2eak - Revision history

OCA at 17:22, 15 December 2021

OCA — Wed, 15 Dec 2021 17:22:43 GMT

←Older revision		Revision as of 17:22, 15 December 2021
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	<StructureSection load='2eak' size='340' side='right'caption='[[2eak]], [[Resolution\|resolution]] 1.97Å' scene=''>		<StructureSection load='2eak' size='340' side='right'caption='[[2eak]], [[Resolution\|resolution]] 1.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2eak]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EAK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2EAK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2eak]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EAK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EAK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTV:(2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL'>DTV</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=~~LBT~~:~~ALPHA~~-~~LACTOSE~~'>~~LBT~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTV:(2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL'>DTV</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2eag\|2eag]], [[2eah\|2eah]], [[2eai\|2eai]], [[2eaj\|2eaj]], [[2eal\|2eal]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2eag\|2eag]], [[2eah\|2eah]], [[2eai\|2eai]], [[2eaj\|2eaj]], [[2eal\|2eal]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2eak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eak OCA], [~~http~~://pdbe.org/2eak PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2eak RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2eak PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2eak ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eak OCA], [https://pdbe.org/2eak PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eak RCSB], [https://www.ebi.ac.uk/pdbsum/2eak PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eak ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/LEG9_HUMAN LEG9_HUMAN]] Binds galactosides. Has high affinity for the Forssman pentasaccharide. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Inhibits cell proliferation. It is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death. Isoform Short acts as an eosinophil chemoattractant.<ref>PMID:16286920</ref> <ref>PMID:18005988</ref> <ref>PMID:18977853</ref>	+	[[https://www.uniprot.org/uniprot/LEG9_HUMAN LEG9_HUMAN]] Binds galactosides. Has high affinity for the Forssman pentasaccharide. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Inhibits cell proliferation. It is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death. Isoform Short acts as an eosinophil chemoattractant.<ref>PMID:16286920</ref> <ref>PMID:18005988</ref> <ref>PMID:18977853</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:30, 11 March 2020

OCA — Wed, 11 Mar 2020 08:30:35 GMT

←Older revision		Revision as of 08:30, 11 March 2020
Line 1:		Line 1:

	==Crystal structure of human galectin-9 N-terminal CRD in complex with lactose==		==Crystal structure of human galectin-9 N-terminal CRD in complex with lactose==
-	<StructureSection load='2eak' size='340' side='right' caption='[[2eak]], [[Resolution\|resolution]] 1.97Å' scene=''>	+	<StructureSection load='2eak' size='340' side='right'caption='[[2eak]], [[Resolution\|resolution]] 1.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2eak]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EAK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EAK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2eak]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EAK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EAK FirstGlance]. <br>
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Galectin\|Galectin]]	+	*[[Galectin 3D structures\|Galectin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Hirabayashi, J]]		[[Category: Hirabayashi, J]]
	[[Category: Kato, R]]		[[Category: Kato, R]]

OCA at 06:42, 6 June 2018

OCA — Wed, 06 Jun 2018 06:42:31 GMT

←Older revision		Revision as of 06:42, 6 June 2018
Line 1:		Line 1:
		+
	==Crystal structure of human galectin-9 N-terminal CRD in complex with lactose==		==Crystal structure of human galectin-9 N-terminal CRD in complex with lactose==
	<StructureSection load='2eak' size='340' side='right' caption='[[2eak]], [[Resolution\|resolution]] 1.97Å' scene=''>		<StructureSection load='2eak' size='340' side='right' caption='[[2eak]], [[Resolution\|resolution]] 1.97Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTV:(2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL'>DTV</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LBT:ALPHA-LACTOSE'>LBT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTV:(2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL'>DTV</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LBT:ALPHA-LACTOSE'>LBT</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2eag\|2eag]], [[2eah\|2eah]], [[2eai\|2eai]], [[2eaj\|2eaj]], [[2eal\|2eal]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2eag\|2eag]], [[2eah\|2eah]], [[2eai\|2eai]], [[2eaj\|2eaj]], [[2eal\|2eal]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eak OCA], [http://pdbe.org/2eak PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2eak RCSB], [http://www.ebi.ac.uk/pdbsum/2eak PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eak OCA], [http://pdbe.org/2eak PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2eak RCSB], [http://www.ebi.ac.uk/pdbsum/2eak PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2eak ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ea/2eak_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ea/2eak_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2eak ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 12:50, 11 September 2015

