2e2o - Revision history

OCA at 17:19, 15 December 2021

OCA — Wed, 15 Dec 2021 17:19:48 GMT

←Older revision		Revision as of 17:19, 15 December 2021
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	<StructureSection load='2e2o' size='340' side='right'caption='[[2e2o]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='2e2o' size='340' side='right'caption='[[2e2o]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2e2o]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~(in_press)_sulfurisphaera_tokodaii (in press) sulfurisphaera tokodaii~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2O OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2E2O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2e2o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dsm_16993 Dsm 16993]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E2O FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2e2n\|2e2n]], [[2e2p\|2e2p]], [[2e2q\|2e2q]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2e2n\|2e2n]], [[2e2p\|2e2p]], [[2e2q\|2e2q]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Hexokinase Hexokinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.1 2.7.1.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Hexokinase Hexokinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.1 2.7.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2e2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e2o OCA], [~~http~~://pdbe.org/2e2o PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2e2o RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2e2o PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2e2o ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e2o OCA], [https://pdbe.org/2e2o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e2o RCSB], [https://www.ebi.ac.uk/pdbsum/2e2o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e2o ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Dsm 16993]]
	[[Category: Hexokinase]]		[[Category: Hexokinase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 08:26, 11 March 2020

OCA — Wed, 11 Mar 2020 08:26:12 GMT

←Older revision		Revision as of 08:26, 11 March 2020
Line 1:		Line 1:

	==Crystal structure of Sulfolobus tokodaii hexokinase in complex with glucose==		==Crystal structure of Sulfolobus tokodaii hexokinase in complex with glucose==
-	<StructureSection load='2e2o' size='340' side='right' caption='[[2e2o]], [[Resolution\|resolution]] 1.65Å' scene=''>	+	<StructureSection load='2e2o' size='340' side='right'caption='[[2e2o]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2e2o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/(in_press)_sulfurisphaera_tokodaii (in press) sulfurisphaera tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E2O FirstGlance]. <br>		<table><tr><td colspan='2'>[[2e2o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/(in_press)_sulfurisphaera_tokodaii (in press) sulfurisphaera tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E2O FirstGlance]. <br>
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Hexokinase\|Hexokinase]]	+	*[[Hexokinase 3D structures\|Hexokinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Hexokinase]]		[[Category: Hexokinase]]
		+	[[Category: Large Structures]]
	[[Category: Fushinobu, S]]		[[Category: Fushinobu, S]]
	[[Category: Nishimasu, H]]		[[Category: Nishimasu, H]]

OCA at 07:01, 6 June 2018

OCA — Wed, 06 Jun 2018 07:01:44 GMT

←Older revision		Revision as of 07:01, 6 June 2018
Line 1:		Line 1:
		+
	==Crystal structure of Sulfolobus tokodaii hexokinase in complex with glucose==		==Crystal structure of Sulfolobus tokodaii hexokinase in complex with glucose==
	<StructureSection load='2e2o' size='340' side='right' caption='[[2e2o]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='2e2o' size='340' side='right' caption='[[2e2o]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2e2o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Dsm_16993 Dsm 16993~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E2O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2e2o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/(in_press)_sulfurisphaera_tokodaii (in press) sulfurisphaera tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E2O FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2e2n\|2e2n]], [[2e2p\|2e2p]], [[2e2q\|2e2q]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2e2n\|2e2n]], [[2e2p\|2e2p]], [[2e2q\|2e2q]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hexokinase Hexokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.1 2.7.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hexokinase Hexokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.1 2.7.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e2o OCA], [http://pdbe.org/2e2o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2e2o RCSB], [http://www.ebi.ac.uk/pdbsum/2e2o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e2o OCA], [http://pdbe.org/2e2o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2e2o RCSB], [http://www.ebi.ac.uk/pdbsum/2e2o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2e2o ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e2/2e2o_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e2/2e2o_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Dsm 16993]]
	[[Category: Hexokinase]]		[[Category: Hexokinase]]
	[[Category: Fushinobu, S]]		[[Category: Fushinobu, S]]

OCA at 04:40, 8 February 2016

OCA — Mon, 08 Feb 2016 04:40:19 GMT

←Older revision		Revision as of 04:40, 8 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e2o ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:57, 10 September 2015

