2dwm - Revision history

OCA at 08:31, 25 October 2023

OCA — Wed, 25 Oct 2023 08:31:24 GMT

←Older revision		Revision as of 08:31, 25 October 2023
Line 3:		Line 3:
	<StructureSection load='2dwm' size='340' side='right'caption='[[2dwm]], [[Resolution\|resolution]] 3.15Å' scene=''>		<StructureSection load='2dwm' size='340' side='right'caption='[[2dwm]], [[Resolution\|resolution]] 3.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2dwm]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DWM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2dwm]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DWM FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[2d7e\|2d7e]]~~, [[~~2d7g~~\|~~2d7g~~]]~~, [[2d7h\|2d7h]], [[2dwl\|2dwl]], [[2dwn\|2dwn]]</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.15Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dwm OCA], [https://pdbe.org/2dwm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dwm RCSB], [https://www.ebi.ac.uk/pdbsum/2dwm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dwm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dwm OCA], [https://pdbe.org/2dwm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dwm RCSB], [https://www.ebi.ac.uk/pdbsum/2dwm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dwm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PRIA_ECOLI PRIA_ECOLI]] Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA. Is also involved in initiation of normal DNA replication in various plasmids and phages. Binds to branched DNA structures that resemble D-loops or to the primosome assembly site (PAS). Binds to DNA in two distinct modes, either dependent on or independent of the 3' terminus recognition.<ref>PMID:2825188</ref> <ref>PMID:8366072</ref> <ref>PMID:10356325</ref> <ref>PMID:10956036</ref> <ref>PMID:11929519</ref> <ref>PMID:12622722</ref> <ref>PMID:12917421</ref> <ref>PMID:15576682</ref> <ref>PMID:17483094</ref> <ref>PMID:23264623</ref>	+	[https://www.uniprot.org/uniprot/PRIA_ECOLI PRIA_ECOLI] Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA. Is also involved in initiation of normal DNA replication in various plasmids and phages. Binds to branched DNA structures that resemble D-loops or to the primosome assembly site (PAS). Binds to DNA in two distinct modes, either dependent on or independent of the 3' terminus recognition.<ref>PMID:2825188</ref> <ref>PMID:8366072</ref> <ref>PMID:10356325</ref> <ref>PMID:10956036</ref> <ref>PMID:11929519</ref> <ref>PMID:12622722</ref> <ref>PMID:12917421</ref> <ref>PMID:15576682</ref> <ref>PMID:17483094</ref> <ref>PMID:23264623</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kohda, D]]	+	[[Category: Kohda D]]
-	[[Category: Maenaka, K]]	+	[[Category: Maenaka K]]
-	[[Category: Masai, H]]	+	[[Category: Masai H]]
-	[[Category: Ose, T]]	+	[[Category: Ose T]]
-	[[Category: Sasaki, K]]	+	[[Category: Sasaki K]]
-	[[Category: Tanaka, T]]	+	[[Category: Tanaka T]]
-	~~[[Category: Hydrolase-dna complex]]~~	+
-	~~[[Category: Protein-dna complex~~]]	+

OCA at 11:39, 10 February 2021

OCA — Wed, 10 Feb 2021 11:39:28 GMT

←Older revision		Revision as of 11:39, 10 February 2021
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	==Crystal structure of the PriA protein complexed with oligonucleotides==		==Crystal structure of the PriA protein complexed with oligonucleotides==
-	<StructureSection load='2dwm' size='340' side='right' caption='[[2dwm]], [[Resolution\|resolution]] 3.15Å' scene=''>	+	<StructureSection load='2dwm' size='340' side='right'caption='[[2dwm]], [[Resolution\|resolution]] 3.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2dwm]] is a 7 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2DWM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2dwm]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DWM FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2d7e\|2d7e]], [[2d7g\|2d7g]], [[2d7h\|2d7h]], [[2dwl\|2dwl]], [[2dwn\|2dwn]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2d7e\|2d7e]], [[2d7g\|2d7g]], [[2d7h\|2d7h]], [[2dwl\|2dwl]], [[2dwn\|2dwn]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2dwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dwm OCA], [~~http~~://pdbe.org/2dwm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2dwm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2dwm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2dwm ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dwm OCA], [https://pdbe.org/2dwm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dwm RCSB], [https://www.ebi.ac.uk/pdbsum/2dwm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dwm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PRIA_ECOLI PRIA_ECOLI]] Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA. Is also involved in initiation of normal DNA replication in various plasmids and phages. Binds to branched DNA structures that resemble D-loops or to the primosome assembly site (PAS). Binds to DNA in two distinct modes, either dependent on or independent of the 3' terminus recognition.<ref>PMID:2825188</ref> <ref>PMID:8366072</ref> <ref>PMID:10356325</ref> <ref>PMID:10956036</ref> <ref>PMID:11929519</ref> <ref>PMID:12622722</ref> <ref>PMID:12917421</ref> <ref>PMID:15576682</ref> <ref>PMID:17483094</ref> <ref>PMID:23264623</ref>	+	[[https://www.uniprot.org/uniprot/PRIA_ECOLI PRIA_ECOLI]] Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA. Is also involved in initiation of normal DNA replication in various plasmids and phages. Binds to branched DNA structures that resemble D-loops or to the primosome assembly site (PAS). Binds to DNA in two distinct modes, either dependent on or independent of the 3' terminus recognition.<ref>PMID:2825188</ref> <ref>PMID:8366072</ref> <ref>PMID:10356325</ref> <ref>PMID:10956036</ref> <ref>PMID:11929519</ref> <ref>PMID:12622722</ref> <ref>PMID:12917421</ref> <ref>PMID:15576682</ref> <ref>PMID:17483094</ref> <ref>PMID:23264623</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Helicase\|Helicase]]	+	*[[Helicase 3D structures\|Helicase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
		+	[[Category: Large Structures]]
	[[Category: Kohda, D]]		[[Category: Kohda, D]]
	[[Category: Maenaka, K]]		[[Category: Maenaka, K]]