OCA — Fri, 11 Sep 2015 12:50:18 GMT

←Older revision		Revision as of 12:50, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2eak' size='340' side='right' caption='[[2eak]], [[Resolution\|resolution]] 1.97Å' scene=''>		<StructureSection load='2eak' size='340' side='right' caption='[[2eak]], [[Resolution\|resolution]] 1.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2eak]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EAK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EAK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2eak]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EAK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EAK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTV:(2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL'>DTV</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LBT:ALPHA-LACTOSE'>LBT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTV:(2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL'>DTV</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LBT:ALPHA-LACTOSE'>LBT</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2eag\|2eag]], [[2eah\|2eah]], [[2eai\|2eai]], [[2eaj\|2eaj]], [[2eal\|2eal]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2eag\|2eag]], [[2eah\|2eah]], [[2eai\|2eai]], [[2eaj\|2eaj]], [[2eal\|2eal]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eak OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2eak RCSB], [http://www.ebi.ac.uk/pdbsum/2eak PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eak OCA], [http://pdbe.org/2eak PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2eak RCSB], [http://www.ebi.ac.uk/pdbsum/2eak PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2eak" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Hirabayashi, J]]		[[Category: Hirabayashi, J]]
	[[Category: Kato, R]]		[[Category: Kato, R]]

OCA at 16:41, 25 December 2014

OCA — Thu, 25 Dec 2014 16:41:32 GMT

←Older revision		Revision as of 16:41, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2eak]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EAK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EAK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2eak]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EAK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EAK FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTV:(2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL'>DTV</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LBT:ALPHA-LACTOSE'>LBT</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTV:(2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL'>DTV</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LBT:ALPHA-LACTOSE'>LBT</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2eag\|2eag]], [[2eah\|2eah]], [[2eai\|2eai]], [[2eaj\|2eaj]], [[2eal\|2eal]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2eag\|2eag]], [[2eah\|2eah]], [[2eai\|2eai]], [[2eaj\|2eaj]], [[2eal\|2eal]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eak OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2eak RCSB], [http://www.ebi.ac.uk/pdbsum/2eak PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eak OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2eak RCSB], [http://www.ebi.ac.uk/pdbsum/2eak PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LEG9_HUMAN LEG9_HUMAN]] Binds galactosides. Has high affinity for the Forssman pentasaccharide. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Inhibits cell proliferation. It is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death. Isoform Short acts as an eosinophil chemoattractant.<ref>PMID:16286920</ref> <ref>PMID:18005988</ref> <ref>PMID:18977853</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Hirabayashi, J.]]	+	[[Category: Hirabayashi, J]]
-	[[Category: Kato, R.]]	+	[[Category: Kato, R]]
-	[[Category: Nagae, M.]]	+	[[Category: Nagae, M]]
-	[[Category: Nakamura, T.]]	+	[[Category: Nakamura, T]]
-	[[Category: Nakamura-Tsuruta, S.]]	+	[[Category: Nakamura-Tsuruta, S]]
-	[[Category: Nishi, N.]]	+	[[Category: Nishi, N]]
-	[[Category: Wakatsuki, S.]]	+	[[Category: Wakatsuki, S]]
	[[Category: Beta sandwich]]		[[Category: Beta sandwich]]
	[[Category: Carbohydrate binding protein]]		[[Category: Carbohydrate binding protein]]
	[[Category: Galectin]]		[[Category: Galectin]]
	[[Category: Sugar binding protein]]		[[Category: Sugar binding protein]]

OCA at 03:57, 29 September 2014

OCA — Mon, 29 Sep 2014 03:57:40 GMT

←Older revision		Revision as of 03:57, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2eak.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of human galectin-9 N-terminal CRD in complex with lactose==
		+	<StructureSection load='2eak' size='340' side='right' caption='[[2eak]], [[Resolution\|resolution]] 1.97Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2eak]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EAK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EAK FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTV:(2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL'>DTV</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LBT:ALPHA-LACTOSE'>LBT</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2eag\|2eag]], [[2eah\|2eah]], [[2eai\|2eai]], [[2eaj\|2eaj]], [[2eal\|2eal]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eak OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2eak RCSB], [http://www.ebi.ac.uk/pdbsum/2eak PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ea/2eak_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Galectins are a family of beta-galactoside-binding lectins that contain a conserved carbohydrate recognition domain (CRD). They exhibit high affinities for small beta-galactosides as well as variable binding specificities for complex glycoconjugates. Structural and biochemical analyses of the mechanism governing specific carbohydrate recognition provide a useful template to elucidate the function of these proteins. Here we report the crystal structures of the human galectin-9 N-terminal CRD (NCRD) in the presence of lactose and Forssman pentasaccharide. Mouse galectin-9 NCRD, the structure of which was previously solved by our group, forms a non-canonical dimer in both the crystal state and in solution. Human galectin-9 NCRD, however, exists as a monomer in crystals, despite a high sequence identity to the mouse homologue. Comparative frontal affinity chromatography analysis of the mouse and human galectin-9 NCRDs revealed different carbohydrate binding specificities, with disparate affinities for complex glycoconjugates. Human galectin-9 NCRD exhibited a high affinity for Forssman pentasaccharide; the association constant for mouse galectin-9 NCRD was 100-fold less than that observed for the human protein. The combination of structural data with mutational studies demonstrated that non-conserved amino acid residues on the concave surface were important for determination of target specificities. The human galectin-9 NCRD exhibited greater inhibition of cell proliferation than the mouse NCRD. We discuss the biochemical and structural differences between highly homologous proteins from different species.