OCA — Thu, 10 Sep 2015 07:57:14 GMT

←Older revision		Revision as of 07:57, 10 September 2015
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	<StructureSection load='2e2o' size='340' side='right' caption='[[2e2o]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='2e2o' size='340' side='right' caption='[[2e2o]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2e2o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Sulfolobus_tokodaii Sulfolobus tokodaii~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E2O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2e2o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dsm_16993 Dsm 16993]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E2O FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2e2n\|2e2n]], [[2e2p\|2e2p]], [[2e2q\|2e2q]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2e2n\|2e2n]], [[2e2p\|2e2p]], [[2e2q\|2e2q]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hexokinase Hexokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.1 2.7.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hexokinase Hexokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.1 2.7.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e2o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e2o RCSB], [http://www.ebi.ac.uk/pdbsum/2e2o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e2o OCA], [http://pdbe.org/2e2o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2e2o RCSB], [http://www.ebi.ac.uk/pdbsum/2e2o PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2e2o" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Dsm 16993]]
	[[Category: Hexokinase]]		[[Category: Hexokinase]]
-	[[Category: Sulfolobus tokodaii]]
	[[Category: Fushinobu, S]]		[[Category: Fushinobu, S]]
	[[Category: Nishimasu, H]]		[[Category: Nishimasu, H]]

OCA at 18:17, 15 January 2015

OCA — Thu, 15 Jan 2015 18:17:45 GMT

←Older revision		Revision as of 18:17, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2e2o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_tokodaii Sulfolobus tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E2O FirstGlance]. <br>		<table><tr><td colspan='2'>[[2e2o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_tokodaii Sulfolobus tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E2O FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2e2n\|2e2n]], [[2e2p\|2e2p]], [[2e2q\|2e2q]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2e2n\|2e2n]], [[2e2p\|2e2p]], [[2e2q\|2e2q]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hexokinase Hexokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.1 2.7.1.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hexokinase Hexokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.1 2.7.1.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e2o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e2o RCSB], [http://www.ebi.ac.uk/pdbsum/2e2o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e2o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e2o RCSB], [http://www.ebi.ac.uk/pdbsum/2e2o PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: Hexokinase]]		[[Category: Hexokinase]]
	[[Category: Sulfolobus tokodaii]]		[[Category: Sulfolobus tokodaii]]
-	[[Category: Fushinobu, S.]]	+	[[Category: Fushinobu, S]]
-	[[Category: Nishimasu, H.]]	+	[[Category: Nishimasu, H]]
-	[[Category: Shoun, H.]]	+	[[Category: Shoun, H]]
-	[[Category: Wakagi, T.]]	+	[[Category: Wakagi, T]]
	[[Category: Acetate and sugar kinase]]		[[Category: Acetate and sugar kinase]]
	[[Category: Actin superfamily]]		[[Category: Actin superfamily]]
	[[Category: Conformational change]]		[[Category: Conformational change]]
	[[Category: Glucose]]		[[Category: Glucose]]
-	[[Category: Hexokinase]]
	[[Category: Hsp70]]		[[Category: Hsp70]]
	[[Category: N-acetylglucosamine]]		[[Category: N-acetylglucosamine]]

