2dt1.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2dt1", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2dt1\| PDB=2dt1 \| SCENE= }}		{{STRUCTURE_2dt1\| PDB=2dt1 \| SCENE= }}

	===Crystal Structure Of The Complex Of Goat Signalling Protein With Tetrasaccharide At 2.09 A Resolution===		===Crystal Structure Of The Complex Of Goat Signalling Protein With Tetrasaccharide At 2.09 A Resolution===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17372347}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17372347 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17372347}}		{{ABSTRACT_PUBMED_17372347}}

	==About this Structure==		==About this Structure==
-	~~2DT1~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Capra_hircus Capra hircus]. This structure supersedes the now removed PDB entries and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1zu7 1zu7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DT1 OCA].	+	[[2dt1]] is a 1 chain structure of [[Chitinase-3-like protein 1]] with sequence from [http://en.wikipedia.org/wiki/Capra_hircus Capra hircus]. This structure supersedes the now removed PDB entries and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1zu7 1zu7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DT1 OCA].
		+
		+	==See Also==
		+	*[[Chitinase-3-like protein 1\|Chitinase-3-like protein 1]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17372347~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017372347</ref><references group="xtra"/>
	[[Category: Capra hircus]]		[[Category: Capra hircus]]
	[[Category: Bhushan, A.]]		[[Category: Bhushan, A.]]
Line 33:		Line 24:
	[[Category: Singh, T P.]]		[[Category: Singh, T P.]]
	[[Category: Srivastava, D B.]]		[[Category: Srivastava, D B.]]
		+	[[Category: Signaling protein]]
	[[Category: Spg-40]]		[[Category: Spg-40]]
	[[Category: Tetrasaccharide]]		[[Category: Tetrasaccharide]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:50:01 2009''