2e5n - Revision history

OCA at 18:47, 29 May 2024

OCA — Wed, 29 May 2024 18:47:18 GMT

←Older revision		Revision as of 18:47, 29 May 2024
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	==Solution structure of the ELL_N2 domain of target of RNA polymerase II elongation factor ELL2==		==Solution structure of the ELL_N2 domain of target of RNA polymerase II elongation factor ELL2==
-	<StructureSection load='2e5n' size='340' side='right'caption='[[2e5n~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2e5n' size='340' side='right'caption='[[2e5n]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2e5n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E5N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2e5n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E5N FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>ELL2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5n OCA], [https://pdbe.org/2e5n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e5n RCSB], [https://www.ebi.ac.uk/pdbsum/2e5n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e5n ProSAT], [https://www.topsan.org/Proteins/RSGI/2e5n TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5n OCA], [https://pdbe.org/2e5n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e5n RCSB], [https://www.ebi.ac.uk/pdbsum/2e5n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e5n ProSAT], [https://www.topsan.org/Proteins/RSGI/2e5n TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ELL2_HUMAN ELL2_HUMAN]] Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression.<ref>PMID:20471948</ref> <ref>PMID:20159561</ref> <ref>PMID:23251033</ref>	+	[https://www.uniprot.org/uniprot/ELL2_HUMAN ELL2_HUMAN] Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression.<ref>PMID:20471948</ref> <ref>PMID:20159561</ref> <ref>PMID:23251033</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dang, W]]	+	[[Category: Dang W]]
-	[[Category: Inoue, M]]	+	[[Category: Inoue M]]
-	[[Category: Kigawa, T]]	+	[[Category: Kigawa T]]
-	[[Category: Muto, Y]]	+	[[Category: Muto Y]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Shirouzu M]]
-	[[Category: Shirouzu, M]]	+	[[Category: Terada T]]
-	[[Category: Terada, T]]	+	[[Category: Yokoyama S]]
-	[[Category: Yokoyama, S]]	+
-	~~[[Category: Ell_n2 domain]]~~	+
-	~~[[Category: National project on protein structural and functional analyse]]~~	+
-	~~[[Category: Nppsfa]]~~	+
-	~~[[Category: Rna polymerase ii elongation factor ell2]]~~	+
-	~~[[Category: Rsgi]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 11:48, 10 February 2021

OCA — Wed, 10 Feb 2021 11:48:25 GMT

←Older revision		Revision as of 11:48, 10 February 2021
Line 1:		Line 1:

	==Solution structure of the ELL_N2 domain of target of RNA polymerase II elongation factor ELL2==		==Solution structure of the ELL_N2 domain of target of RNA polymerase II elongation factor ELL2==
-	<StructureSection load='2e5n' size='340' side='right' caption='[[2e5n]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2e5n' size='340' side='right'caption='[[2e5n]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2e5n]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5N OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2E5N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2e5n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E5N FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ELL2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ELL2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2e5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5n OCA], [~~http~~://pdbe.org/2e5n PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2e5n RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2e5n PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2e5n ProSAT], [~~http~~://www.topsan.org/Proteins/RSGI/2e5n TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5n OCA], [https://pdbe.org/2e5n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e5n RCSB], [https://www.ebi.ac.uk/pdbsum/2e5n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e5n ProSAT], [https://www.topsan.org/Proteins/RSGI/2e5n TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ELL2_HUMAN ELL2_HUMAN]] Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression.<ref>PMID:20471948</ref> <ref>PMID:20159561</ref> <ref>PMID:23251033</ref>	+	[[https://www.uniprot.org/uniprot/ELL2_HUMAN ELL2_HUMAN]] Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression.<ref>PMID:20471948</ref> <ref>PMID:20159561</ref> <ref>PMID:23251033</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Elongation factor\|Elongation factor]]	+	*[[Elongation factor 3D structures\|Elongation factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Dang, W]]		[[Category: Dang, W]]
	[[Category: Inoue, M]]		[[Category: Inoue, M]]