OCA at 05:16, 29 September 2014

OCA — Mon, 29 Sep 2014 05:16:45 GMT

←Older revision		Revision as of 05:16, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2e2o.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of Sulfolobus tokodaii hexokinase in complex with glucose==
		+	<StructureSection load='2e2o' size='340' side='right' caption='[[2e2o]], [[Resolution\|resolution]] 1.65Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2e2o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_tokodaii Sulfolobus tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E2O FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2e2n\|2e2n]], [[2e2p\|2e2p]], [[2e2q\|2e2q]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hexokinase Hexokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.1 2.7.1.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e2o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e2o RCSB], [http://www.ebi.ac.uk/pdbsum/2e2o PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e2/2e2o_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Hexokinase catalyzes the phosphorylation of glucose to glucose 6-phosphate by using ATP as a phosphoryl donor. Recently, we identified and characterized an ATP-dependent hexokinase (StHK) from the hyperthermophilic archaeon Sulfolobus tokodaii, which can phosphorylate a broad range of sugar substrates, including glucose, mannose, glucosamine, and N-acetylglucosamine. Here we present the crystal structures of StHK in four different forms: (i) apo-form, (ii) binary complex with glucose, (iii) binary complex with ADP, and (iv) quaternary complex with xylose, Mg(2+), and ADP. Forms i and iii are in the open state, and forms ii and iv are in the closed state, indicating that sugar binding induces a large conformational change, whereas ADP binding does not. The four different crystal structures of the same enzyme provide "snapshots" of the conformational changes during the catalytic cycle. StHK exhibits a core fold characteristic of the hexokinase family, but the structures of several loop regions responsible for substrate binding are significantly different from those of other known hexokinase family members. Structural comparison of StHK with human N-acetylglucosamine kinase and other hexokinases provides an explanation for the ability of StHK to phosphorylate both glucose and N-acetylglucosamine. A Mg(2+) ion and coordinating water molecules are well defined in the electron density of the quaternary complex structure. This structure represents the first direct visualization of the binding mode for magnesium to hexokinase and thus allows for a better understanding of the catalytic mechanism proposed for the entire hexokinase family.

-	~~{{STRUCTURE_2e2o\| PDB=2e2o \| SCENE= }}~~	+	Crystal structures of an ATP-dependent hexokinase with broad substrate specificity from the hyperthermophilic archaeon Sulfolobus tokodaii.,Nishimasu H, Fushinobu S, Shoun H, Wakagi T J Biol Chem. 2007 Mar 30;282(13):9923-31. Epub 2007 Jan 17. PMID:17229727<ref>PMID:17229727</ref>

-	~~===Crystal structure~~ of ~~Sulfolobus tokodaii hexokinase in complex with glucose===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17229727}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2e2o]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Sulfolobus_tokodaii Sulfolobus tokodaii]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2E2O OCA].~~	+

	==See Also==		==See Also==
	*[[Hexokinase\|Hexokinase]]		*[[Hexokinase\|Hexokinase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:017229727<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Hexokinase]]		[[Category: Hexokinase]]
	[[Category: Sulfolobus tokodaii]]		[[Category: Sulfolobus tokodaii]]

OCA at 08:56, 20 October 2012

OCA — Sat, 20 Oct 2012 08:56:38 GMT

←Older revision		Revision as of 08:56, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2e2o]] is a 1 chain structure ~~of [[Hexokinase]]~~ with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_tokodaii Sulfolobus tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2O OCA].	+	[[2e2o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_tokodaii Sulfolobus tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2O OCA].

	==See Also==		==See Also==

OCA: Protected "2e2o" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 21:16:41 GMT

Protected "2e2o" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:16, 25 July 2012

OCA at 21:16, 25 July 2012

OCA — Wed, 25 Jul 2012 21:16:40 GMT

←Older revision		Revision as of 21:16, 25 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2e2o.png\|left\|200px]]		[[Image:2e2o.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2e2o", creates the "Structure Box" on the page.
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-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_2e2o\| PDB=2e2o \| SCENE= }}		{{STRUCTURE_2e2o\| PDB=2e2o \| SCENE= }}

	===Crystal structure of Sulfolobus tokodaii hexokinase in complex with glucose===		===Crystal structure of Sulfolobus tokodaii hexokinase in complex with glucose===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17229727}}, adds the Publication Abstract to the page
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	{{ABSTRACT_PUBMED_17229727}}		{{ABSTRACT_PUBMED_17229727}}

	==About this Structure==		==About this Structure==
-	~~2E2O~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Sulfolobus_tokodaii Sulfolobus tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2O OCA].	+	[[2e2o]] is a 1 chain structure of [[Hexokinase]] with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_tokodaii Sulfolobus tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2O OCA].
		+
		+	==See Also==
		+	*[[Hexokinase\|Hexokinase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17229727~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017229727</ref><references group="xtra"/>
	[[Category: Hexokinase]]		[[Category: Hexokinase]]
	[[Category: Sulfolobus tokodaii]]		[[Category: Sulfolobus tokodaii]]
Line 41:		Line 32:
	[[Category: Sugar kinase]]		[[Category: Sugar kinase]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 20 15:45:55 2009''