OCA at 15:41, 27 February 2019

OCA — Wed, 27 Feb 2019 15:41:52 GMT

←Older revision		Revision as of 15:41, 27 February 2019
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dwm ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dwm ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In eubacteria, PriA helicase detects the stalled DNA replication forks. This critical role of PriA is ascribed to its ability to bind to the 3' end of a nascent leading DNA strand in the stalled replication forks. The crystal structures in complexes with oligonucleotides and the combination of fluorescence correlation spectroscopy and mutagenesis reveal that the N-terminal domain of PriA possesses a binding pocket for the 3'-terminal nucleotide residue of DNA. The interaction with the deoxyribose 3'-OH is essential for the 3'-terminal recognition. In contrast, the direct interaction with 3'-end nucleobase is unexpected, considering the same affinity for oligonucleotides carrying the four bases at the 3' end. Thus, the N-terminal domain of PriA recognizes the 3'-end base in a base-non-selective manner, in addition to the deoxyribose and 5'-side phosphodiester group, of the 3'-terminal nucleotide to acquire both sufficient affinity and non-selectivity to find all of the stalled replication forks generated during DNA duplication. This unique feature is prerequisite for the proper positioning of the helicase domain of PriA on the unreplicated double-stranded DNA.
		+
		+	Structural basis of the 3'-end recognition of a leading strand in stalled replication forks by PriA.,Sasaki K, Ose T, Okamoto N, Maenaka K, Tanaka T, Masai H, Saito M, Shirai T, Kohda D EMBO J. 2007 May 16;26(10):2584-93. doi: 10.1038/sj.emboj.7601697. Epub 2007 Apr , 26. PMID:17464287<ref>PMID:17464287</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 2dwm" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 06:50, 6 June 2018

OCA — Wed, 06 Jun 2018 06:50:55 GMT

←Older revision		Revision as of 06:50, 6 June 2018
Line 1:		Line 1:
		+
	==Crystal structure of the PriA protein complexed with oligonucleotides==		==Crystal structure of the PriA protein complexed with oligonucleotides==
	<StructureSection load='2dwm' size='340' side='right' caption='[[2dwm]], [[Resolution\|resolution]] 3.15Å' scene=''>		<StructureSection load='2dwm' size='340' side='right' caption='[[2dwm]], [[Resolution\|resolution]] 3.15Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2dwm]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DWM FirstGlance]. <br>		<table><tr><td colspan='2'>[[2dwm]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DWM FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2d7e\|2d7e]], [[2d7g\|2d7g]], [[2d7h\|2d7h]], [[2dwl\|2dwl]], [[2dwn\|2dwn]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2d7e\|2d7e]], [[2d7g\|2d7g]], [[2d7h\|2d7h]], [[2dwl\|2dwl]], [[2dwn\|2dwn]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dwm OCA], [http://pdbe.org/2dwm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dwm RCSB], [http://www.ebi.ac.uk/pdbsum/2dwm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dwm OCA], [http://pdbe.org/2dwm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dwm RCSB], [http://www.ebi.ac.uk/pdbsum/2dwm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2dwm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dw/2dwm_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dw/2dwm_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 18:27, 8 February 2016

OCA — Mon, 08 Feb 2016 18:27:54 GMT

←Older revision		Revision as of 18:27, 8 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dwm ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