OCA at 06:49, 6 June 2018

OCA — Wed, 06 Jun 2018 06:49:42 GMT

←Older revision		Revision as of 06:49, 6 June 2018
Line 1:		Line 1:
		+
	==Solution structure of the ELL_N2 domain of target of RNA polymerase II elongation factor ELL2==		==Solution structure of the ELL_N2 domain of target of RNA polymerase II elongation factor ELL2==
	<StructureSection load='2e5n' size='340' side='right' caption='[[2e5n]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2e5n' size='340' side='right' caption='[[2e5n]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2e5n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E5N FirstGlance]. <br>		<table><tr><td colspan='2'>[[2e5n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E5N FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ELL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ELL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5n OCA], [http://pdbe.org/2e5n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2e5n RCSB], [http://www.ebi.ac.uk/pdbsum/2e5n PDBsum], [http://www.topsan.org/Proteins/RSGI/2e5n TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5n OCA], [http://pdbe.org/2e5n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2e5n RCSB], [http://www.ebi.ac.uk/pdbsum/2e5n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2e5n ProSAT], [http://www.topsan.org/Proteins/RSGI/2e5n TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e5/2e5n_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e5/2e5n_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 20:31, 9 February 2016

OCA — Tue, 09 Feb 2016 20:31:20 GMT

←Older revision		Revision as of 20:31, 9 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e5n ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

OCA at 01:47, 11 September 2015

OCA — Fri, 11 Sep 2015 01:47:02 GMT

←Older revision		Revision as of 01:47, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2e5n' size='340' side='right' caption='[[2e5n]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2e5n' size='340' side='right' caption='[[2e5n]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2e5n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E5N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2e5n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E5N FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ELL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ELL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e5n RCSB], [http://www.ebi.ac.uk/pdbsum/2e5n PDBsum], [http://www.topsan.org/Proteins/RSGI/2e5n TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5n OCA], [http://pdbe.org/2e5n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2e5n RCSB], [http://www.ebi.ac.uk/pdbsum/2e5n PDBsum], [http://www.topsan.org/Proteins/RSGI/2e5n TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Dang, W]]		[[Category: Dang, W]]
	[[Category: Inoue, M]]		[[Category: Inoue, M]]

OCA at 09:21, 25 December 2014

OCA — Thu, 25 Dec 2014 09:21:33 GMT

←Older revision		Revision as of 09:21, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2e5n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E5N FirstGlance]. <br>		<table><tr><td colspan='2'>[[2e5n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E5N FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ELL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ELL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e5n RCSB], [http://www.ebi.ac.uk/pdbsum/2e5n PDBsum], [http://www.topsan.org/Proteins/RSGI/2e5n TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e5n RCSB], [http://www.ebi.ac.uk/pdbsum/2e5n PDBsum], [http://www.topsan.org/Proteins/RSGI/2e5n TOPSAN]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ELL2_HUMAN ELL2_HUMAN]] Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression.<ref>PMID:20471948</ref> <ref>PMID:20159561</ref> <ref>PMID:23251033</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 21:
	==See Also==		==See Also==
	*[[Elongation factor\|Elongation factor]]		*[[Elongation factor\|Elongation factor]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Dang, W.]]	+	[[Category: Dang, W]]
-	[[Category: Inoue, M.]]	+	[[Category: Inoue, M]]
-	[[Category: Kigawa, T.]]	+	[[Category: Kigawa, T]]
-	[[Category: Muto, Y.]]	+	[[Category: Muto, Y]]
-	[[Category: ~~RSGI, RIKEN~~ Structural ~~Genomics/Proteomics Initiative.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Shirouzu, M.]]	+	[[Category: Shirouzu, M]]
-	[[Category: Terada, T.]]	+	[[Category: Terada, T]]
-	[[Category: Yokoyama, S.]]	+	[[Category: Yokoyama, S]]
	[[Category: Ell_n2 domain]]		[[Category: Ell_n2 domain]]
	[[Category: National project on protein structural and functional analyse]]		[[Category: National project on protein structural and functional analyse]]
	[[Category: Nppsfa]]		[[Category: Nppsfa]]
-	[[Category: Riken structural genomics/proteomics initiative]]
	[[Category: Rna polymerase ii elongation factor ell2]]		[[Category: Rna polymerase ii elongation factor ell2]]
	[[Category: Rsgi]]		[[Category: Rsgi]]
-	[[Category: Structural genomic]]
	[[Category: Transcription]]		[[Category: Transcription]]