-	~~{{STRUCTURE_2eak\| PDB=2eak \| SCENE= }}~~	+	Structural analysis of the human galectin-9 N-terminal carbohydrate recognition domain reveals unexpected properties that differ from the mouse orthologue.,Nagae M, Nishi N, Nakamura-Tsuruta S, Hirabayashi J, Wakatsuki S, Kato R J Mol Biol. 2008 Jan 4;375(1):119-35. Epub 2007 Sep 26. PMID:18005988<ref>PMID:18005988</ref>

-	~~===Crystal structure~~ of ~~human galectin-9 N-terminal CRD in complex with lactose===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18005988}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2eak]] is a 3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2EAK OCA].~~	+

	==See Also==		==See Also==
	*[[Galectin\|Galectin]]		*[[Galectin\|Galectin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:018005988<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hirabayashi, J.]]		[[Category: Hirabayashi, J.]]

OCA at 19:01, 20 October 2012

OCA — Sat, 20 Oct 2012 19:01:40 GMT

←Older revision		Revision as of 19:01, 20 October 2012
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	[[Image:2eak.png\|left\|200px]]		[[Image:2eak.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_2eak\| PDB=2eak \| SCENE= }}		{{STRUCTURE_2eak\| PDB=2eak \| SCENE= }}

	===Crystal structure of human galectin-9 N-terminal CRD in complex with lactose===		===Crystal structure of human galectin-9 N-terminal CRD in complex with lactose===

-
-	<!--
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	{{ABSTRACT_PUBMED_18005988}}		{{ABSTRACT_PUBMED_18005988}}

	==About this Structure==		==About this Structure==
	[[2eak]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EAK OCA].		[[2eak]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EAK OCA].
		+
		+	==See Also==
		+	*[[Galectin\|Galectin]]

	==Reference==		==Reference==

OCA: Protected "2eak" [edit=sysop:move=sysop]

OCA — Wed, 22 Feb 2012 06:53:49 GMT

Protected "2eak" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:53, 22 February 2012

OCA at 06:53, 22 February 2012

OCA — Wed, 22 Feb 2012 06:53:48 GMT

←Older revision		Revision as of 06:53, 22 February 2012
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	[[Image:2eak.png\|left\|200px]]		[[Image:2eak.png\|left\|200px]]

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	===Crystal structure of human galectin-9 N-terminal CRD in complex with lactose===		===Crystal structure of human galectin-9 N-terminal CRD in complex with lactose===

		+
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		+	The line below this paragraph, {{ABSTRACT_PUBMED_18005988}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18005988 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18005988}}

	==About this Structure==		==About this Structure==
-	~~2EAK~~ is a 3 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EAK OCA].	+	[[2eak]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EAK OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:018005988</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hirabayashi, J.]]		[[Category: Hirabayashi, J.]]
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	[[Category: Galectin]]		[[Category: Galectin]]
	[[Category: Sugar binding protein]]		[[Category: Sugar binding protein]]
-
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OCA at 20:01, 17 February 2009

OCA — Tue, 17 Feb 2009 20:01:56 GMT

←Older revision		Revision as of 20:01, 17 February 2009
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-	~~'''~~Crystal structure of human galectin-9 N-terminal CRD in complex with lactose~~'''~~	+	===Crystal structure of human galectin-9 N-terminal CRD in complex with lactose===


	==About this Structure==		==About this Structure==
-	2EAK is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EAK OCA].	+	2EAK is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EAK OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Hirabayashi, J.]]		[[Category: Hirabayashi, J.]]
	[[Category: Kato, R.]]		[[Category: Kato, R.]]
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	[[Category: Galectin]]		[[Category: Galectin]]
	[[Category: Sugar binding protein]]		[[Category: Sugar binding protein]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 02~~:14:~~29 2008~~''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 22:01:55 2009''