OCA at 14:14, 10 September 2015

OCA — Thu, 10 Sep 2015 14:14:26 GMT

←Older revision		Revision as of 14:14, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2dwm' size='340' side='right' caption='[[2dwm]], [[Resolution\|resolution]] 3.15Å' scene=''>		<StructureSection load='2dwm' size='340' side='right' caption='[[2dwm]], [[Resolution\|resolution]] 3.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2dwm]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DWM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2dwm]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DWM FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2d7e\|2d7e]], [[2d7g\|2d7g]], [[2d7h\|2d7h]], [[2dwl\|2dwl]], [[2dwn\|2dwn]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2d7e\|2d7e]], [[2d7g\|2d7g]], [[2d7h\|2d7h]], [[2dwl\|2dwl]], [[2dwn\|2dwn]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dwm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dwm RCSB], [http://www.ebi.ac.uk/pdbsum/2dwm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dwm OCA], [http://pdbe.org/2dwm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dwm RCSB], [http://www.ebi.ac.uk/pdbsum/2dwm PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia~~ coli]]	+	[[Category: Bacillus coli migula 1895]]
	[[Category: Kohda, D]]		[[Category: Kohda, D]]
	[[Category: Maenaka, K]]		[[Category: Maenaka, K]]

OCA at 01:18, 25 December 2014

OCA — Thu, 25 Dec 2014 01:18:15 GMT

←Older revision		Revision as of 01:18, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2dwm]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DWM FirstGlance]. <br>		<table><tr><td colspan='2'>[[2dwm]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DWM FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2d7e\|2d7e]], [[2d7g\|2d7g]], [[2d7h\|2d7h]], [[2dwl\|2dwl]], [[2dwn\|2dwn]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2d7e\|2d7e]], [[2d7g\|2d7g]], [[2d7h\|2d7h]], [[2dwl\|2dwl]], [[2dwn\|2dwn]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dwm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dwm RCSB], [http://www.ebi.ac.uk/pdbsum/2dwm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dwm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dwm RCSB], [http://www.ebi.ac.uk/pdbsum/2dwm PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PRIA_ECOLI PRIA_ECOLI]] Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA. Is also involved in initiation of normal DNA replication in various plasmids and phages. Binds to branched DNA structures that resemble D-loops or to the primosome assembly site (PAS). Binds to DNA in two distinct modes, either dependent on or independent of the 3' terminus recognition.<ref>PMID:2825188</ref> <ref>PMID:8366072</ref> <ref>PMID:10356325</ref> <ref>PMID:10956036</ref> <ref>PMID:11929519</ref> <ref>PMID:12622722</ref> <ref>PMID:12917421</ref> <ref>PMID:15576682</ref> <ref>PMID:17483094</ref> <ref>PMID:23264623</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 21:
	==See Also==		==See Also==
	*[[Helicase\|Helicase]]		*[[Helicase\|Helicase]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Kohda, D.]]	+	[[Category: Kohda, D]]
-	[[Category: Maenaka, K.]]	+	[[Category: Maenaka, K]]
-	[[Category: Masai, H.]]	+	[[Category: Masai, H]]
-	[[Category: Ose, T.]]	+	[[Category: Ose, T]]
-	[[Category: Sasaki, K.]]	+	[[Category: Sasaki, K]]
-	[[Category: Tanaka, T.]]	+	[[Category: Tanaka, T]]
	[[Category: Hydrolase-dna complex]]		[[Category: Hydrolase-dna complex]]
	[[Category: Protein-dna complex]]		[[Category: Protein-dna complex]]

OCA at 05:10, 29 September 2014

OCA — Mon, 29 Sep 2014 05:10:12 GMT

←Older revision		Revision as of 05:10, 29 September 2014
Line 1:		Line 1:
-	~~[[Image:2dwm.png\|left\|200px]]~~	+	==Crystal structure of the PriA protein complexed with oligonucleotides==
-		+	<StructureSection load='2dwm' size='340' side='right' caption='[[2dwm]], [[Resolution\|resolution]] 3.15Å' scene=''>
-	~~{{STRUCTURE_2dwm\| PDB=2dwm \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2dwm]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DWM FirstGlance]. <br>
-	===Crystal structure of the PriA protein complexed with oligonucleotides===	+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2d7e\|2d7e]], [[2d7g\|2d7g]], [[2d7h\|2d7h]], [[2dwl\|2dwl]], [[2dwn\|2dwn]]</td></tr>
-		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dwm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dwm RCSB], [http://www.ebi.ac.uk/pdbsum/2dwm PDBsum]</span></td></tr>
-		+	<table>
-	==~~About this Structure~~==	+	== Evolutionary Conservation ==
-	[[2dwm]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWM OCA].	+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dw/2dwm_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>

	==See Also==		==See Also==
	*[[Helicase\|Helicase]]		*[[Helicase\|Helicase]]
		+	__TOC__
		+	</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Kohda, D.]]		[[Category: Kohda, D.]]

OCA at 11:04, 20 October 2012

OCA — Sat, 20 Oct 2012 11:04:12 GMT

←Older revision		Revision as of 11:04, 20 October 2012
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[2dwm]] is a 7 chain structure ~~of [[Helicase]]~~ with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWM OCA].	+	[[2dwm]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWM OCA].

	==See Also==		==See Also==

OCA: Protected "2dwm" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 04:08:53 GMT

Protected "2dwm" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:08, 26 July 2012