OCA at 04:37, 29 September 2014

OCA — Mon, 29 Sep 2014 04:37:42 GMT

←Older revision		Revision as of 04:37, 29 September 2014
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-	~~[[Image:2e5n.png\|left\|200px]]~~	+	==Solution structure of the ELL_N2 domain of target of RNA polymerase II elongation factor ELL2==
-		+	<StructureSection load='2e5n' size='340' side='right' caption='[[2e5n]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~{{STRUCTURE_2e5n\| PDB=2e5n \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2e5n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E5N FirstGlance]. <br>
-	===Solution structure of the ELL_N2 domain of target of RNA polymerase II elongation factor ELL2===	+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ELL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e5n RCSB], [http://www.ebi.ac.uk/pdbsum/2e5n PDBsum], [http://www.topsan.org/Proteins/RSGI/2e5n TOPSAN]</span></td></tr>
-		+	<table>
-	==~~About this Structure~~==	+	== Evolutionary Conservation ==
-	[[2e5n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5N OCA].	+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e5/2e5n_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>

	==See Also==		==See Also==
	*[[Elongation factor\|Elongation factor]]		*[[Elongation factor\|Elongation factor]]
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Dang, W.]]		[[Category: Dang, W.]]

OCA: Protected "2e5n" [edit=sysop:move=sysop]

OCA — Sat, 20 Oct 2012 15:02:58 GMT

Protected "2e5n" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:02, 20 October 2012

OCA at 15:02, 20 October 2012

OCA — Sat, 20 Oct 2012 15:02:56 GMT

←Older revision		Revision as of 15:02, 20 October 2012
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-	{{Seed}}
	[[Image:2e5n.png\|left\|200px]]		[[Image:2e5n.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2e5n", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2e5n\| PDB=2e5n \| SCENE= }}		{{STRUCTURE_2e5n\| PDB=2e5n \| SCENE= }}

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	==About this Structure==		==About this Structure==
-	~~2E5N~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5N OCA].	+	[[2e5n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5N OCA].
		+
		+	==See Also==
		+	*[[Elongation factor\|Elongation factor]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Dang, W.]]		[[Category: Dang, W.]]
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	[[Category: Ell_n2 domain]]		[[Category: Ell_n2 domain]]
	[[Category: National project on protein structural and functional analyse]]		[[Category: National project on protein structural and functional analyse]]
-	[[Category: Nmr]]
	[[Category: Nppsfa]]		[[Category: Nppsfa]]
	[[Category: Riken structural genomics/proteomics initiative]]		[[Category: Riken structural genomics/proteomics initiative]]
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	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Transcription]]		[[Category: Transcription]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 13 10:08:29 2009''

OCA at 07:08, 13 May 2009

OCA — Wed, 13 May 2009 07:08:30 GMT

←Older revision		Revision as of 07:08, 13 May 2009
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	==About this Structure==		==About this Structure==
-	2E5N is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full ~~experimental~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5N OCA].	+	2E5N is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5N OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Dang, W.]]		[[Category: Dang, W.]]
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	[[Category: Rsgi]]		[[Category: Rsgi]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
		+	[[Category: Transcription]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Nov 16 15:~~10:~~39 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 13 10:08:29 2009''